DE3850203D1 - Benzimidazolin-2-oxo-1-carboxylsäure-Derivate, verwendbar als Antagonisten von 5-HT-Rezeptoren. - Google Patents

Benzimidazolin-2-oxo-1-carboxylsäure-Derivate, verwendbar als Antagonisten von 5-HT-Rezeptoren.

Info

Publication number: DE3850203D1
Authority: DE; Germany
Prior art keywords: alkyl; hydrogen atom; substituted; mono; optionally
Prior art date: 1987-09-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE3850203T

Other languages

English (en)

Other versions

DE3850203T2 (de

Inventor

Marco Turconi

Arturo Donetti

Rosamaria Micheletti

Annamaria Uberti

Massimo Nicola

Antonio Giachetti

Ernesto Montagna

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Italia SpA

Original Assignee

Boehringer Ingelheim Italia SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-23

Filing date

1988-09-19

Publication date

1994-07-21

1988-09-19 Application filed by Boehringer Ingelheim Italia SpA filed Critical Boehringer Ingelheim Italia SpA

1994-07-21 Publication of DE3850203D1 publication Critical patent/DE3850203D1/de

1994-09-22 Application granted granted Critical

1994-09-22 Publication of DE3850203T2 publication Critical patent/DE3850203T2/de

2008-09-20 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. ***e
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DE3850203T 1987-09-23 1988-09-19 Benzimidazolin-2-oxo-1-carboxylsäure-Derivate, verwendbar als Antagonisten von 5-HT-Rezeptoren. Expired - Lifetime DE3850203T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8721997A IT1231413B (it)	1987-09-23	1987-09-23	Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht

Publications (2)

Publication Number	Publication Date
DE3850203D1 true DE3850203D1 (de)	1994-07-21
DE3850203T2 DE3850203T2 (de)	1994-09-22

Family

ID=11189966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE3850203T Expired - Lifetime DE3850203T2 (de)	1987-09-23	1988-09-19	Benzimidazolin-2-oxo-1-carboxylsäure-Derivate, verwendbar als Antagonisten von 5-HT-Rezeptoren.

Country Status (28)

Country	Link
EP (1)	EP0309423B1 (de)
JP (1)	JPH0631225B2 (de)
KR (1)	KR960003604B1 (de)
AT (1)	ATE107305T1 (de)
BR (1)	BR1100514A (de)
CA (1)	CA1337347C (de)
CZ (1)	CZ279864B6 (de)
DD (1)	DD285354A5 (de)
DE (1)	DE3850203T2 (de)
DK (1)	DK172226B1 (de)
ES (1)	ES2054872T3 (de)
FI (1)	FI89920C (de)
HK (1)	HK142195A (de)
HU (2)	HU200770B (de)
IE (1)	IE63234B1 (de)
IL (1)	IL87795A (de)
IT (1)	IT1231413B (de)
LV (1)	LV11035B (de)
MX (1)	MX9203249A (de)
NO (1)	NO169286C (de)
NZ (1)	NZ226291A (de)
PH (1)	PH29923A (de)
PL (2)	PL152951B1 (de)
SK (1)	SK278812B6 (de)
SU (1)	SU1676451A3 (de)
UA (1)	UA8022A1 (de)
YU (1)	YU46925B (de)
ZA (1)	ZA887083B (de)

Families Citing this family (37)

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IT1230881B (it) *	1989-06-20	1991-11-08	Angeli Inst Spa	Derivati del r(-) 3-chinuclidinolo
CA2030051C (en) *	1989-11-17	2001-08-07	Haruhiko Kikuchi	Indole derivatives
EP0436245A1 (de) *	1989-12-27	1991-07-10	Duphar International Research B.V	Substituierte 3,4-annelierte Benzimidazol-2(1H)-one
JP3122671B2 (ja) *	1990-05-23	2001-01-09	協和醗酵工業株式会社	複素環式化合物
US5192770A (en) *	1990-12-07	1993-03-09	Syntex (U.S.A.) Inc.	Serotonergic alpha-oxoacetamides
JP3026845B2 (ja) *	1991-02-20	2000-03-27	日清製粉株式会社	ピペリジン誘導体
IT1250629B (it) *	1991-07-04	1995-04-21	Boehringer Ingelheim Italia	Uso dei derivati dell'acido benzimidazolin-2-oxo-1-carbossilico.
GB9204565D0 (en) *	1992-03-03	1992-04-15	Smithkline Beecham Plc	Pharmaceuticals
JP2699794B2 (ja) *	1992-03-12	1998-01-19	三菱化学株式会社	チエノ〔３，２−ｂ〕ピリジン誘導体
JPH05310732A (ja) *	1992-03-12	1993-11-22	Mitsubishi Kasei Corp	シンノリン−３−カルボン酸誘導体
EP0641198A1 (de) *	1992-05-23	1995-03-08	Smithkline Beecham Plc	Arzneimittel zur behandlung von angstzuständen
US5300512A (en) *	1992-06-24	1994-04-05	G. D. Searle & Co.	Benzimidazole compounds
US5280028A (en) *	1992-06-24	1994-01-18	G. D. Searle & Co.	Benzimidazole compounds
US5521193A (en) *	1992-06-24	1996-05-28	G. D. Searle & Co.	Benzimidazole compounds
AU4350493A (en) *	1992-06-27	1994-01-24	Smithkline Beecham Plc	Medicaments containing 5-ht4 receptor antagonists
FR2694292B1 (fr) *	1992-07-29	1994-10-21	Esteve Labor Dr	Dérivés de benzimidazole-2-thione-, leur préparation et leur application en tant que médicament.
US5534521A (en) *	1993-06-23	1996-07-09	G. D. Searle & Co.	Benzimidazole compounds
GB9502582D0 (en) *	1995-02-10	1995-03-29	Smithkline Beecham Plc	Novel process
AU755117B2 (en) *	1999-05-12	2002-12-05	Sydney Gordon Low	A message processing system
TW200533348A (en)	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en)	2004-04-07	2010-06-01	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en)	2004-04-07	2012-11-13	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en)	2004-04-07	2011-11-01	Theravance Inc	Quinolinone-carboxamide compounds as 5-ht4 recepto
JP4129445B2 (ja) *	2004-06-15	2008-08-06	ファイザー・インク	ベンズイミダゾロンカルボン酸誘導体
DE602005014566D1 (de)	2004-11-05	2009-07-02	Theravance Inc	Chinolinon-carboxamid-verbindungen
DE602005016446D1 (de)	2004-11-05	2009-10-15	Theravance Inc	5-HT4-Rezeptoragonistenverbindungen
CA2588037A1 (en)	2004-12-22	2006-06-29	Theravance, Inc.	Indazole-carboxamide compounds
NZ560828A (en)	2005-03-02	2011-01-28	Theravance Inc	Quinolinone compounds as 5-HT4 receptor agonists
JP5086248B2 (ja)	2005-06-07	2012-11-28	セラヴァンス，インコーポレーテッド	５−ｈｔ４受容体アゴニストとしてのベンゾイミダゾロン−カルボキサミド化合物
MY143574A (en)	2005-11-22	2011-05-31	Theravance Inc	Carbamate compounds as 5-ht4 receptor agonists
NZ583487A (en) *	2007-07-27	2011-09-30	Actelion Pharmaceuticals Ltd	2-aza-bicyclo[3.3.0]octane derivatives
KR101779991B1 (ko)	2009-05-20	2017-09-19	인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔)	병소성 전정 질환을 치료하기 위한 세로토닌 5-ｈｔ3 수용체 길항제의 용도
EP2253316B1 (de)	2009-05-20	2013-08-14	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serotonin-5-HT3-Rezeptorantagonisten zur Verwendung bei der Behandlung oder Prävention einer Innenohr-Pathologie mit Vestibularisdefiziten
EP2712655B1 (de)	2011-04-28	2019-12-18	The Broad Institute, Inc.	Histondeacetylase-Hemmer
US9790184B2 (en)	2012-07-27	2017-10-17	The Broad Institute, Inc.	Inhibitors of histone deacetylase
WO2014100438A1 (en)	2012-12-20	2014-06-26	The Broad Institute, Inc.	Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
WO2016007630A1 (en) *	2014-07-11	2016-01-14	Alpharmagen, Llc	Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4250176A (en) *	1976-12-21	1981-02-10	Janssen Pharmaceutica N.V.	Piperazine derivatives
EP0093488A3 (de) *	1982-03-18	1984-05-23	Beecham Group Plc	Nortropyl-Benzopyrrolinon-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
ES2053451T3 (es) *	1986-01-07	1994-08-01	Beecham Group Plc	Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.

1987
- 1987-09-23 IT IT8721997A patent/IT1231413B/it active
1988
- 1988-09-19 IL IL87795A patent/IL87795A/xx active Protection Beyond IP Right Term
- 1988-09-19 ES ES88830375T patent/ES2054872T3/es not_active Expired - Lifetime
- 1988-09-19 AT AT88830375T patent/ATE107305T1/de not_active IP Right Cessation
- 1988-09-19 PL PL1988279346A patent/PL152951B1/pl unknown
- 1988-09-19 PL PL1988274751A patent/PL151434B1/pl unknown
- 1988-09-19 DD DD88319929A patent/DD285354A5/de not_active IP Right Cessation
- 1988-09-19 EP EP88830375A patent/EP0309423B1/de not_active Expired - Lifetime
- 1988-09-19 DE DE3850203T patent/DE3850203T2/de not_active Expired - Lifetime
- 1988-09-20 JP JP63236179A patent/JPH0631225B2/ja not_active Expired - Lifetime
- 1988-09-20 CA CA000577840A patent/CA1337347C/en not_active Expired - Lifetime
- 1988-09-21 NZ NZ226291A patent/NZ226291A/xx unknown
- 1988-09-21 YU YU177888A patent/YU46925B/sh unknown
- 1988-09-22 DK DK526188A patent/DK172226B1/da not_active IP Right Cessation
- 1988-09-22 CZ CS886307A patent/CZ279864B6/cs not_active IP Right Cessation
- 1988-09-22 IE IE286988A patent/IE63234B1/en not_active IP Right Cessation
- 1988-09-22 UA UA4356601A patent/UA8022A1/uk unknown
- 1988-09-22 HU HU884970A patent/HU200770B/hu not_active IP Right Cessation
- 1988-09-22 FI FI884350A patent/FI89920C/fi not_active IP Right Cessation
- 1988-09-22 SU SU884356601A patent/SU1676451A3/ru active
- 1988-09-22 ZA ZA887083A patent/ZA887083B/xx unknown
- 1988-09-22 NO NO884202A patent/NO169286C/no not_active IP Right Cessation
- 1988-09-22 SK SK6307-88A patent/SK278812B6/sk unknown
- 1988-09-22 PH PH37579A patent/PH29923A/en unknown
- 1988-09-23 KR KR88012299A patent/KR960003604B1/ko not_active IP Right Cessation
1992
- 1992-06-24 MX MX9203249A patent/MX9203249A/es unknown
1995
- 1995-02-17 LV LVP-95-33A patent/LV11035B/en unknown
- 1995-06-30 HU HU95P/P00691P patent/HU211566A9/hu unknown
- 1995-09-07 HK HK142195A patent/HK142195A/xx not_active IP Right Cessation
1997
- 1997-05-13 BR BR1100514-9A patent/BR1100514A/pt active IP Right Grant

Also Published As

Publication number	Publication date
CA1337347C (en)	1995-10-17
LV11035B (en)	1996-08-20
PH29923A (en)	1996-09-16
FI89920B (fi)	1993-08-31
NO884202L (no)	1989-03-28
FI89920C (fi)	1993-12-10
NO169286B (no)	1992-02-24
HUT48250A (en)	1989-05-29
IL87795A0 (en)	1989-03-31
SU1676451A3 (ru)	1991-09-07
ES2054872T3 (es)	1994-08-16
LV11035A (lv)	1996-02-20
JPH0631225B2 (ja)	1994-04-27
HU200770B (en)	1990-08-28
PL152951B1 (en)	1991-02-28
DD285354A5 (de)	1990-12-12
ZA887083B (en)	1990-05-30
UA8022A1 (uk)	1995-12-26
PL151434B1 (en)	1990-09-28
FI884350A0 (fi)	1988-09-22
NZ226291A (en)	1991-05-28
IT1231413B (it)	1991-12-04
IT8721997A0 (it)	1987-09-23
PL274751A1 (en)	1989-09-04
EP0309423B1 (de)	1994-06-15
DK172226B1 (da)	1998-01-12
CZ279864B6 (cs)	1995-07-12
NO884202D0 (no)	1988-09-22
KR890005105A (ko)	1989-05-11
JPH01106882A (ja)	1989-04-24
ATE107305T1 (de)	1994-07-15
NO169286C (no)	1992-06-03
PL279346A1 (en)	1990-01-08
BR1100514A (pt)	2002-04-02
IE63234B1 (en)	1995-04-05
IE882869L (en)	1989-03-23
SK630788A3 (en)	1998-03-04
SK278812B6 (sk)	1998-03-04
AU2237888A (en)	1989-03-23
DK526188D0 (da)	1988-09-22
AU610040B2 (en)	1991-05-09
DE3850203T2 (de)	1994-09-22
IL87795A (en)	1993-02-21
YU46925B (sh)	1994-06-24
HU211566A9 (en)	1995-12-28
EP0309423A3 (en)	1989-11-29
EP0309423A2 (de)	1989-03-29
DK526188A (da)	1989-03-24
CZ630788A3 (en)	1995-04-12
MX9203249A (es)	1992-07-01
HK142195A (en)	1995-09-15
YU177888A (en)	1990-06-30
KR960003604B1 (en)	1996-03-20
FI884350A (fi)	1989-03-24

Legal Events

Date	Code	Title	Description
1995-07-13	8364	No opposition during term of opposition

Publication	Publication Date	Title
DE3850203D1 (de)	1994-07-21	Benzimidazolin-2-oxo-1-carboxylsäure-Derivate, verwendbar als Antagonisten von 5-HT-Rezeptoren.
DE69230926T2 (de)	2000-10-05	Benzimidazolonderivate als 5-HT1A und 5-HT2-Antagonisten
HUP0401855A2 (hu)	2004-12-28	Pirimidin-származékok mint az inzulinszerű növekedési faktor-1 receptor (IGF-1R) modulátorai, eljárás előállításukra, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények
PT93066A (pt)	1990-08-31	Processo para a preparacao de derivados heterociclicos contendo nucleos bengenicos fundidos com nucleos monoazotados substituidos e de composicoes farmaceuticas que os contem