DE3752363D1 - Herstellung synthetischer dns und deren verwendung bei der synthese grosser polypeptide - Google Patents
Herstellung synthetischer dns und deren verwendung bei der synthese grosser polypeptideInfo
- Publication number
- DE3752363D1 DE3752363D1 DE3752363T DE3752363T DE3752363D1 DE 3752363 D1 DE3752363 D1 DE 3752363D1 DE 3752363 T DE3752363 T DE 3752363T DE 3752363 T DE3752363 T DE 3752363T DE 3752363 D1 DE3752363 D1 DE 3752363D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- large polypeptides
- synthesis
- synthetic dna
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000002306 biochemical method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Mycology (AREA)
- Insects & Arthropods (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92725886A | 1986-11-04 | 1986-11-04 | |
US927258 | 1986-11-04 | ||
PCT/US1987/002822 WO1988003533A1 (en) | 1986-11-04 | 1987-10-29 | Construction of synthetic dna and its use in large polypeptide synthesis |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3752363D1 true DE3752363D1 (de) | 2003-04-03 |
DE3752363T2 DE3752363T2 (de) | 2004-02-19 |
Family
ID=25454485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3752363T Expired - Fee Related DE3752363T2 (de) | 1986-11-04 | 1987-10-29 | Herstellung synthetischer dns und deren verwendung bei der synthese grosser polypeptide |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0293443B1 (de) |
JP (3) | JPH01501755A (de) |
AT (1) | ATE233273T1 (de) |
AU (1) | AU612340B2 (de) |
DE (1) | DE3752363T2 (de) |
DK (1) | DK369788D0 (de) |
FI (1) | FI101720B (de) |
NO (1) | NO311982B1 (de) |
NZ (1) | NZ222450A (de) |
WO (1) | WO1988003533A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5496712A (en) * | 1990-11-06 | 1996-03-05 | Protein Polymer | High molecular weight collagen-like protein polymers |
US5830713A (en) * | 1986-11-04 | 1998-11-03 | Protein Polymer Technologies, Inc. | Methods for preparing synthetic repetitive DNA |
US5773249A (en) * | 1986-11-04 | 1998-06-30 | Protein Polymer Technologies, Inc. | High molecular weight collagen-like protein polymers |
US5606019A (en) * | 1987-10-29 | 1997-02-25 | Protien Polymer Technologies, Inc. | Synthetic protein as implantables |
WO1990003438A1 (en) * | 1988-09-30 | 1990-04-05 | Allied-Signal Inc. | Improved bacterial strains for heterologous gene expression |
ATE161879T1 (de) * | 1988-11-09 | 1998-01-15 | Protein Polymer Tech Inc | Funktionelles, durch ein rekombinantes verfahren hergestelltes synthetisches proteinpolymer |
FR2656626B1 (fr) * | 1989-12-29 | 1994-08-12 | Pasteur Institut | Fragment peptidique comprenant une sequence issue de la proteine 28 kda de schistosoma mansoni et compositions vaccinantes et/ou therapeutiques comprenant ledit fragment. |
US5245012A (en) * | 1990-04-19 | 1993-09-14 | The United States Of America As Represented By The Secretary Of The Army | Method to achieve solubilization of spider silk proteins |
US5925540A (en) * | 1990-09-25 | 1999-07-20 | Virginia Tech Intellectual Properties, Inc. | Synthetic antifreeze peptide and synthetic gene coding for its production |
US5171505A (en) * | 1990-11-28 | 1992-12-15 | E. I. Du Pont De Nemours And Company | Process for spinning polypeptide fibers |
DE69233300T2 (de) * | 1991-11-12 | 2004-11-25 | Protein Polymer Technologies, Inc., San Diego | Kollagenartige Proteinpolymere mit hohen Molikularmassen |
DE69433299T2 (de) * | 1993-06-15 | 2004-09-09 | E.I. Du Pont De Nemours And Co., Wilmington | Rekombinante spinnerseide analoge |
US5670616A (en) * | 1995-02-03 | 1997-09-23 | Eastman Kodak Company | Collagen-like polypeptides and biopolymers and nucleic acids encoding same |
US5710252A (en) * | 1995-02-03 | 1998-01-20 | Eastman Kodak Company | Method for recombinant yeast expression and isolation of water-soluble collagen-type polypeptides |
US5833991A (en) * | 1995-04-10 | 1998-11-10 | Cobra Therapeutics, Ltd. | Glycine-containing sequences conferring invisibility to the immune system |
US6489446B1 (en) | 1996-08-07 | 2002-12-03 | Hsc Research And Development Limited Partnership | Self-aligning peptides modeled on human elastin and other fibrous proteins |
AU728480B2 (en) * | 1996-08-07 | 2001-01-11 | Hospital For Sick Children, The | Self-aligning peptides derived from elastin and other fibrous proteins |
GB9718463D0 (en) * | 1997-08-29 | 1997-11-05 | Dynal As | Biomolecules |
GB9727512D0 (en) * | 1997-12-31 | 1998-02-25 | Adprotech Plc | Fuzzy genes and their application in molecular adjuvants |
CA2404825A1 (en) * | 2000-03-24 | 2001-09-27 | Japan As Represented By President Of Tokyo University Of Agriculture Andtechnology | Precursors of silk-like materials, silk-like materials and processes for producing both |
GB0008582D0 (en) * | 2000-04-08 | 2000-05-31 | Adprotech Plc | DNA immunization vectors |
WO2002020565A2 (en) * | 2000-09-08 | 2002-03-14 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
US7714020B2 (en) | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
AU2002303856A1 (en) | 2001-05-24 | 2002-12-03 | Neuronz Limited | Gpe analogs and peptidomimetics |
US7605177B2 (en) | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
JPWO2003100065A1 (ja) * | 2002-05-23 | 2005-09-22 | 国立大学法人東京農工大学 | 絹タンパク質、及び、機能性を付与した遺伝子組換え絹様タンパク質の大量生産方法 |
JP4629046B2 (ja) * | 2003-05-14 | 2011-02-09 | ダニスコ・ユーエス・インコーポレーテッド | 反復配列タンパク質ポリマー活性剤結合体、方法および使用 |
CA2524710C (en) * | 2003-05-14 | 2012-07-31 | Dow Corning Corporation | Controlled release of active agents utilizing repeat sequence protein polymers |
WO2008140703A2 (en) | 2007-05-10 | 2008-11-20 | Elastin Specialties, Inc. | Synthetic peptide materials for joint reconstruction, repair and cushioning |
JP6050609B2 (ja) * | 2012-05-31 | 2016-12-21 | 三洋化成工業株式会社 | 皮膚弾性向上材及び皮膚弾性向上用タンパク質溶液 |
AR091774A1 (es) | 2012-07-16 | 2015-02-25 | Dow Agrosciences Llc | Proceso para el diseño de las secuencias de adn repetidas, largas, divergentes de codones optimizados |
JP6326287B2 (ja) * | 2013-05-22 | 2018-05-16 | 三洋化成工業株式会社 | 創傷治癒剤 |
TR201807610T1 (tr) | 2015-12-21 | 2018-06-21 | Brainon Inc | Hafizanin, öğrenme beceri̇si̇ni̇n ve bi̇li̇şsel beceri̇ni̇n geli̇şti̇ri̇lmesi̇ i̇çi̇n kompozi̇syon |
KR101706296B1 (ko) | 2015-12-21 | 2017-02-13 | 주식회사 브레인온 | 기억력, 학습력, 인지력 향상용 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3004249A1 (de) * | 1980-02-06 | 1981-08-13 | Desowag-Bayer Holzschutz GmbH, 4000 Düsseldorf | Holzschutzmittelkonzentrat und daraus hergestelltes mittel zum konservieren von holz und holzwerkstoffen |
US4589882A (en) * | 1983-09-19 | 1986-05-20 | Urry Dan W | Enzymatically crosslinked bioelastomers |
US4585585A (en) * | 1984-03-07 | 1986-04-29 | University Of Connecticut Research & Development Corporation | Decapeptides produced from bioadhesive polyphenolic proteins |
GB2162190A (en) * | 1984-07-06 | 1986-01-29 | Pa Consulting Services | Improvements in or relating to production of silk |
CA1282020C (en) * | 1984-09-13 | 1991-03-26 | Kathy Jean Maugh | Proteins for the production of bioadhesives |
CN86100979A (zh) * | 1985-02-07 | 1986-12-17 | 史密丝克莱恩贝克曼公司 | 疟疾疫苗的制备方法 |
-
1987
- 1987-10-29 EP EP88900275A patent/EP0293443B1/de not_active Expired - Lifetime
- 1987-10-29 AT AT88900275T patent/ATE233273T1/de not_active IP Right Cessation
- 1987-10-29 WO PCT/US1987/002822 patent/WO1988003533A1/en active IP Right Grant
- 1987-10-29 AU AU10528/88A patent/AU612340B2/en not_active Ceased
- 1987-10-29 JP JP63500640A patent/JPH01501755A/ja active Pending
- 1987-10-29 DE DE3752363T patent/DE3752363T2/de not_active Expired - Fee Related
- 1987-11-04 NZ NZ222450A patent/NZ222450A/xx unknown
-
1988
- 1988-06-28 FI FI883082A patent/FI101720B/fi not_active IP Right Cessation
- 1988-07-01 NO NO19882946A patent/NO311982B1/no unknown
- 1988-07-01 DK DK369788A patent/DK369788D0/da not_active Application Discontinuation
-
1997
- 1997-03-03 JP JP06387097A patent/JP3250968B2/ja not_active Expired - Lifetime
-
1999
- 1999-04-07 JP JP11100595A patent/JP2000135092A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
NO882946L (no) | 1988-08-31 |
FI101720B1 (fi) | 1998-08-14 |
DK369788A (da) | 1988-07-01 |
JPH1014586A (ja) | 1998-01-20 |
JP2000135092A (ja) | 2000-05-16 |
AU612340B2 (en) | 1991-07-11 |
EP0293443A1 (de) | 1988-12-07 |
DK369788D0 (da) | 1988-07-01 |
FI883082A0 (fi) | 1988-06-28 |
JPH01501755A (ja) | 1989-06-22 |
NZ222450A (en) | 1990-09-26 |
WO1988003533A1 (en) | 1988-05-19 |
ATE233273T1 (de) | 2003-03-15 |
NO882946D0 (no) | 1988-07-01 |
FI101720B (fi) | 1998-08-14 |
AU1052888A (en) | 1988-06-01 |
EP0293443B1 (de) | 2003-02-26 |
EP0293443A4 (de) | 1990-04-10 |
JP3250968B2 (ja) | 2002-01-28 |
NO311982B1 (no) | 2002-02-25 |
FI883082A (fi) | 1988-06-28 |
DE3752363T2 (de) | 2004-02-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3752363D1 (de) | Herstellung synthetischer dns und deren verwendung bei der synthese grosser polypeptide | |
DE3650751D1 (de) | Antikörper gegen Saugetier-Interleukin-4 und Peptide verwendbar als Antigenen für deren Herstellung | |
DE68925083D1 (de) | Rekombinante DNS, diese rekombinante DNS enthaltender Mikroorganismus und Verfahren zur Herstellung von L-Aminosäure unter Verwendung dieses Mikroorganismus | |
AT383606B (de) | Verfahren zur herstellung von neuen transparenten copolyamiden mischungen daraus, und deren verwendung zur herstellung von formkoerpern | |
ES2142363T3 (es) | Materiales y metodos para la hipersecrecion de aminoacidos. | |
DK306386A (da) | Fibronectin og polypeptidsekvenser omfattende de collagenbindende og/eller fibrinbindende dele deraf, cdna-sekvenser, som koder herfor, vektorer indeholdende cdna-sekvenserne mikroorganismer transformeret dermed og fremgangsmaade til rensning af stoffer | |
DE3689196D1 (de) | Verfahren zur Herstellung von Amiden unter Verwendung von Mikroorganismen. | |
DE3673112D1 (de) | Elektroden zur verwendung bei elektrochemischen verfahren und herstellung. | |
ES545725A0 (es) | Procedimiento para preparar peptidos de interferon | |
ATE152481T1 (de) | Neue polypeptide, dna-sequenzen, die deren expression erlauben, verfahren zur vorbereitung und verwendung | |
PT87809A (pt) | Promotoren zur expression von freemd-dna in methylotrophen bakterien deren gewinnung und deren verwendung | |
DE3280175D1 (de) | Rekombinante dns und coliformer bazillus genetisches material enthaltend zur herstellung von staphylokinase und die herstellung von staphylokinase. | |
DE69533905D1 (de) | Interferon alpha/beta bindendes Protein, seine Herstellung und Anwendung | |
DE69000596D1 (de) | Katalytische zusammensetzung und deren verwendung zur oligomerisation von monoolefinen. | |
DE58904702D1 (de) | Beta-phenoxyethylamine und deren verwendung zur herstellung von farbstoffen. | |
ATE34396T1 (de) | Verfahren zur herstellung von aspartylpeptiden und bei deren synthese gebrauchte derivate von aspartinsaeure. | |
ATE83800T1 (de) | Rekombinantes dns-plasmid zur herstellung von xanthangummi. | |
ATE74968T1 (de) | Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens. | |
ATE40152T1 (de) | Verfahren zur herstellung von menschlichen hepatozyten kulturen, die erhaltenen kulturen und ihre biologischen und biochemischen verwendungen. | |
IT8485664A0 (it) | Procedimento per il trattamento di liquami di conceria con ricupero di torbide proteiche utilizzabili in zootecnia. | |
ATE9005T1 (de) | Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen interferon-alpha aehnlichen polypeptiden. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |