DE3869880D1 - Azithromycin und seine derivate als antiprotozoenmittel. - Google Patents

Azithromycin und seine derivate als antiprotozoenmittel.

Info

Publication number
DE3869880D1
DE3869880D1 DE8888308024T DE3869880T DE3869880D1 DE 3869880 D1 DE3869880 D1 DE 3869880D1 DE 8888308024 T DE8888308024 T DE 8888308024T DE 3869880 T DE3869880 T DE 3869880T DE 3869880 D1 DE3869880 D1 DE 3869880D1
Authority
DE
Germany
Prior art keywords
azithromycin
antiprotozene
derivatives
agent
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888308024T
Other languages
English (en)
Inventor
Jack Samuel Remington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE3869880D1 publication Critical patent/DE3869880D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8888308024T 1987-09-10 1988-08-31 Azithromycin und seine derivate als antiprotozoenmittel. Expired - Lifetime DE3869880D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/002317 WO1989002271A1 (en) 1987-09-10 1987-09-10 Azithromycin and derivatives as antiprotozoal agents

Publications (1)

Publication Number Publication Date
DE3869880D1 true DE3869880D1 (de) 1992-05-14

Family

ID=22202554

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888308024T Expired - Lifetime DE3869880D1 (de) 1987-09-10 1988-08-31 Azithromycin und seine derivate als antiprotozoenmittel.

Country Status (18)

Country Link
US (1) US4963531A (de)
EP (1) EP0307128B1 (de)
JP (1) JPH0667847B2 (de)
KR (1) KR930011996B1 (de)
AT (1) ATE74508T1 (de)
AU (1) AU596029B2 (de)
CA (1) CA1334574C (de)
DE (1) DE3869880D1 (de)
DK (1) DK175544B1 (de)
HU (1) HUT47553A (de)
IE (1) IE61507B1 (de)
IL (1) IL87698A (de)
MY (1) MY103388A (de)
NZ (1) NZ226112A (de)
PH (1) PH26229A (de)
PT (1) PT88448B (de)
WO (1) WO1989002271A1 (de)
ZA (1) ZA886727B (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO107257B1 (ro) 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
TW271400B (de) * 1992-07-30 1996-03-01 Pfizer
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
US5529994A (en) * 1993-05-05 1996-06-25 Palo Alto Medical Foundation Treatment for toxoplasmosis
ES2095772T3 (es) * 1993-05-05 1997-02-16 Palo Alto Medical Found Utilizacion de derivados de rifamicina para producir un medicamento destinado al tratamiento de la toxoplasmosis.
WO1995028939A1 (fr) * 1994-04-26 1995-11-02 Nobuhiro Narita Composition medicinale servant de medicament contre le cancer bronchopulmonaire 'non a petites cellules'
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
AU744318B2 (en) * 1994-04-29 2002-02-21 Pfizer Inc. Method of administering azithromycin
MX9605419A (es) * 1994-05-06 1997-12-31 Pfizer Formas de dosificacion de liberacion controlada de azitromicina.
US20030212123A1 (en) * 1997-05-05 2003-11-13 Pfizer Inc. COX-2 selective carprofen for treating pain and inflammation in dogs
US6407074B1 (en) * 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
JP2003512290A (ja) * 1997-09-10 2003-04-02 メルク エンド カムパニー インコーポレーテッド 家畜抗菌剤としての８ａ−アザライド
BR9812808A (pt) * 1997-10-16 2005-04-12 Pliva Pharm & Chem Works 3,6-hemicetais da classe de 9a-azalidas, processo para preparação dos mesmos, seuuso farmacêutico, bem como composição farmacêutica compreendendo os mesmos
PT1152765E (pt) * 1998-11-30 2004-12-31 Teva Pharma Etanolato de azitromicina, processo de preparacao e composicoes farmaceuticas que os contem
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
IT1313610B1 (it) 1999-08-09 2002-09-09 S I F I Societa Ind Farmaceuti Processo per la preparazione di formulazioni acquose per uso oftalmico
US6608033B1 (en) 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
US6586576B2 (en) 2000-01-04 2003-07-01 Teva Pharmaceutical Industries Ltd Preparation method of azithromycin hydrates
WO2002007736A1 (en) * 2000-07-24 2002-01-31 Cadila Pharmaceuticals Limited The process for manufacturing of clear liquid pharmaceutical composition of azithromycin
ES2260047T3 (es) 2000-07-25 2006-11-01 Laboratorio Silanes, S.A. De C.V. Proceso de etapa unica para la preparacion de 7,16-deoxi-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihidroxi-6-etil-3,5,9,11,13,15-hexametilbiciclo(11.2.1)hexadeca-1(2)-en-ona y obtencion de una forma nueva de 9-deoxo-9a-metil-9a-homoeritromicina a.
AU2001214115A1 (en) * 2000-08-01 2002-02-13 Habil F. Khorakiwala Process for the preparation of anhydrous azithromycin
WO2002015842A2 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
AU2002221895A1 (en) * 2000-11-27 2002-06-03 Biochemie S.A. Macrolide solvates
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
EP1390377B1 (de) * 2001-05-22 2006-03-08 Pfizer Products Inc. Neue kristallforme von azithromycin
US6861413B2 (en) * 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1671978A1 (de) 2001-05-22 2006-06-21 Pfizer Products Inc. Neue Kristallforme von Azithromycin
HUP0401332A2 (hu) * 2001-08-21 2004-11-29 Pfizer Products Inc. Azitromicin egyszeri adagolási formája
DE60232005D1 (de) * 2001-10-18 2009-05-28 Teva Pharma Stabilisierte azithromycin-zusammensetzungen
US20080149521A9 (en) * 2001-10-18 2008-06-26 Michael Pesachovich Methods of stabilizing azithromycin
KR100669279B1 (ko) * 2001-12-21 2007-01-16 화이자 프로덕츠 인크. 아지트로마이신의 습식 제립 방법
JP2005513099A (ja) * 2001-12-21 2005-05-12 ファイザー・プロダクツ・インク アジスロマイシンの直接的に圧縮可能な配合品
CN1646104A (zh) * 2002-02-01 2005-07-27 辉瑞产品公司 阿齐霉素的干颗粒制剂
ES2220229B1 (es) * 2003-05-29 2005-10-16 Quimica Sintetica, S.A. Sales de adicion de azitromicina y acido citrico y procedimiento para su obtencion.
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
BRPI0417348A (pt) 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
CN1889931A (zh) * 2003-12-04 2007-01-03 辉瑞产品公司 利用挤压器制备优选含泊洛沙姆和甘油酯的多重粒子阿奇霉素组合物的喷雾－冻凝方法
WO2005053640A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
US6984403B2 (en) 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
PL1691787T3 (pl) 2003-12-04 2008-11-28 Pfizer Prod Inc Sposób wytwarzania farmaceutycznych systemów wielocząstkowych
CN1295719C (zh) * 2003-12-30 2007-01-17 郑玉庆 远程智能型变压器
WO2006115494A1 (en) * 2005-04-26 2006-11-02 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060046970A1 (en) * 2004-08-31 2006-03-02 Insite Vision Incorporated Topical otic compositions and methods of topical treatment of prevention of otic infections
US20060198895A1 (en) * 2005-03-07 2006-09-07 Kotliar Eleonora M Azithromycin powder for oral suspension compositions
CN100427499C (zh) * 2005-12-20 2008-10-22 山东诚创医药技术开发有限公司 一种阿奇霉素的可溶性盐及其制备方法
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
ZA835204B (en) * 1982-07-19 1985-02-27 Pfizer N-methyl 11-aza-10-deoxo-10-dihydroerythromycin a,intermediates therefor and processes for their preparation
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
AU8280087A (en) * 1987-09-10 1989-04-17 Pfizer Inc. Azithromycin and derivatives as antiprotozoal agents

Also Published As

Publication number Publication date
EP0307128A3 (en) 1990-07-04
DK502888A (da) 1989-03-13
DK175544B1 (da) 2004-11-29
JPH0283326A (ja) 1990-03-23
KR930011996B1 (ko) 1993-12-23
IL87698A0 (en) 1989-02-28
EP0307128B1 (de) 1992-04-08
HUT47553A (en) 1989-03-28
CA1334574C (en) 1995-02-28
WO1989002271A1 (en) 1989-03-23
PT88448B (pt) 1992-10-30
AU2206188A (en) 1989-05-11
IL87698A (en) 1992-12-01
ATE74508T1 (de) 1992-04-15
US4963531A (en) 1990-10-16
JPH0667847B2 (ja) 1994-08-31
DK502888D0 (da) 1988-09-09
ZA886727B (en) 1990-04-25
PT88448A (pt) 1989-07-31
IE882762L (en) 1989-03-10
NZ226112A (en) 1997-03-24
PH26229A (en) 1992-04-01
KR890004709A (ko) 1989-05-09
IE61507B1 (en) 1994-11-02
EP0307128A2 (de) 1989-03-15
MY103388A (en) 1993-06-30
AU596029B2 (en) 1990-04-12

Similar Documents

Publication Publication Date Title
DE3869880D1 (de) Azithromycin und seine derivate als antiprotozoenmittel.
DK588487D0 (da) Forbedrede metalholdige farmaceutiske midler
ATE161836T1 (de) 4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate
ATE205472T1 (de) 9-((substituierte glycyl)amido)-6-demethyl-6- deoxytetracycline als antibiotische mittel
FI932104A0 (fi) Nya 4-arylpiperaziner och 4-arylpiperidiner
FI920023A0 (fi) Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
FI831230L (fi) N-glykosylerade karboxylsyraamidderivat, foerfarande foer deras framstaellning samt deras anvaendnifoer att paoverka kroppens eget foersvar
GR1000118B (el) Συνθεσις 1,2-διοξετανων & ενδιαμεσαι ουσιαι δι αυτην.
IT7926970A0 (it) Mezzi per l'attivazione e la disattivazione di innesti.
NO934197D0 (no) Vitamin D-3-analoger
DE69612056D1 (de) Terpenderivate (sarcodictyine) als antikrebsmittel
FI892222A (fi) Peptidalkoholer med antikoagulantverkan.
ATE204752T1 (de) Therapeutische anwendungen von 2',5'- oligoadenylat-derivaten
ATE118209T1 (de) Pyridin-3-percarboxylsäure monopersulfat.
ES2058196T3 (es) Derivados de azacromano.
ES2055030T3 (es) Antibioticos de 1-carbacefalosporina.
IT1241927B (it) 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono
SU860463A1 (ru) Производные 4-амино-1,3-диметилимидазо [4,5-с] пиридин-2-она, обладающие акарицидным действием
ES2078380T3 (es) Oligofosfatos de accion antiviral.
ATE104966T1 (de) 9-(acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde mittel davon als aktiver wirkstoff.
IT8603380A1 (it) Ventilatore perfezionato per l'areazione di ambienti chiusi
OA07522A (fr) Dérivés de 1,8-naphtyridine et de 1,5-8-azanaphtyridine.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition