DE3852140T2 - Produktion von Proteinen in aktiven Formen. - Google Patents
Produktion von Proteinen in aktiven Formen.Info
- Publication number
- DE3852140T2 DE3852140T2 DE3852140T DE3852140T DE3852140T2 DE 3852140 T2 DE3852140 T2 DE 3852140T2 DE 3852140 T DE3852140 T DE 3852140T DE 3852140 T DE3852140 T DE 3852140T DE 3852140 T2 DE3852140 T2 DE 3852140T2
- Authority
- DE
- Germany
- Prior art keywords
- protein
- proteins
- production
- rupturing
- active forms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 239000004202 carbamide Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPI046287 | 1987-02-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3852140D1 DE3852140D1 (de) | 1995-01-05 |
DE3852140T2 true DE3852140T2 (de) | 1995-04-06 |
Family
ID=3772028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3852140T Expired - Fee Related DE3852140T2 (de) | 1987-02-20 | 1988-02-16 | Produktion von Proteinen in aktiven Formen. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4966963A (de) |
EP (1) | EP0279619B1 (de) |
JP (1) | JPS63264598A (de) |
AT (1) | ATE114319T1 (de) |
AU (1) | AU612133B2 (de) |
CA (1) | CA1326106C (de) |
DE (1) | DE3852140T2 (de) |
ES (1) | ES2065906T3 (de) |
NZ (1) | NZ223559A (de) |
ZA (1) | ZA881067B (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU612133B2 (en) * | 1987-02-20 | 1991-07-04 | Natinco Nv | Production of proteins in active forms |
AU609824B2 (en) * | 1987-06-15 | 1991-05-09 | Southern Cross Biotech Pty Ltd. | Production of proteins in active forms |
JPH03500601A (ja) * | 1987-06-26 | 1991-02-14 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼイション | ウィルス中和及び保護モノクローナル抗体により認識されるibdv vp2エピトープ |
US5136027A (en) * | 1989-05-02 | 1992-08-04 | Abbott Laboratories | Method for renaturing proteins in the presence of alkyl sulfate detergents |
US5101018A (en) * | 1989-06-12 | 1992-03-31 | International Minerals & Chemical Corp. | Method for recovering recombinant proteins |
DE69013475T2 (de) * | 1989-12-05 | 1995-05-04 | American Cyanamid Co | Methode zur Auflösung und Naturation von Somatotropin unter Verwendung von einer niedrigen Harnstoffkonzentration. |
EP0547102B1 (de) * | 1990-09-05 | 1998-07-08 | Southern Cross Biotech Pty.Ltd. | In lösung bringen von proteinen in aktiver form |
US6566098B1 (en) * | 1990-09-14 | 2003-05-20 | The United States Of America As Represented By The Department Of Health And Human Services | DNA encoding truncated hepatocyte growth factor variants |
GB2281558B (en) * | 1993-09-07 | 1997-02-19 | Joseph Matthew Gaugas | Supplying sulphur to plants |
US5861372A (en) * | 1996-02-22 | 1999-01-19 | The Children's Medical Center Corporation | Aggregate angiostatin and method of use |
US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
US5840838A (en) * | 1996-02-29 | 1998-11-24 | University Of Kentucky Research Foundation | Process for enhancing the activity of amyloid β peptides |
US20030190307A1 (en) * | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
US6566583B1 (en) | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
CN102161984B (zh) | 1998-08-06 | 2016-06-01 | 山景药品公司 | 分离四聚体尿酸氧化酶的方法 |
US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
WO2006110761A2 (en) | 2005-04-11 | 2006-10-19 | Savient Pharmaceuticals, Inc. | A variant form of urate oxidase and use thereof |
HUE052976T2 (hu) | 2005-04-11 | 2021-06-28 | Horizon Pharma Rheumatology Llc | Urát-oxidáz variáns formái és azok alkalmazása |
US20080159976A1 (en) * | 2005-04-11 | 2008-07-03 | Jacob Hartman | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
US20090081122A1 (en) * | 2005-05-23 | 2009-03-26 | Universite De Geneve | Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant |
PL2013225T3 (pl) * | 2006-04-12 | 2015-06-30 | Crealta Pharmaceuticals Llc | Oczyszczanie białek z zastosowaniem kationowego środka powierzchniowo czynnego |
US9388406B2 (en) | 2008-11-17 | 2016-07-12 | Cornell University | System useful for reporting protein-protein interactions in the bacterial periplasm |
MX347903B (es) | 2009-06-25 | 2017-05-18 | Crealta Pharmaceuticals Llc | Metodos y equipos para predecir el riesgo de reaccion a la infusion y perdida de respuesta mediada por anticuerpos al supervisar el acido urico en suero durante una terapia con uricasa conjugada con peg. |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2829089A1 (de) * | 1977-07-13 | 1979-02-01 | Sandoz Ag | Subunit-vakzine |
US4462940A (en) * | 1982-09-23 | 1984-07-31 | Cetus Corporation | Process for the recovery of human β-interferon-like polypeptides |
GR79124B (de) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
US4731440A (en) * | 1985-02-22 | 1988-03-15 | Monsanto Company | Method of somatotropin solubilization using dimethylsulfone and naturation |
ES8800957A1 (es) * | 1985-02-22 | 1987-12-01 | Monsanto Co | Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina |
US4766224A (en) * | 1985-08-19 | 1988-08-23 | International Minerals & Chemical Corp. | Purification and activation of proteins from insoluble inclusion bodies |
AU597924B2 (en) * | 1985-12-11 | 1990-06-14 | Natinco Nv | Solubilization of protein aggregates |
AU612133B2 (en) * | 1987-02-20 | 1991-07-04 | Natinco Nv | Production of proteins in active forms |
AU607988B2 (en) * | 1987-04-21 | 1991-03-21 | Southern Cross Biotech Pty Ltd. | Production of proteins in active forms |
AU1763188A (en) * | 1987-06-15 | 1988-12-15 | Bunge (Australia) Pty Ltd | Recovery of proteins in active form |
-
1988
- 1988-02-08 AU AU11412/88A patent/AU612133B2/en not_active Ceased
- 1988-02-11 US US07/154,938 patent/US4966963A/en not_active Expired - Lifetime
- 1988-02-16 ES ES88301257T patent/ES2065906T3/es not_active Expired - Lifetime
- 1988-02-16 ZA ZA881067A patent/ZA881067B/xx unknown
- 1988-02-16 CA CA000558944A patent/CA1326106C/en not_active Expired - Fee Related
- 1988-02-16 DE DE3852140T patent/DE3852140T2/de not_active Expired - Fee Related
- 1988-02-16 AT AT88301257T patent/ATE114319T1/de not_active IP Right Cessation
- 1988-02-16 EP EP88301257A patent/EP0279619B1/de not_active Expired - Lifetime
- 1988-02-18 NZ NZ223559A patent/NZ223559A/xx unknown
- 1988-02-19 JP JP63037341A patent/JPS63264598A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE3852140D1 (de) | 1995-01-05 |
EP0279619B1 (de) | 1994-11-23 |
CA1326106C (en) | 1994-01-11 |
NZ223559A (en) | 1989-09-27 |
ES2065906T3 (es) | 1995-03-01 |
AU612133B2 (en) | 1991-07-04 |
ATE114319T1 (de) | 1994-12-15 |
ZA881067B (en) | 1988-08-11 |
EP0279619A2 (de) | 1988-08-24 |
AU1141288A (en) | 1988-08-25 |
EP0279619A3 (en) | 1990-04-11 |
JPS63264598A (ja) | 1988-11-01 |
US4966963A (en) | 1990-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NANTINCO, NV, WILLENSTED, CURACAO, AN |
|
8339 | Ceased/non-payment of the annual fee |