DE1967178C2 - Verfahren zur Herstellung von Chinuclidinyl-4-chinolinmethanolderivaten - Google Patents

Verfahren zur Herstellung von Chinuclidinyl-4-chinolinmethanolderivaten

Info

Publication number
DE1967178C2
DE1967178C2 DE1967178A DE1967178A DE1967178C2 DE 1967178 C2 DE1967178 C2 DE 1967178C2 DE 1967178 A DE1967178 A DE 1967178A DE 1967178 A DE1967178 A DE 1967178A DE 1967178 C2 DE1967178 C2 DE 1967178C2
Authority
DE
Germany
Prior art keywords
racemic
mixture
benzene
melting point
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1967178A
Other languages
German (de)
English (en)
Inventor
Juerg Albert Walter Bettingen Gutzwiller
Milan Radoje Upper Montclair N.J. Uskokovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE1967178C2 publication Critical patent/DE1967178C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE1967178A 1968-07-02 1969-07-02 Verfahren zur Herstellung von Chinuclidinyl-4-chinolinmethanolderivaten Expired DE1967178C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74191368A 1968-07-02 1968-07-02

Publications (1)

Publication Number Publication Date
DE1967178C2 true DE1967178C2 (de) 1984-11-22

Family

ID=24982727

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19691933599 Ceased DE1933599A1 (de) 1968-07-02 1969-07-02 Chinolinderivate
DE1967178A Expired DE1967178C2 (de) 1968-07-02 1969-07-02 Verfahren zur Herstellung von Chinuclidinyl-4-chinolinmethanolderivaten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19691933599 Ceased DE1933599A1 (de) 1968-07-02 1969-07-02 Chinolinderivate

Country Status (14)

Country Link
JP (1) JPS4915278B1 (ja)
AT (2) AT319481B (ja)
BE (1) BE735450A (ja)
CA (2) CA956312A (ja)
CH (2) CH533123A (ja)
DE (2) DE1933599A1 (ja)
DK (2) DK136069B (ja)
FR (1) FR2012151A1 (ja)
GB (1) GB1253741A (ja)
IE (1) IE33474B1 (ja)
IL (1) IL32534A (ja)
NL (1) NL166475C (ja)
PH (1) PH12608A (ja)
SE (2) SE367823B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH590274A5 (ja) * 1970-03-16 1977-07-29 Hoffmann La Roche
GB1441244A (en) * 1972-11-17 1976-06-30 Rech Et Dapplications Scient S Derivatives of quinoline and method of preparing the same
NL7908031A (nl) * 1979-11-01 1981-06-01 Acf Chemiefarma Nv Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.
FR2844270B1 (fr) 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. American Chem.Soc., 67, 1945, 1428 *
Tetrahedron Letters, 1967, 3261 *

Also Published As

Publication number Publication date
AT319481B (de) 1974-12-27
PH12608A (en) 1979-06-27
SE367823B (ja) 1974-06-10
NL166475C (nl) 1981-08-17
DK136069C (ja) 1978-01-16
NL6910144A (ja) 1970-01-06
SE375775B (ja) 1975-04-28
JPS4915278B1 (ja) 1974-04-13
DE1933599A1 (de) 1970-02-26
BE735450A (ja) 1970-01-02
IE33474B1 (en) 1974-07-10
DK136982C (ja) 1978-07-10
GB1253741A (en) 1971-11-17
NL166475B (nl) 1981-03-16
CA956312A (en) 1974-10-15
CH533123A (de) 1973-01-31
IL32534A0 (en) 1969-09-25
AT341115B (de) 1978-01-25
DK136069B (da) 1977-08-08
DK136982B (da) 1977-12-27
IL32534A (en) 1975-07-28
FR2012151A1 (ja) 1970-03-13
CA962682A (en) 1975-02-11
IE33474L (en) 1970-01-02
CH521975A (de) 1972-04-30
ATA49171A (de) 1977-05-15

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