DE3775278D1 - Topische methotrexatzubereitung zur behandlung hyperproliferativer epithelerkrankungen. - Google Patents
Topische methotrexatzubereitung zur behandlung hyperproliferativer epithelerkrankungen.Info
- Publication number
- DE3775278D1 DE3775278D1 DE8787304797T DE3775278T DE3775278D1 DE 3775278 D1 DE3775278 D1 DE 3775278D1 DE 8787304797 T DE8787304797 T DE 8787304797T DE 3775278 T DE3775278 T DE 3775278T DE 3775278 D1 DE3775278 D1 DE 3775278D1
- Authority
- DE
- Germany
- Prior art keywords
- topical
- diseases
- epithelic
- treating hyperproliferative
- methotrexate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000699 topical effect Effects 0.000 title abstract 3
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000003463 hyperproliferative effect Effects 0.000 title abstract 2
- 229960000485 methotrexate Drugs 0.000 title abstract 2
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86893686A | 1986-05-30 | 1986-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3775278D1 true DE3775278D1 (de) | 1992-01-30 |
Family
ID=25352598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787304797T Expired - Lifetime DE3775278D1 (de) | 1986-05-30 | 1987-05-29 | Topische methotrexatzubereitung zur behandlung hyperproliferativer epithelerkrankungen. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0247900B1 (de) |
JP (1) | JPS6327432A (de) |
AT (1) | ATE70444T1 (de) |
CA (1) | CA1300508C (de) |
DE (1) | DE3775278D1 (de) |
DK (1) | DK277387A (de) |
ES (1) | ES2038663T3 (de) |
NZ (1) | NZ220495A (de) |
ZA (1) | ZA873928B (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993007874A1 (en) * | 1991-10-26 | 1993-04-29 | Ian Flockhart | Medicament composition for topical application |
WO1998031369A1 (fr) * | 1997-01-16 | 1998-07-23 | Sekisui Chemical Co., Ltd. | Preparations a usage externe a absorption percutanee |
KR100439204B1 (ko) * | 2000-10-25 | 2004-07-07 | 주식회사 삼양사 | 메토트렉세이트를 유효성분으로 함유하는 경피투여용 조성물 |
BR102012009350B1 (pt) * | 2012-04-20 | 2020-12-29 | Biolab Sanus Farmacêutica Ltda | composição farmacêutica tópica, processo de produção da composição farmacêutica tópica e uso da composição farmacêutica tópica |
US20210186862A1 (en) * | 2017-12-05 | 2021-06-24 | Shilpa Medicare Ltd | Methotrexate topical solution for treatment of psoriasis |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1553310A (en) * | 1975-06-19 | 1979-09-26 | Nelson Res & Dev | Vehicle composition containing 1-substituted azacycloalkan-2-ones |
GB2143433A (en) * | 1983-06-20 | 1985-02-13 | Hariprasad Manibhai Patel | Methotrexate ointment |
US4557934A (en) * | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
US4743588A (en) * | 1984-06-13 | 1988-05-10 | Allergan Pharmaceuticals, Inc. | Compositions and methods of enhancing transdermal and transmembrane penetration systemic agents |
-
1987
- 1987-05-29 EP EP87304797A patent/EP0247900B1/de not_active Expired - Lifetime
- 1987-05-29 DK DK277387A patent/DK277387A/da not_active Application Discontinuation
- 1987-05-29 JP JP62137609A patent/JPS6327432A/ja active Pending
- 1987-05-29 AT AT87304797T patent/ATE70444T1/de not_active IP Right Cessation
- 1987-05-29 ES ES198787304797T patent/ES2038663T3/es not_active Expired - Lifetime
- 1987-05-29 DE DE8787304797T patent/DE3775278D1/de not_active Expired - Lifetime
- 1987-05-29 NZ NZ220495A patent/NZ220495A/xx unknown
- 1987-06-01 CA CA000538541A patent/CA1300508C/en not_active Expired - Lifetime
- 1987-06-02 ZA ZA873928A patent/ZA873928B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ZA873928B (en) | 1988-02-24 |
NZ220495A (en) | 1990-07-26 |
CA1300508C (en) | 1992-05-12 |
EP0247900B1 (de) | 1991-12-18 |
ES2038663T3 (es) | 1993-08-01 |
ATE70444T1 (de) | 1992-01-15 |
DK277387A (da) | 1987-12-01 |
JPS6327432A (ja) | 1988-02-05 |
EP0247900A1 (de) | 1987-12-02 |
DK277387D0 (da) | 1987-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |