DE3854956D1 - Nukleinsäuremultimere und amplifizierte Nukleinsäurehybridisierungstests damit - Google Patents
Nukleinsäuremultimere und amplifizierte Nukleinsäurehybridisierungstests damitInfo
- Publication number
- DE3854956D1 DE3854956D1 DE3854956T DE3854956T DE3854956D1 DE 3854956 D1 DE3854956 D1 DE 3854956D1 DE 3854956 T DE3854956 T DE 3854956T DE 3854956 T DE3854956 T DE 3854956T DE 3854956 D1 DE3854956 D1 DE 3854956D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- multimers
- oligonucleotide
- hybridization tests
- acid hybridization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/03—Herpetoviridae, e.g. pseudorabies virus
- G01N2333/04—Varicella-zoster virus
- G01N2333/045—Cytomegalovirus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10928287A | 1987-10-15 | 1987-10-15 | |
US18520188A | 1988-04-22 | 1988-04-22 | |
US25263888A | 1988-09-30 | 1988-09-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3854956D1 true DE3854956D1 (de) | 1996-03-14 |
DE3854956T2 DE3854956T2 (de) | 1996-06-13 |
Family
ID=27380635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3854956T Expired - Fee Related DE3854956T2 (de) | 1987-10-15 | 1988-10-17 | Nukleinsäuremultimere und amplifizierte Nukleinsäurehybridisierungstests damit |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0317077B1 (de) |
AT (1) | ATE133713T1 (de) |
CA (1) | CA1339351C (de) |
DE (1) | DE3854956T2 (de) |
DK (1) | DK175932B1 (de) |
ES (1) | ES2083363T3 (de) |
GR (1) | GR3019046T3 (de) |
IE (1) | IE75211B1 (de) |
WO (1) | WO1989003891A1 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5430136A (en) * | 1984-10-16 | 1995-07-04 | Chiron Corporation | Oligonucleotides having selectably cleavable and/or abasic sites |
US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
US5175270A (en) * | 1986-09-10 | 1992-12-29 | Polyprobe, Inc. | Reagents for detecting and assaying nucleic acid sequences |
US5656731A (en) * | 1987-10-15 | 1997-08-12 | Chiron Corporation | Nucleic acid-amplified immunoassay probes |
US5359100A (en) * | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
US5047523A (en) * | 1988-08-02 | 1991-09-10 | Ortho Diagnostic Systems Inc. | Nucleic acid probe for detection of neisseria gonorrhoea |
JP3068848B2 (ja) * | 1988-12-09 | 2000-07-24 | アムラド・コーポレイション・リミテッド | 増幅dna検定 |
DE3925613A1 (de) * | 1989-06-22 | 1991-01-03 | Boehringer Mannheim Gmbh | Neisseria-spezifische dna-sonde |
CA2065287C (en) | 1989-09-15 | 1999-12-21 | Tatsuo Miyamura | New hcv isolates |
US5232829A (en) * | 1989-09-29 | 1993-08-03 | Hoffmann-La Roche Inc. | Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes |
CA2025180A1 (en) * | 1989-10-12 | 1991-04-13 | William G. Weisburg | Nucleic acid probes and methods for detecting pathogenic candida yeasts |
CA2025179A1 (en) * | 1989-10-12 | 1991-04-13 | William G. Weisburg | Nucleic acid probes and methods for detecting cryptococcus neoformans |
GB8924989D0 (en) * | 1989-11-06 | 1989-12-28 | Scotgen Ltd | Method and device for the detection of antibiotic resistance |
US5629153A (en) * | 1990-01-10 | 1997-05-13 | Chiron Corporation | Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays |
EP0510085B1 (de) * | 1990-01-10 | 1999-09-08 | Chiron Diagnostics Corporation | Dns-abhängige rns-polymerase-transkripte als reportermoleküle zur signalverstärkung in nukleinsäure-hybridisierungsuntersuchungen |
CA2037349C (en) | 1990-03-26 | 2008-06-17 | James G. Wetmur | Branch migration of nucleotides |
CA2039517C (en) * | 1990-04-03 | 2006-11-07 | David Segev | Dna probe signal amplification |
CA2081455A1 (en) * | 1990-05-04 | 1991-11-05 | Michael S. Urdea | Protein-nucleic acid probes and immunoassays using same |
EP0541693B1 (de) * | 1990-07-27 | 1998-12-09 | Chiron Corporation | Grosse kammförmig verzweigte polynukleotide |
US5849481A (en) * | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
US5430138A (en) * | 1990-07-27 | 1995-07-04 | Chiron Corporation | Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable |
US5420330A (en) * | 1990-09-07 | 1995-05-30 | Pharmacia P-L Biochemicals Inc. | Lipo-phosphoramidites |
EP0610215A1 (de) * | 1991-06-17 | 1994-08-17 | Chiron Corporation | Polynukleotid-Bestimmung mit selektierbaren Spaltstellen. |
CA2125144A1 (en) * | 1991-12-23 | 1993-07-08 | Chiron Diagnostics Corporation | Htlv-1 probes for use in solution phase sandwich hybridization assays |
CA2124928C (en) * | 1991-12-23 | 2003-06-17 | Bruce D. Irvine | Hbv amplifier probes for use in solution phase sandwich hybridization assays |
US5747244A (en) * | 1991-12-23 | 1998-05-05 | Chiron Corporation | Nucleic acid probes immobilized on polystyrene surfaces |
EP0672175A4 (de) * | 1991-12-23 | 1997-08-06 | Chiron Corp | Hav-proben in sandwichhybridisierungsverfahren in lösungen. |
CA2124796A1 (en) * | 1991-12-23 | 1993-07-08 | Chiron Diagnostics Corporation | Cmv probes for use in solution phase sandwich hybridization assays |
ATE329054T1 (de) * | 1991-12-23 | 2006-06-15 | Chiron Corp | Sätze von hiv sonden für solution sandwich hybridationsverfahren |
WO1993013221A1 (en) * | 1991-12-23 | 1993-07-08 | Chiron Corporation | Chlamydiae probes for use in solution phase sandwich hybridization assays |
AU4596893A (en) * | 1992-05-29 | 1993-12-30 | Gen Trak, Inc. | Signal amplification probe and methods of use |
US5985548A (en) * | 1993-02-04 | 1999-11-16 | E. I. Du Pont De Nemours And Company | Amplification of assay reporters by nucleic acid replication |
BE1007918A3 (fr) * | 1993-02-19 | 1995-11-21 | Wallone Region | Sondes d'acides nucleiques chimiquement modifiees en 5'(oh) et/ou en 3'(oh) en vue de l'introduction en ces positions d'un ou plusieurs elements de marquage non radioactif et procede de preparation. |
FR2710075B1 (fr) * | 1993-09-15 | 1995-10-27 | Bio Merieux | Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal. |
US5561043A (en) * | 1994-01-31 | 1996-10-01 | Trustees Of Boston University | Self-assembling multimeric nucleic acid constructs |
US5648213A (en) * | 1994-08-30 | 1997-07-15 | Beckman Instruments, Inc. | Compositions and methods for use in detection of analytes |
US5780227A (en) * | 1995-06-07 | 1998-07-14 | Sheridan; Patrick J. | Oligonucleotide probe conjugated to a purified hydrophilic alkaline phosphatase and uses thereof |
US5853974A (en) | 1995-06-07 | 1998-12-29 | Chiron Corporation | Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates |
US6632936B2 (en) | 1995-09-06 | 2003-10-14 | Icos Corp | Cell-cycle checkpoint genes |
CA2218440A1 (en) * | 1996-12-21 | 1998-06-21 | Boehringer Mannheim Gmbh | Method of analysis using signal amplification |
EP1025220B1 (de) | 1997-10-21 | 2007-01-03 | The University Court Of The University Of Glasgow | Jmy, mit-aktivator für p300/cbp, dafür kodierendenucleinsäure und deren verwendungen |
US5962273A (en) * | 1997-11-04 | 1999-10-05 | Becton Dickinson And Company | Detection of Neisseria gonorrhoeae by amplification and detection of its nucleic acid |
GB9806093D0 (en) | 1998-03-20 | 1998-05-20 | Taylor John Hermon | Diagnostics and vaccines for mycobacterial infections of animals and humans |
US5976805A (en) * | 1998-04-27 | 1999-11-02 | Becton Dickinson And Company | Neisseria gonorrhoeae specific DNA fragment--GC3 |
US6468743B1 (en) | 1998-05-18 | 2002-10-22 | Conagra Grocery Products Company | PCR techniques for detecting microbial contaminants in foodstuffs |
GB9811403D0 (en) * | 1998-05-27 | 1998-07-22 | Isis Innovation | Polynucleotide multimers and their use in hybridisation assays |
US6203989B1 (en) | 1998-09-30 | 2001-03-20 | Affymetrix, Inc. | Methods and compositions for amplifying detectable signals in specific binding assays |
GB9914943D0 (en) * | 1999-06-25 | 1999-08-25 | Imp College Innovations Ltd | Methods |
EP1268508A4 (de) * | 2000-03-29 | 2004-11-03 | Polyprobe Inc | Reagentien zur qualitätskontrolle von nukleinsäure-mikroanordnungen |
US7763421B2 (en) | 2000-06-05 | 2010-07-27 | Ventana Medical Systems, Inc. | Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation |
EP1356298B1 (de) | 2000-11-30 | 2011-05-18 | Crawford Healthcare Holdings Limited | Krankheitsdiagnose |
US7625872B2 (en) | 2002-12-23 | 2009-12-01 | Dynavax Technologies Corporation | Branched immunomodulatory compounds and methods of using the same |
US7229800B2 (en) | 2004-04-16 | 2007-06-12 | Becton, Dickinson And Company | Neisseria gonorrhoeae assay |
JP2009533023A (ja) * | 2006-04-07 | 2009-09-17 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド | ナイセリア・ゴノレー(Neisseriagonorrhoeae)特異的オリゴヌクレオチド配列 |
JP2008043332A (ja) * | 2006-08-17 | 2008-02-28 | Panomics Inc | 組織スライドからの核酸定量 |
EP2116618A1 (de) | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnose und Behandlung des Kawasaki-Syndroms |
US20110081367A1 (en) | 2008-06-14 | 2011-04-07 | Veredus Laboratories Pte Ltd | Influenza sequences |
WO2010071610A1 (en) | 2008-12-19 | 2010-06-24 | Agency For Science, Technology And Research (A*Star) | Severe chikungunya biomarkers |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI71768C (fi) * | 1984-02-17 | 1987-02-09 | Orion Yhtymae Oy | Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning. |
GB8405437D0 (en) * | 1984-03-01 | 1984-04-04 | Amersham Int Plc | Detecting polynucleotide sequences |
DE3420925A1 (de) * | 1984-06-05 | 1985-12-05 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagenz zum nachweis einer nukleinsaeure-sequenz |
US4755458A (en) * | 1984-08-30 | 1988-07-05 | Enzo Biochem, Inc. | Composition and method for the detection of the presence of a polynucleotide sequence of interest |
US4883750A (en) * | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
CA1272443A (en) * | 1985-02-22 | 1990-08-07 | Nanibhushan Dattagupta | Solution-phase dual hybridization assay for detecting polynucleotide sequences |
US5252760A (en) | 1985-03-28 | 1993-10-12 | Chiron Corporation | Method of using colored phosphorylating reagents |
ATE65092T1 (de) * | 1985-05-31 | 1991-07-15 | Amoco Corp | Verstaerkung von hybridisierungssignalen durch verwendung von komplementarischen dns-straengen. |
US4868105A (en) * | 1985-12-11 | 1989-09-19 | Chiron Corporation | Solution phase nucleic acid sandwich assay |
US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
AU7015287A (en) * | 1986-03-19 | 1987-09-24 | Cetus Corporation | Detection of nucleic acid sequence using liquid hybridization method |
-
1988
- 1988-10-07 CA CA000579610A patent/CA1339351C/en not_active Expired - Fee Related
- 1988-10-14 WO PCT/US1988/003644 patent/WO1989003891A1/en unknown
- 1988-10-14 IE IE313188A patent/IE75211B1/en not_active IP Right Cessation
- 1988-10-17 ES ES88309697T patent/ES2083363T3/es not_active Expired - Lifetime
- 1988-10-17 AT AT88309697T patent/ATE133713T1/de not_active IP Right Cessation
- 1988-10-17 DE DE3854956T patent/DE3854956T2/de not_active Expired - Fee Related
- 1988-10-17 EP EP88309697A patent/EP0317077B1/de not_active Expired - Lifetime
-
1989
- 1989-06-15 DK DK198902945A patent/DK175932B1/da active
-
1996
- 1996-02-21 GR GR960400449T patent/GR3019046T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK175932B1 (da) | 2005-07-18 |
IE883131L (en) | 1989-04-15 |
DE3854956T2 (de) | 1996-06-13 |
IE75211B1 (en) | 1997-08-27 |
DK294589A (da) | 1989-08-15 |
ES2083363T3 (es) | 1996-04-16 |
DK294589D0 (da) | 1989-06-15 |
EP0317077B1 (de) | 1996-01-31 |
EP0317077A1 (de) | 1989-05-14 |
CA1339351C (en) | 1997-08-26 |
ATE133713T1 (de) | 1996-02-15 |
WO1989003891A1 (en) | 1989-05-05 |
GR3019046T3 (en) | 1996-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: CHIRON DIAGNOSTICS CORP. (N.D.GES.D. STAATES DELAW |
|
8339 | Ceased/non-payment of the annual fee |