DE59606062D1 - Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the manufacture of pharmaceutical preparations, and pharmaceutical preparations containing them - Google Patents

Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the manufacture of pharmaceutical preparations, and pharmaceutical preparations containing them

Info

Publication number: DE59606062D1
Authority: DE; Germany
Prior art keywords: pharmaceutical preparations; thioureas; manufacture; processes; preparation
Prior art date: 1995-02-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE59606062T

Other languages

German (de)

Inventor

Heinrich Dr Englert

Dr Gerlach

Dr Crause

Dr Mania

Dr Goegelein

Dr Kaiser

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee

Hoechst AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-10

Filing date

1996-02-05

Publication date

2000-12-07

1996-02-05 Application filed by Hoechst AG filed Critical Hoechst AG

1996-02-05 Priority to DE59606062T priority Critical patent/DE59606062D1/en

2000-12-07 Application granted granted Critical

2000-12-07 Publication of DE59606062D1 publication Critical patent/DE59606062D1/en

2016-02-06 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Surgery (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Pyrrole Compounds (AREA)
Pyridine Compounds (AREA)

DE59606062T 1995-02-10 1996-02-05 Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the manufacture of pharmaceutical preparations, and pharmaceutical preparations containing them Expired - Lifetime DE59606062D1 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DE59606062T DE59606062D1 (en)	1995-02-10	1996-02-05	Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the manufacture of pharmaceutical preparations, and pharmaceutical preparations containing them

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19504379A DE19504379A1 (en)	1995-02-10	1995-02-10	Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the manufacture of pharmaceutical preparations and pharmaceutical preparations containing them
DE59606062T DE59606062D1 (en)	1995-02-10	1996-02-05	Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the manufacture of pharmaceutical preparations, and pharmaceutical preparations containing them

Publications (1)

Publication Number	Publication Date
DE59606062D1 true DE59606062D1 (en)	2000-12-07

Family

ID=7753608

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE19504379A Withdrawn DE19504379A1 (en)	1995-02-10	1995-02-10	Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the manufacture of pharmaceutical preparations and pharmaceutical preparations containing them
DE59606062T Expired - Lifetime DE59606062D1 (en)	1995-02-10	1996-02-05	Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the manufacture of pharmaceutical preparations, and pharmaceutical preparations containing them

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE19504379A Withdrawn DE19504379A1 (en)	1995-02-10	1995-02-10	Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the manufacture of pharmaceutical preparations and pharmaceutical preparations containing them

Country Status (30)

Country	Link
US (1)	US5607976A (en)
EP (1)	EP0726250B1 (en)
JP (1)	JP3774773B2 (en)
KR (1)	KR100446565B1 (en)
CN (1)	CN1064041C (en)
AR (1)	AR001082A1 (en)
AT (1)	ATE197291T1 (en)
AU (1)	AU700883B2 (en)
BR (1)	BR9600370A (en)
CA (1)	CA2169219C (en)
CZ (1)	CZ290809B6 (en)
DE (2)	DE19504379A1 (en)
DK (1)	DK0726250T3 (en)
ES (1)	ES2152440T3 (en)
FI (1)	FI120394B (en)
GR (1)	GR3034886T3 (en)
HR (1)	HRP960063B1 (en)
HU (1)	HU224211B1 (en)
IL (1)	IL117078A (en)
MY (1)	MY114693A (en)
NO (1)	NO305750B1 (en)
NZ (1)	NZ280954A (en)
PL (1)	PL181656B1 (en)
PT (1)	PT726250E (en)
RU (1)	RU2155750C2 (en)
SI (1)	SI9600040B (en)
SK (1)	SK281357B6 (en)
TR (1)	TR199600747A2 (en)
TW (1)	TW419457B (en)
ZA (1)	ZA961050B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19832009A1 (en)	1998-07-16	2000-01-20	Hoechst Marion Roussel De Gmbh	New 2,5-disubstituted benzenesulfonyl-ureas or -thioureas, used as ATP-sensitive potassium channel blockers for treating cardiovascular disorders such as arrhythmia or cardiac insufficiency
DE19858253A1 (en) *	1998-12-17	2000-06-21	Aventis Pharma Gmbh	Use of KQt1 channel inhibitors for the manufacture of a medicament for the treatment of diseases caused by helminths and ectoparasites
DE10060809A1 (en)	2000-12-07	2002-06-20	Aventis Pharma Gmbh	Substituted anthranilic acids, their use as medicaments or diagnostic agents, as well as medicaments containing them, and a combined pharmaceutical preparation with a sodium / hydrogen exchange (NHE) blocker
DE10129704A1 (en) *	2001-06-22	2003-01-02	Aventis Pharma Gmbh	Use of benzenesulfonyl (thio) ureas in the treatment of septic shock
CN1330630C (en) *	2004-03-10	2007-08-08	中国药科大学	Sultonyl (thio)urea derivants, their preparation process and pharmaceutical composition containing them
UA87854C2 (en) *	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
AU2007238755B2 (en)	2006-04-12	2012-07-12	Merck Sharp & Dohme Llc	Pyridyl amide T-type calcium channel antagonists
KR20100072266A (en) *	2007-10-24	2010-06-30	머크 샤프 앤드 돔 코포레이션	Heterocycle phenyl amide t-type calcium channel antagonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE243821C (en) *
DE1493672C3 (en) *	1964-08-01	1974-05-02	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Process for the preparation of benzenesulfonylureas
DE1518874C3 (en) *	1964-10-07	1975-03-13	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Benzenesulfonylureas and process for their preparation
DE1443919C3 (en) *	1964-12-28	1973-11-29	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Benzenesulfonylureas, processes for their production and pharmaceutical preparations containing them
US3917690A (en) *	1966-11-29	1975-11-04	Hoechst Ag	Benzenesulfonyl ureas and process for their manufacture
DE1568648C3 (en) *	1966-12-19	1975-03-27	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Benzenesulfonylureas, processes for their preparation and pharmaceutical preparations containing them
BE754454A (en) *	1969-08-06	1971-02-05	Bayer Ag	NEW HYPOGLYCEMIC COMPOUNDS OF THE TYPE OF ARYLSULFONYLURIDES AND ARLSULFONYLSEMICARBAZIDES CONTAINING CARBONAMIDE GROUPS
DE2413514C3 (en) *	1974-03-21	1982-03-04	Hoechst Ag, 6000 Frankfurt	N-Acylaminoathylbenzenesulfonyl-N'-methylureas, process for their preparation and their use
DE3011153A1 (en) *	1980-03-22	1981-10-15	Hoechst Ag, 6000 Frankfurt	Serum insulin normalising sulphonyl-urea deriv. - N-chloro-methoxy-benzamido-ethyl-benzene:sulphonyl-N'-methyl-urea
US5215985A (en) *	1990-07-20	1993-06-01	E. R. Squibb & Sons, Inc.	Method for treating ischemic insult to neurons employing an ATP-sensitive potassium channel blocker
ATE146775T1 (en) *	1993-02-23	1997-01-15	Hoechst Ag	SUBSTITUTED BENZENESULFONYL UREAS AND THIOUREAS - METHOD FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS

1995
- 1995-02-10 DE DE19504379A patent/DE19504379A1/en not_active Withdrawn
- 1995-12-29 HU HU9503932A patent/HU224211B1/en not_active IP Right Cessation
1996
- 1996-01-29 PL PL96312531A patent/PL181656B1/en not_active IP Right Cessation
- 1996-02-05 ES ES96101585T patent/ES2152440T3/en not_active Expired - Lifetime
- 1996-02-05 AT AT96101585T patent/ATE197291T1/en active
- 1996-02-05 PT PT96101585T patent/PT726250E/en unknown
- 1996-02-05 EP EP96101585A patent/EP0726250B1/en not_active Expired - Lifetime
- 1996-02-05 DE DE59606062T patent/DE59606062D1/en not_active Expired - Lifetime
- 1996-02-05 DK DK96101585T patent/DK0726250T3/en active
- 1996-02-05 TW TW085101375A patent/TW419457B/en not_active IP Right Cessation
- 1996-02-06 SI SI9600040A patent/SI9600040B/en not_active IP Right Cessation
- 1996-02-07 CN CN96101370A patent/CN1064041C/en not_active Expired - Fee Related
- 1996-02-08 HR HR960063A patent/HRP960063B1/en not_active IP Right Cessation
- 1996-02-08 CZ CZ1996382A patent/CZ290809B6/en not_active IP Right Cessation
- 1996-02-08 SK SK175-96A patent/SK281357B6/en not_active IP Right Cessation
- 1996-02-08 MY MYPI96000472A patent/MY114693A/en unknown
- 1996-02-08 AR AR33535596A patent/AR001082A1/en unknown
- 1996-02-08 TR TR96/00102A patent/TR199600747A2/en unknown
- 1996-02-08 IL IL11707896A patent/IL117078A/en not_active IP Right Cessation
- 1996-02-08 FI FI960587A patent/FI120394B/en not_active IP Right Cessation
- 1996-02-08 NZ NZ280954A patent/NZ280954A/en not_active IP Right Cessation
- 1996-02-08 AU AU44429/96A patent/AU700883B2/en not_active Ceased
- 1996-02-08 US US08/598,319 patent/US5607976A/en not_active Expired - Lifetime
- 1996-02-09 ZA ZA961050A patent/ZA961050B/en unknown
- 1996-02-09 JP JP02392796A patent/JP3774773B2/en not_active Expired - Fee Related
- 1996-02-09 CA CA002169219A patent/CA2169219C/en not_active Expired - Fee Related
- 1996-02-09 RU RU96102420/04A patent/RU2155750C2/en not_active IP Right Cessation
- 1996-02-09 BR BR9600370A patent/BR9600370A/en not_active Application Discontinuation
- 1996-02-09 NO NO960529A patent/NO305750B1/en not_active IP Right Cessation
- 1996-02-10 KR KR1019960003232A patent/KR100446565B1/en not_active IP Right Cessation
2000
- 2000-11-22 GR GR20000402575T patent/GR3034886T3/en unknown

Also Published As

Publication number	Publication date
HRP960063B1 (en)	2001-08-31
FI960587A0 (en)	1996-02-08
CN1064041C (en)	2001-04-04
KR100446565B1 (en)	2004-12-03
KR960031431A (en)	1996-09-17
HU224211B1 (en)	2005-06-28
NO305750B1 (en)	1999-07-19
CA2169219A1 (en)	1996-08-11
PL181656B1 (en)	2001-08-31
PT726250E (en)	2001-03-30
PL312531A1 (en)	1996-08-19
AU4442996A (en)	1996-08-22
HU9503932D0 (en)	1996-03-28
CN1137519A (en)	1996-12-11
EP0726250B1 (en)	2000-11-02
CZ290809B6 (en)	2002-10-16
BR9600370A (en)	1998-03-03
IL117078A (en)	2001-01-11
NZ280954A (en)	1996-10-28
DE19504379A1 (en)	1996-08-14
US5607976A (en)	1997-03-04
FI960587A (en)	1996-08-11
FI120394B (en)	2009-10-15
EP0726250A1 (en)	1996-08-14
SI9600040A (en)	1996-10-31
JP3774773B2 (en)	2006-05-17
SI9600040B (en)	2001-12-31
AR001082A1 (en)	1997-09-24
SK281357B6 (en)	2001-02-12
HRP960063A2 (en)	1997-10-31
AU700883B2 (en)	1999-01-14
HUT73975A (en)	1996-10-28
IL117078A0 (en)	1996-06-18
NO960529L (en)	1996-08-12
DK0726250T3 (en)	2001-01-08
TW419457B (en)	2001-01-21
ATE197291T1 (en)	2000-11-15
RU2155750C2 (en)	2000-09-10
CA2169219C (en)	2009-01-06
GR3034886T3 (en)	2001-02-28
NO960529D0 (en)	1996-02-09
CZ38296A3 (en)	1996-08-14
ES2152440T3 (en)	2001-02-01
ZA961050B (en)	1996-08-29
JPH08245553A (en)	1996-09-24
SK17596A3 (en)	1996-10-02
MY114693A (en)	2002-12-31
TR199600747A2 (en)	1996-08-21

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Legal Events

Date	Code	Title	Description
2001-11-29	8364	No opposition during term of opposition