DE3441711A1 - Vitamin-containing skin protectives - Google Patents

Vitamin-containing skin protectives

Info

Publication number
DE3441711A1
DE3441711A1 DE19843441711 DE3441711A DE3441711A1 DE 3441711 A1 DE3441711 A1 DE 3441711A1 DE 19843441711 DE19843441711 DE 19843441711 DE 3441711 A DE3441711 A DE 3441711A DE 3441711 A1 DE3441711 A1 DE 3441711A1
Authority
DE
Germany
Prior art keywords
vitamin
skin protection
carotene
emulsifiers
canthaxanthin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19843441711
Other languages
German (de)
Inventor
Roshdy Dipl.-Chem. Dr. 5000 Köln Ismail
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19843441711 priority Critical patent/DE3441711A1/en
Priority to EP85102222A priority patent/EP0158090B1/en
Priority to CA000475486A priority patent/CA1257200A/en
Priority to EP89112798A priority patent/EP0343694B1/en
Priority to DE8989112798T priority patent/DE3586859D1/en
Priority to AT85102222T priority patent/ATE55905T1/en
Priority to DE8585102222T priority patent/DE3579343D1/en
Priority to AT89112798T priority patent/ATE82684T1/en
Publication of DE3441711A1 publication Critical patent/DE3441711A1/en
Priority to US07/211,125 priority patent/US4938960A/en
Priority to US07/877,377 priority patent/US5541220A/en
Priority to US08/298,612 priority patent/US5652261A/en
Priority to US08/819,097 priority patent/US5786384A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

Skin protectives by using vitamin E with beta-carotene and/or canthaxanthin in the presence of emulsifiers.

Description

Vitaminhaltige Haut schutzmittelSkin protection products containing vitamins

n der Anmeldung Nr. P 34I064I.3. sind die Kombination von VitaminE mit Canthaxanthin und oder B-Carotin beanspruncht. In registration no. P 34I064I.3. are the combination of vitamin E. with canthaxanthin and or B-carotene claimed.

i)ie Herstellung dieser Kapseln zeigt kollosal Resorptionsprobleme.i) The manufacture of these capsules shows colossal absorption problems.

Canthaxanthin steht in IO %iger Form zu Verfugung, so das die Mischung mit dem öligen Vitamin E sofort zur Klumpenbildung funrt una die Hesorption sehr beeinträchtigt wird.Canthaxanthin is available in IO% form, so that is the mixture with the oily vitamin E immediately to the formation of lumps and the absorption works very well is affected.

bs wurde überraschender herrausgefunden,das ci er Zusatz von geringer Menge Emulgatoren vor allen Tween 80 diesen Nachteil vollständig beseitigt.It was found out, surprisingly, that the addition of less Amount of emulsifiers before all Tween 80 completely eliminates this disadvantage.

Die Resorption steigt um ca. 40% sowohl an Vitamin b als auch an B-Carotin bezw. Vitamin A.The absorption increases by approx. 40% for both vitamin b and B-carotene respectively Vitamin A.

Es reicht eine Menge von 0,4 - 5 % Emulgator vorzugsweise I-3 %.An amount of 0.4-5% emulsifier, preferably 1-3%, is sufficient.

Üiese Ergebnisse sind völlig überraschend.These results are completely surprising.

kann kann auch phosphorlipide in eine Menge zwischen 2 - 20% als Emulgator vorzugsweise IO.% verwenden.can also use phospholipids in an amount between 2 - 20% as an emulsifier preferably use IO.%.

Entweder alleine vorzugsweise in Kombination mit herkömmlichen Emulgatoren wie Tween d0, Tween 20 oder Cetiol oder Oremophor.Either alone, preferably in combination with conventional emulsifiers like Tween d0, Tween 20 or Cetiol or Oremophor.

Mann kann auch die Ph osphorlipide höher bis 20% zum Beispiel 50% in aen Inhalt der Kapseln oder mehr als 50% verwenden. Es wird jedenfalls die Verwendung von herkömmlichen Emulgatoren in einer Menge zwischen 0,4 und 5% bevorzugt.You can also use ph osphorlipids higher up to 20% for example 50% Use in the contents of the capsules or more than 50%. It will be the use anyway preferred by conventional emulsifiers in an amount between 0.4 and 5%.

Vorzugsweise jedoch zwischen I und 5% bevorzugte Emulgatoren sind Ethoxylate von Fettalkoholmittel, hydriertem Rizinusöl, Estermittel- und langkettiger Fettalkohole, Cetylstearyalkohole, aliphatische Partialesten der Triglyceride oder andere mehrwertige Alkohole wie Sorbit und Mannit. Ganz besonders bevorzugt wird Polysorbat 80. Eigene Untersuchungen haben gezeigt, daß mit Polysorbat 80 die genannten erfindungsgemäßen Effekte besonders gut sind.Preferably, however, between 1 and 5% are preferred emulsifiers Fatty alcohol agent, hydrogenated castor oil, ester medium and long chain ethoxylates Fatty alcohols, cetylstearyl alcohols, aliphatic partial residues of triglycerides or other polyhydric alcohols such as sorbitol and mannitol. Is very particularly preferred Polysorbate 80. Our own studies have shown that with polysorbate 80 the aforementioned Effects according to the invention are particularly good.

Weitere herkömmliche Emulgatoren sind ebenfalls geeignet.Other conventional emulsifiers are also suitable.

Vitamin E in oraler Form muß hoch genug dosiert sein und zwar zwischen 200 bis 500 mg pro Darreichungsform bzw.Kapsel,vorzugsweise zwischen 300 und 500 mg pro Einheit bezw.Kapsel.Vitamin E in oral form must be dosed in high enough doses between 200 to 500 mg per dosage form or capsule, preferably between 300 and 500 mg per unit or capsule.

B-Carotin kann bis maximal 50 mg pro einheit verwendet werden, wahrend Oanthaxanthin zwischen 10 una 50 mg, vorzugsweise zwischen 20 und 40 mg verwendet werden kann.B-carotene can be used up to a maximum of 50 mg per unit while Oanthaxanthin used between 10 and 50 mg, preferably between 20 and 40 mg can be.

an kann auch einen oder mehere Vitamine der B-Reihe oder Dexapanthenol bzw. Calcium Pantothenat zusetzen0 Beispiel I Kapseln aus: 30 mg Canthaxanthin 8 mh ß-Carotin 250 mg Lecithin 700 mg Dl-alpha-Tocopherolacetat 80 mg Sojabohnenöl IO mg Tween 80 Beispiel 2 Kapseln aus: 30 mg Canthaxanthin 300 mg D-alpha-Tocopherol-Konzentrat 150 mg Sojabohnenöl 8 mg Cetiol Beispiel 5 Kapseln aus: 9 mg B-Carotin 400 mh D-alpha-Tocopherol 120 mg Sojabohnenöl 7 mg Tween 80You can also use one or more B-series vitamins or dexapanthenol or add calcium pantothenate 0 Example I Capsules from: 30 mg Canthaxanthin 8 mh ß-carotene 250 mg lecithin 700 mg Dl-alpha-tocopherol acetate 80 mg soybean oil IO mg Tween 80 Example 2 capsules made from: 30 mg canthaxanthin 300 mg D-alpha-tocopherol concentrate 150 mg soybean oil 8 mg cetiol Example 5 capsules from: 9 mg B-carotene 400 mh D-alpha-tocopherol 120 mg soybean oil 7 mg Tween 80

Claims (5)

Patentanspruche I.) Hautschutzmittel, dadurch gekennzeichnet, daß man Vitamin E in Kombination mit Hautpigmentveränderung bzw. Bräunungsmitteln, wie z.Bsp. B-Carotin und/oder Canthaxanthin bzw. Claims I.) Skin protection agents, characterized in that one vitamin E in combination with skin pigment changes or tanning agents, such as e.g. B-carotene and / or canthaxanthin or aeren Derivate in oraler Form, in Gegenwart von Emulgatoren allein und oder Lecithin, vorzugsweise mit den beiden zusammen. Aeren derivatives in oral form, in the presence of emulsifiers alone and or lecithin, preferably with the two together. 2.) Hautschutzmittel nach Anspruch I dadurch gekennzeichnet, daß man Vitamin S zwischen 200 und 500 mg pro Darreichungsform bezw.Kapseln vorzugsweise zwischen 500 - 500 mg verwendet.2.) Skin protection agent according to claim I, characterized in that one Vitamin S between 200 and 500 mg per dosage form or capsules preferably used between 500 - 500 mg. 3.) Hautschutzmittel nach Anspruch I und 2 sind dadurch gekenn zeichnet,daß man B-Carotin mit Vitamin E zusammen kombiniert.3.) Skin protection agent according to claim I and 2 are characterized in that B-carotene is combined with vitamin E together. 4.) Hautschutzmittel nach Anspruch I - 5 sind dadurch gekennzeichnet, daß man Emulgatoren in einer Konzentration zwischen I bis 5 % verwendet.4.) Skin protection agents according to claim I - 5 are characterized in that one uses emulsifiers in a concentration between I to 5%. 5.) Hautschutzmittel nach Anspruch I bis 4 sind dadurch geKennzeichnet,daf3 man in den Kombinationspräparat Lecithin und Emulgator verwendet.5.) Skin protection agents according to claims I to 4 are characterized in that daf3 lecithin and emulsifier are used in the combination preparation.
DE19843441711 1984-03-07 1984-11-15 Vitamin-containing skin protectives Withdrawn DE3441711A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE19843441711 DE3441711A1 (en) 1984-11-15 1984-11-15 Vitamin-containing skin protectives
AT85102222T ATE55905T1 (en) 1984-03-07 1985-02-28 MEANS FOR TREATMENT AND PROTECTION OF THE SKIN.
CA000475486A CA1257200A (en) 1984-03-07 1985-02-28 Agents for the treatment and protection of the skin
EP89112798A EP0343694B1 (en) 1984-03-07 1985-02-28 Agent for the treatmment and protection of the skin
DE8989112798T DE3586859D1 (en) 1984-03-07 1985-02-28 AGENTS FOR TREATING AND PROTECTING THE SKIN.
EP85102222A EP0158090B1 (en) 1984-03-07 1985-02-28 Drug for the treatment and the protection of the skin
DE8585102222T DE3579343D1 (en) 1984-03-07 1985-02-28 AGENTS FOR TREATING AND PROTECTING THE SKIN.
AT89112798T ATE82684T1 (en) 1984-03-07 1985-02-28 MEANS FOR TREATMENT AND PROTECTION OF THE SKIN.
US07/211,125 US4938960A (en) 1984-03-07 1988-06-21 Agents for the treatment and protection of the skin
US07/877,377 US5541220A (en) 1984-03-07 1992-04-29 Agents for the treatment and protection of the skin
US08/298,612 US5652261A (en) 1984-03-07 1994-08-31 Method for the treatment and protection of the skin
US08/819,097 US5786384A (en) 1984-03-07 1997-03-18 Agents for the treatment and protection of the skin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843441711 DE3441711A1 (en) 1984-11-15 1984-11-15 Vitamin-containing skin protectives

Publications (1)

Publication Number Publication Date
DE3441711A1 true DE3441711A1 (en) 1986-05-15

Family

ID=6250342

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843441711 Withdrawn DE3441711A1 (en) 1984-03-07 1984-11-15 Vitamin-containing skin protectives

Country Status (1)

Country Link
DE (1) DE3441711A1 (en)

Similar Documents

Publication Publication Date Title
DE3926658C2 (en) Fatty acid composition
DE2521815C3 (en) Diet food preparations and mixtures and processes for their manufacture
DE60318390T2 (en) LUTEIN / ZEAXANTHIN AGAINST GLOSSY
EP0866117B1 (en) Microemulsion
US5326790A (en) Administration of skin medications by use of dicarboxylic acids and derivatives
DE69933518T2 (en) STABLE LIQUID COMPOSITIONS OF CALCIUM ASCORBATE AND METHOD FOR THE PRODUCTION AND USE THEREOF
DE60111362T2 (en) STABILIZED ASCORBIC ACID SOLUTIONS
DE165352T1 (en) CLEAR MICELLAR SOLUTIONS OF FAT-SOLUBLE ESSENTIAL FOOD.
DE60122927T2 (en) SKIN CREAM COMPOSITION
DE3634152C2 (en) Novel cosmetic or dermatological compositions rich in triglycerides and in free or salt form, essential fatty acids
DD206324A5 (en) METHOD FOR THE PRODUCTION OF ANTI-HERPETICALLY EFFECTIVE LIPSTICKS
DE3300491A1 (en) Composition for promoting hair growth and for reducing dandruff
DE4101122A1 (en) COSMETIC OR PHARMACEUTICAL AGENT
DE60003434T2 (en) SPRAYERS FOR TOPICAL USE OF A PREPARATION CONTAINING VITAMIN E AND ESSENTIAL FATTY ACIDS
DE2352797A1 (en) NUTRITIONAL SUPPLEMENT
DE2129653A1 (en) Light stabilizers
JPS6456623A (en) Iodine-containing emulsion
DE69824326T2 (en) Pharmaceutical emulsion containing sorbic acid, Na-EDTA and boric acid
EP0198172B1 (en) Pharmaceutical preparation
DE1467809B2 (en) Use of salts of phosphoric acid esters for the production of products that are cariostatic in the oral cavity
EP1781119B1 (en) Lipoic acid concentrate
DE1617629A1 (en) Process for the stabilization of bromeline in pharmaceutical preparations
DE9321577U1 (en) Lyophilized, active ingredient-containing emulsion
DE3441711A1 (en) Vitamin-containing skin protectives
DE1668171A1 (en) PROCESS FOR THE PRODUCTION OF STABLE Aqueous SOLUTIONS OF NEW COMPLEX ORGANOSILICIUM COMPOUNDS

Legal Events

Date Code Title Description
AF Is addition to no.

Ref country code: DE

Ref document number: 3410641

Format of ref document f/p: P

8162 Independent application
8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: A61K 7/48

8139 Disposal/non-payment of the annual fee