DE1068428B - Process and device for the production of oxygenated blood - Google Patents
Process and device for the production of oxygenated bloodInfo
- Publication number
- DE1068428B DE1068428B DE1957J0013243 DEJ0013243A DE1068428B DE 1068428 B DE1068428 B DE 1068428B DE 1957J0013243 DE1957J0013243 DE 1957J0013243 DE J0013243 A DEJ0013243 A DE J0013243A DE 1068428 B DE1068428 B DE 1068428B
- Authority
- DE
- Germany
- Prior art keywords
- vessel
- blood
- treatment
- quartz burner
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims description 5
- 210000004369 blood Anatomy 0.000 title description 22
- 239000008280 blood Substances 0.000 title description 22
- 238000004519 manufacturing process Methods 0.000 title description 3
- 230000005855 radiation Effects 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000010453 quartz Substances 0.000 claims description 4
- 238000006385 ozonation reaction Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 description 10
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 9
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 238000006213 oxygenation reaction Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000005187 foaming Methods 0.000 description 3
- 208000013210 hematogenous Diseases 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002927 oxygen compounds Chemical class 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000011034 rock crystal Substances 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B3/00—Ohmic-resistance heating
- H05B3/0033—Heating devices using lamps
- H05B3/0038—Heating devices using lamps for industrial applications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
- B01J19/122—Incoherent waves
- B01J19/128—Infrared light
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
Description
Verfahren und Einrichtung zur Herstellung von oxygeniertem Blut Es ist I,ekannt, für die hämatogene Oxydationstherapie menschliches oder tierisches Blut nach Zusatz eines Stabilisierungsmittels gegen Gerinnen mit Luft unter Belichtung mit ultravioletter Strahlung zu behandeln, wobei das Blut durch den zugeführten Luftstrom in einen innerhalb einer Ultraviolettstrahlung sich bewegenden Schaum umgewandelt wird, der anschließend unter Zuriickbildung einer Flüssigkeit zerstört wird. Das so behandelte oxygenierte Blut kann intramuskulär oder intravenös eingespritzt werden. Process and device for the production of oxygenated blood Es I, known for hematogenous oxidation therapy, is human or animal Blood after the addition of a stabilizer against clotting with air under exposure Treat with ultraviolet radiation, the blood being fed through the Air flow into a foam moving within ultraviolet radiation which is then destroyed with the formation of a liquid will. The oxygenated blood thus treated can be injected intramuscularly or intravenously will.
Das in der beschriebenen Weise oxygenierte Blut löst jedoch unter gewissen, noch nicht näher erforschten Umständen Schockwirkungen aus, welche die hämatogene Oxydationstherapie erschweren. Die Störungen können mit dem Zufall von Erythrozyten, erkennbar an einem üblen Geruch der Reaktionsmedien, bei der Einwirkung von Sauerstoff auf ver-- schäumtes Blut zusammenhängen. The blood oxygenated in the manner described, however, dissolves Certain, as yet unexplored circumstances, shock effects from which the make hematogenous oxidation therapy difficult. The glitches can be caused by the coincidence of Erythrocytes, recognizable by a foul odor in the reaction media, upon exposure from oxygen to foamed blood.
Demgegenüber wird nach der Erfindung menschliches oder tierisches Blut nach der Stabilisierung mit Ozon bzw. ozonangereichertem Sauerstoff unter Erwärmung auf vorteilhaft etwa 450 C und unter gleichzeitiger Bestrahlung mit ultraviolettem Licht behandelt, wobei das Ozon enthaltende Gas durch eine Fliissigkeitssäule hindurchgeleitet wird, derart, daß eine Verschäumung des Blutes oder der sonstigen Flüssigkeit nicht eintritt. Ein derart behandeltes Blut läßt sich, wie gefunden wurde, für die hämatogene Oxydationstherapie verwenden, ohne daß die bisher beobachteten Schockwirkungen auftreten. In contrast, according to the invention, it becomes human or animal Blood after stabilization with ozone or ozone-enriched oxygen under warming to advantageously about 450 C and with simultaneous irradiation with ultraviolet Treated light, the ozone-containing gas being passed through a column of liquid is in such a way that a foaming of the blood or other liquid does not entry. Blood treated in this way can be found to be hematogenous Use oxidation therapy without the previously observed shock effects occurring.
Dies dürfte damit zusammenhängen, daß bei der Ozonhehandlung des Blutes in einer Flüssigkeitssäule ohne Verschäumung andere Sauerstoffverbindungen, insbesondere Peroxyde entstehen, welche als Katalysatoren die Ausnutzbarkeit des im Blut kreisenden Sauerstoffs verbessern. Hierbei spielt auch die wesentlich geringere Reaktionszeit bei der Blutoxygenierung mit Ozon eine Rolle. Während man bei der OO-Oxygenierung etwa 2 Stunden Einwirkungszeit benötigt, dauert die Eehandlung bei dem erfindungsgemäßen Verfahren nur etwa 15 bis 20 Minuten. Dadurch werden offenbar die empfindlichen Erythrozyten geschont. Vorteilhaft ist schließlich, daß man für die Therapie mit O3-oxygeniertem Blut nur etwa t/4 bis lis der Menge gebraucht, die bei der bekannten OO-Oxygenierung erfahrungsgemäß erforderlich sind. This is likely to be related to the fact that in the ozone treatment of the Blood in a column of liquid without foaming other oxygen compounds, in particular peroxides arise, which as catalysts the exploitability of the improve oxygen circulating in the blood. The much lower one also plays here Reaction time in blood oxygenation with ozone plays a role. While the OO oxygenation requires about 2 hours of exposure time, the treatment lasts the method according to the invention only about 15 to 20 minutes. This will become evident the sensitive erythrocytes are spared. Finally, it is advantageous that one for the therapy with O3-oxygenated blood only needs about t / 4 to lis the amount, which experience has shown to be necessary in the case of the known OO oxygenation.
Bekannt ist zwar an sich die Behandlung von Blut mit \Vasserstoffsuperoxyd. Hierbei tritt jedoch, ahgesehen von der Unbestimmtheit der dabei vor sich elenden Umwandlungen. eine fiir die hiimatogene ()xvdatiollstllerapie nachteilige Vcrrliinnung (ies Blutes auf. Dieser Nachteil liegt beim Erfindung gegenstand nicht vor. The treatment of blood with hydrogen peroxide is known per se. Here, however, apart from the indeterminacy of the miserable ones before them Conversions. a line which is disadvantageous for the hiimatogenic () xdatogenetic therapy (ies blood. This disadvantage does not exist in the subject matter of the invention.
Die zur Herstellung des oxygenierten Blutes gemäß der Erfindung verwendete Einrichtung umfaßt ein für Ultraviolettstrahlung durchlässiges, etwa aus Bergkristallglas bestehendes Behandlungsgefäß, welches sich zweckmäßig nach oben erweitert und die zu behandelnde Flüssigkeit aufnimmt. Dieses Behandlungsgefäß ist von einem schraubenlinienartig gebogenen Niederdruck-Quarzroh rbrenner umgeben, dem zum Zwecke der Zuführung der Wärme durch Infrarotstrahlung ein in einem elektrischen Stromkreis liegendes Drahtwendel zugeordnet ist. In den Flüssigkeitsraum des Behandlungsgefäßes ragt von oben bis annähernd an den Gefäßboden ein Zuleitungsrohr für Ozon hinein, das mit einer einen Niederdruck-Quarzbrenner enthaltenden Özonisierungskammer verbunden ist, welcher vorteilhaft reiner Sauerstoff zugeführt wird. Mit der erfindungsgemäßen Apparatur ergibt sich eine starke Durchwirbelung der Flüssigkeit in dem Behandlungsgefäß durch das zugeführte Ozongas, ohne daß eine wesentliche Schaumbildung stattfindet. Die Dauer der Oxygenierung beträgt nur etwa 5 bis 10 Minuten, was wesentlich ist, da die kurze Behandlung der Bildung von Nebenreaktionen entgegenwirkt. The one used to produce the oxygenated blood according to the invention The device comprises an ultraviolet radiation permeable, for example made of rock crystal glass existing treatment vessel, which expediently expands upwards and the absorbs liquid to be treated. This treatment vessel is of a helical shape curved low-pressure quartz tube burner, which is used for the purpose of feeding the Heat through infrared radiation from a wire coil lying in an electrical circuit assigned. In the liquid space of the treatment vessel protrudes from the top to Approximately to the bottom of the vessel a feed pipe for ozone into it, which with a one Low pressure quartz burner containing ozonization chamber is connected, which pure oxygen is advantageously supplied. With the apparatus according to the invention this results in a strong swirling of the liquid in the treatment vessel the supplied ozone gas without any substantial foaming taking place. the Oxygenation duration is only about 5 to 10 minutes, which is essential because the brief treatment counteracts the formation of side reactions.
Das erfindungsgemäß behandelte Blut kann unmittelbar nach der Behandlung intramuskulär oder intravenös eingespritzt werden. Man kann das behandelte Blut aber auch als nlutkonserve in geeignetell flefäßen verschließen, um es nach Bedarf therapeutisch zu verwenden. The blood treated according to the invention can be used immediately after the treatment be injected intramuscularly or intravenously. You can get the treated blood but also as canned blood in suitable containers to close it as required to use therapeutically.
Bei der Behandlung der Flüssigkeit mit Ozon wird vorteilhaft zunächst normale Körpertemperatur (etwa 36 bis 380 C) eingehalten und die Temperatur de, Flüssigkeit bis zum Ende der Behandlung langsam auf die Endtemperatur von etwa 450 C gesteigert. When treating the liquid with ozone it will be beneficial initially normal body temperature (about 36 to 380 C) is maintained and the temperature de, liquid by the end of the treatment slowly increased to the final temperature of about 450 ° C.
PATENTANSPII liCH E 1. Verfahren zur Herstellung von oxygeniertem Blut, dadurch gekennzeichnet, daß man durch eine zusammenhängende Flüssigkeitssäule von stabilisiertem venösem Blut Ozon im Bereich einer Ultraviolettstrahlung derart durchleitet, daß eine wesentliche Schaumbildung nicht eintritt, wobei die Temperatur während der Behandlung allmählich bis auf etwa 450 C gesteigert wird. PATENT APPLICATION 1. Process for the production of oxygenated Blood, characterized in that one passes through a coherent column of liquid of stabilized venous blood ozone in the range of an ultraviolet radiation such passes through that a substantial foam formation does not occur, the temperature is gradually increased during the treatment up to about 450 ° C.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1957J0013243 DE1068428C2 (en) | 1957-05-21 | 1957-05-21 | Process and device for the production of oxygenated blood |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1957J0013243 DE1068428C2 (en) | 1957-05-21 | 1957-05-21 | Process and device for the production of oxygenated blood |
Publications (2)
Publication Number | Publication Date |
---|---|
DE1068428B true DE1068428B (en) | 1959-11-05 |
DE1068428C2 DE1068428C2 (en) | 1960-04-21 |
Family
ID=35840711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1957J0013243 Expired DE1068428C2 (en) | 1957-05-21 | 1957-05-21 | Process and device for the production of oxygenated blood |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE1068428C2 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2242367B (en) * | 1987-03-26 | 1992-03-11 | Mueller Quarzlampenfab Dr F | Apparatus for the production of oxygenated blood |
US5834030A (en) * | 1992-02-07 | 1998-11-10 | Vasogen, Inc. | Method of increasing the concentration of nitric oxide in human blood |
US6264646B1 (en) | 1998-11-13 | 2001-07-24 | Vasogen Ireland Limited | Method for preventing and reversing atherosclerosis in mammals |
US6432399B1 (en) | 1997-09-12 | 2002-08-13 | Vasogen Ireland Limited | Treatment of stress and preconditioning against stress |
US6569467B1 (en) | 1992-02-07 | 2003-05-27 | Vasogen Ireland Limited | Treatment of autoimmune diseases |
US6669965B2 (en) | 1992-02-07 | 2003-12-30 | Vasogen Ireland Limited | Method of treating atherosclerosis |
US6736788B1 (en) | 1999-09-16 | 2004-05-18 | Vasogen Ireland Limited | Apparatus and process for conditioning mammalian blood |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE8704467U1 (en) * | 1987-01-15 | 1988-05-26 | Quarzlampenfabrik Dr.-Ing. Felix W. Mueller Gmbh & Co Kg, 4300 Essen, De |
-
1957
- 1957-05-21 DE DE1957J0013243 patent/DE1068428C2/en not_active Expired
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2242367B (en) * | 1987-03-26 | 1992-03-11 | Mueller Quarzlampenfab Dr F | Apparatus for the production of oxygenated blood |
US5834030A (en) * | 1992-02-07 | 1998-11-10 | Vasogen, Inc. | Method of increasing the concentration of nitric oxide in human blood |
EP0680346B1 (en) * | 1992-02-07 | 2002-07-03 | Vasogen Inc. | Method of increasing the concentration of nitric oxide in blood |
EP1243278A3 (en) * | 1992-02-07 | 2003-02-26 | Vasogen, Inc. | Method of increasing the concentration of nitric oxide in blood |
US6569467B1 (en) | 1992-02-07 | 2003-05-27 | Vasogen Ireland Limited | Treatment of autoimmune diseases |
US6669965B2 (en) | 1992-02-07 | 2003-12-30 | Vasogen Ireland Limited | Method of treating atherosclerosis |
US6432399B1 (en) | 1997-09-12 | 2002-08-13 | Vasogen Ireland Limited | Treatment of stress and preconditioning against stress |
US6264646B1 (en) | 1998-11-13 | 2001-07-24 | Vasogen Ireland Limited | Method for preventing and reversing atherosclerosis in mammals |
US6736788B1 (en) | 1999-09-16 | 2004-05-18 | Vasogen Ireland Limited | Apparatus and process for conditioning mammalian blood |
US7128873B2 (en) | 1999-09-16 | 2006-10-31 | Vasogen Ireland Limited | Apparatus and process for conditioning mammalian blood |
US7250137B2 (en) | 1999-09-16 | 2007-07-31 | Vasogen Ireland Limited | Apparatus and process for conditioning mammalian blood |
US7273586B2 (en) | 1999-09-16 | 2007-09-25 | Vasogen Ireland Limited | Apparatus and process for conditioning mammalian blood |
Also Published As
Publication number | Publication date |
---|---|
DE1068428C2 (en) | 1960-04-21 |
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