DE60008730D1 - Methode zur konzentrationsbestimmung einer amphipathischen antihistaminischen verbindung durch bestimmung ihrer oberflächen aktivitäts einstufung - Google Patents

Methode zur konzentrationsbestimmung einer amphipathischen antihistaminischen verbindung durch bestimmung ihrer oberflächen aktivitäts einstufung

Info

Publication number
DE60008730D1
DE60008730D1 DE60008730T DE60008730T DE60008730D1 DE 60008730 D1 DE60008730 D1 DE 60008730D1 DE 60008730 T DE60008730 T DE 60008730T DE 60008730 T DE60008730 T DE 60008730T DE 60008730 D1 DE60008730 D1 DE 60008730D1
Authority
DE
Germany
Prior art keywords
determining
surface activity
amphipathic
concentration
activity classification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60008730T
Other languages
English (en)
Other versions
DE60008730T2 (de
Inventor
Gustav Graff
John M Yanni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Research LLC
Original Assignee
Alcon Manufacturing Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Manufacturing Ltd filed Critical Alcon Manufacturing Ltd
Publication of DE60008730D1 publication Critical patent/DE60008730D1/de
Application granted granted Critical
Publication of DE60008730T2 publication Critical patent/DE60008730T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60008730T 1999-06-18 2000-03-16 Methode zur konzentrationsbestimmung einer amphipathischen antihistaminischen verbindung durch bestimmung ihrer oberflächen aktivitäts einstufung Expired - Lifetime DE60008730T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13994599P 1999-06-18 1999-06-18
US139945P 1999-06-18
US15817799P 1999-10-07 1999-10-07
US158177P 1999-10-07
PCT/US2000/006890 WO2000078396A2 (en) 1999-06-18 2000-03-16 Topical ophthalmic mast cell stabilizers for treating allergic eye diseases

Publications (2)

Publication Number Publication Date
DE60008730D1 true DE60008730D1 (de) 2004-04-08
DE60008730T2 DE60008730T2 (de) 2004-08-05

Family

ID=26837695

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60008730T Expired - Lifetime DE60008730T2 (de) 1999-06-18 2000-03-16 Methode zur konzentrationsbestimmung einer amphipathischen antihistaminischen verbindung durch bestimmung ihrer oberflächen aktivitäts einstufung

Country Status (11)

Country Link
US (1) US6420399B1 (de)
EP (1) EP1187617B1 (de)
JP (1) JP4851035B2 (de)
AT (1) ATE260660T1 (de)
AU (1) AU770975B2 (de)
CA (1) CA2374002A1 (de)
DE (1) DE60008730T2 (de)
DK (1) DK1187617T3 (de)
ES (1) ES2213001T3 (de)
PT (1) PT1187617E (de)
WO (1) WO2000078396A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE506929T1 (de) 2001-06-12 2011-05-15 Univ Johns Hopkins Med Reservoirvorrichtung für die intraokulare arzneimittelabgabe
US7276050B2 (en) * 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
US20050239745A1 (en) * 2004-03-03 2005-10-27 Ophthalmic Research Associates, Inc. Novel topical ophthalmic formulations
CN101217937A (zh) * 2005-07-08 2008-07-09 千寿制药株式会社 包含奥洛他定的透皮吸收眼科制剂
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US8399006B2 (en) 2009-01-29 2013-03-19 Forsight Vision4, Inc. Posterior segment drug delivery
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
PL2600930T3 (pl) 2010-08-05 2021-09-06 Forsight Vision4, Inc. Urządzenie wstrzykujące do dostarczania leku
CN103153316B (zh) 2010-08-05 2015-08-19 弗赛特影像4股份有限公司 组合药物递送方法和设备
EP2640360A2 (de) 2010-11-19 2013-09-25 Forsight Vision4, Inc. Therapeutische wirkstoffformulierungen für implantierte vorrichtungen
TWI544922B (zh) 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物
US10398592B2 (en) 2011-06-28 2019-09-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
ES2864203T3 (es) 2011-09-16 2021-10-13 Forsight Vision4 Inc Aparato de intercambio de fluido
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
WO2014152959A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
EP2978393B1 (de) 2013-03-28 2023-12-27 ForSight Vision4, Inc. Augenimplantat zur abgabe von therapeutischen substanzen
RU2695563C2 (ru) 2014-07-15 2019-07-24 Форсайт Вижн4, Инк. Способ и устройство для доставки глазного имплантата
RU2017105844A (ru) 2014-08-08 2018-09-11 Форсайт Вижн4, Инк. Стабильные и растворимые составы ингибиторов рецепторных тирозинкиназ и способы их получения
JP7037360B2 (ja) 2014-11-10 2022-03-16 フォーサイト・ビジョン フォー・インコーポレーテッド 拡張可能な薬物送達デバイス
EP3377009B1 (de) 2015-11-20 2020-10-28 ForSight Vision4, Inc. Poröse strukturen für arzneimittelabgabevorrichtungen mit verlängerter freisetzung
EP3439591B1 (de) 2016-04-05 2020-09-23 ForSight Vision4, Inc. Implantierbare okulare arzneimittelabgabevorrichtungen
KR20200093581A (ko) 2017-11-21 2020-08-05 포사이트 비젼4, 인크. 확장 가능한 포트 전달 시스템을 위한 유체 교환 기기 및 사용 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8520662D0 (en) 1985-08-17 1985-09-25 Wellcome Found Tricyclic aromatic compounds
US4923892A (en) 1985-08-17 1990-05-08 Burroughs Wellcome Co. Tricyclic aromatic compounds
US4778814A (en) 1987-03-18 1988-10-18 Ciba-Geigy Corporation Method of treating ocular allergy by topical application of a 2-substituted-1,2-benzisoselenazol-3(2H)-one
AU636685B2 (en) 1989-12-18 1993-05-06 Alcon Laboratories, Inc. Compositions of antiallergics and antihistamines and methods for their use
US5192780A (en) * 1989-12-18 1993-03-09 Alcon Laboratories, Inc. Methods using antiallergics and antihistamines
US5641805A (en) 1995-06-06 1997-06-24 Alcon Laboratories, Inc. Topical ophthalmic formulations for treating allergic eye diseases
ATE470441T1 (de) * 1997-03-25 2010-06-15 Duska Scient Co Modulator der menschlichen mastzellaktivierung
WO1998056381A1 (en) * 1997-06-09 1998-12-17 Bridge Pharma, Inc. Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use
CN1114401C (zh) * 1998-07-14 2003-07-16 阿尔康实验室公司 11－(3－二甲氨基亚丙基)－6,11－二氢二苯并[b,e]噁庚英－2－乙酸用于制药的新用途
SE9803279D0 (sv) * 1998-09-25 1998-09-25 Astra Pharma Prod Novel compounds

Also Published As

Publication number Publication date
DK1187617T3 (da) 2004-04-13
EP1187617A2 (de) 2002-03-20
WO2000078396A2 (en) 2000-12-28
ATE260660T1 (de) 2004-03-15
EP1187617B1 (de) 2004-03-03
PT1187617E (pt) 2004-06-30
ES2213001T3 (es) 2004-08-16
US6420399B1 (en) 2002-07-16
AU3888300A (en) 2001-01-09
CA2374002A1 (en) 2000-12-28
AU770975B2 (en) 2004-03-11
JP2003502393A (ja) 2003-01-21
WO2000078396A3 (en) 2001-08-16
JP4851035B2 (ja) 2012-01-11
DE60008730T2 (de) 2004-08-05

Similar Documents

Publication Publication Date Title
DE60008730D1 (de) Methode zur konzentrationsbestimmung einer amphipathischen antihistaminischen verbindung durch bestimmung ihrer oberflächen aktivitäts einstufung
Harding et al. Filaggrin–revisited
ATE250605T1 (de) Piperidin verbindung zur behandlung von psoriasis
Meek et al. Synthesis and in vitro and in vivo inhibition potencies of highly relevant nerve agent surrogates
NL188862C (nl) Behandelingsmiddel voor vloerkleden, adipinezuurester en fluoralifatische groep bevattende alcohol.
ATE485835T1 (de) Antikörper enthaltende pharmazeutische lösungen
ES8702793A1 (es) Un procedimiento para desinfectar un substrato
ID21897A (id) Asam b-sulfonil hidroksamat sebagai bahan penghambat matriks metaloproteinase
HUP0302384A2 (hu) Sejtek bioenergia metabolizmusában szerepet játszó biokémiai vegyületeket tartalmazó készítmények és alkalmazásuk
PL415001A1 (pl) Kompozycje farmaceutyczne zawierające kwas mykofenolowy lub sól mykofenolanową
AR054806A1 (es) Formulaciones de estrogenos conjugados y bazedoxifeno
DE60021381D1 (de) Chinonverbindungen zur behandlung von krankheiten
IT1271456B (it) Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono
DE69821376D1 (de) Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht
DE69800310D1 (de) Verfahren zur Herstellung von Acrolein aus Propylen durch Redox Reaktion
CO5271712A1 (es) Procesos quimicos e intermediarios
Katewa et al. The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models
FR2703249B1 (fr) Composition pharmaceutique ayant une activité analgésique contenant du naproxène.
BR0112245A (pt) éster de ácido 4-alcóxi-ciclohexano-1-amino-carboxìlico e processo para sua preparação
PT1274685E (pt) Derivado de piridina-n-oxido e processo para a sua transformacao em compostos farmaceuticamente eficazes
NO975028D0 (no) Piperazinoderivater som neurokininantagonister
ATE17727T1 (de) Alkylenverbrueckte guanidinothiazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
DE60134430D1 (de) Verfahren zur behandlung von erkrankungen im zusammenhang mit apoe
CA2331461A1 (en) Analogs of 2-phthalimidinoglutaric acid and their use as inhibitors of angiogenesis
BR9713841A (pt) Agentes supressores de crescimento, composições contendo-os e método de uso em processos de polimerização

Legal Events

Date Code Title Description
8364 No opposition during term of opposition