DE122006000007I1 - Antigene epitope, die sich ausschlisslich auf ige-tragenden B-Lymphocyten befinden. - Google Patents
Antigene epitope, die sich ausschlisslich auf ige-tragenden B-Lymphocyten befinden.Info
- Publication number
- DE122006000007I1 DE122006000007I1 DE19883853636 DE3853636C DE122006000007I1 DE 122006000007 I1 DE122006000007 I1 DE 122006000007I1 DE 19883853636 DE19883853636 DE 19883853636 DE 3853636 C DE3853636 C DE 3853636C DE 122006000007 I1 DE122006000007 I1 DE 122006000007I1
- Authority
- DE
- Germany
- Prior art keywords
- ige
- lymphocytes
- bearing
- exclusively
- epitopes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003719 b-lymphocyte Anatomy 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 210000003651 basophil Anatomy 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6873—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an immunoglobulin; the antibody being an anti-idiotypic antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14003687A | 1987-12-31 | 1987-12-31 | |
US07/226,421 US5422258A (en) | 1987-12-31 | 1988-07-29 | Methods for producing high affinity anti-human IgE-monoclonal antibodies which binds to IgE on IgEabearing B cells but not basophils |
US22917888A | 1988-08-05 | 1988-08-05 | |
US07/272,243 US5091313A (en) | 1988-08-05 | 1988-11-16 | Antigenic epitopes of IgE present on B cell but not basophil surface |
US29106888A | 1988-12-28 | 1988-12-28 | |
PCT/US1988/004706 WO1989006138A1 (en) | 1987-12-31 | 1988-12-29 | UNIQUE ANTIGENIC EPITOPES ON IgE-BEARING B LYMPHOCYTES |
Publications (1)
Publication Number | Publication Date |
---|---|
DE122006000007I1 true DE122006000007I1 (de) | 2006-04-27 |
Family
ID=27538114
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3853636T Expired - Lifetime DE3853636T3 (de) | 1987-12-31 | 1988-12-29 | Antigene epitope, die sich ausschliesslich auf ige-tragenden b-lymphocyten befinden. |
DE19883853636 Pending DE122006000007I1 (de) | 1987-12-31 | 1988-12-29 | Antigene epitope, die sich ausschlisslich auf ige-tragenden B-Lymphocyten befinden. |
DE122006000007C Active DE122006000007I2 (de) | 1987-12-31 | 1988-12-29 | -tragenden b-lymphocyten befinden. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3853636T Expired - Lifetime DE3853636T3 (de) | 1987-12-31 | 1988-12-29 | Antigene epitope, die sich ausschliesslich auf ige-tragenden b-lymphocyten befinden. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE122006000007C Active DE122006000007I2 (de) | 1987-12-31 | 1988-12-29 | -tragenden b-lymphocyten befinden. |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP0617127A1 (de) |
JP (1) | JP2724625B2 (de) |
AT (1) | ATE121299T1 (de) |
AU (1) | AU618317B2 (de) |
CA (1) | CA1340233C (de) |
DE (3) | DE3853636T3 (de) |
HK (1) | HK31096A (de) |
LU (1) | LU91218I2 (de) |
NL (1) | NL300222I2 (de) |
WO (1) | WO1989006138A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5449760A (en) * | 1987-12-31 | 1995-09-12 | Tanox Biosystems, Inc. | Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils |
US5362643A (en) * | 1989-06-21 | 1994-11-08 | Tanox Biosystems | Antibodies to epitopes present on membrane-bound but not secreted IGA |
US5254671A (en) * | 1990-04-27 | 1993-10-19 | Tanox Biosystems, Inc. | Extracellular segments of human e immunoglobulin anchoring peptides and antibodies specific therefor |
US5089603A (en) * | 1989-06-21 | 1992-02-18 | Tanox Biosystems, Inc. | Antigenic epitopes present on membrane-bound but not secreted iga |
EP0327283B1 (de) * | 1988-02-02 | 1993-08-18 | Schering Biotech Corporation | Methode zur Verminderung der Immunglobulin-E-Reaktion |
ATE148348T1 (de) * | 1989-09-15 | 1997-02-15 | Tanox Biosystems Inc | Behandlung von einer autoimmun-krankheit |
SG70982A1 (en) * | 1990-01-23 | 2000-03-21 | Tanox Biosystems Inc | Extracellular segments of human and immunoglobulin anchoring peptides and antibodies specific therefor |
WO1992017207A1 (en) * | 1991-03-26 | 1992-10-15 | Tanox Biosystems, Inc. | MONOCLONAL ANTIBODIES WHICH BIND TO SECRETED AND MEMBRANE-BOUND IgE, BUT NOT TO IgE ON BASOPHILS |
US6329509B1 (en) | 1991-08-14 | 2001-12-11 | Genentech, Inc. | Anti-IgE antibodies |
US5994514A (en) * | 1991-08-14 | 1999-11-30 | Genentech, Inc. | Immunoglobulin variants |
EP0602126B1 (de) * | 1991-08-14 | 2003-03-05 | Genentech, Inc. | Veränderte Immunglobuline für spezifische FC-Epsilon Rezeptoren |
US6685939B2 (en) | 1991-08-14 | 2004-02-03 | Genentech, Inc. | Method of preventing the onset of allergic disorders |
US5965709A (en) * | 1991-08-14 | 1999-10-12 | Genentech, Inc. | IgE antagonists |
SE9102808L (sv) * | 1991-09-26 | 1993-03-27 | Lars T Hellman Inst F Immunolo | Vaccin, foer humant bruk, vars avsedda effekt aer att lindra symptomen eller foerhindra uppkomsten av ige-medierade allergiska reaktioner |
JP3156237B2 (ja) * | 1991-12-24 | 2001-04-16 | 雪印乳業株式会社 | 抗ヒトIgE モノクローナル抗体 |
GB9220228D0 (en) * | 1992-09-24 | 1992-11-04 | Ciba Geigy Ag | Reshaped monoclonal antibodies against an immunologlobulin isotype |
DK0589840T3 (da) * | 1992-09-24 | 2004-07-26 | Novartis Ag | Omdannede monoklonale antistoffer mod en immunoglobulinisotype |
US5958708A (en) * | 1992-09-25 | 1999-09-28 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
US6066718A (en) * | 1992-09-25 | 2000-05-23 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
WO1994020533A1 (en) * | 1993-03-11 | 1994-09-15 | Tanox Biosystems, Inc. | PEPTIDES REPRESENTING ANTIGENIC EPITOPES OF IgE PRESENT ON B CELL BUT NOT BASOPHIL SURFACE |
EP0619323A1 (de) * | 1993-04-09 | 1994-10-12 | Schering-Plough | Menschliche monoklonale Antikörper und Verfahren und Material zu deren Herstellung |
DK0739214T3 (da) * | 1994-01-18 | 1998-10-07 | Genentech Inc | Fremgangsmåde til behandling af parasitinfektionerunder anvendelse af IgE antagonister |
US6037453A (en) * | 1995-03-15 | 2000-03-14 | Genentech, Inc. | Immunoglobulin variants |
ZA966075B (en) * | 1995-07-27 | 1998-01-19 | Genentech Inc | Protein formulation. |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
JP2788979B2 (ja) * | 1995-08-28 | 1998-08-20 | タノックス バイオシステムズ インコーポレイテッド | 新規抗体及びその用途 |
US7026446B1 (en) | 1997-12-24 | 2006-04-11 | Diatech Pty Ltd. | Bifunctional molecules |
US6504013B1 (en) | 2000-02-01 | 2003-01-07 | Idexx Laboratories, Inc. | Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody |
US7393529B2 (en) | 1998-04-09 | 2008-07-01 | Idexx Laboratories, Inc. | Methods and compositions for inhibiting binding of IgE to a high affinity receptor |
US6734287B1 (en) | 1998-04-09 | 2004-05-11 | Idexx Laboratories, Inc. | Specific binding proteins for treating canine allergy |
US6913749B2 (en) | 1998-11-02 | 2005-07-05 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
US6602719B1 (en) | 1999-03-26 | 2003-08-05 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6511814B1 (en) | 1999-03-26 | 2003-01-28 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
GB9908533D0 (en) | 1999-04-14 | 1999-06-09 | Novartis Ag | Organic compounds |
JP3597140B2 (ja) | 2000-05-18 | 2004-12-02 | 日本たばこ産業株式会社 | 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途 |
US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
WO2004041862A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
EP1592776A4 (de) | 2003-02-01 | 2008-06-04 | Tanox Inc | Hochaffine anti-mensch-ige-antikörper |
JP5389442B2 (ja) | 2005-09-29 | 2014-01-15 | メディミューン,エルエルシー | 膜Ig特異的抗体を同定する方法および免疫グロブリンを生成する前駆体細胞を標的化するための使用 |
AR065368A1 (es) | 2007-02-15 | 2009-06-03 | Astrazeneca Ab | Anticuerpos para moleculas de ige |
KR101555068B1 (ko) | 2007-03-22 | 2015-10-06 | 제넨테크, 인크. | 막 결합형 ige에 결합하는 세포자멸성 항-ige 항체 |
EP1972640A1 (de) * | 2007-03-23 | 2008-09-24 | Biomay AG | Apoptoseerzeugende Antikörper |
CN102482351B (zh) | 2009-02-25 | 2015-03-18 | 中央研究院 | 能与人B淋巴细胞上的mIgE结合的抗CεmX抗体 |
US9587034B2 (en) | 2012-04-20 | 2017-03-07 | Academia Sinica | Anti-mIgE antibodies that bind to the junction between CH4 and CεmX domains |
WO2015013668A1 (en) * | 2013-07-26 | 2015-01-29 | Ke Zhang | Anti-immunoglobulin e antibodies and methods of use thereof |
KR20200110302A (ko) | 2017-10-31 | 2020-09-23 | 원니스 바이오테크 컴퍼니 리미티드 | IgE-매개 알레르기성 질환들의 치료 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4946788A (en) * | 1985-06-11 | 1990-08-07 | Ciba-Geigy Corporation | Purified immunoglobulin-related factor, novel monoclonal antibodies, hybridoma cell lines, processes and applications |
US4714759A (en) * | 1985-12-02 | 1987-12-22 | Whitaker Jr Robert B | Immunotoxin therapy of allergy |
CA1338777C (en) * | 1986-11-04 | 1996-12-10 | Dominic Man-Kit Lam | Methods and compositions for preventing secondary cataracts |
GB8800078D0 (en) * | 1988-01-05 | 1988-02-10 | Ciba Geigy Ag | Novel antibodies |
AU625613B2 (en) * | 1988-01-05 | 1992-07-16 | Novartis Ag | Novel chimeric antibodies |
-
1988
- 1988-12-29 DE DE3853636T patent/DE3853636T3/de not_active Expired - Lifetime
- 1988-12-29 AU AU30310/89A patent/AU618317B2/en not_active Expired
- 1988-12-29 AT AT89901649T patent/ATE121299T1/de active
- 1988-12-29 EP EP94103256A patent/EP0617127A1/de not_active Withdrawn
- 1988-12-29 DE DE19883853636 patent/DE122006000007I1/de active Pending
- 1988-12-29 JP JP1501629A patent/JP2724625B2/ja not_active Expired - Lifetime
- 1988-12-29 WO PCT/US1988/004706 patent/WO1989006138A1/en active IP Right Grant
- 1988-12-29 DE DE122006000007C patent/DE122006000007I2/de active Active
- 1988-12-29 EP EP89901649A patent/EP0407392B2/de not_active Expired - Lifetime
-
1989
- 1989-01-03 CA CA000587431A patent/CA1340233C/en not_active Expired - Lifetime
-
1996
- 1996-02-22 HK HK31096A patent/HK31096A/xx not_active IP Right Cessation
-
2006
- 2006-02-02 LU LU91218C patent/LU91218I2/fr unknown
- 2006-02-03 NL NL300222C patent/NL300222I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
AU3031089A (en) | 1989-08-01 |
EP0407392A1 (de) | 1991-01-16 |
WO1989006138A1 (en) | 1989-07-13 |
ATE121299T1 (de) | 1995-05-15 |
JP2724625B2 (ja) | 1998-03-09 |
EP0617127A1 (de) | 1994-09-28 |
EP0407392B1 (de) | 1995-04-19 |
DE122006000007I2 (de) | 2008-03-27 |
EP0407392B2 (de) | 1998-10-28 |
DE3853636D1 (de) | 1995-05-24 |
NL300222I1 (nl) | 2006-04-03 |
NL300222I2 (nl) | 2006-10-02 |
DE3853636T3 (de) | 1999-04-08 |
JPH03501927A (ja) | 1991-05-09 |
CA1340233C (en) | 1998-12-15 |
AU618317B2 (en) | 1991-12-19 |
HK31096A (en) | 1996-03-01 |
LU91218I2 (fr) | 2006-04-03 |
DE3853636T2 (de) | 1995-08-24 |
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