DE60023187D1 - Herstellung und reinigung von mycophenolsäure - Google Patents
Herstellung und reinigung von mycophenolsäureInfo
- Publication number
- DE60023187D1 DE60023187D1 DE60023187T DE60023187T DE60023187D1 DE 60023187 D1 DE60023187 D1 DE 60023187D1 DE 60023187 T DE60023187 T DE 60023187T DE 60023187 T DE60023187 T DE 60023187T DE 60023187 D1 DE60023187 D1 DE 60023187D1
- Authority
- DE
- Germany
- Prior art keywords
- mycophenolic acid
- purification
- preparation
- campactum
- pencillium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 title abstract 2
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title abstract 2
- 229960000951 mycophenolic acid Drugs 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2000/000017 WO2001064931A1 (en) | 2000-02-29 | 2000-02-29 | Manufacture and purification of mycophenolic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60023187D1 true DE60023187D1 (de) | 2006-02-23 |
Family
ID=11076227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60023187T Expired - Lifetime DE60023187D1 (de) | 2000-02-29 | 2000-02-29 | Herstellung und reinigung von mycophenolsäure |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6927047B1 (de) |
| EP (1) | EP1259631B1 (de) |
| JP (1) | JP2003525052A (de) |
| AT (1) | ATE306557T1 (de) |
| AU (1) | AU2000233225A1 (de) |
| CA (1) | CA2401699A1 (de) |
| CZ (1) | CZ20022913A3 (de) |
| DE (1) | DE60023187D1 (de) |
| WO (1) | WO2001064931A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0124953D0 (en) * | 2001-10-17 | 2001-12-05 | Novartis Ag | Organic Compounds |
| MXPA06005659A (es) * | 2004-04-26 | 2007-04-10 | Teva Gyogyszergyar Zartkoruen | Proceso para preparacion de acido micofenolico y derivados de ester del mismo. |
| CA2555461A1 (en) | 2004-04-27 | 2005-11-10 | Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
| CN101014584A (zh) | 2004-07-20 | 2007-08-08 | 特瓦药厂私人有限公司 | 结晶霉酚酸钠的制备方法 |
| US20080293110A1 (en) * | 2004-09-10 | 2008-11-27 | Ivax Pharmaceuticals S.R.O. | Process for Isolation of Mycophenolic Acid |
| EP1873235A1 (de) * | 2006-06-26 | 2008-01-02 | Universita' degli Studi di Milano | Verfahren zur Herstellung von Penicillium-Sporen und deren Verwendung in der Nahrungsmittelindustrie |
| EP2032712B1 (de) * | 2006-06-29 | 2010-02-10 | Ivax Pharmaceuticals S.R.O. | Regulation der säuremetabolitproduktion |
| WO2008127663A1 (en) * | 2007-04-11 | 2008-10-23 | Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság | Method for reducing impurity level in mycophenolic acid fermentation |
| WO2008125616A2 (en) * | 2007-04-12 | 2008-10-23 | Dsm Ip Assets B.V. | Method for the purification of bio-molecules |
| CN101348810B (zh) * | 2008-09-02 | 2011-12-21 | 天津北洋百川生物技术有限公司 | 麦考酚酸的固态发酵方法 |
| CN108727318A (zh) * | 2017-04-25 | 2018-11-02 | 鲁南制药集团股份有限公司 | 麦考酚酸的晶型物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH469806A (fr) * | 1966-12-01 | 1969-03-15 | Afico Sa | Procédé de fermentation et fermenteur pour la mise en oeuvre de ce procédé |
| US4212949A (en) * | 1978-08-21 | 1980-07-15 | Golger Leonid I | Apparatus for cultivating microorganisms |
| US4452891A (en) | 1980-09-08 | 1984-06-05 | Ajinomoto Company Incorporated | Method for production of mycophenolic acid by fermentation |
| PL188683B1 (pl) * | 1998-04-30 | 2005-03-31 | Prophyta Biolog Pflanzenschutz | Sposób fermentacji na podłożu stałym oraz fermentor z podłożem stałym |
| US6197573B1 (en) * | 1998-11-17 | 2001-03-06 | Biocon India Limited | Solid state fermentation |
-
2000
- 2000-02-29 AU AU2000233225A patent/AU2000233225A1/en not_active Abandoned
- 2000-02-29 US US10/220,225 patent/US6927047B1/en not_active Expired - Fee Related
- 2000-02-29 EP EP00911239A patent/EP1259631B1/de not_active Expired - Lifetime
- 2000-02-29 JP JP2001563619A patent/JP2003525052A/ja active Pending
- 2000-02-29 WO PCT/IN2000/000017 patent/WO2001064931A1/en active IP Right Grant
- 2000-02-29 CA CA002401699A patent/CA2401699A1/en not_active Abandoned
- 2000-02-29 CZ CZ20022913A patent/CZ20022913A3/cs unknown
- 2000-02-29 AT AT00911239T patent/ATE306557T1/de not_active IP Right Cessation
- 2000-02-29 DE DE60023187T patent/DE60023187D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1259631A1 (de) | 2002-11-27 |
| ATE306557T1 (de) | 2005-10-15 |
| AU2000233225A1 (en) | 2001-09-12 |
| US6927047B1 (en) | 2005-08-09 |
| WO2001064931A1 (en) | 2001-09-07 |
| CZ20022913A3 (cs) | 2003-02-12 |
| CA2401699A1 (en) | 2001-09-07 |
| JP2003525052A (ja) | 2003-08-26 |
| EP1259631B1 (de) | 2005-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |