DE10399007I2 - Osteoinduktive Mittel - Google Patents

Osteoinduktive Mittel

Info

Publication number
DE10399007I2
DE10399007I2 DE2003199007 DE10399007C DE10399007I2 DE 10399007 I2 DE10399007 I2 DE 10399007I2 DE 2003199007 DE2003199007 DE 2003199007 DE 10399007 C DE10399007 C DE 10399007C DE 10399007 I2 DE10399007 I2 DE 10399007I2
Authority
DE
Germany
Prior art keywords
osteoinductive agents
bone
research
factors
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE2003199007
Other languages
English (en)
Other versions
DE10399007I1 (de
Inventor
Elizabeth Wang
John Wozney
Vicki Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/031,346 external-priority patent/US4877864A/en
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of DE10399007I1 publication Critical patent/DE10399007I1/de
Application granted granted Critical
Publication of DE10399007I2 publication Critical patent/DE10399007I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
DE2003199007 1986-07-01 1987-06-30 Osteoinduktive Mittel Active DE10399007I2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US88077686A 1986-07-01 1986-07-01
US94333286A 1986-12-17 1986-12-17
US2828587A 1987-03-20 1987-03-20
US07/031,346 US4877864A (en) 1987-03-26 1987-03-26 Osteoinductive factors
PCT/US1987/001537 WO1988000205A1 (en) 1986-07-01 1987-06-30 Novel osteoinductive compositions

Publications (2)

Publication Number Publication Date
DE10399007I1 DE10399007I1 (de) 2003-07-31
DE10399007I2 true DE10399007I2 (de) 2006-03-16

Family

ID=27487661

Family Applications (4)

Application Number Title Priority Date Filing Date
DE2003199007 Active DE10399007I2 (de) 1986-07-01 1987-06-30 Osteoinduktive Mittel
DE3751887T Expired - Lifetime DE3751887T2 (de) 1986-07-01 1987-06-30 Osteoinduktive mittel
DE3752393T Expired - Lifetime DE3752393D1 (de) 1986-07-01 1987-06-30 Osteoinduktive Zusammensetzungen
DE3752364T Expired - Lifetime DE3752364T2 (de) 1986-07-01 1987-06-30 Osteoinduktive Zusammensetzungen

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE3751887T Expired - Lifetime DE3751887T2 (de) 1986-07-01 1987-06-30 Osteoinduktive mittel
DE3752393T Expired - Lifetime DE3752393D1 (de) 1986-07-01 1987-06-30 Osteoinduktive Zusammensetzungen
DE3752364T Expired - Lifetime DE3752364T2 (de) 1986-07-01 1987-06-30 Osteoinduktive Zusammensetzungen

Country Status (18)

Country Link
EP (3) EP1254956B1 (de)
JP (3) JP2713715B2 (de)
AT (3) ATE419349T1 (de)
AU (1) AU613314B2 (de)
CA (1) CA1341212C (de)
DE (4) DE10399007I2 (de)
DK (2) DK172275B1 (de)
ES (1) ES2007625A6 (de)
GR (1) GR871028B (de)
IE (1) IE75881B1 (de)
IL (1) IL83003A (de)
LU (1) LU91005I2 (de)
MX (1) MX170919B (de)
MY (1) MY102505A (de)
NL (1) NL300116I2 (de)
NZ (1) NZ220894A (de)
PT (1) PT85225B (de)
WO (1) WO1988000205A1 (de)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5035901A (en) * 1987-10-09 1991-07-30 University Of Kansas Bone inducing agent from a human osteosarcoma cell line
US6020313A (en) * 1987-10-09 2000-02-01 University Of Kansas Method for inducing bone formation using an extract of human osteosarcoma cell line SAOS-2
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5344654A (en) * 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
DE01201555T1 (de) * 1988-04-08 2004-07-08 Stryker Corp., Kalamazoo Biosynthetische osteogene Proteine und solche enthaltende osteogene Einrichtungen
WO1989010409A1 (en) * 1988-04-08 1989-11-02 Genetics Institute, Inc. Bone and cartilage inductive compositions
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US4915301A (en) * 1988-11-15 1990-04-10 International Flavors & Fragrances, Inc. Container with sorbent member and microporous membrane for dispensing vapor from volatile liquid
ES2113857T3 (es) * 1989-03-28 1998-05-16 Genetics Inst Composiciones osteoinductoras.
PT94241A (pt) * 1989-06-02 1991-02-08 Chiron Corp Processo para a preparacao de factor calcificacao ossea e de composicoes farmaceuticas que os contem
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
CA2064878A1 (en) * 1989-08-21 1991-02-22 Hanne Bentz Bone-specific protein
EP0416578B1 (de) * 1989-09-06 1996-07-31 Takeda Chemical Industries, Ltd. Protein, DNA und ihre Verwendung
DK0448704T3 (da) * 1989-10-17 1999-04-06 Stryker Corp Osteogene anordninger
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
US5645591A (en) * 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
WO1992005199A1 (en) * 1990-09-26 1992-04-02 Genetics Institute, Inc. Bmp-5 derivatives
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6399569B1 (en) 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
JPH07500315A (ja) 1991-05-10 1995-01-12 セルトリックス　ファーマシューティカルズ，インコーポレイテッド 骨成長因子の標的送達
MX9203083A (es) * 1991-06-21 1994-08-31 Genetics Inst Formulaciones farmaceuticas de proteinas osteogenicas.
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
JP3504263B2 (ja) 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
PT625989E (pt) * 1992-02-12 2000-06-30 Bioph Biotech Entw Pharm Gmbh Sequencias de adn que codificam novos factores de crescimento/diferenciacao
IL106278A0 (en) * 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
AU670334B2 (en) * 1992-09-15 1996-07-11 Creative Biomolecules, Inc. Morphogen-induced periodontal tissue regeneration
EP0665739B1 (de) * 1992-09-15 1999-08-04 Creative Biomolecules, Inc. Durch morphogen induzierte periodontolgeweberegeneration
DE69434875T2 (de) * 1993-05-12 2007-09-06 Genetics Institute, LLC, Cambridge BMP-11 Zusammenstellungen
US6333168B1 (en) * 1993-05-20 2001-12-25 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of dorsalin-1
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
EP1364656B1 (de) * 1995-06-05 2013-11-20 Genetics Institute, LLC Verwendung von Knochenmorphogeneseproteinen zur Heilung und Reparatur von Bindegewebebefestigung
CN1198775A (zh) 1995-08-08 1998-11-11 托马斯杰弗逊大学 重组c－蛋白酶及其加工、方法和用途
US5807981A (en) * 1995-12-13 1998-09-15 Fibrogen Inc. Peptides which are cleaved by C-proteinase
JP4847634B2 (ja) 1996-03-22 2011-12-28 ストライカー・コーポレーション 中枢神経系の虚血または外傷の機能的回復を増大させる方法
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
AU5558498A (en) * 1996-11-22 1998-06-22 Akzo Nobel N.V. Bmp-4 promoter and use thereof in screening of therapeutic agents for the prevention and/or treatment of osteoporosis
DE69814352T3 (de) * 1997-02-07 2009-08-13 Stryker Corp., Kalamazoo Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
ATE278414T1 (de) 1997-05-05 2004-10-15 Curis Inc Therapien zur behandlung von akutem nierenversagen
EP0985149A1 (de) 1997-05-30 2000-03-15 Creative Biomolecules, Inc. Verfahren zur bestimmung der gewebemorphogenese und morphogenesische tätigkeit
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
CA2322792C (en) 1998-03-17 2010-09-14 Genentech, Inc. Polypeptides homologous to vegf and bmp1
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
AU756785B2 (en) 1998-07-13 2003-01-23 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US6916783B2 (en) 1998-07-13 2005-07-12 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
AU770725B2 (en) 1998-10-06 2004-02-26 Howard An Method of chemonucleolysis
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
JP3786533B2 (ja) 1998-11-12 2006-06-14 善彦 西村 ペプチド及び骨形成促進剤
PT1148897E (pt) * 1999-02-01 2004-04-30 Genetics Inst Llc Metodos e composicoes para cicatrizacao e reparacao de cartilagem articular
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
WO2001016323A2 (en) * 1999-09-01 2001-03-08 Subsidiary N0.3, Inc. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
CA2382030A1 (en) * 1999-09-01 2001-03-08 Subsidiary No. 3, Inc. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
AU6865100A (en) * 1999-09-02 2001-04-10 Mitsubishi Pharma Corporation Osteogenesis promoting agents
WO2002053592A1 (fr) * 2000-12-28 2002-07-11 Shionogi & Co., Ltd. Nouveau polypeptide et son adn
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
US7160725B2 (en) 2001-11-13 2007-01-09 Curis, Inc. Hedgehog signaling promotes the formation of three dimensional cartilage matrices
WO2003043673A1 (en) 2001-11-19 2003-05-30 Scil Technology Gmbh Device having osteoinductive and osteoconductive properties
US8067557B2 (en) 2002-03-28 2011-11-29 The Trustees Of The University Of Pennsylvania OCL-2A3 compositions and uses thereof
US7160994B2 (en) 2002-03-28 2007-01-09 Trustees Of The University Of Pennsylvania Osteoclast-specific genes and proteins and uses thereof
EP1539261B1 (de) 2002-09-10 2006-04-12 Scil Technology GmbH Unter verringerter sauerstoffkonzentration mit einem osteoinduktiven protein beschichtetes metallimplantat
RU2363478C2 (ru) 2003-09-12 2009-08-10 Вайет Инъецируемые стержни из фосфата кальция для доставки остеогенных белков
WO2005065396A2 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
EP1571159A1 (de) * 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein von Knochenmorphogenetisches Protein und seine Verwendung
ES2350939T3 (es) 2004-03-10 2011-01-28 Scil Technology Gmbh Implantes recubiertos, su fabricación y uso de los mismos.
AU2005247440B2 (en) 2004-05-25 2011-09-29 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
WO2007053850A2 (en) 2005-11-01 2007-05-10 Osteotech, Inc. Bone matrix compositions and methods
EP2540310A1 (de) 2006-05-17 2013-01-02 Stryker Corporation Verfahren zum Behandeln von Knorpeldefekten unter Verwendung eines löslichen morphogenen Proteinkomplexes
SG176476A1 (en) 2006-11-02 2011-12-29 Daniel J Capon Hybrid immunoglobulins with moving parts
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
AU2007339280B2 (en) 2006-12-21 2013-12-05 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
WO2008157495A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Bone matrix compositions and methods
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
WO2009020744A1 (en) 2007-08-07 2009-02-12 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations comprising gdf-5 in aqueous acidic solution
CA2718592A1 (en) 2008-02-13 2009-08-20 Keith Hruska Method of treating vascular sclerosis
AU2009236459B2 (en) 2008-04-14 2013-07-25 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered GDF-5 formulations
EP2396026A2 (de) 2009-02-12 2011-12-21 Stryker Corporation Zusammensetzungen und verfahren für die minimal invasive systemische abgabe von proteinen einschliesslich mitglieder der tgf-superfamilie
WO2010093955A1 (en) 2009-02-12 2010-08-19 Osteotech,Inc. Segmented delivery system
SG2014010680A (en) 2009-02-12 2014-04-28 Stryker Corp Peripheral administration of proteins including tgf-beta superfamily members for treatment of systemic disorders and disease
US8828937B2 (en) * 2009-03-12 2014-09-09 Haase Investments Ug Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity
WO2010110974A1 (en) 2009-03-24 2010-09-30 Stryker Corporation Methods and compositions for tissue engineering
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
WO2011010966A1 (en) * 2009-07-23 2011-01-27 Agency For Science, Technology And Research (A*Star) Pre-natal mesenchymal stem cells
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
ES2387379T3 (es) 2009-09-17 2012-09-21 Stryker Corporation Tampones para controlar el pH de las proteínas morfogenéticas óseas
CN102822197A (zh) 2009-12-22 2012-12-12 史赛克公司 具有降低的免疫原性的bmp-7变体
WO2018122794A1 (en) 2016-12-30 2018-07-05 Biogend Therapeutics Co., Ltd. Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4588684A (en) 1983-04-26 1986-05-13 Chiron Corporation a-Factor and its processing signals
EP0128041A3 (de) * 1983-06-06 1986-12-03 David Jeston Baylink Polypeptide mit einer Skelettwachstumsfaktor-Wirksamkeit
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
NZ210699A (en) * 1984-01-04 1989-06-28 Int Genetic Eng Isolation of an osteogenic protein of the p3 immunologically related family
DK518384A (da) 1984-01-31 1985-07-01 Idaho Res Found Vektor til fremstilling af et gen-produkt i insektceller, fremgangsmaade til dens fremstilling samt dens anvendelse
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
EP0188479B1 (de) 1984-07-06 1991-09-11 Sandoz Ag Herstellung und reinigung von lymphokinen
ATE128715T1 (de) 1984-07-16 1995-10-15 Celtrix Pharma Polypeptide induzierende faktoren in knochen und knorpel.
DE3586386T2 (de) 1984-10-05 1993-01-14 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation

Also Published As

Publication number Publication date
MX170919B (es) 1993-09-22
EP1254956B1 (de) 2008-12-31
DE3752364D1 (de) 2003-04-24
EP1254956A2 (de) 2002-11-06
DE10399007I1 (de) 2003-07-31
DK106288A (da) 1988-04-28
PT85225A (en) 1987-08-01
IL83003A (en) 1995-07-31
EP0313578B1 (de) 1996-08-28
JP2729222B2 (ja) 1998-03-18
JPH1070989A (ja) 1998-03-17
ATE419349T1 (de) 2009-01-15
EP0688869B1 (de) 2003-03-19
DK53497A (da) 1997-05-09
PT85225B (pt) 1990-03-30
DE3751887T2 (de) 1997-03-06
DK106288D0 (da) 1988-02-29
NL300116I1 (nl) 2003-05-01
EP1254956A3 (de) 2002-11-13
DK172275B1 (da) 1998-02-16
NL300116I2 (nl) 2003-06-02
EP0313578A1 (de) 1989-05-03
DE3752364T2 (de) 2004-03-04
ATE141928T1 (de) 1996-09-15
GR871028B (de) 1988-01-11
WO1988000205A1 (en) 1988-01-14
MY102505A (en) 1992-07-31
AU613314B2 (en) 1991-08-01
EP0313578A4 (en) 1990-10-03
NZ220894A (en) 1990-05-28
DE3751887D1 (de) 1996-10-02
JPH06298800A (ja) 1994-10-25
DE3752393D1 (de) 2009-02-12
EP0688869A1 (de) 1995-12-27
LU91005I2 (en) 2003-03-31
ATE234921T1 (de) 2003-04-15
IE871739L (en) 1988-01-01
JPH02500241A (ja) 1990-02-01
IE970378L (en) 1988-01-01
DK172503B1 (da) 1998-10-26
IE75881B1 (en) 1997-09-24
CA1341212C (en) 2001-04-10
JP3093682B2 (ja) 2000-10-03
JP2713715B2 (ja) 1998-02-16
ES2007625A6 (es) 1989-07-01
AU7783587A (en) 1988-01-29
IL83003A0 (en) 1987-12-20

Similar Documents

Publication Publication Date Title
DE10399007I2 (de) Osteoinduktive Mittel
DE69028535D1 (de) Herstellung des vaskulären endothelialen zellwachstumsfaktors
DK0536186T3 (da) Knogle- og brusk-dannelsesfremkaldende proteiner
DE69018457D1 (de) Gegenstände zur behandlung von periodontitis und knochendefekten.
ATE78406T1 (de) Neue mittel zur abdeckung unverletzter und/oder verletzter bereiche menschlicher oder tierischer haut.
DE68928051D1 (de) Behandlung von humanem Kollagen und Verwendung als Auto-Implantat
ATE78399T1 (de) Verwendung von buspiron zur verbesserung des kurzzeitgedaechtnisses.
GB2211192B (en) Composition and process for the treatment and care of the hair
ATE143804T1 (de) Zusammensetzung zur behandlung von mastitis und metritis
ATE42462T1 (de) Licht- und sonnenschutzmittel.
ATE45675T1 (de) Verwendung von interferon gamma (ifn-gamma) zur herstellung von praeparationen zur behandlung rheumatischer erkrankungen.
IT8767494A0 (it) Composizione liquida per il trattamento preventivo e curativo di malattie crittogamiche di tipo oidio e procedimento per la messa in opera di tale composizione
ATE56136T1 (de) Haarwuchsstimulierende mittel und deren verwendung.
FI871737A0 (fi) Kraftanlaeggning med foerbraenning i en fluidiserad baedd.
RO90502A2 (ro) Metoda de tratament biotrofic in cosmetica geriatrica
DE3768595D1 (de) Einrichtung zur kontrolle und behandlung von gegenstaenden.
DE68909617D1 (de) Verfahren zur herstellung von proteinen mit fviii aktivitaet und/oder fviii derivate.

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: GENETICS INSTITUTE, LLC, CAMBRIDGE, MASS., US