DE3340872A1 - Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel former - Google Patents

Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel former

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Publication number
DE3340872A1
DE3340872A1 DE19833340872 DE3340872A DE3340872A1 DE 3340872 A1 DE3340872 A1 DE 3340872A1 DE 19833340872 DE19833340872 DE 19833340872 DE 3340872 A DE3340872 A DE 3340872A DE 3340872 A1 DE3340872 A1 DE 3340872A1
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DE
Germany
Prior art keywords
urea
polyacrylic acid
absorption
production
methacrylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19833340872
Other languages
German (de)
Inventor
Theodor Prof Dr Eckert
Barbara Mueller
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Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Individual filed Critical Individual
Priority to DE19833340872 priority Critical patent/DE3340872A1/en
Publication of DE3340872A1 publication Critical patent/DE3340872A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)

Abstract

The production of aqueous gels based on polyacrylic acid or methacrylic acid copolymers using urea as gel former is described. In addition, a very wide variety of possible uses of a gel base of this type for a variety of dermatological purposes is described.

Description

Herstellunq von resorptionsfördernden waßrigen Salbengelen ausManufacture of absorption-promoting aqueous ointment gels

Polvacrylsäure oder Methacrylsäure-Mischpolymerisaten unter Verwendung von Harnstoff als Gelbildner Polvacrylsäure oder Mischpolymerisate von Methacrylsäure der unterschiedlichsten Kettenlänge (z.B. CarbopolR934, CarbopolR94O, EudispertR)1) werden vielfach zur Herstellung von hydrophilen Salbengelen verwendet. Die Herstellung erfolgt in der Weise, daß. Polyacrylsäure in Wasser dispergiert wird und die Dispersion mit organischen oder anorganischen Basen neutralisiert wird. Es bildet sich beim Rühren durch Salzbildung ein transparentes, streichfähiqes Gel, in das die verschiedenartigsten Arzneistoffe zur topischen Applikation eingearbeitet werden können.Polyacrylic acid or methacrylic acid copolymers using of urea as a gel-forming agent, polyacrylic acid or copolymers of methacrylic acid the most varied chain lengths (e.g. CarbopolR934, CarbopolR94O, EudispertR) 1) are widely used for the production of hydrophilic ointment gels. The production takes place in such a way that. Polyacrylic acid is dispersed in water and the dispersion is neutralized with organic or inorganic bases. It forms at the Stirring through salt formation a transparent, spreadable gel in which the most diverse Medicinal substances for topical application can be incorporated.

Es wurde nun gefunden, daß eine solche Gelbildung auch dann erfolgt, wenn in die wäßrige Dispersion von Polyacrylsäure neutrale Verbindungen, wie beispielsweise Harnstoff eingearbeitet werden.It has now been found that such a gel formation also takes place if in the aqueous dispersion of polyacrylic acid neutral compounds, such as Urea can be incorporated.

Die Konzentration an Polyacrylsäure oder Methacrylsäure-Mischpolymerisaten kann dabei zwischen 1% und 10% variieren, die Konzentration an Harnstoff zwischen 1% und 30%.The concentration of polyacrylic acid or methacrylic acid copolymers can vary between 1% and 10%, the concentration of urea between 1% and 30%.

Die entstehenden transparenten Gele sind vielseitig anwendbar.The resulting transparent gels can be used in many ways.

Zum einen ist der Harnstoff selbst eine Substanz mit dermatoloqischer Eiqenwirkung. Darüber hinaus besitzt der Harnstoff keratolytische Wirkung, die zu einer verstärkten Penetration zugesetzter Wirkstoffe führt. Weiterhin kann Harnstoff aufgrund 1) Hersteller: Carbopol R - BF Goodrich Chemical GmbH EudispertR - Röhm Pharma GmbH seiner solubilisierenden Eigenschaften dazu dienen, wasserunlösliche Wirkstoffe zu solubilisieren und auf diesem Wege besser resorbierbar zu machen. Oberraschenderweise sind mit Harnstoff hergestellte Gele auch im sauren Milieu stabil. Darüber hinaus erlaubt die Verwendung von Harnstoff die Einarbeitunq von l!irkstoffen, die entweder mit Polyacrylsäure unvertranlich sind, oder die nur im sauren Medium beständig sind. So eist beispielsweise ein unter Verwendung von Harnstoff hergestelltes Polvacrylsäure-Gel, das saurer gemacht wurde, noch die typischen Eigenschaften von Polyacrylsäure-Gelen auf.For one, the urea itself is a dermatological substance Own effect. In addition, the urea has keratolytic effects that lead to leads to an increased penetration of added active ingredients. Urea can also be used based on 1) Manufacturer: Carbopol R - BF Goodrich Chemical GmbH EudispertR - Röhm Pharma GmbH its solubilizing properties serve to Solubilize water-insoluble active ingredients and in this way make them more absorbable close. Surprisingly, gels made with urea are also acidic Stable milieu. In addition, the use of urea allows incorporation of active ingredients that are either incompatible with polyacrylic acid, or that are only are stable in the acidic medium. For example, a using Urea made polyacrylic acid gel made more acidic, still the typical ones Properties of polyacrylic acid gels.

Die folgenden Beispiele kennzeichnen die Erfindunn: Beispiel 1: Carbopol R934 2,0 Harnstoff 2,5 Wasser ad 50,0 Beispiel 2: CarbopolR940 3,0 Harnstoff 5,0 Wasser ad 50,0 Beispiel 3: CarbopolR940 4,0 Harnstoff 10,0 Milchsäure 4,0 Wasser ad 50,0 Beispiel 4: Carbopol R940 4,0 Harnstoff 10,0 TetracyclinHCl 0,5 Milchsäure 4,0 Wasser ad sn,oThe following examples characterize the invention: Example 1: Carbopol R934 2.0 urea 2.5 water ad 50.0 Example 2: Carbopol R940 3.0 urea 5.0 Water ad 50.0 Example 3: Carbopol R940 4.0 urea 10.0 lactic acid 4.0 water ad 50.0 Example 4: Carbopol R940 4.0 Urea 10.0 TetracyclineHCl 0.5 Lactic acid 4.0 water ad sn, o

Claims (5)

Patentansprüche: 1. Herstelluna von resorptionsfbrdernden wßriQen Gelen auf der Basis von Polyacrylsäure oder Methacrylsäure-Mischpolymerisaten, dadurch gekennzeichnet, daß Harnstoff als Gelbildner verwendet wird.Claims: 1. Manufacture of absorption promoting water Gels based on polyacrylic acid or methacrylic acid copolymers, thereby characterized in that urea is used as a gelling agent. 2. Verwendung eines Salbengeles nach Anspruch 1 zur dermatoloqischen Anwendunq von Harnstoff.2. Use of an ointment gel according to claim 1 for dermatological Use of urea. 3. Verwendung eines Salbenqeles nach Anspruch 1 zur Resorptionserhöhung von eingearbeiteten :lirkstoffen.3. Use of a Salbenqeles according to claim 1 to increase absorption of incorporated: active substances. 4. Verwendung eines Salbengeles nach Anspruch 1 zur Lnslichmachen eines in Wasser unlöslichen !!irkstoffes.4. Use of an ointment gel according to claim 1 for solubilizing an active ingredient which is insoluble in water. 5. Verwendunq eines Salbengeles nach Anspruch 1, dadurch neVennzeichnet, daß dem Salbengel eine Saure zugesetzt wird mit dem Ziel, Wirkstoffe anwendbar zu machen, die nur in sauren Medien applizierbar sind.5. Use of an ointment gel according to claim 1, characterized in that that an acid is added to the ointment gel with the aim of making active ingredients usable make that can only be applied in acidic media.
DE19833340872 1983-11-11 1983-11-11 Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel former Withdrawn DE3340872A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19833340872 DE3340872A1 (en) 1983-11-11 1983-11-11 Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel former

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833340872 DE3340872A1 (en) 1983-11-11 1983-11-11 Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel former

Publications (1)

Publication Number Publication Date
DE3340872A1 true DE3340872A1 (en) 1985-05-23

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DE19833340872 Withdrawn DE3340872A1 (en) 1983-11-11 1983-11-11 Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel former

Country Status (1)

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DE (1) DE3340872A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0355152A1 (en) * 1988-01-15 1990-02-28 Curatek Pharmaceuticals Topical metronidazole formulations and therapeutic uses thereof.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0355152A1 (en) * 1988-01-15 1990-02-28 Curatek Pharmaceuticals Topical metronidazole formulations and therapeutic uses thereof.
EP0355152A4 (en) * 1988-01-15 1990-06-27 Curatek Pharmaceuticals Topical metronidazole formulations and therapeutic uses thereof.

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