DE3877869D1 - METHOD FOR THE BIOLOGICAL PRODUCTION OF AMIDES. - Google Patents

METHOD FOR THE BIOLOGICAL PRODUCTION OF AMIDES.

Info

Publication number
DE3877869D1
DE3877869D1 DE8888115182T DE3877869T DE3877869D1 DE 3877869 D1 DE3877869 D1 DE 3877869D1 DE 8888115182 T DE8888115182 T DE 8888115182T DE 3877869 T DE3877869 T DE 3877869T DE 3877869 D1 DE3877869 D1 DE 3877869D1
Authority
DE
Germany
Prior art keywords
amides
nitrile
biological production
hydrated
microorganism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888115182T
Other languages
German (de)
Other versions
DE3877869T2 (en
Inventor
Hideaki Yamada
Toru Nagasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
YAMADA, HIDEAKI, KYOTO, JP MITSUBISHI RAYON CO., L
Original Assignee
Nitto Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Chemical Industry Co Ltd filed Critical Nitto Chemical Industry Co Ltd
Application granted granted Critical
Publication of DE3877869D1 publication Critical patent/DE3877869D1/en
Publication of DE3877869T2 publication Critical patent/DE3877869T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/0014—Use of organic additives
    • C08J9/0023—Use of organic additives containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2325/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Derivatives of such polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Emergency Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

In a process for biological production of an amide wherein a nitrile is hydrated into a corresponding amide by the action of a nitrile hydratase originated in a microorganism, the improvement which comprises the use of nitrile hydratase which is obtained by culturing a microorganism of the species Rhodococcus rhodochrous in the presence of a cobalt ion. Aromatic nitriles such as a cyanopyridine as well as aliphatic nitrile such as acrylonitrile are hydrated into the corresponding amides.
DE8888115182T 1987-09-18 1988-09-16 METHOD FOR THE BIOLOGICAL PRODUCTION OF AMIDES. Expired - Lifetime DE3877869T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23459787 1987-09-18
JP7276688 1988-03-26

Publications (2)

Publication Number Publication Date
DE3877869D1 true DE3877869D1 (en) 1993-03-11
DE3877869T2 DE3877869T2 (en) 1993-06-09

Family

ID=26413903

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888115182T Expired - Lifetime DE3877869T2 (en) 1987-09-18 1988-09-16 METHOD FOR THE BIOLOGICAL PRODUCTION OF AMIDES.

Country Status (21)

Country Link
US (1) US5334519A (en)
EP (1) EP0307926B1 (en)
JP (1) JPH0655148B2 (en)
KR (1) KR0134094B1 (en)
CN (1) CN1015473B (en)
AT (1) ATE85082T1 (en)
BG (1) BG48934A3 (en)
BR (1) BR8804804A (en)
CA (1) CA1298222C (en)
DD (1) DD274631A5 (en)
DE (1) DE3877869T2 (en)
DK (1) DK174516B1 (en)
ES (1) ES2043752T3 (en)
FI (1) FI93858C (en)
HU (1) HU204099B (en)
MX (1) MX169933B (en)
NO (1) NO175489C (en)
PL (2) PL160904B1 (en)
PT (1) PT88540B (en)
RO (1) RO101578B (en)
RU (1) RU1838416C (en)

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JP3009421B2 (en) * 1990-02-28 2000-02-14 秀明 山田 Biological production of organic acids
US5648256A (en) * 1990-02-28 1997-07-15 Nitto Chemical Industry Co., Ltd. Gene encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant
AU627648B2 (en) * 1990-02-28 1992-08-27 Teruhiko Beppu Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant
SG48037A1 (en) * 1990-11-14 1998-04-17 Nitto Chemical Industry Co Ltd Biology process for production-alpha-hydroxyamide or alpha-hydroxy acid
US5753472A (en) * 1991-05-02 1998-05-19 Nitto Chemical Industry Co. Ltd. DNA fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant
JPH05244968A (en) * 1991-08-16 1993-09-24 Mitsui Toatsu Chem Inc Production of alpha-hydroxyisobutyramide
GEP20012441B (en) * 1993-04-02 2001-05-25 Lonza Ag Process for Preparing 3-Methylpiperidine and 3-Methylpyridine
RU2053300C1 (en) * 1993-12-17 1996-01-27 Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Strain of bacterium rhodococcus rhodochrous - a producer of nitrile hydratase
KR100339723B1 (en) * 1994-02-01 2002-09-25 스미또모 가가꾸 고오교오 가부시끼가이샤 Process for production of amide compounds using microorganism
JP3235934B2 (en) 1994-08-04 2001-12-04 三菱レイヨン株式会社 Kanamycin resistance gene from Rhodococcus bacteria
JP3163224B2 (en) * 1994-10-14 2001-05-08 三菱レイヨン株式会社 Method of storing cells or suspension of immobilized cells
ZA968485B (en) 1995-11-01 1997-05-20 Lonza Ag Process for preparing nicotinamide
CH689831A5 (en) * 1995-11-07 1999-12-15 Eprova Ag Stable crystalline tetrahydrofolic acid salts.
GB9525372D0 (en) * 1995-12-12 1996-02-14 Allied Colloids Ltd Enzymes, their preparation and their use in the production of ammonium acrylate
CN1240833C (en) 1996-02-14 2006-02-08 三井化学株式会社 Novel nitrile hydratase
US5728556A (en) * 1996-03-14 1998-03-17 E. I. Du Pont De Nemours And Company Production of ω-cyanocarboxamides from aliphatic α,ω-dinitriles using pseudomonas putida-derived biocatalysts
US5863750A (en) * 1996-12-18 1999-01-26 Cytec Tech Corp Methods for the detoxification of nitrile and/or amide compounds
US5866379A (en) * 1997-01-28 1999-02-02 Novus International Enzymatic conversion of α-hydroxynitriles to the corresponding .alpha.
CN1108372C (en) 1997-07-22 2003-05-14 隆萨股份公司 Process for preparing amides
JP3428404B2 (en) * 1997-10-23 2003-07-22 三菱レイヨン株式会社 Method for producing amide compound
US6153415A (en) 1998-04-29 2000-11-28 Board Of Trustees Operating Michigan State University Method for producing amide compounds using a nitrile hydratase from a thermophilic bacillus
NL1011867C2 (en) * 1999-04-22 2000-10-24 Dsm Nv Production of linear unsaturated amides, e.g. useful as caprolactam intermediates, comprises treating the corresponding nitriles with a nitrile hydratase
AU4314200A (en) 1999-04-27 2000-11-10 Nok Corporation Gasket
WO2001070936A1 (en) * 2000-03-21 2001-09-27 Mitsubishi Rayon Co., Ltd. Method of culturing microorganism
US6562603B2 (en) * 2000-08-04 2003-05-13 E. I. Du Pont De Nemours And Company 3-hydroxycarboxylic acid production and use in branched polymers
KR100407470B1 (en) * 2000-08-08 2003-11-28 동서석유화학주식회사 A method for producing Rhodococcus rhodochrous by a fed-batch culture method and process for manufacturing amide compound thereby
US7749739B2 (en) 2000-12-20 2010-07-06 Dia-Nitrix Co., Ltd. Process for producing amide compound using microbial catalyst
EP1352050B1 (en) * 2001-01-09 2008-12-17 Lonza AG Microbiological method for producing amides
DE10120546A1 (en) * 2001-04-26 2002-10-31 Stockhausen Chem Fab Gmbh Process for the preparation of an aqueous acrylamide solution with a biocatalyst
DE10120550A1 (en) * 2001-04-26 2002-10-31 Stockhausen Chem Fab Gmbh Process for the preparation of an aqueous acrylamide solution with a biocatalyst
DE10120555A1 (en) * 2001-04-26 2002-10-31 Stockhausen Chem Fab Gmbh Process for the preparation of an aqueous acrylamide solution with a bio-catalyst
WO2003033716A1 (en) * 2001-10-12 2003-04-24 Dia-Nitrix Co., Ltd. Process for producing acrylamide and/or methacrylamide with microorganism catalyst
JP2004194588A (en) 2002-12-19 2004-07-15 Mitsui Chemicals Inc New nitrile hydratase
GB0327900D0 (en) 2003-12-02 2004-01-07 Ciba Spec Chem Water Treat Ltd Process for preparing unsaturated amides and carboxylic acids
WO2005054489A1 (en) 2003-12-02 2005-06-16 Ciba Specialty Chemicals Water Treatments Limited Manufacture of amides
GB0327906D0 (en) * 2003-12-02 2004-01-07 Ciba Spec Chem Water Treat Ltd Biocatalyst composition
AU2004295409B2 (en) 2003-12-02 2010-07-29 Ciba Specialty Chemicals Water Treatments Limited Strain of Rhodococcus rhodochrous NCIMB 41164 and its use as producer of nitrile hydratase
GB0327901D0 (en) 2003-12-02 2004-01-07 Ciba Spec Chem Water Treat Ltd Process for producing polymers
JP2005328787A (en) * 2004-05-21 2005-12-02 Mitsubishi Rayon Co Ltd New microorganism having nitrile hydratase activity, gene encoding nitrile hydrase and method for producing amide compound
JP4493011B2 (en) * 2004-06-11 2010-06-30 三菱レイヨン株式会社 Trimethoprim-resistant dihydrofolate reductase and its gene from Rhodococcus spp.
JP2008306928A (en) * 2005-10-06 2008-12-25 Mitsui Chemicals Inc Method for culturing microorganism capable of producing cobalt-containing nitrile hydratase
US7531343B2 (en) 2006-01-30 2009-05-12 Georgia State University Research Foundation, Inc. Induction and stabilization of enzymatic activity in microorganisms
US7943549B2 (en) 2007-04-02 2011-05-17 Georgia State University Research Foundation, Inc. Biological-based catalyst to delay plant development processes
JP5132979B2 (en) * 2007-04-27 2013-01-30 ダイヤニトリックス株式会社 Polyacrylamide and method for producing the same
WO2009009117A2 (en) * 2007-07-11 2009-01-15 Bioverdant, Inc. Chemoenzymatic processes for preparation of levetiracetam
KR101598643B1 (en) * 2008-03-14 2016-02-29 다이야니트릭스 가부시키가이샤 Method for stabilization of aqueous acrylamide solution
CN101481713B (en) * 2008-12-30 2011-12-21 浙江工业大学 Method for producing aldinamide by biological catalysis of 2-cyano pyrazine and bacterial strain thereof
JP5733299B2 (en) 2010-02-22 2015-06-10 三菱レイヨン株式会社 Stable acrylamide aqueous solution
JP5987825B2 (en) 2011-05-19 2016-09-07 三菱レイヨン株式会社 Acrylamide aqueous solution, stabilization method of acrylamide aqueous solution
AU2012256707B2 (en) 2011-05-19 2015-07-16 Mitsubishi Chemical Corporation Method for producing aqueous acrylamide solution
AU2012256709B2 (en) 2011-05-19 2016-07-07 Mitsubishi Chemical Corporation Method for producing acrylamide aqueous solution
AU2013227585B2 (en) 2012-02-28 2016-02-25 Mitsubishi Chemical Corporation Method for preserving enzyme
FR3002542B1 (en) * 2013-02-28 2016-01-22 Servier Lab PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S) 3,4-DIMETHOXYBICYCLO [4.2.0] OCTA-1,3,5-TRIENE 7-CARBOXYLIC ACID AND APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS
CA2903704A1 (en) 2013-03-14 2014-10-02 Georgia State University Research Foundation, Inc. Inhibiting or reducing fungal growth
JP6454320B2 (en) 2013-03-14 2019-01-16 ジョージア・ステイト・ユニバーシティ・リサーチ・ファウンデーション・インコーポレイテッドＧｅｏｒｇｉａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ， Ｉｎｃ． Prevention or delay of cold injury reactions in plants
AU2015274627A1 (en) 2014-06-10 2017-01-19 Georgia State University And Research Foundation, Inc. Inhibiting or reducing fungal infections
CN104762338A (en) * 2015-03-17 2015-07-08 安徽国星生物化学有限公司 Method of producing nicotinamide by catalysis of rhodococcus
GB201601558D0 (en) 2016-01-28 2016-03-16 Verdant Bioproducts Ltd Method for producing 3-hydroxypropionamide
CN111662938B (en) * 2020-06-23 2021-05-04 浙江恒康药业股份有限公司 Application of nitrile hydratase in catalyzing hydration reaction of cyanopyrazine compound to generate amide pyrazine compound
CN112625065A (en) * 2020-12-22 2021-04-09 北京师范大学 Technetium-99 m marked FAPI (FAPI) derivative containing hydrazino nicotinamide and archaea, and preparation method and application thereof

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* Cited by examiner, † Cited by third party
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US4629700A (en) * 1983-11-30 1986-12-16 Standard Oil Company (Indiana) Selective conversion of cyano compounds to amides and carboxylic acids
JPS61162193A (en) * 1985-01-08 1986-07-22 Nitto Chem Ind Co Ltd Production of amide with bacterium
JPH0740948B2 (en) * 1985-06-04 1995-05-10 旭化成工業株式会社 Microbiological production of amides
JP3009421B2 (en) * 1990-02-28 2000-02-14 秀明 山田 Biological production of organic acids

Also Published As

Publication number Publication date
PL274710A1 (en) 1989-05-02
FI884279A0 (en) 1988-09-16
PL160904B1 (en) 1993-05-31
RO101578B (en) 1992-01-13
EP0307926A3 (en) 1990-02-07
HUT50215A (en) 1989-12-28
ATE85082T1 (en) 1993-02-15
NO884114D0 (en) 1988-09-16
BR8804804A (en) 1989-04-25
KR0134094B1 (en) 1998-04-14
US5334519A (en) 1994-08-02
NO884114L (en) 1989-03-20
CA1298222C (en) 1992-03-31
JPH02470A (en) 1990-01-05
EP0307926B1 (en) 1993-01-27
EP0307926A2 (en) 1989-03-22
FI93858B (en) 1995-02-28
JPH0655148B2 (en) 1994-07-27
RU1838416C (en) 1993-08-30
PT88540B (en) 1992-11-30
DE3877869T2 (en) 1993-06-09
CN1032436A (en) 1989-04-19
KR890005274A (en) 1989-05-13
DK516688A (en) 1989-03-19
ES2043752T3 (en) 1994-01-01
HU204099B (en) 1991-11-28
DK516688D0 (en) 1988-09-16
PL161959B1 (en) 1993-08-31
BG48934A3 (en) 1991-06-14
NO175489B (en) 1994-07-11
PT88540A (en) 1988-10-01
CN1015473B (en) 1992-02-12
MX169933B (en) 1993-08-02
NO175489C (en) 1994-10-19
DK174516B1 (en) 2003-05-05
DD274631A5 (en) 1989-12-27
FI884279A (en) 1989-03-19
FI93858C (en) 1995-06-12

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Owner name: YAMADA, HIDEAKI, KYOTO, JP MITSUBISHI RAYON CO., L