DE3751081D1 - [Leu 13] Motilin, dessen kodierende DNS-Moleküle und Verfahren zu dessen Herstellung. - Google Patents
[Leu 13] Motilin, dessen kodierende DNS-Moleküle und Verfahren zu dessen Herstellung.Info
- Publication number
- DE3751081D1 DE3751081D1 DE3751081T DE3751081T DE3751081D1 DE 3751081 D1 DE3751081 D1 DE 3751081D1 DE 3751081 T DE3751081 T DE 3751081T DE 3751081 T DE3751081 T DE 3751081T DE 3751081 D1 DE3751081 D1 DE 3751081D1
- Authority
- DE
- Germany
- Prior art keywords
- motilin
- leu
- production
- dna molecules
- coding dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- GFOZQXMKARUPQI-HYOAWBISSA-N [leu13]motilin Chemical compound C([C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C)C1=CC=CC=C1 GFOZQXMKARUPQI-HYOAWBISSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/63—Motilins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61215088A JP2862870B2 (ja) | 1986-09-12 | 1986-09-12 | 新規ペプチド |
JP5192104A JP2634132B2 (ja) | 1986-09-12 | 1993-08-03 | 新規ペプチド |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3751081D1 true DE3751081D1 (de) | 1995-03-30 |
DE3751081T2 DE3751081T2 (de) | 1995-10-19 |
Family
ID=26507110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3751081T Expired - Fee Related DE3751081T2 (de) | 1986-09-12 | 1987-09-11 | [Leu 13] Motilin, dessen kodierende DNS-Moleküle und Verfahren zu dessen Herstellung. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0259891B1 (de) |
JP (2) | JP2862870B2 (de) |
CA (1) | CA1339464C (de) |
DE (1) | DE3751081T2 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2575022B2 (ja) * | 1987-05-07 | 1997-01-22 | 株式会社 三和化学研究所 | ヒトモチリン前駆体、該前駆体含有クローン化dna、その調製法並びに該クローン化dnaが組込まれたプラスミド |
JP2753274B2 (ja) * | 1988-08-24 | 1998-05-18 | 株式会社三和化学研究所 | モチリン様ポリペプチドの製法並びにそのための組換えdna及び発現用プラスミド |
JPH0722517B2 (ja) * | 1989-08-24 | 1995-03-15 | 株式会社三和化学研究所 | モチリン様ポリペプチドの製法並びにそのための組換えdna及び発現用プラスミド |
EP0378078A1 (de) * | 1989-01-06 | 1990-07-18 | Sanwa Kagaku Kenkyusho Co., Ltd. | Dem Motilin ähnliches Polypeptid und seine Verwendung |
US5459049A (en) * | 1989-01-06 | 1995-10-17 | Sanwa Kagaku Kenkyushko Co., Ltd. | Motilin-like polypeptide and use thereof |
JPH0742319B2 (ja) * | 1989-01-06 | 1995-05-10 | 株式会社三和化学研究所 | モチリン様活性を有するポリペプチド及びその用途 |
EP0463450B1 (de) * | 1990-06-26 | 1994-02-16 | Sanwa Kagaku Kenkyusho Co., Ltd. | VIP-Analogen und ihre Verwendung |
JPH07108232B2 (ja) * | 1990-10-09 | 1995-11-22 | エム・ディ・リサーチ株式会社 | ペプチド又は蛋白質の製造方法 |
JPH0740926B2 (ja) * | 1990-10-09 | 1995-05-10 | エム・ディ・リサーチ株式会社 | 形質転換体およびペプチド前駆体タンパク質の製造方法 |
ES2156869T5 (es) † | 1992-04-15 | 2008-07-01 | The Johns Hopkins University | Sintesis de colecciones diversas y utiles de oligonucleotidos. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5239670A (en) * | 1975-09-22 | 1977-03-28 | Eisai Co Ltd | Process for synthesizing motilin |
DE2544348C3 (de) * | 1975-10-03 | 1979-12-13 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | L-Leucin-13-Motilin, Verfahren zu dessen Herstellung und dasselbe enthaltendes Mittel |
CA1213537A (en) * | 1984-05-01 | 1986-11-04 | Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee | Polypeptide expression method |
WO1986007383A1 (en) * | 1985-06-04 | 1986-12-18 | Biotechnology Research Partners, Ltd. | Autoantigen vaccines |
-
1986
- 1986-09-12 JP JP61215088A patent/JP2862870B2/ja not_active Expired - Lifetime
-
1987
- 1987-09-10 CA CA000546627A patent/CA1339464C/en not_active Expired - Fee Related
- 1987-09-11 DE DE3751081T patent/DE3751081T2/de not_active Expired - Fee Related
- 1987-09-11 EP EP87113347A patent/EP0259891B1/de not_active Expired - Lifetime
-
1993
- 1993-08-03 JP JP5192104A patent/JP2634132B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3751081T2 (de) | 1995-10-19 |
EP0259891A2 (de) | 1988-03-16 |
CA1339464C (en) | 1997-09-16 |
EP0259891A3 (en) | 1989-08-09 |
EP0259891B1 (de) | 1995-02-22 |
JPS6371195A (ja) | 1988-03-31 |
JP2862870B2 (ja) | 1999-03-03 |
JP2634132B2 (ja) | 1997-07-23 |
JPH0690759A (ja) | 1994-04-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |