DE3650429D1 - Griseolsäurederivate, ihre Herstellung und ihre Verwendung. - Google Patents

Griseolsäurederivate, ihre Herstellung und ihre Verwendung.

Info

Publication number: DE3650429D1
Authority: DE; Germany
Prior art keywords: griseolic acid; acid derivatives; preparation; griseolic; acid
Prior art date: 1985-04-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE3650429T

Other languages

English (en)

Other versions

DE3650429T2 (de

Inventor

Masakatsu C O Sankyo Co Kaneko

Yoshinobu C O Sankyo Murofushi

Misako C O Sankyo Compa Kimura

Mitsuo C O Sankyo Com Yamazaki

Yasuteru C O Sankyo Com Iijima

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sankyo Co Ltd

Original Assignee

Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-19

Filing date

1986-04-21

Publication date

1995-11-30

1986-04-21 Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd

1995-11-30 Application granted granted Critical

1995-11-30 Publication of DE3650429D1 publication Critical patent/DE3650429D1/de

1996-06-13 Publication of DE3650429T2 publication Critical patent/DE3650429T2/de

2006-04-22 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

IAPZXUKYTCQQFE-QZKDJMESSA-N (2r,3r,3as,5s)-2-(6-aminopurin-9-yl)-5-[carboxy(hydroxy)methyl]-3-hydroxy-3,3a-dihydro-2h-furo[3,2-b]furan-5-carboxylic acid Chemical class NC1=NC=NC2=C1N=CN2[C@H]1[C@H](O)[C@@H]2O[C@](C(O)=O)(C(O)C(O)=O)C=C2O1 IAPZXUKYTCQQFE-QZKDJMESSA-N 0.000 title abstract 4
IAPZXUKYTCQQFE-UHFFFAOYSA-N Griseolic acid Natural products NC1=NC=NC2=C1N=CN2C1C(O)C2OC(C(O)=O)(C(O)C(O)=O)C=C2O1 IAPZXUKYTCQQFE-UHFFFAOYSA-N 0.000 abstract 2
GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical group N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 2
150000003212 purines Chemical class 0.000 abstract 2
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
229940083251 peripheral vasodilators purine derivative Drugs 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DE3650429T 1985-04-19 1986-04-21 Griseolsäurederivate, ihre Herstellung und ihre Verwendung. Expired - Fee Related DE3650429T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP8213285		1985-04-19
JP9198985		1985-04-27
JP9198785		1985-04-27

Publications (2)

Publication Number	Publication Date
DE3650429D1 true DE3650429D1 (de)	1995-11-30
DE3650429T2 DE3650429T2 (de)	1996-06-13

Family

ID=27303820

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE3650429T Expired - Fee Related DE3650429T2 (de)	1985-04-19	1986-04-21	Griseolsäurederivate, ihre Herstellung und ihre Verwendung.
DE8686303000T Expired - Fee Related DE3667470D1 (de)	1985-04-19	1986-04-21	Griseolinsaeurederivate, ihre herstellung und ihre verwendung.
DE3650297T Expired - Fee Related DE3650297T2 (de)	1985-04-19	1986-04-21	Griseolsäurederivate, ihre Herstellung und ihre Verwendung.

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DE8686303000T Expired - Fee Related DE3667470D1 (de)	1985-04-19	1986-04-21	Griseolinsaeurederivate, ihre herstellung und ihre verwendung.
DE3650297T Expired - Fee Related DE3650297T2 (de)	1985-04-19	1986-04-21	Griseolsäurederivate, ihre Herstellung und ihre Verwendung.

Country Status (11)

Country	Link
US (5)	US5498819A (de)
EP (1)	EP0214708B1 (de)
KR (1)	KR930007385B1 (de)
AT (2)	ATE129501T1 (de)
CA (1)	CA1267409A (de)
DE (3)	DE3650429T2 (de)
DK (1)	DK167878B1 (de)
ES (4)	ES8802054A1 (de)
FI (1)	FI94133C (de)
HK (2)	HK1005738A1 (de)
NO (1)	NO169901C (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE319316T1 (de) *	1987-12-02	1989-10-26	Sankyo Co., Ltd., Tokio/Tokyo	Monoester von griseolsaeure, ihre herstellung und verwendung.
US5091431A (en) *	1988-02-08	1992-02-25	Schering Corporation	Phosphodiesterase inhibitors
US4971972A (en) *	1989-03-23	1990-11-20	Schering Corporation	Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
JPH04112889A (ja) *	1990-09-04	1992-04-14	Kyowa Hakko Kogyo Co Ltd	Ｋｓ―５０５誘導体
US5866702A (en) *	1996-08-02	1999-02-02	Cv Therapeutics, Incorporation	Purine inhibitors of cyclin dependent kinase 2
CA2238283C (en) *	1997-05-30	2002-08-20	Cell Pathways, Inc.	Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions
US6558787B1 (en) *	1999-12-27	2003-05-06	Kodak Polychrome Graphics Llc	Relation to manufacture of masks and electronic parts
EP1312363A1 (de) *	2001-09-28	2003-05-21	Pfizer Products Inc.	Behandlungsverfahren und kits bestehend aus Wachstumshormonsekretionsförderern
US7342884B2 (en) *	2002-03-13	2008-03-11	Harmonic, Inc.	Method and apparatus for one directional communications in bidirectional communications channel
US20040043014A1 (en) *	2002-08-30	2004-03-04	Hiroyoshi Moriyama	Platelet aggregation inhibitor and supplement food effective for inhibiting platelet aggregation
WO2005018563A2 (en) *	2003-08-22	2005-03-03	Pharmacia Corporation	Compositions of a cyclooxygenase-2 selective inhibitor and a phosphodiesterase inhibitor for the treatment of ischemic mediated central nervous system disorders or injury
GB0601951D0 (en)	2006-01-31	2006-03-15	Novartis Ag	Organic compounds
WO2011081915A2 (en) *	2009-12-15	2011-07-07	Cebix Inc.	Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
EP3033348B1 (de)	2013-08-12	2017-11-29	Saudi Basic Industries Corporation	Katalysatorsystem zur olefinpolymerisation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4035370A (en) *	1971-11-03	1977-07-12	Richter Gedeon Vegyeszeti Gyar Rt.	Alkaloid esters
US4167565A (en) *	1976-11-08	1979-09-11	Abbott Laboratories	Adenosine-5'-carboxamides and method of use
JPS5668695A (en) *	1979-11-10	1981-06-09	Sankyo Co Ltd	Enzyme inhibitor griseolic acid and its preparation
US4803271A (en) *	1982-02-01	1989-02-07	Syntex (U.S.A.) Inc.	Process for preparing guanine derivatives
JPS6094992A (ja) *	1983-10-28	1985-05-28	Sankyo Co Ltd	グリゼオ−ル酸誘導体
US4783532A (en) *	1983-10-28	1988-11-08	Sankyo Company Limited	Process for preparing griseolic acid derivatives
JPS60246396A (ja) *	1984-05-22	1985-12-06	Sankyo Co Ltd	酵素阻害物質ジヒドロデスオキシグリゼオ−ル酸及びその塩類
US4788190A (en) *	1986-12-24	1988-11-29	Schering Corporation	2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds
US5091431A (en) *	1988-02-08	1992-02-25	Schering Corporation	Phosphodiesterase inhibitors
US4966912A (en) *	1989-09-29	1990-10-30	Uniroyal Chemical Company, Inc.	Fungicidal 3-imino-1,4-oxathiins
EP0492430A1 (de) *	1990-12-27	1992-07-01	Nippon Kayaku Kabushiki Kaisha	Oxetanocinderivate mit Imidazolbasisgruppe
JPH0639472B2 (ja) *	1991-12-21	1994-05-25	メルシャン株式会社	アゾール誘導体

1986
- 1986-04-18 FI FI861655A patent/FI94133C/fi not_active IP Right Cessation
- 1986-04-18 DK DK179586A patent/DK167878B1/da not_active IP Right Cessation
- 1986-04-18 NO NO861533A patent/NO169901C/no not_active IP Right Cessation
- 1986-04-19 KR KR1019860003049A patent/KR930007385B1/ko not_active IP Right Cessation
- 1986-04-19 ES ES554178A patent/ES8802054A1/es not_active Expired
- 1986-04-21 DE DE3650429T patent/DE3650429T2/de not_active Expired - Fee Related
- 1986-04-21 EP EP86303000A patent/EP0214708B1/de not_active Expired
- 1986-04-21 AT AT88121487T patent/ATE129501T1/de not_active IP Right Cessation
- 1986-04-21 CA CA000507140A patent/CA1267409A/en not_active Expired - Fee Related
- 1986-04-21 DE DE8686303000T patent/DE3667470D1/de not_active Expired - Fee Related
- 1986-04-21 DE DE3650297T patent/DE3650297T2/de not_active Expired - Fee Related
- 1986-04-21 AT AT88121486T patent/ATE121097T1/de not_active IP Right Cessation
1987
- 1987-05-21 ES ES557558A patent/ES8801664A1/es not_active Expired
- 1987-05-21 ES ES557559A patent/ES8801665A1/es not_active Expired
- 1987-05-21 ES ES557560A patent/ES8801666A1/es not_active Expired
1993
- 1993-09-30 US US08/130,154 patent/US5498819A/en not_active Expired - Fee Related
1994
- 1994-10-06 US US08/319,413 patent/US5760042A/en not_active Expired - Fee Related
1995
- 1995-05-09 US US08/437,644 patent/US5616600A/en not_active Expired - Fee Related
- 1995-05-09 US US08/437,634 patent/US5556975A/en not_active Expired - Fee Related
- 1995-05-09 US US08/437,632 patent/US5532369A/en not_active Expired - Fee Related
1998
- 1998-06-03 HK HK98104838A patent/HK1005738A1/xx not_active IP Right Cessation
- 1998-06-03 HK HK98104840A patent/HK1005739A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5760042A (en)	1998-06-02
KR860008206A (ko)	1986-11-14
HK1005739A1 (en)	1999-01-22
ES557560A0 (es)	1988-02-16
DE3650297T2 (de)	1996-01-25
DK179586A (da)	1986-10-20
ES8801666A1 (es)	1988-02-16
FI94133B (fi)	1995-04-13
HK1005738A1 (en)	1999-01-22
EP0214708B1 (de)	1989-12-13
ATE129501T1 (de)	1995-11-15
FI94133C (fi)	1995-07-25
EP0214708A2 (de)	1987-03-18
DE3650429T2 (de)	1996-06-13
ES8802054A1 (es)	1988-03-16
NO861533L (no)	1986-11-21
NO169901C (no)	1992-08-19
DK167878B1 (da)	1993-12-27
US5556975A (en)	1996-09-17
FI861655A0 (fi)	1986-04-18
DE3667470D1 (de)	1990-01-18
US5616600A (en)	1997-04-01
CA1267409A (en)	1990-04-03
DE3650297D1 (de)	1995-05-18
NO169901B (no)	1992-05-11
EP0214708A3 (en)	1987-08-26
DK179586D0 (da)	1986-04-18
US5498819A (en)	1996-03-12
ES557559A0 (es)	1988-02-16
ATE121097T1 (de)	1995-04-15
ES8801665A1 (es)	1988-02-16
ES8801664A1 (es)	1988-02-16
ES554178A0 (es)	1988-03-16
KR930007385B1 (ko)	1993-08-09
ES557558A0 (es)	1988-02-16
FI861655A (fi)	1986-10-20
US5532369A (en)	1996-07-02

Legal Events

Date	Code	Title	Description
1996-11-21	8364	No opposition during term of opposition
2004-02-12	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
ATE90092T1 (de)	1993-06-15	Thiazolidinon-derivate, ihre herstellung und ihre verwendung.
DE3650429D1 (de)	1995-11-30	Griseolsäurederivate, ihre Herstellung und ihre Verwendung.
ES2130111T3 (es)	1999-07-01	Derivados de ciclohexano, preparaciones que los contienen y su utilizacion.
MX9200396A (es)	1992-08-01	Derivados de benciloxifenilo, procedimiento para su preparacion y composicion farmaceutica que los contiene.
ATE46146T1 (de)	1989-09-15	Phenylpiperidinderivat und seine salze, ihre herstellung, sie enthaltende zusammensetzungen und ihre therapeutische verwendung.
ATE39357T1 (de)	1989-01-15	Derivate von griseolicsaeure und ihre verwendung.
IT1224405B (it)	1990-10-04	Composti attivi sul sistema cardiovascolare
SE8700555D0 (sv)	1987-02-12	Purine derivatives, their production and medicaments containing them
IT1197516B (it)	1988-11-30	Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono
ATE48611T1 (de)	1989-12-15	Griseolinsaeurederivate, ihre herstellung und ihre verwendung.
EP0294069A3 (de)	1990-08-22	Purinverbindungen, Verfahren zu ihrer Herstellung, Zwischenverbindungen und pharmazeutische Präparate
DE3853958D1 (de)	1995-07-13	Substituierte Pyridin-Verbindungen, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.
ATE95180T1 (de)	1993-10-15	Berbanderivate und ihre herstellung und pharmazeutische zubereitung.
RU93005243A (ru)	1996-02-27	Производные гризеоловой кислоты
IT1205114B (it)	1989-03-15	2-selenometil-1,4-diidropiridine,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
IT1224404B (it)	1990-10-04	Composti attivi sul sistema cardiovascolare
EP0264951A3 (en)	1988-09-14	Procaterol-derivatives