DE3382786D1 - Annielled aminopyrimidinones and their use for the treatment and prophylaxis of viral infections. - Google Patents
Annielled aminopyrimidinones and their use for the treatment and prophylaxis of viral infections.Info
- Publication number
- DE3382786D1 DE3382786D1 DE3382786T DE3382786T DE3382786D1 DE 3382786 D1 DE3382786 D1 DE 3382786D1 DE 3382786 T DE3382786 T DE 3382786T DE 3382786 T DE3382786 T DE 3382786T DE 3382786 D1 DE3382786 D1 DE 3382786D1
- Authority
- DE
- Germany
- Prior art keywords
- prophylaxis
- treatment
- viral infections
- annielled
- aminopyrimidinones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000036142 Viral infection Diseases 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 230000009385 viral infection Effects 0.000 title abstract 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
Abstract
Novel compounds, and their use in the treatment and prophylaxis of viral infections, are described.
<??>In one aspect, the compounds have the general formula:
<CHEM>
wherein each R<2>, independently, is H or lower (fewer than 6 carbon atoms) alkyl; each R<3>, independently, is H or lower alkyl, R<0> is H or lower alkyl, R<1> is H or lower alkyl; 1</=n</=11 n-2</=m</=2n; 0</=p</=3; z is 0 or 1; and p</=q</=2p; each n, m, p and q being selected so that the sp<3> valence shell of each carbon atom in each ring is filled; or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45473282A | 1982-12-30 | 1982-12-30 | |
US06/541,777 US4625026A (en) | 1982-12-30 | 1983-10-13 | 2-amino-4-oxo-tricyclicpyrimidines having antiviral activities against herpes simplex virus type II infections |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3382786D1 true DE3382786D1 (en) | 1995-06-01 |
DE3382786T2 DE3382786T2 (en) | 1995-08-31 |
Family
ID=27037588
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3382786T Expired - Fee Related DE3382786T2 (en) | 1982-12-30 | 1983-12-29 | Annielled aminopyrimidinones and their use for the treatment and prophylaxis of viral infections. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4625026A (en) |
EP (1) | EP0123750B1 (en) |
AT (1) | ATE121734T1 (en) |
AU (1) | AU570664B2 (en) |
CA (1) | CA1262728A (en) |
DE (1) | DE3382786T2 (en) |
GR (1) | GR82340B (en) |
IE (1) | IE70312B1 (en) |
MA (1) | MA19991A1 (en) |
PT (1) | PT77912B (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4814335A (en) * | 1982-12-30 | 1989-03-21 | Biomeasure, Incorporated | Antiviral compounds |
US4939156A (en) * | 1987-07-11 | 1990-07-03 | Meiji Seika Kaisha, Ltd. | New tetramethyl-cis-diaza-bicyclo{4.2.0}octane-3,5-dione derivatives having differentiation-inducing activity and antiviral activity |
US5316775A (en) * | 1988-08-04 | 1994-05-31 | Kremers-Urban Company | Method of treating hepatitis B infection |
US5055296A (en) * | 1988-08-04 | 1991-10-08 | Wagle Sudhakar S | Method of treating chronic fatigue syndrome |
US5284664A (en) * | 1988-08-04 | 1994-02-08 | Kremers-Urban Company | Method of treating the symptoms of Alzheimer's disease |
US5334395A (en) * | 1988-08-04 | 1994-08-02 | Kremers-Urban Company | Method of treating an epstein-barr viral infection |
DE58909370D1 (en) * | 1988-09-30 | 1995-09-07 | Landis & Gry Tech Innovat Ag | Bar code field and bar code reader. |
US6551608B2 (en) | 2000-03-06 | 2003-04-22 | Porex Technologies Corporation | Porous plastic media with antiviral or antimicrobial properties and processes for making the same |
WO2006041405A1 (en) * | 2004-10-15 | 2006-04-20 | Astrazeneca Ab | Substituted amino-pyrimidones and uses thereof |
JP2008516945A (en) * | 2004-10-15 | 2008-05-22 | アストラゼネカ・アクチエボラーグ | Substituted amino compounds and their use |
US20080318985A1 (en) * | 2005-11-15 | 2008-12-25 | Astrazeneca Ab | Novel 2-Aminopyrimidinone Or 2-Aminopyridinone Derivatives and Their Use |
CN101360720A (en) * | 2005-11-15 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | Novel 2-aminopyrimidinone derivatives and their use |
AR058381A1 (en) * | 2005-12-19 | 2008-01-30 | Astrazeneca Ab | COMPOUNDS DERIVED FROM 2-AMINOPIRIDIN-4-ONAS AND A PHARMACEUTICAL COMPOSITION |
EP2004630A4 (en) * | 2006-04-05 | 2010-05-19 | Astrazeneca Ab | 2-aminopyrimidin-4-ones and their use for treating or preventing a -related pathologies |
JP5739820B2 (en) | 2008-12-30 | 2015-06-24 | アークル インコーポレイテッド | Substituted 5,6-dihydro-6-phenylbenzo [f] isoquinolin-2-amine compounds |
JP2015515364A (en) | 2012-03-06 | 2015-05-28 | ポレックス コーポレーション | Sintered porous plastic plugs for serological pipettes |
US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
MX2015003359A (en) | 2012-09-14 | 2015-10-22 | Klox Technologies Inc | Cosmetic biophotonic compositions. |
CA2916337C (en) | 2013-07-03 | 2022-03-22 | Klox Technologies Inc. | Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds |
AR101656A1 (en) | 2014-06-09 | 2017-01-04 | Klox Tech Inc | SILICONE BASED BIOPHOTONIC MATERIALS AND USES OF THE SAME |
EP3397283A4 (en) | 2015-12-28 | 2019-05-22 | Klox Technologies Limited | Peroxide-less biophotonic compositions and methods |
CA3011156A1 (en) | 2016-01-11 | 2017-07-20 | Klox Technologies Limited | Biophotonic compositions for the treatment of otitis externa |
EP3402524A4 (en) | 2016-01-11 | 2019-08-07 | Klox Technologies Limited | Biophotonic compositions for treating skin and soft tissue wounds having either or both non-resistant and resistant infections |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3185691A (en) * | 1965-05-25 | Gycloocteno-pyrimroines | ||
US3057467A (en) * | 1959-11-18 | 1962-10-09 | Colgate Palmolive Co | Package for treating agents and disposable applicator forming a part thereof |
US3257400A (en) * | 1964-06-10 | 1966-06-21 | Searle & Co | 2-amino-5, 6-dihydrobenzo[h]quinazolin-4(3h)-one and congeners |
US3257401A (en) * | 1964-06-18 | 1966-06-21 | Searle & Co | 5-hydroxy-2-methylcycloalkyl[d] imidazo[1, 2-a]pyrimidines |
GB1062357A (en) * | 1965-03-23 | 1967-03-22 | Pfizer & Co C | Quinazolone derivatives |
US3398826A (en) * | 1966-10-12 | 1968-08-27 | Colgate Palmolive Co | Narrow fold moist towelette package |
JPS4742271A (en) * | 1971-04-24 | 1972-12-15 | ||
US3786615A (en) * | 1972-11-13 | 1974-01-22 | Pfizer | Process for preparing pre-moistened antimicrobial towels |
US3941787A (en) * | 1974-07-22 | 1976-03-02 | Sandoz, Inc. | 1,4-Disubstituted-5,8-methano-tetrahydro-quinazolinones |
US4345195A (en) | 1979-12-13 | 1982-08-17 | Sperry Corporation | Strapdown multifunction servoactuator apparatus for aircraft |
-
1983
- 1983-10-13 US US06/541,777 patent/US4625026A/en not_active Expired - Lifetime
- 1983-12-29 GR GR73384A patent/GR82340B/el unknown
- 1983-12-29 EP EP83307993A patent/EP0123750B1/en not_active Expired - Lifetime
- 1983-12-29 AT AT83307993T patent/ATE121734T1/en not_active IP Right Cessation
- 1983-12-29 DE DE3382786T patent/DE3382786T2/en not_active Expired - Fee Related
- 1983-12-30 MA MA20212A patent/MA19991A1/en unknown
- 1983-12-30 IE IE308783A patent/IE70312B1/en not_active IP Right Cessation
- 1983-12-30 PT PT77912A patent/PT77912B/en not_active IP Right Cessation
- 1983-12-30 AU AU23013/83A patent/AU570664B2/en not_active Ceased
- 1983-12-30 CA CA000444529A patent/CA1262728A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IE833087L (en) | 1984-06-30 |
AU570664B2 (en) | 1988-03-24 |
GR82340B (en) | 1984-12-13 |
ATE121734T1 (en) | 1995-05-15 |
MA19991A1 (en) | 1984-07-01 |
CA1262728A (en) | 1989-11-07 |
DE3382786T2 (en) | 1995-08-31 |
EP0123750A1 (en) | 1984-11-07 |
PT77912A (en) | 1984-01-01 |
PT77912B (en) | 1986-04-30 |
IE70312B1 (en) | 1996-11-13 |
US4625026A (en) | 1986-11-25 |
AU2301383A (en) | 1984-07-05 |
EP0123750B1 (en) | 1995-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |