DE60017461D1 - APPARATUS AND METHOD FOR THE MANUFACTURE OF MICROPARTICLES BASED ON IN-LINE SOLVENT EXTRACTION - Google Patents

APPARATUS AND METHOD FOR THE MANUFACTURE OF MICROPARTICLES BASED ON IN-LINE SOLVENT EXTRACTION

Info

Publication number
DE60017461D1
DE60017461D1 DE60017461T DE60017461T DE60017461D1 DE 60017461 D1 DE60017461 D1 DE 60017461D1 DE 60017461 T DE60017461 T DE 60017461T DE 60017461 T DE60017461 T DE 60017461T DE 60017461 D1 DE60017461 D1 DE 60017461D1
Authority
DE
Germany
Prior art keywords
static mixer
solvent extraction
manufacture
line solvent
microparticles based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017461T
Other languages
German (de)
Other versions
DE60017461T2 (en
Inventor
L Lyons
G Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Alkermes Controlled Therapeutics Inc II
Original Assignee
Alkermes Inc
Alkermes Controlled Therapeutics Inc II
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc, Alkermes Controlled Therapeutics Inc II filed Critical Alkermes Inc
Application granted granted Critical
Publication of DE60017461D1 publication Critical patent/DE60017461D1/en
Publication of DE60017461T2 publication Critical patent/DE60017461T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Abstract

Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.
DE60017461T 1999-11-12 2000-11-03 APPARATUS AND METHOD FOR THE MANUFACTURE OF MICROPARTICLES BASED ON IN-LINE SOLVENT EXTRACTION Expired - Lifetime DE60017461T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US438656 1989-11-17
US09/438,656 US6495166B1 (en) 1999-11-12 1999-11-12 Apparatus and method for preparing microparticles using in-line solvent extraction
PCT/US2000/041845 WO2001034120A1 (en) 1999-11-12 2000-11-03 Apparatus and method for preparing microparticles using in-line solvent extraction

Publications (2)

Publication Number Publication Date
DE60017461D1 true DE60017461D1 (en) 2005-02-17
DE60017461T2 DE60017461T2 (en) 2005-12-22

Family

ID=23741486

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60017461T Expired - Lifetime DE60017461T2 (en) 1999-11-12 2000-11-03 APPARATUS AND METHOD FOR THE MANUFACTURE OF MICROPARTICLES BASED ON IN-LINE SOLVENT EXTRACTION

Country Status (11)

Country Link
US (1) US6495166B1 (en)
EP (1) EP1242053B1 (en)
JP (1) JP4838471B2 (en)
AT (1) ATE286722T1 (en)
AU (1) AU773734B2 (en)
CA (1) CA2390563C (en)
DE (1) DE60017461T2 (en)
DK (1) DK1242053T3 (en)
ES (1) ES2236035T3 (en)
PT (1) PT1242053E (en)
WO (1) WO2001034120A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331317B1 (en) * 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles
US6705757B2 (en) * 1999-11-12 2004-03-16 Alkermes Controlled Therapeutics, Inc. Ii Method and apparatus for preparing microparticles using in-line solvent extraction
US6264987B1 (en) * 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
US6932502B2 (en) * 2002-05-01 2005-08-23 Hewlett-Packard Development Company, L.P. Mixing apparatus
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
EP1615959B1 (en) * 2003-04-10 2013-06-05 Evonik Corporation A method for the production of emulsion-based micro particles
EP2444069B1 (en) 2003-07-23 2019-06-05 Evonik Corporation Controlled release compositions
JPWO2005089926A1 (en) * 2004-03-23 2007-08-09 協和醗酵工業株式会社 Method for producing coated fine particles
US20070099947A1 (en) * 2005-11-03 2007-05-03 Alkermes, Inc. Methods and compositions for the treatment of brain reward system disorders by combination therapy
JP5757872B2 (en) * 2008-09-11 2015-08-05 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ Solvent extraction microencapsulation with adjustable extraction rate
US20100143479A1 (en) 2008-12-04 2010-06-10 Oakwood Laboratories, Llc Method of making sustained release microparticles
HUE041981T2 (en) 2010-08-23 2019-06-28 Alkermes Pharma Ireland Ltd Methods for treating antipsychotic-induced weight gain
RU2590928C2 (en) 2010-12-23 2016-07-10 Эвоник Корпорейшн Device and method for preparation of emulsion
KR101543507B1 (en) * 2013-05-15 2015-08-11 씨제이헬스케어 주식회사 A continuous process for preparing microspheres and microspheres prepared thereby
EP3034159B1 (en) * 2014-12-18 2020-11-04 The Procter and Gamble Company Static mixer and method of mixing fluids

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137652C (en) 1962-07-11
BE744162A (en) 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd ENCAPSULATION PROCESS
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2010115A1 (en) 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Process for the production of micro-granules
DE2106526C3 (en) 1971-02-11 1979-03-15 Agfa-Gevaert Ag, 5090 Leverkusen Process and apparatus for the continuous preparation of photographic emulsions
JPS523342B2 (en) 1972-01-26 1977-01-27
GB1413186A (en) 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
US4050676A (en) 1974-04-19 1977-09-27 Yasushi Morishima Mixing device and element therefor
JPS523653A (en) 1975-06-27 1977-01-12 Fuji Photo Film Co Ltd Process for producing fine polymer particles
US4384975A (en) 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
GB8706148D0 (en) * 1987-03-16 1987-04-23 Exxon Chemical Patents Inc Dispersions & emulsions
WO1989003678A1 (en) 1987-10-30 1989-05-05 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
IL92344A0 (en) 1989-01-04 1990-07-26 Gist Brocades Nv Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules
CA2050911C (en) 1989-05-04 1997-07-15 Thomas R. Tice Encapsulation process and products therefrom
US5478564A (en) 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
IT1243390B (en) 1990-11-22 1994-06-10 Vectorpharma Int PHARMACEUTICAL COMPOSITIONS IN THE FORM OF PARTICLES SUITABLE FOR THE CONTROLLED RELEASE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PROCEDURE FOR THEIR PREPARATION.
HU222501B1 (en) 1991-06-28 2003-07-28 Endorecherche Inc. Controlled release pharmaceutical composition containing mpa or mga and process for its preparation
DE669128T1 (en) 1992-11-17 1996-03-14 Yoshitomi Pharmaceutical AN ANTIPSYCHOTIC-CONTAINING MICROBALL FOR DELAYED RELEASE AND METHOD FOR THEIR PRODUCTION.
WO1995013814A1 (en) 1993-11-19 1995-05-26 Janssen Pharmaceutica N.V. Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US5650173A (en) 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
AU684324B2 (en) 1993-11-19 1997-12-11 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US5945126A (en) 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
GB9718986D0 (en) 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
IL135989A0 (en) * 1997-11-14 2001-05-20 Skyepharma Inc Processes for the production of multivesicular liposomes
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
US6331317B1 (en) * 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles

Also Published As

Publication number Publication date
AU773734B2 (en) 2004-06-03
PT1242053E (en) 2005-04-29
WO2001034120A1 (en) 2001-05-17
WO2001034120B1 (en) 2001-12-20
ATE286722T1 (en) 2005-01-15
DE60017461T2 (en) 2005-12-22
AU2750801A (en) 2001-06-06
US6495166B1 (en) 2002-12-17
JP4838471B2 (en) 2011-12-14
EP1242053B1 (en) 2005-01-12
JP2003513905A (en) 2003-04-15
EP1242053A1 (en) 2002-09-25
CA2390563C (en) 2009-02-24
ES2236035T3 (en) 2005-07-16
CA2390563A1 (en) 2001-05-17
DK1242053T3 (en) 2005-05-30

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