DE1207876T1 - Benützung von proteinaseinhibitoren, um die spaltung von wachstumfaktorvorläufern zu verhindern - Google Patents

Benützung von proteinaseinhibitoren, um die spaltung von wachstumfaktorvorläufern zu verhindern

Info

Publication number
DE1207876T1
DE1207876T1 DE1207876T DE00951521T DE1207876T1 DE 1207876 T1 DE1207876 T1 DE 1207876T1 DE 1207876 T DE1207876 T DE 1207876T DE 00951521 T DE00951521 T DE 00951521T DE 1207876 T1 DE1207876 T1 DE 1207876T1
Authority
DE
Germany
Prior art keywords
cutting
prevent
growth factor
protein inhibitors
factor precursors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE1207876T
Other languages
English (en)
Inventor
Axel Ullrich
Norbert Prenzel
Henrik Daub
Esther Zwick-Wallasch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/461,090 external-priority patent/US7632645B1/en
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Publication of DE1207876T1 publication Critical patent/DE1207876T1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE1207876T 1999-08-16 2000-08-16 Benützung von proteinaseinhibitoren, um die spaltung von wachstumfaktorvorläufern zu verhindern Pending DE1207876T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99116056 1999-08-16
US09/461,090 US7632645B1 (en) 1999-08-16 1999-12-14 EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
PCT/EP2000/008007 WO2001012182A1 (en) 1999-08-16 2000-08-16 Use of proteinase inhibitor in order to inhibit the cleavage of growth factor precursor

Publications (1)

Publication Number Publication Date
DE1207876T1 true DE1207876T1 (de) 2003-01-09

Family

ID=26153086

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1207876T Pending DE1207876T1 (de) 1999-08-16 2000-08-16 Benützung von proteinaseinhibitoren, um die spaltung von wachstumfaktorvorläufern zu verhindern

Country Status (6)

Country Link
EP (2) EP1207876B9 (de)
JP (1) JP2003506489A (de)
AU (1) AU779298B2 (de)
CA (1) CA2380753C (de)
DE (1) DE1207876T1 (de)
WO (1) WO2001012182A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050176633A1 (en) * 2002-03-08 2005-08-11 Axel Ullrich Use of egfr transactivation inhibitors in human cancer
EP1493445A1 (de) * 2003-07-04 2005-01-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibierung von Stress-induzierter Liganden-abhängiger EGFR Aktivierung
EP2561759A1 (de) 2011-08-26 2013-02-27 Bayer Cropscience AG Fluoralkyl-substituierte 2-amidobenzimidazole und ihre Wirkung auf das Pflanzenwachstum

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE225343T1 (de) * 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren

Also Published As

Publication number Publication date
JP2003506489A (ja) 2003-02-18
CA2380753C (en) 2013-10-08
WO2001012182A1 (en) 2001-02-22
AU779298B2 (en) 2005-01-13
EP1207876B1 (de) 2011-06-22
CA2380753A1 (en) 2001-02-22
EP1207876A1 (de) 2002-05-29
EP1820500A1 (de) 2007-08-22
AU6442600A (en) 2001-03-13
EP1207876B9 (de) 2012-04-18

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