DE3262037D1 - 17-cyclopropylmethyl-3-hydroxy-14-methoxy 7 alpha-methylmorphinan-6-one - Google Patents
17-cyclopropylmethyl-3-hydroxy-14-methoxy 7 alpha-methylmorphinan-6-oneInfo
- Publication number
- DE3262037D1 DE3262037D1 DE8282105424T DE3262037T DE3262037D1 DE 3262037 D1 DE3262037 D1 DE 3262037D1 DE 8282105424 T DE8282105424 T DE 8282105424T DE 3262037 T DE3262037 T DE 3262037T DE 3262037 D1 DE3262037 D1 DE 3262037D1
- Authority
- DE
- Germany
- Prior art keywords
- cyclopropylmethyl
- methoxy
- alpha
- hydroxy
- methylmorphinan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/278,760 US4370333A (en) | 1981-06-29 | 1981-06-29 | 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7α-methyl-morphinan-6-one and therapeutic method of treating pain with it |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3262037D1 true DE3262037D1 (de) | 1985-03-07 |
Family
ID=23066241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8282105424T Expired DE3262037D1 (de) | 1981-06-29 | 1982-06-21 | 17-cyclopropylmethyl-3-hydroxy-14-methoxy 7 alpha-methylmorphinan-6-one |
Country Status (6)
Country | Link |
---|---|
US (1) | US4370333A (de) |
EP (1) | EP0068384B1 (de) |
JP (1) | JPS588067A (de) |
AT (1) | ATE11410T1 (de) |
CA (1) | CA1172251A (de) |
DE (1) | DE3262037D1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4715703A (en) * | 1982-10-12 | 1987-12-29 | Rodenstock Instrument Corporation | Ocular-fundus analyzer |
TWI483944B (zh) | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
WO2006126529A1 (ja) * | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | 6,7-不飽和-7-カルバモイル置換モルヒナン誘導体 |
JP6159417B2 (ja) | 2012-12-28 | 2017-07-05 | パーデュー、ファーマ、リミテッド、パートナーシップ | 置換モルフィナンおよびその使用 |
US8957084B2 (en) * | 2012-12-28 | 2015-02-17 | Purdue Pharma L.P. | 7,8-cyclicmorphinan analogs |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654280A (en) * | 1968-03-21 | 1972-04-04 | Shionogi & Co | L-n allylic-3-hydroxy-6-oxomorphinans |
CA1093070A (en) * | 1978-02-10 | 1981-01-06 | Michael P. Kotick | 8.beta.-ALKYL-SUBSTITUTED MORPHINAN-6-ONE COMPOUNDS |
US4272540A (en) * | 1979-04-24 | 1981-06-09 | Sisa, Incorporated | 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them |
CA1135692A (en) * | 1979-05-21 | 1982-11-16 | Michael P. Kotick | 7-methyl and 7-methyl-8-lower alkyl b/c cis or trans morphinan-6-one compounds |
-
1981
- 1981-06-29 US US06/278,760 patent/US4370333A/en not_active Expired - Fee Related
-
1982
- 1982-05-21 CA CA000403504A patent/CA1172251A/en not_active Expired
- 1982-06-21 EP EP82105424A patent/EP0068384B1/de not_active Expired
- 1982-06-21 AT AT82105424T patent/ATE11410T1/de active
- 1982-06-21 DE DE8282105424T patent/DE3262037D1/de not_active Expired
- 1982-06-22 JP JP57106278A patent/JPS588067A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US4370333A (en) | 1983-01-25 |
EP0068384B1 (de) | 1985-01-23 |
EP0068384A1 (de) | 1983-01-05 |
JPS588067A (ja) | 1983-01-18 |
ATE11410T1 (de) | 1985-02-15 |
CA1172251A (en) | 1984-08-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |