DE3365631D1 - Oxazinobenzothiazine-6,6-dioxide derivatives, their preparation and their use as medicament - Google Patents
Oxazinobenzothiazine-6,6-dioxide derivatives, their preparation and their use as medicamentInfo
- Publication number
- DE3365631D1 DE3365631D1 DE8383401168T DE3365631T DE3365631D1 DE 3365631 D1 DE3365631 D1 DE 3365631D1 DE 8383401168 T DE8383401168 T DE 8383401168T DE 3365631 T DE3365631 T DE 3365631T DE 3365631 D1 DE3365631 D1 DE 3365631D1
- Authority
- DE
- Germany
- Prior art keywords
- oxazinobenzothiazine
- nitrogen
- atom
- heterocycle
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical group N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Abstract
This invention relates to new derivatives of oxazinobenzothiazine-6,6-dioxide, to a process for the production thereof and to the use thereof as medicaments. The new derivatives according to the present invention correspond to the general formula I: <IMAGE> (I) wherein: R represents a linear or branched lower C1-C4 alkyl radical, in particular the methyl and ethyl radicals, X represents an oxygen atom or a sulphur atom, and Het represents a mono- or bicyclic unsaturated heterocycle containing a nitrogen heteroatom in the ortho position relative to the link between the said heterocycle and the nitrogen atom of the oxazine ring, the said heterocycle optionally containing one or two other additional heteroatoms selected from nitrogen, oxygen and sulphur, and also being able to be substituted by one or two methyl radicals.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8210409A FR2528433A1 (en) | 1982-06-15 | 1982-06-15 | NOVEL OXAZINOBENZOTHIAZINE-6,6-DIOXIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3365631D1 true DE3365631D1 (en) | 1986-10-02 |
Family
ID=9275018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383401168T Expired DE3365631D1 (en) | 1982-06-15 | 1983-06-08 | Oxazinobenzothiazine-6,6-dioxide derivatives, their preparation and their use as medicament |
Country Status (18)
Country | Link |
---|---|
US (1) | US4563452A (en) |
EP (1) | EP0099770B1 (en) |
JP (1) | JPS5980687A (en) |
AT (1) | ATE21700T1 (en) |
BR (1) | BR8303143A (en) |
CA (1) | CA1257589A (en) |
CS (1) | CS239942B2 (en) |
DE (1) | DE3365631D1 (en) |
ES (1) | ES8402842A1 (en) |
FR (1) | FR2528433A1 (en) |
GR (1) | GR78613B (en) |
HU (1) | HU187086B (en) |
MX (1) | MX157060A (en) |
PL (1) | PL142244B1 (en) |
PT (1) | PT76861B (en) |
RO (1) | RO86084B (en) |
SU (1) | SU1195910A3 (en) |
YU (1) | YU45135B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4656265A (en) * | 1984-06-21 | 1987-04-07 | Pfizer Inc. | Cyclic prodrugs of antiinflammatory oxicams |
FR2597103B1 (en) * | 1986-04-15 | 1988-12-16 | Provesan Sa | PROCESS FOR THE PREPARATION OF OXAZINOBENZOTHIAZINE 6,6-DIOXIDE DERIVATIVES |
US5196410A (en) * | 1986-10-31 | 1993-03-23 | Pfizer Inc. | Transdermal flux enhancing compositions |
US5244981A (en) * | 1990-04-10 | 1993-09-14 | Permeable Technologies, Inc. | Silicone-containing contact lens polymers, oxygen permeable contact lenses and methods for making these lenses and treating patients with visual impairment |
US5371147A (en) * | 1990-10-11 | 1994-12-06 | Permeable Technologies, Inc. | Silicone-containing acrylic star polymers, block copolymers and macromonomers |
WO2002076463A1 (en) * | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3492298A (en) * | 1968-02-21 | 1970-01-27 | Mcneilab Inc | Oxazino-benzothiazine-6,6-dioxides |
US3855216A (en) * | 1973-05-29 | 1974-12-17 | Warner Lambert Co | Substituted pyrano(3,2-c)(1,2)benzothiazine 6,6-dioxides |
US3923801A (en) * | 1974-09-23 | 1975-12-02 | Mcneilab Inc | Oxazinobenzothiazine 6,6-dioxides |
EP0043961A1 (en) * | 1980-07-14 | 1982-01-20 | MEDIOLANUM FARMACEUTICI s.r.l. | 1,2-Benzothiazinopyrazoles having pharmacological activity |
-
1982
- 1982-06-15 FR FR8210409A patent/FR2528433A1/en active Granted
-
1983
- 1983-06-07 MX MX197568A patent/MX157060A/en unknown
- 1983-06-07 YU YU1264/83A patent/YU45135B/en unknown
- 1983-06-08 EP EP83401168A patent/EP0099770B1/en not_active Expired
- 1983-06-08 US US06/502,216 patent/US4563452A/en not_active Expired - Lifetime
- 1983-06-08 AT AT83401168T patent/ATE21700T1/en not_active IP Right Cessation
- 1983-06-08 DE DE8383401168T patent/DE3365631D1/en not_active Expired
- 1983-06-09 ES ES523120A patent/ES8402842A1/en not_active Expired
- 1983-06-10 GR GR71634A patent/GR78613B/el unknown
- 1983-06-13 RO RO111241A patent/RO86084B/en unknown
- 1983-06-13 CA CA000430279A patent/CA1257589A/en not_active Expired
- 1983-06-14 SU SU833602726A patent/SU1195910A3/en active
- 1983-06-14 PT PT76861A patent/PT76861B/en not_active IP Right Cessation
- 1983-06-14 BR BR8303143A patent/BR8303143A/en unknown
- 1983-06-14 CS CS834311A patent/CS239942B2/en unknown
- 1983-06-14 HU HU832114A patent/HU187086B/en not_active IP Right Cessation
- 1983-06-15 JP JP58107610A patent/JPS5980687A/en active Granted
- 1983-06-15 PL PL1983242536A patent/PL142244B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
SU1195910A3 (en) | 1985-11-30 |
CA1257589A (en) | 1989-07-18 |
YU126483A (en) | 1986-02-28 |
GR78613B (en) | 1984-09-27 |
ATE21700T1 (en) | 1986-09-15 |
BR8303143A (en) | 1984-01-31 |
RO86084A (en) | 1985-02-25 |
ES523120A0 (en) | 1984-03-16 |
RO86084B (en) | 1985-03-02 |
CS239942B2 (en) | 1986-01-16 |
FR2528433A1 (en) | 1983-12-16 |
PL242536A1 (en) | 1984-08-13 |
PT76861A (en) | 1983-07-01 |
JPH0113713B2 (en) | 1989-03-07 |
MX157060A (en) | 1988-10-25 |
ES8402842A1 (en) | 1984-03-16 |
HU187086B (en) | 1985-11-28 |
EP0099770A1 (en) | 1984-02-01 |
FR2528433B1 (en) | 1984-12-28 |
JPS5980687A (en) | 1984-05-10 |
EP0099770B1 (en) | 1986-08-27 |
PT76861B (en) | 1985-12-16 |
PL142244B1 (en) | 1987-10-31 |
YU45135B (en) | 1992-03-10 |
US4563452A (en) | 1986-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8328 | Change in the person/name/address of the agent |
Free format text: HENKEL, G., DR.PHIL. FEILER, L., DR.RER.NAT. HAENZEL, W., DIPL.-ING. KOTTMANN, D., DIPL.-ING, PAT.-ANW., 8000 MUENCHEN |
|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: LABORATORIOS DEL DR. ESTEVE S.A., BARCELONA, ES |
|
8339 | Ceased/non-payment of the annual fee |