DE3867512D1 - 1,4-disubstituierte piperazin-verbindungen, ihre herstellung und ihre verwendung. - Google Patents

1,4-disubstituierte piperazin-verbindungen, ihre herstellung und ihre verwendung.

Info

Publication number
DE3867512D1
DE3867512D1 DE8888302523T DE3867512T DE3867512D1 DE 3867512 D1 DE3867512 D1 DE 3867512D1 DE 8888302523 T DE8888302523 T DE 8888302523T DE 3867512 T DE3867512 T DE 3867512T DE 3867512 D1 DE3867512 D1 DE 3867512D1
Authority
DE
Germany
Prior art keywords
group
piperazine compounds
production
disubstituted piperazine
disubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888302523T
Other languages
English (en)
Inventor
Hirosada Sugihara
Katsumi Itoh
Kohei Nishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE3867512D1 publication Critical patent/DE3867512D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8888302523T 1987-03-24 1988-03-23 1,4-disubstituierte piperazin-verbindungen, ihre herstellung und ihre verwendung. Expired - Fee Related DE3867512D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6980487 1987-03-24

Publications (1)

Publication Number Publication Date
DE3867512D1 true DE3867512D1 (de) 1992-02-20

Family

ID=13413302

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888302523T Expired - Fee Related DE3867512D1 (de) 1987-03-24 1988-03-23 1,4-disubstituierte piperazin-verbindungen, ihre herstellung und ihre verwendung.

Country Status (13)

Country Link
US (1) US4880809A (de)
EP (1) EP0284359B1 (de)
CN (1) CN88101588A (de)
AT (1) ATE71373T1 (de)
AU (1) AU608580B2 (de)
DE (1) DE3867512D1 (de)
DK (1) DK155088A (de)
FI (1) FI881380A (de)
HU (1) HU202509B (de)
IL (1) IL85700A0 (de)
NO (1) NO881253L (de)
PT (1) PT87056B (de)
ZA (1) ZA882073B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY102447A (en) * 1986-06-16 1992-06-30 Ciba Geigy Ag Disubtituted piperazines
EP0318235A3 (de) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. PAF-Antagonist, 1,4-disubstituierte Piperazin-Verbindungen und deren Herstellung
KR900018073A (ko) * 1988-05-23 1990-12-20 추후보충 피페라진 화합물
GB8823775D0 (en) * 1988-10-11 1988-11-16 Scras New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines
GB8823776D0 (en) * 1988-10-11 1988-11-16 Scras New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use
EP0369810A3 (de) * 1988-11-18 1991-05-02 Takeda Chemical Industries, Ltd. PAF-Antagonisten als Antihyperendothelinemie-Mittel
GB8908587D0 (en) * 1989-04-15 1989-06-01 Scras Societe De Conseils De R New 2-substituted n,n'-ditrimethoxybenzoyl piperazines
US5369106A (en) * 1989-04-28 1994-11-29 Sankyo Company, Limited N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists
US5192766A (en) * 1989-04-28 1993-03-09 Sankyo Company, Limited N-acryloylpiperazine derivatives, their preparation and their use as PAF antagonists
EP0489690A1 (de) * 1990-12-05 1992-06-10 Ciba-Geigy Ag Substituierte N-Benzoyl-N'-(2-phenylethyl)-piperazine
ES2036926B1 (es) * 1991-08-08 1994-01-16 Uriach & Cia Sa J "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
ES2062943B1 (es) * 1993-03-23 1995-11-16 Uriach & Cia Sa J Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas.
CN1151744A (zh) * 1994-07-04 1997-06-11 武田药品工业株式会社 膦酸化合物及其制备和应用
ES2087038B1 (es) * 1994-11-07 1997-03-16 Uriach & Cia Sa J Nuevas piperidinas con actividad antagonista del paf.
US5859295A (en) * 1994-12-05 1999-01-12 University Of Kentucky Research Foundation Canavanine analogs and their use as chemotherapeutic agents
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
DE19754490A1 (de) * 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
CN1181065C (zh) * 2002-05-08 2004-12-22 上海医药工业研究院 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用
AU2003229142A1 (en) * 2002-06-07 2003-12-22 Cortical Pty Ltd Naphthalene derivatives which inhibit the cytokine or biological activity of macrophage inhibitory factor (MIF)
CN1867336B (zh) 2002-06-12 2010-05-12 凯莫森特里克斯股份有限公司 1-芳基-4-取代的哌嗪衍生物及其制药用途
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
AU2005219438B2 (en) * 2004-03-03 2011-02-17 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130646A (en) * 1975-07-25 1978-12-19 E. R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof
JPS52133993A (en) * 1976-04-29 1977-11-09 Takeda Chem Ind Ltd 1.2-dihydronaphthalene derivatives and method of preparing the same
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
DK309678A (da) * 1977-07-18 1979-01-19 Sandoz Ag Fremgangsmaade til fremstilling af tetralinderivater
US4173998A (en) * 1978-02-16 1979-11-13 Carrier Corporation Formed coil assembly
CH643549A5 (de) * 1979-08-25 1984-06-15 Merz & Co N-(trimethoxybenzyl)-n'-phenylpiperazine.
IT1176613B (it) * 1984-08-14 1987-08-18 Ravizza Spa Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
DE3685829T2 (de) * 1985-02-04 1992-12-17 Searle & Co Heterocyclische amide.
MY102447A (en) * 1986-06-16 1992-06-30 Ciba Geigy Ag Disubtituted piperazines
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체

Also Published As

Publication number Publication date
EP0284359A1 (de) 1988-09-28
FI881380A (fi) 1988-09-25
AU1353988A (en) 1988-09-22
NO881253D0 (no) 1988-03-22
CN88101588A (zh) 1988-11-23
ZA882073B (en) 1989-11-29
FI881380A0 (fi) 1988-03-23
HU202509B (en) 1991-03-28
EP0284359B1 (de) 1992-01-08
DK155088A (da) 1988-09-25
IL85700A0 (en) 1988-08-31
DK155088D0 (da) 1988-03-22
US4880809A (en) 1989-11-14
PT87056A (pt) 1988-04-01
PT87056B (pt) 1992-07-31
AU608580B2 (en) 1991-04-11
NO881253L (no) 1988-09-26
HUT46899A (en) 1988-12-28
ATE71373T1 (de) 1992-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee