DE60011463D1 - Verfahren zur herstellung von 24(s)-hydroxyvitamin d2 - Google Patents

Verfahren zur herstellung von 24(s)-hydroxyvitamin d2

Info

Publication number
DE60011463D1
DE60011463D1 DE60011463T DE60011463T DE60011463D1 DE 60011463 D1 DE60011463 D1 DE 60011463D1 DE 60011463 T DE60011463 T DE 60011463T DE 60011463 T DE60011463 T DE 60011463T DE 60011463 D1 DE60011463 D1 DE 60011463D1
Authority
DE
Germany
Prior art keywords
hydroxyvitamin
producing
making
provides
stereospecific synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60011463T
Other languages
English (en)
Other versions
DE60011463T2 (de
Inventor
Harold Meckler
A Helle
B Geiss
T Gregg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bone Care International Inc
Original Assignee
Bone Care International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bone Care International Inc filed Critical Bone Care International Inc
Application granted granted Critical
Publication of DE60011463D1 publication Critical patent/DE60011463D1/de
Publication of DE60011463T2 publication Critical patent/DE60011463T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60011463T 1999-12-22 2000-12-19 Verfahren zur herstellung von 24(s)-hydroxyvitamin d2 Expired - Lifetime DE60011463T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US470581 1999-12-22
US09/470,581 US6359012B1 (en) 1999-12-22 1999-12-22 Method for making 24(S)-hydroxyvitamin D2
PCT/US2000/034560 WO2001046131A1 (en) 1999-12-22 2000-12-19 Method for making 24(s)-hydroxyvitamin d¿2?

Publications (2)

Publication Number Publication Date
DE60011463D1 true DE60011463D1 (de) 2004-07-15
DE60011463T2 DE60011463T2 (de) 2005-06-30

Family

ID=23868183

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60011463T Expired - Lifetime DE60011463T2 (de) 1999-12-22 2000-12-19 Verfahren zur herstellung von 24(s)-hydroxyvitamin d2

Country Status (8)

Country Link
US (1) US6359012B1 (de)
EP (1) EP1240137B1 (de)
JP (1) JP2003518089A (de)
AT (1) ATE268753T1 (de)
CA (1) CA2394624A1 (de)
DE (1) DE60011463T2 (de)
ES (1) ES2222937T3 (de)
WO (1) WO2001046131A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491712B1 (en) 2007-12-10 2009-02-17 Formosa Laboratories, Inc. Process for preparation of paricalcitol and intermediates thereof
US8026379B2 (en) * 2008-06-20 2011-09-27 Formosa Laboratories, Inc. Paricalcitol intermediates
CN101875664B (zh) * 2009-04-28 2013-07-10 武汉启瑞药业有限公司 维生素d2双保护产物的制备方法
EP2613632A1 (de) * 2010-09-10 2013-07-17 Genzyme Corporation Kontinuierliches photolytisches verfahren zur herstellung von vitamin-d-haltigen stoffen
CN103163306B (zh) * 2013-02-05 2015-06-17 北京九强生物技术股份有限公司 25羟维生素d检测试剂盒及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260549A (en) 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
JPS57149224A (en) 1981-03-13 1982-09-14 Chugai Pharmaceut Co Ltd Tumor-suppressing agent
US4554106A (en) 1984-11-01 1985-11-19 Wisconsin Alumni Research Foundation Method for preparing 1α-hydroxyvitamin D compounds
US4749710A (en) 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
JPH0755960B2 (ja) * 1986-11-14 1995-06-14 日清製粉株式会社 ステロイド誘導体およびその製造方法
US5562910A (en) 1989-09-25 1996-10-08 University Of Utah Research Foundation Vaccine compositions and method for enhancing an immune response
DK0494224T3 (da) 1989-09-25 2000-08-07 Univ Utah Res Found Anvendelse af steroidhormoner i sammensætninger til induktion af T-cellelymfokinproduktion
US5518725A (en) 1989-09-25 1996-05-21 University Of Utah Research Foundation Vaccine compositions and method for induction of mucosal immune response via systemic vaccination
GB9220439D0 (en) 1992-09-28 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
US5559107A (en) 1994-10-20 1996-09-24 Gates; Stephen Regulation of immune response
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US6262283B1 (en) * 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds

Also Published As

Publication number Publication date
US6359012B1 (en) 2002-03-19
DE60011463T2 (de) 2005-06-30
WO2001046131A1 (en) 2001-06-28
EP1240137A1 (de) 2002-09-18
ATE268753T1 (de) 2004-06-15
ES2222937T3 (es) 2005-02-16
CA2394624A1 (en) 2001-06-28
EP1240137B1 (de) 2004-06-09
JP2003518089A (ja) 2003-06-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition