DE1151030T1 - Neue membrane oder matrix zur kontrolle der penetration von medikamenten - Google Patents
Neue membrane oder matrix zur kontrolle der penetration von medikamentenInfo
- Publication number
- DE1151030T1 DE1151030T1 DE1151030T DE99954021T DE1151030T1 DE 1151030 T1 DE1151030 T1 DE 1151030T1 DE 1151030 T DE1151030 T DE 1151030T DE 99954021 T DE99954021 T DE 99954021T DE 1151030 T1 DE1151030 T1 DE 1151030T1
- Authority
- DE
- Germany
- Prior art keywords
- siloxane
- elastomer
- atoms
- polymer
- trifluoropropyl groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims 4
- 239000011159 matrix material Substances 0.000 title claims 2
- 239000012528 membrane Substances 0.000 title claims 2
- 230000035515 penetration Effects 0.000 title 1
- -1 3,3,3-trifluoropropyl groups Chemical group 0.000 claims 13
- 229920000642 polymer Polymers 0.000 claims 8
- 229920001971 elastomer Polymers 0.000 claims 7
- 239000000806 elastomer Substances 0.000 claims 7
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 239000000945 filler Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 2
- 229910021486 amorphous silicon dioxide Inorganic materials 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/009—Sachets, pouches characterised by the material or function of the envelope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/2036—Silicones; Polysiloxanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
- Silicon Polymers (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
Claims (5)
1. Verfahren zur Kontrolle der Permeation eines Arzneimittels im Verlauf verlängerter Zeitperioden unter Verwendung
eines Elastomeren auf Siloxangrundlage, umfassend: Dispersion des Arzneimittels innerhalb des Elastomeren
auf Siloxangrundlage unter Bildung einer Matrix oder
Umhüllen des Arzneimittels als Kern innerhalb* einer
Membran, umfassend das Elastomere auf Siloxangrundlage,
wobei das Elastomere 3,3,3-Trifluorpropylgruppen,
gebunden an die Si-Atome der Siloxaneinheiten, umfasst,
wobei 1 bis ungefähr 50% der Substituenten, die an die Si-Atome in den Siloxaneinheiten gebunden sind,
3,3,3-Trifluorpropylgruppen sind, und wobei das Elastomere hergestellt ist aus entweder
i) einem Gemisch umfassend, a) ein nichtfluorsubstituiertes Polymeres auf Siloxangrundlage und b)
ein fluorsubstituiertes Polymeres auf Siloxangrundlage, wobei das Polymere 3,3,3-Trifluorpropylgruppen,
gebunden an die Si-Atome der Siloxaneinheiten, umfasst, oder
ii) einem einzigen Polymeren auf Siloxangrundlage, umfassend 3,3,3-Trifluorpropylgruppen, gebunden an
die Si-Atome der Siloxaneinheiten,
wobei das Polymere oder das Gemisch aus Polymeren unter Bildung des Elastomeren vernetzt ist.
&igr; &igr; &ugr; &ogr;
2. Verfahren nach Anspruch 1, dadurch gekennzeichnet , dass das Gemisch der Polymeren ein Gemisch
aus a) Poly(dimethylsiloxan) und b) Poly (dimethylsiloxan) , worin mindestens 30% der Methylgruppen,
gebunden an die Si-Atome der Siloxaneinheiten, durch 3,3,3-Trifluorpropylgruppen ersetzt wurden, ist.
3. Verfahren nach Anspruch 2, dadurch gekennzeichnet, dass ungefähr 50% der Methylgruppen in
dem Polymeren b) durch 3,3,3-Trifluorpropylgruppen ersetzt
wurden.
4. Verfahren nach Anspruch 1, dadurch gekennzeichnet , dass das Elastomere einen Füllstoff enthält.
5. Verfahren nach Anspruch 6, dadurch gekennzeichnet , dass der Füllstoff amorphes Siliciumdioxid
ist.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/190,608 US6056976A (en) | 1998-11-12 | 1998-11-12 | Elastomer, its preparation and use |
PCT/FI1999/000888 WO2000029464A1 (en) | 1998-11-12 | 1999-10-26 | Novel membrane or matrix for controlling drug permeation |
Publications (1)
Publication Number | Publication Date |
---|---|
DE1151030T1 true DE1151030T1 (de) | 2002-04-04 |
Family
ID=22702039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1151030T Pending DE1151030T1 (de) | 1998-11-12 | 1999-10-26 | Neue membrane oder matrix zur kontrolle der penetration von medikamenten |
Country Status (25)
Country | Link |
---|---|
US (1) | US6056976A (de) |
EP (1) | EP1151030A1 (de) |
JP (1) | JP2002530447A (de) |
KR (1) | KR20010075701A (de) |
CN (1) | CN1127535C (de) |
AR (1) | AR025815A1 (de) |
AU (1) | AU756089B2 (de) |
BG (1) | BG105499A (de) |
BR (1) | BR9915325A (de) |
CA (1) | CA2351091A1 (de) |
CZ (1) | CZ291399B6 (de) |
DE (1) | DE1151030T1 (de) |
EE (1) | EE05528B1 (de) |
HK (1) | HK1041895B (de) |
HU (1) | HUP0104380A3 (de) |
ID (1) | ID29223A (de) |
IL (2) | IL142525A0 (de) |
NO (1) | NO20012045L (de) |
NZ (1) | NZ511215A (de) |
PE (1) | PE20001019A1 (de) |
PL (1) | PL348115A1 (de) |
RU (1) | RU2231531C2 (de) |
SK (1) | SK5142001A3 (de) |
WO (1) | WO2000029464A1 (de) |
ZA (1) | ZA200103297B (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6214926B1 (en) * | 1999-04-01 | 2001-04-10 | Rhodia Inc. | Silicone membranes formed without the use of 1-1-1 trichloroethane |
US6436428B1 (en) * | 2000-03-21 | 2002-08-20 | Enhance Pharmaceuticals, Inc. | Device and method for treating urinary incontinence in females |
US6299894B1 (en) | 2000-05-10 | 2001-10-09 | Leiras Oy | Drug delivery device, especially for the delivery of gestodene |
WO2001085132A1 (en) * | 2000-05-10 | 2001-11-15 | Leiras Oy | Drug delivery device, especially for the delivery of levonorgestrel |
US6550480B2 (en) * | 2001-01-31 | 2003-04-22 | Numed/Tech Llc | Lumen occluders made from thermodynamic materials |
EP1438942A1 (de) * | 2003-01-17 | 2004-07-21 | Schering Oy | Medikamentenabgabevorrichtung für das Mittelohr und Nase |
US20050038188A1 (en) * | 2003-08-14 | 2005-02-17 | Dongchan Ahn | Silicones having improved chemical resistance and curable silicone compositions having improved migration resistance |
US7045586B2 (en) * | 2003-08-14 | 2006-05-16 | Dow Corning Corporation | Adhesives having improved chemical resistance and curable silicone compositions for preparing the adhesives |
US20050038183A1 (en) * | 2003-08-14 | 2005-02-17 | Dongchan Ahn | Silicones having improved surface properties and curable silicone compositions for preparing the silicones |
US7862552B2 (en) * | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
US20090168013A1 (en) * | 2007-12-27 | 2009-07-02 | Kunzler Jay F | Trimethylsilyl-Capped Polysiloxane Macromonomers Containing Polar Fluorinated Side-Chains |
BRPI0905946B8 (pt) | 2008-02-04 | 2021-05-25 | Ferring Bv | anel intravaginal monolítico e processo para a produção de um anel intravaginal monolítico |
EP2140860A1 (de) | 2008-07-03 | 2010-01-06 | Bayer Schering Pharma Oy | Verbessertes Verhütungsverfahren |
DK2349143T4 (en) | 2008-09-17 | 2016-11-28 | Bayer Oy | introducer |
FI20080523A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
FI20080524A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
US11992431B2 (en) | 2008-09-17 | 2024-05-28 | Bayer Oy | Inserter |
FI122579B (fi) | 2010-10-29 | 2012-03-30 | Bayer Oy | Insertteri |
US10028858B2 (en) | 2011-07-11 | 2018-07-24 | Medicines360 | Intrauterine systems, IUD insertion devices, and related methods and kits therefor |
TW201350122A (zh) | 2012-04-23 | 2013-12-16 | Bayer Pharma AG | 18-甲基-15β,16β-亞甲基-19-降-20-螺氧-4-烯-3-酮的子宮內用途,包含18-甲基-15β,16β-亞甲基-19-降-20-螺氧-4-烯-3-酮的子宮內系統,及其於避孕及婦科治療之用途 |
MX2014012848A (es) | 2012-04-23 | 2015-02-05 | Bayer Pharma AG | Uso de 18-metil-15b,16b-metilen-19-nor-20-espirox-4-en-3-onas en el tratamiento de menorragia, y sistemas intrauterinos que comprenden 18-metil-15b,16b-metilen-19-nor-20-espirox-4-en-3-onas para el tratamiento de trastornos con sangrado uterino. |
EP3057573A1 (de) * | 2013-10-18 | 2016-08-24 | Bayer Oy | Intrauterines freisetzungssystem |
EP3040388B1 (de) | 2014-12-31 | 2017-08-23 | LG Display Co., Ltd. | Berührungsempfindliche vorrichtung mit elektroaktivem film, anzeigevorrichtung damit und verfahren zur herstellung des elektroaktiven films |
KR102431597B1 (ko) * | 2014-12-31 | 2022-08-11 | 엘지디스플레이 주식회사 | 전기활성 필름을 포함하는 접촉 감응 소자, 이를 포함하는 표시 장치 및 전기활성 필름의 제조 방법 |
JP6898856B2 (ja) | 2015-05-13 | 2021-07-07 | バイエル・オーイュー | 長時間作用型薬物送達装置および避妊におけるその使用 |
WO2018202574A1 (en) | 2017-05-04 | 2018-11-08 | Bayer Oy | Intravaginal drug delivery system, method for manufacturing such system and its use in gynecological therapies and contraception |
US11571328B2 (en) | 2018-04-09 | 2023-02-07 | Medicines360 | IUD insertion devices |
US20200261258A1 (en) | 2019-02-19 | 2020-08-20 | Medicines360 | Devices, systems, methods and kits for insertion and removal of iuds |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3179619A (en) * | 1965-04-20 | Xow swell, high temperature organosi- loxane rubbeks containing silicon- bonded fluokjnated aliphatic radicals | ||
US3050492A (en) * | 1962-08-21 | Degrees of twist at indicated centigrade temperature | ||
US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
US3661833A (en) * | 1970-07-09 | 1972-05-09 | Dow Corning | Fast curing organosiloxane resins |
US3974120A (en) * | 1975-05-05 | 1976-08-10 | General Electric Company | Fluorosilicone copolymers and process for the preparation thereof |
CH657779A5 (de) * | 1982-10-05 | 1986-09-30 | Sandoz Ag | Galenische zusammensetzungen enthaltend calcitonin. |
US4525528A (en) * | 1983-10-11 | 1985-06-25 | General Electric Company | Peroxide-curable fluorosilicone copolymer compositions |
NZ217844A (en) * | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
US5310572A (en) * | 1987-02-03 | 1994-05-10 | Dow Corning Corporation | Process for forming a coated active agent-containing article |
GB8704755D0 (en) * | 1987-02-28 | 1987-04-01 | Dow Corning Ltd | Pharmaceutical delivery device |
FR2643572A1 (fr) * | 1988-12-22 | 1990-08-31 | Rhone Poulenc Chimie | Procede d'encapsulation de particules par pelliculage au moyen d'un copolymere silicone thermoplastique |
JPH07216233A (ja) * | 1992-09-21 | 1995-08-15 | Toray Dow Corning Silicone Co Ltd | フルオロシリコーンゴム組成物 |
US5492993A (en) * | 1994-02-03 | 1996-02-20 | Dow Corning Corporation | Strain-crystallizing poly(methyl(3,3,3-trifluoropropyl)-siloxane) elastomers and methods for making |
DE69511180T2 (de) * | 1994-06-20 | 1999-12-23 | Dow Corning Corp., Midland | Verfahren zur Steuerung der Freisetzung einer Wirksubstanz oder eines Arzneistoffs aus einer Silikongummi-Matrix |
-
1998
- 1998-11-12 US US09/190,608 patent/US6056976A/en not_active Expired - Lifetime
-
1999
- 1999-10-26 KR KR1020017006011A patent/KR20010075701A/ko not_active Application Discontinuation
- 1999-10-26 EP EP99954021A patent/EP1151030A1/de not_active Withdrawn
- 1999-10-26 CZ CZ20011570A patent/CZ291399B6/cs not_active IP Right Cessation
- 1999-10-26 BR BR9915325-4A patent/BR9915325A/pt not_active IP Right Cessation
- 1999-10-26 PL PL99348115A patent/PL348115A1/xx not_active Application Discontinuation
- 1999-10-26 NZ NZ511215A patent/NZ511215A/en not_active IP Right Cessation
- 1999-10-26 WO PCT/FI1999/000888 patent/WO2000029464A1/en not_active Application Discontinuation
- 1999-10-26 CA CA002351091A patent/CA2351091A1/en not_active Abandoned
- 1999-10-26 AU AU10489/00A patent/AU756089B2/en not_active Ceased
- 1999-10-26 DE DE1151030T patent/DE1151030T1/de active Pending
- 1999-10-26 IL IL14252599A patent/IL142525A0/xx active IP Right Grant
- 1999-10-26 SK SK514-2001A patent/SK5142001A3/sk unknown
- 1999-10-26 ID IDW00200101066A patent/ID29223A/id unknown
- 1999-10-26 HU HU0104380A patent/HUP0104380A3/hu unknown
- 1999-10-26 CN CN99813193A patent/CN1127535C/zh not_active Expired - Fee Related
- 1999-10-26 EE EEP200100257A patent/EE05528B1/xx not_active IP Right Cessation
- 1999-10-26 RU RU2001116121/04A patent/RU2231531C2/ru not_active IP Right Cessation
- 1999-10-26 JP JP2000582447A patent/JP2002530447A/ja active Pending
- 1999-11-05 PE PE1999001124A patent/PE20001019A1/es not_active Application Discontinuation
- 1999-11-11 AR ARP990105742A patent/AR025815A1/es not_active Application Discontinuation
-
2001
- 2001-04-10 IL IL142525A patent/IL142525A/en not_active IP Right Cessation
- 2001-04-23 ZA ZA200103297A patent/ZA200103297B/xx unknown
- 2001-04-26 NO NO20012045A patent/NO20012045L/no unknown
- 2001-05-11 BG BG105499A patent/BG105499A/bg unknown
-
2002
- 2002-05-07 HK HK02103478.3A patent/HK1041895B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1151030A1 (de) | 2001-11-07 |
ZA200103297B (en) | 2001-10-25 |
CZ20011570A3 (cs) | 2001-09-12 |
AR025815A1 (es) | 2002-12-18 |
SK5142001A3 (en) | 2001-11-06 |
CN1127535C (zh) | 2003-11-12 |
HUP0104380A3 (en) | 2003-04-28 |
EE05528B1 (et) | 2012-04-16 |
ID29223A (id) | 2001-08-16 |
AU1048900A (en) | 2000-06-05 |
WO2000029464A1 (en) | 2000-05-25 |
HK1041895A1 (en) | 2002-07-26 |
BG105499A (bg) | 2001-12-29 |
PL348115A1 (en) | 2002-05-06 |
EE200100257A (et) | 2002-12-16 |
PE20001019A1 (es) | 2000-10-12 |
RU2231531C2 (ru) | 2004-06-27 |
KR20010075701A (ko) | 2001-08-09 |
IL142525A0 (en) | 2002-03-10 |
NO20012045D0 (no) | 2001-04-26 |
HK1041895B (zh) | 2004-07-23 |
US6056976A (en) | 2000-05-02 |
AU756089B2 (en) | 2003-01-02 |
HUP0104380A2 (hu) | 2002-03-28 |
NZ511215A (en) | 2002-04-26 |
CA2351091A1 (en) | 2000-05-25 |
BR9915325A (pt) | 2001-10-09 |
IL142525A (en) | 2006-07-05 |
CN1326478A (zh) | 2001-12-12 |
JP2002530447A (ja) | 2002-09-17 |
NO20012045L (no) | 2001-06-28 |
CZ291399B6 (cs) | 2003-02-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE1151030T1 (de) | Neue membrane oder matrix zur kontrolle der penetration von medikamenten | |
DE2515484C3 (de) | Beschichtungsmittel auf Basis PoIyorganosiloxanen und dessen Verwendung | |
EP0391322B1 (de) | Wässriger Nagellack | |
DE2809588C2 (de) | Verwendung eines Gemischs aus einem Polysiloxan und einem Silan als Haftvermittler in einer Siliconelastomermasse | |
EP0089066B1 (de) | Verfahren zum Verstärken des Haftens von Organopolysiloxanelastomeren | |
DE2631955C3 (de) | Verfahren zur Herstellung eines Trennuberzugs auf einem Trager und Mittel zu dessen Durchfuhrung | |
DE60222454T2 (de) | Thermoplastische polyurethan-silikon-elastomere | |
DE69206565T2 (de) | Polypropylenfaser zur Verstärkung von Zement. | |
DE69601351T2 (de) | Bei Zimmertemperatur härtende Silikon-Elastomer-Mischung | |
DE2433697C3 (de) | Herstellen von zu Elastomeren vernetzbaren Organopolysiloxanformmassen | |
DE2614667C3 (de) | Verfahren zur Herstellung einer Polysiloxanmasse | |
EP0097333A3 (de) | Neue Organopolysiloxane, Verfahren zu ihrer Herstellung und Verwendung dieser Organopolysiloxane | |
DE2354759A1 (de) | Gemisch von mitteln mit oberflaechenaktivitaet | |
DE69312101T2 (de) | Siliconelastomere | |
DE3927362A1 (de) | Verfahren zur herstellung einer polyorganosiloxanmasse | |
DE2058810A1 (de) | Membran mit verbesserter Gaspermeabilitaet und Verfahren zu ihrer Herstellung | |
DE2737303A1 (de) | Zu elastomeren vernetzende massen | |
DE2210595A1 (de) | Blockmischpolymerisate aus Organopolysiloxanen und Polyphenylenoxide^ | |
DE3447254A1 (de) | Verfahren zum dissoziieren ionisch vernetzter siloxan-polymerer | |
WO2004052994A1 (de) | Additionsvernetzende zweikomponenten-siliconmaterialien mit hoher shore d-härte | |
EP0169592A1 (de) | Optische Glasfaser mit einer Kunststoffbedeckung | |
DE1570693A1 (de) | Organopolysiloxan-Hydrolysat sowie Verfahren zu seiner Herstellung | |
DE2551592A1 (de) | Organopolysiloxan-zusammensetzungen | |
DE2035976A1 (de) | Zum Aufbringen auf ein Substrat be stimmte Organosiloxanmassen | |
EP0138103A2 (de) | RTV-Siliconpasten |