DE502004011919D1 - -TRIEN-3-YL SULFAMATE - Google Patents

-TRIEN-3-YL SULFAMATE

Info

Publication number
DE502004011919D1
DE502004011919D1 DE502004011919T DE502004011919T DE502004011919D1 DE 502004011919 D1 DE502004011919 D1 DE 502004011919D1 DE 502004011919 T DE502004011919 T DE 502004011919T DE 502004011919 T DE502004011919 T DE 502004011919T DE 502004011919 D1 DE502004011919 D1 DE 502004011919D1
Authority
DE
Germany
Prior art keywords
trien
sulfamate
sulfamates
triene
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE502004011919T
Other languages
German (de)
Inventor
Alexander Hillisch
Olaf Peters
Christian Gege
Wilko Regenhardt
Dirk Kosemund
Gerhard Siemeister
Eberhard Unger
Ulrich Bothe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterix Ltd
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Publication of DE502004011919D1 publication Critical patent/DE502004011919D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Abstract

The invention relates to the use of 2-substituted estra-1,3,5(10)-triene-3-yl sulfamates of general formula I, in addition to their pharmaceutically acceptable salts for producing a medicament. Said compounds have an anti-tumour action.
DE502004011919T 2003-02-19 2004-02-19 -TRIEN-3-YL SULFAMATE Expired - Lifetime DE502004011919D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10307104A DE10307104A1 (en) 2003-02-19 2003-02-19 Anti-tumor effective 2-substituted Estra-1,3,5 (10) -trien-3-yl sulfamate
PCT/EP2004/001606 WO2004074307A1 (en) 2003-02-19 2004-02-19 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action

Publications (1)

Publication Number Publication Date
DE502004011919D1 true DE502004011919D1 (en) 2011-01-05

Family

ID=32891761

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10307104A Ceased DE10307104A1 (en) 2003-02-19 2003-02-19 Anti-tumor effective 2-substituted Estra-1,3,5 (10) -trien-3-yl sulfamate
DE502004011919T Expired - Lifetime DE502004011919D1 (en) 2003-02-19 2004-02-19 -TRIEN-3-YL SULFAMATE

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10307104A Ceased DE10307104A1 (en) 2003-02-19 2003-02-19 Anti-tumor effective 2-substituted Estra-1,3,5 (10) -trien-3-yl sulfamate

Country Status (13)

Country Link
US (2) US7427610B2 (en)
EP (1) EP1599493B1 (en)
JP (1) JP4933250B2 (en)
CN (1) CN1751059A (en)
AT (1) ATE489399T1 (en)
AU (1) AU2004213146A1 (en)
BR (1) BRPI0407679A (en)
CA (1) CA2516177A1 (en)
DE (2) DE10307104A1 (en)
ES (1) ES2355379T3 (en)
MX (1) MXPA05008906A (en)
RU (1) RU2005128831A (en)
WO (1) WO2004074307A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10307103A1 (en) 2003-02-19 2004-09-09 Schering Ag Anti-tumor effective 2-substituted D-homostra-1,3,5 (10) -trien-3-yl sulfamate
DE10307104A1 (en) 2003-02-19 2004-09-23 Schering Ag Anti-tumor effective 2-substituted Estra-1,3,5 (10) -trien-3-yl sulfamate
DE10307105A1 (en) * 2003-02-19 2004-09-09 Schering Ag Antitumor active 2-substituted 18a-homoestra-1,3,5 (10) -trien-3-yl sulfamate
WO2005020928A2 (en) 2003-08-29 2005-03-10 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
AU2005222934B2 (en) * 2004-03-12 2010-06-17 Entremed, Inc. Antiangiogenic agents
GB0421106D0 (en) * 2004-09-22 2004-10-27 Sterix Ltd Compound
AU2007217366A1 (en) 2006-02-27 2007-08-30 The Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
WO2007109312A2 (en) 2006-03-20 2007-09-27 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol
AU2008331808B2 (en) 2007-03-16 2014-08-21 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
EP2847206A4 (en) 2012-05-07 2016-01-20 Univ California Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis
JP2016517888A (en) 2013-05-02 2016-06-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Oxysterol bone targeting drug for osteoselective bone formation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2006A (en) * 1841-03-16 Clamp for crimping leather
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
DE4429397C2 (en) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5 (10) -triene derivatives, processes for their preparation and pharmaceutical compositions containing these compounds
DE4447715C2 (en) * 1994-08-09 1998-02-05 Jenapharm Gmbh Oestrogen compsn contg. 3-sulphamoyl:oxy-oestratriene cpd.
DE19540233B4 (en) * 1995-10-19 2005-08-25 Schering Ag Sulfamate derivatives of 1,3,5 (10) estratriene derivatives, process for their preparation and pharmaceutical compositions containing them
DE19712488A1 (en) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroid sulfamates, processes for their preparation and use thereof
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
AU765386B2 (en) * 1998-06-10 2003-09-18 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-(o)-sulphamate for inhibition of estrone sulphatase
GB9913536D0 (en) 1999-06-10 1999-08-11 Sterix Ltd Use
DE19943708B4 (en) 1999-09-08 2007-12-20 Bayer Schering Pharma Ag New C13-substituted Estra-1,3,5 (10) -trien-3-yl-sulfamates, processes for their preparation and pharmaceutical compositions containing them
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
CA2430100A1 (en) 2000-11-27 2002-05-30 Entremed, Inc. Antiangiogenic agents
EP1480645A4 (en) * 2002-02-15 2006-03-29 Rigel Pharmaceuticals Inc Inhibitors of tubulin polymerization
DE10307104A1 (en) 2003-02-19 2004-09-23 Schering Ag Anti-tumor effective 2-substituted Estra-1,3,5 (10) -trien-3-yl sulfamate
DE10307105A1 (en) * 2003-02-19 2004-09-09 Schering Ag Antitumor active 2-substituted 18a-homoestra-1,3,5 (10) -trien-3-yl sulfamate

Also Published As

Publication number Publication date
US8492570B2 (en) 2013-07-23
EP1599493B1 (en) 2010-11-24
JP2006517945A (en) 2006-08-03
EP1599493A1 (en) 2005-11-30
ATE489399T1 (en) 2010-12-15
US20090221841A1 (en) 2009-09-03
CN1751059A (en) 2006-03-22
CA2516177A1 (en) 2004-09-02
US20060160782A1 (en) 2006-07-20
ES2355379T3 (en) 2011-03-25
BRPI0407679A (en) 2006-03-01
US7427610B2 (en) 2008-09-23
WO2004074307A1 (en) 2004-09-02
AU2004213146A1 (en) 2004-09-02
DE10307104A1 (en) 2004-09-23
RU2005128831A (en) 2007-03-27
JP4933250B2 (en) 2012-05-16
MXPA05008906A (en) 2005-10-05

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