DE3315463A1 - Pharmaceutical compositions for the topical treatment of psoriasis - Google Patents

Pharmaceutical compositions for the topical treatment of psoriasis

Info

Publication number
DE3315463A1
DE3315463A1 DE19833315463 DE3315463A DE3315463A1 DE 3315463 A1 DE3315463 A1 DE 3315463A1 DE 19833315463 DE19833315463 DE 19833315463 DE 3315463 A DE3315463 A DE 3315463A DE 3315463 A1 DE3315463 A1 DE 3315463A1
Authority
DE
Germany
Prior art keywords
psoriasis
pharmaceutical compositions
emodin
topical treatment
frangula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19833315463
Other languages
German (de)
Inventor
Erfinder Wird Nachtraeglich Benannt Der
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALEXA MIHAI DIPL CHEM
Original Assignee
ALEXA MIHAI DIPL CHEM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALEXA MIHAI DIPL CHEM filed Critical ALEXA MIHAI DIPL CHEM
Priority to DE19833315463 priority Critical patent/DE3315463A1/en
Priority to DE19843447953 priority patent/DE3447953A1/en
Publication of DE3315463A1 publication Critical patent/DE3315463A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones

Abstract

Pharmaceutical compositions containing emodins of the general formula <IMAGE> in which R1 = H; R2 = CH2OH(aloe emodin) or R1 = H; R2 = CH3(frangula emodin) or R1 = OH; R2 = CH3(chrysophanol) are possible or else different. In particular containing aloe emodin or frangula emodin is suitable for the topical treatment of psoriasis and other skin disorders.

Description

Arzneimittel zur lokalenMedicinal for local

Behandlung von Psoriasis Beschreibung Die Erfindung betrifft Arzneimittel zur lokalen Behandlung der Psoriasis (Schuppenflechte) und anderer Hautkrankheiten.Treatment of Psoriasis Description The invention relates to pharmaceuticals for the local treatment of psoriasis (psoriasis) and other skin diseases.

Das Arzneimittel der Erfindung weist einen Gehalt an Emodinen der in Anspruch 1 angegebenen allgemeinen Formel auf.The medicament of the invention has an emodine content in claim 1 given general formula.

Die Gruppen Rl und R2 können z.B. wie in Anspruch 2 angegeben oder auch verschieden sein.The groups R1 and R2 can, for example, as indicated in claim 2 or also be different.

Das Arzneimittel der Erfindung kann übliche pharmazeutische Träger und/oder Verdünnungsmittel enthalten.Es kann z.B. in Form einer Lösung eingesetzt werden,insbesonders gelöst in Dimethylsulfoxid (DMSO).Der Wirkstoff kann weiterhin in üblichen Gelen und Salbenformulierungen oder zusammen mit Filmbildnern verabreicht werden.The medicament of the invention can be conventional pharmaceutical carriers and / or diluents. It can be used, for example, in the form of a solution especially dissolved in dimethyl sulfoxide (DMSO). The active ingredient can still be used administered in common gels and ointment formulations or together with film-forming agents will.

Die Konzentration des Wirkstoffs in dem Arzneimittel der Erfindung hängt von der speziellen Sensibilisierung des Patienten ab,sie kann von 0,01 bis 1 Gew.-ah betragen.The concentration of the active ingredient in the medicament of the invention depends on the specific sensitization of the patient, it can range from 0.01 to 1% by weight.

Die therapeutische Anwendung des Arzneimittels der Erfindung erfolgt bei der Psoriasis in der Weise,daß die erkrankten Hautpartien ca. 1 mal pro Tag mit dem Arzneimittel bestrichen werden,wobei die behandelten mit Psoriasis befallenen Herde abends mit dem Arzneimittel bestrichen werden und über Nacht abgedeckt,einwirken sollen.The drug of the invention is used therapeutically in psoriasis in such a way that the diseased skin areas about 1 time per day be smeared with the drug, the treated with psoriasis Herd can be smeared with the medicine in the evening and overnight covered, act should.

Wach kurzer Behandlungsdauer findet nach Verschwinden der Psoriasis Herde eine Regeneration des Epitheis statt (z.B.Awake brief treatment takes place after the psoriasis disappears Regeneration of the epithelium takes place (e.g.

an den 2'ingerkuppen).Das Arzneimittel ist uarüberhinaus auch zur Behandlung anderer Hautkrankheiten (z.B.-Verbrennungen) geeignet.The remedy is also used for Treatment of other skin diseases (e.g. burns) suitable.

Claims (1)

Patentansprüche 1. Arzneimittel zur lokalen Behandlung von Psoriasis und anderer Hautkrankheiten gekennzeichnet durch einen Gehalt an Emodine der allgemeinen Formel 2. Bekämpfung von Psoriasis (und anderen Hautkrankheiten), gekennzeichnet durch die Verwendung von Aloe-Emodin (R1=H; R2=cH2oH) ,Frangula-Emodin (R1=H;R2=CH3),oder Chrysophanol (R1=OH;R2=CH3).Claims 1. Medicaments for the local treatment of psoriasis and other skin diseases characterized by an emodine content of the general formula 2. Combating psoriasis (and other skin diseases), characterized by the use of aloe emodin (R1 = H; R2 = cH2oH), frangula emodin (R1 = H; R2 = CH3), or chrysophanol (R1 = OH; R2 = CH3).
DE19833315463 1983-04-28 1983-04-28 Pharmaceutical compositions for the topical treatment of psoriasis Ceased DE3315463A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19833315463 DE3315463A1 (en) 1983-04-28 1983-04-28 Pharmaceutical compositions for the topical treatment of psoriasis
DE19843447953 DE3447953A1 (en) 1983-04-28 1984-05-24 Pharmaceutical composition for treating the symptoms of pain associated with burns

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833315463 DE3315463A1 (en) 1983-04-28 1983-04-28 Pharmaceutical compositions for the topical treatment of psoriasis

Publications (1)

Publication Number Publication Date
DE3315463A1 true DE3315463A1 (en) 1984-10-31

Family

ID=6197623

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19833315463 Ceased DE3315463A1 (en) 1983-04-28 1983-04-28 Pharmaceutical compositions for the topical treatment of psoriasis

Country Status (1)

Country Link
DE (1) DE3315463A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3447953A1 (en) * 1983-04-28 1986-02-20 Mihai Dipl.-Chem. Dr. 7000 Stuttgart Alexa Pharmaceutical composition for treating the symptoms of pain associated with burns
EP0374890A1 (en) * 1988-12-21 1990-06-27 Gerum Establishment Process for the production of anthraquinone derivatives
US5039707A (en) * 1989-09-08 1991-08-13 Mobley James R 1,3,6,8 tetrahydroxyanthraquinone
US5852060A (en) * 1996-03-22 1998-12-22 Moady Marzook Antipsoriatic compositions, method of making, and method of using
US7994141B2 (en) * 2006-12-15 2011-08-09 Biospectrum, Inc. Compositions comprising compounds of natural origin for damaged skin
US9066974B1 (en) * 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
CN106370767A (en) * 2016-08-29 2017-02-01 贵州信邦制药股份有限公司 Identification method of polygonum cuspidatum in arthralgia eliminating pill
WO2017019651A1 (en) * 2015-07-29 2017-02-02 Sirbal Ltd. Herbal combinations for treating psoriasis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, Vol. 74, 1971, Referat 84338e *
Chemical Abstracts, Vol. 74, 1971, Referat 97509m *
Chemical Abstracts, Vol. 89, 1978, Referat 12032n *
Chemical Abstracts, Vol. 92, 1980, Referat 121581y *
DE-Z.: Seifen-Öle-Fette-Wachse 105, 1979, S. 499-502 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3447953A1 (en) * 1983-04-28 1986-02-20 Mihai Dipl.-Chem. Dr. 7000 Stuttgart Alexa Pharmaceutical composition for treating the symptoms of pain associated with burns
EP0374890A1 (en) * 1988-12-21 1990-06-27 Gerum Establishment Process for the production of anthraquinone derivatives
US5039707A (en) * 1989-09-08 1991-08-13 Mobley James R 1,3,6,8 tetrahydroxyanthraquinone
US5852060A (en) * 1996-03-22 1998-12-22 Moady Marzook Antipsoriatic compositions, method of making, and method of using
USRE39199E1 (en) * 1996-03-22 2006-07-18 Naseba Moady Antipsoriatic compositions, method of making, and method of using
US7994141B2 (en) * 2006-12-15 2011-08-09 Biospectrum, Inc. Compositions comprising compounds of natural origin for damaged skin
US9066974B1 (en) * 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US9662363B2 (en) 2010-11-13 2017-05-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
WO2017019651A1 (en) * 2015-07-29 2017-02-02 Sirbal Ltd. Herbal combinations for treating psoriasis
CN106370767A (en) * 2016-08-29 2017-02-01 贵州信邦制药股份有限公司 Identification method of polygonum cuspidatum in arthralgia eliminating pill

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