DE3879478T2 - Ornithin-derivate und deren verwendung als inhibitoren von methothrexat resistenten zellen. - Google Patents

Ornithin-derivate und deren verwendung als inhibitoren von methothrexat resistenten zellen.

Info

Publication number
DE3879478T2
DE3879478T2 DE8888909452T DE3879478T DE3879478T2 DE 3879478 T2 DE3879478 T2 DE 3879478T2 DE 8888909452 T DE8888909452 T DE 8888909452T DE 3879478 T DE3879478 T DE 3879478T DE 3879478 T2 DE3879478 T2 DE 3879478T2
Authority
DE
Germany
Prior art keywords
resistant cells
ornithin
methothrexate
inhibitors
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888909452T
Other languages
English (en)
Other versions
DE3879478D1 (de
Inventor
Andre Rosowsky
Henry Bader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Application granted granted Critical
Publication of DE3879478D1 publication Critical patent/DE3879478D1/de
Publication of DE3879478T2 publication Critical patent/DE3879478T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE8888909452T 1987-11-04 1988-10-12 Ornithin-derivate und deren verwendung als inhibitoren von methothrexat resistenten zellen. Expired - Fee Related DE3879478T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/117,212 US4767761A (en) 1987-11-04 1987-11-04 Ornithine derivatives and their use as methotrexate-resistant cell inhibitors
PCT/US1988/003545 WO1989004312A1 (en) 1987-11-04 1988-10-12 Ornithine derivatives and their use as inhibitors of methotrexate resistant cells

Publications (2)

Publication Number Publication Date
DE3879478D1 DE3879478D1 (de) 1993-04-22
DE3879478T2 true DE3879478T2 (de) 1993-06-24

Family

ID=22371547

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888909452T Expired - Fee Related DE3879478T2 (de) 1987-11-04 1988-10-12 Ornithin-derivate und deren verwendung als inhibitoren von methothrexat resistenten zellen.

Country Status (7)

Country Link
US (1) US4767761A (de)
EP (1) EP0345308B1 (de)
JP (1) JPH02502095A (de)
AT (1) ATE86994T1 (de)
CA (1) CA1316533C (de)
DE (1) DE3879478T2 (de)
WO (1) WO1989004312A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
DE3833393A1 (de) * 1988-10-01 1990-04-05 Thomae Gmbh Dr K Verwendung von pteridinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel
US4956461A (en) * 1988-10-19 1990-09-11 Dana Farber Cancer Institute, Inc. Desamino-aminopterin and -methotrexate
GB9105771D0 (en) * 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
US5403843A (en) * 1991-08-12 1995-04-04 Takeda Chemical Industries, Ltd. Pyrrolopyrimidinyalglutaminate derivatives and their use
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
US6989386B2 (en) * 2002-04-30 2006-01-24 Dana-Farber Cancer Institute Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same
US20050032807A1 (en) * 2003-08-06 2005-02-10 Rosenwald Lindsay A. Methods of treating inflammatory diseases with ammonium salts of ornitihine derivatives
WO2006113536A2 (en) * 2005-04-14 2006-10-26 Hana Biosciences, Inc. Use of pt523 for treating cancers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393064A (en) * 1976-03-05 1983-07-12 Sri International Process and composition for treatment of leukemia and process for preparing the same
US4374987A (en) * 1980-08-14 1983-02-22 American Cyanamid Company Process for the preparation of high purity methotrexate and derivatives thereof
US4490529A (en) * 1983-09-06 1984-12-25 Dana-Farber Cancer Institute, Inc. Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin
US4628090A (en) * 1984-08-21 1986-12-09 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutanayte formation related compounds

Also Published As

Publication number Publication date
EP0345308B1 (de) 1993-03-17
EP0345308A4 (de) 1990-05-14
JPH02502095A (ja) 1990-07-12
ATE86994T1 (de) 1993-04-15
CA1316533C (en) 1993-04-20
JPH0450314B2 (de) 1992-08-13
EP0345308A1 (de) 1989-12-13
DE3879478D1 (de) 1993-04-22
US4767761A (en) 1988-08-30
WO1989004312A1 (en) 1989-05-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee