DE103553T1 - Zwischenverbindungen fuer die herstellung von omeprazol. - Google Patents

Zwischenverbindungen fuer die herstellung von omeprazol.

Info

Publication number
DE103553T1
DE103553T1 DE198383850185T DE83850185T DE103553T1 DE 103553 T1 DE103553 T1 DE 103553T1 DE 198383850185 T DE198383850185 T DE 198383850185T DE 83850185 T DE83850185 T DE 83850185T DE 103553 T1 DE103553 T1 DE 103553T1
Authority
DE
Germany
Prior art keywords
compound
formula
compound according
preparation
omeprazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198383850185T
Other languages
English (en)
Inventor
Arne Elof S-415 06 Goeteborg Braendstroem
Bo Robert S-412 62 Goeteborg Lamm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20347627&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE103553(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hassle AB filed Critical Hassle AB
Publication of DE103553T1 publication Critical patent/DE103553T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)

Claims (1)

1 83 850 185.6 Aktiebolaget Hässle
Patenansprüche
1. Verbindung der Formel
OCH.
worin R H oder CH~ ist.
2. Verbindung nach Anspruch 1 der Formel
CH,
3. Verbindung nach Anspruch 1 der Formel
OCH-
4. Verbindung nach den Ansprüchen 1 bis 3 in Form einer Masse
15. Verfahren zur Herstellung einer Verbindung der Formel
OCH
CH.
worin R H oder CH ist, dadurch gekennzeichnet, daß
a) eine Verbindung der Formel
mit einem Nitriermittel, wie
NHO.
III
unter Bildung einer Verbindung der Formel
IV
umgesetzt wird, wobei in diesen Formeln R H oder CH. bedeutet, wonach
b) die so erhaltene Verbindung der Formel IV direkt mit Alkali unter Bildung einer Verbindung der Formel
worin R H oder CH, ist,
10
umgesetzt wird.
6. Verwendung einer Verbindung nach den Ansprüchen 1 bis 4 als ein Zwischenprodukt bei der Herstellung pharmazeu-tisch verwendbarer Verbindungen.
7. Verwendung einer Verbindung nach den Ansprüchen 1 bis 4 als ein Zwischenprodukt bei der Herstellung substituierter Benzimidazole, die einen Pyridinrest enthalten.
8. Verwendung einer Verbindung nach den Ansprüchen 1 bis 4 als ein Zwischenprodukt bei der Herstellung von Omeprazol.
9. Verbindungen, Verfahren zu ihrer Herstellung und ihrer Verwendung, wie in den Ansprüchen 1 bis 8 beansprucht und im wesentlichen wie beschrieben.
DE198383850185T 1982-08-26 1983-06-30 Zwischenverbindungen fuer die herstellung von omeprazol. Pending DE103553T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8204879A SE8204879D0 (sv) 1982-08-26 1982-08-26 Novel chemical intermediates

Publications (1)

Publication Number Publication Date
DE103553T1 true DE103553T1 (de) 1984-09-27

Family

ID=20347627

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8383850185T Expired DE3379222D1 (en) 1982-08-26 1983-06-30 Intermediates for the preparation of omeprazole
DE198383850185T Pending DE103553T1 (de) 1982-08-26 1983-06-30 Zwischenverbindungen fuer die herstellung von omeprazol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8383850185T Expired DE3379222D1 (en) 1982-08-26 1983-06-30 Intermediates for the preparation of omeprazole

Country Status (28)

Country Link
US (2) US4544750A (de)
EP (1) EP0103553B1 (de)
JP (1) JPS5959662A (de)
KR (1) KR880000091B1 (de)
AT (1) ATE40884T1 (de)
AU (1) AU560028B2 (de)
CA (1) CA1234118A (de)
CY (1) CY1328A (de)
DD (1) DD233126A5 (de)
DE (2) DE3379222D1 (de)
DK (1) DK381583A (de)
ES (1) ES8404993A1 (de)
FI (1) FI79701C (de)
GB (1) GB2126226B (de)
GR (1) GR79374B (de)
HK (1) HK19486A (de)
HU (1) HU189738B (de)
IE (1) IE55865B1 (de)
IL (1) IL69175A (de)
IS (1) IS1438B6 (de)
MY (1) MY8600503A (de)
NO (1) NO164093C (de)
NZ (1) NZ204959A (de)
OA (1) OA07498A (de)
PH (1) PH17786A (de)
PT (1) PT77249B (de)
SE (1) SE8204879D0 (de)
ZA (1) ZA835143B (de)

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SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
SE8504409D0 (sv) * 1985-09-24 1985-09-24 Haessle Ab Novel chemical intermediates
EP0243012B1 (de) * 1986-04-17 1993-01-13 Imperial Chemical Industries Plc Pyridylacrylsäureester-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Fungizide
US5221316A (en) * 1986-04-17 1993-06-22 Imperial Chemical Industries Plc Fungicides
US4920230A (en) * 1987-06-29 1990-04-24 Takeda Chemical Industries, Ltd. Method of producing nitrogen-containing heteroaromatic compounds having an alkoxy group
AT391693B (de) * 1988-11-15 1990-11-12 Cl Pharma Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
ES2026761A6 (es) * 1990-10-31 1992-05-01 Genesis Para La Investigacion Procedimiento de obtencion del omeprazol.
ES2036948B1 (es) * 1991-11-21 1994-09-01 Genesis Para La Investigacion Procedimiento de obtencion de compuestos derivados de piridina.
ES2060541B1 (es) * 1993-02-26 1995-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
ES2097089B1 (es) * 1995-02-01 1997-12-16 Esteve Quimica Sa Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina.
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
CA2204580A1 (en) * 1997-05-06 1998-11-06 Michel Zoghbi Synthesis of pharmaceutically useful pyridine derivatives
GB9717849D0 (en) * 1997-08-23 1997-10-29 Seal Sands Chemicals Limited Preparation of pyridene derivatives
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
AU1656699A (en) * 1997-12-24 1999-07-19 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
US6350876B2 (en) 1998-01-26 2002-02-26 Kuraray Co., Ltd. 4-chloro-3,5-dimethyl-2-sulfonyl pyridines
US6197962B1 (en) * 1998-01-26 2001-03-06 Kuraray Co., Ltd. Method for producing 2-sulfonylpyridine derivatives and method for producing 2-{[(2-pyridyl)methyl]thio}-1H-benzimidazole derivatives
US6303787B1 (en) 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
AU4387799A (en) * 1998-06-26 2000-01-17 Russinsky Limited Pyridine building blocks as intermediates in the synthesis of pharmaceutically active compounds
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6353005B1 (en) 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6362202B1 (en) 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
GB9921578D0 (en) * 1999-09-13 1999-11-17 Cipla Limited Omeprazole synthesis
ES2171116B1 (es) 2000-04-14 2003-08-01 Esteve Quimica Sa Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.
WO2003097606A1 (en) * 2000-07-28 2003-11-27 Herbex, Produtos Químicos, Sa New method for the preparation of the anti-ulcer compounds omeprazole, lansoprazole and pantoprazole
US7622490B2 (en) 2001-05-11 2009-11-24 Tibotec Pharmaceuticals, Ltd. Broadspecturm 2-amino-benzoxazole sulfonamide HIV protease inhibitors
JP2005521662A (ja) * 2002-01-25 2005-07-21 サンタラス インコーポレイティッド プロトンポンプ阻害剤の経粘膜送達
FR2848555B1 (fr) 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CN100376574C (zh) * 2006-06-14 2008-03-26 浙江大学 泰妥拉唑的制备方法
WO2008092939A2 (en) 2007-01-31 2008-08-07 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically pure omeprazole via salt formation with a chiral amine or treatment with an entiomer converting enzyme and chromatographic separation
CN101648907B (zh) * 2009-09-14 2011-08-03 南京第一农药集团有限公司 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的纯化方法
CN101648912B (zh) * 2009-09-14 2012-07-04 南京第一农药集团有限公司 一种4-硝基-3,5-二甲基吡啶-n-氧化物的连续化制备方法
CN102603620B (zh) * 2012-01-13 2014-10-29 江苏中邦制药有限公司 一种氯甲基吡啶或其吡啶衍生物盐酸盐的合成方法
MX2022002949A (es) 2019-09-24 2022-04-06 Prolacta Bioscience Inc Composiciones y metodos para el tratamiento de enfermedades inflamatorias e inmunes.
CN112142653B (zh) * 2020-10-22 2022-02-11 成都百泉生物医药科技有限公司 奥美拉唑中间体的制备方法
CN113307773A (zh) * 2021-06-17 2021-08-27 上海毕得医药科技股份有限公司 6-溴-3-甲氧基-1-苯基-1h-吲唑及其合成方法和应用
CN114805193B (zh) * 2022-04-19 2023-06-20 南京红太阳医药研究院有限公司 一种奥美拉唑中间体的制备方法

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Also Published As

Publication number Publication date
NO164093B (no) 1990-05-21
AU1710183A (en) 1984-03-01
EP0103553A1 (de) 1984-03-21
ATE40884T1 (de) 1989-03-15
GB2126226A (en) 1984-03-21
PH17786A (en) 1984-12-13
NZ204959A (en) 1985-12-13
NO164093C (no) 1990-08-29
IE831787L (en) 1984-02-26
US4544750A (en) 1985-10-01
ES525122A0 (es) 1984-05-16
IL69175A0 (en) 1983-11-30
HK19486A (en) 1986-03-27
EP0103553B1 (de) 1989-02-22
CA1234118A (en) 1988-03-15
IS1438B6 (is) 1990-09-25
HU189738B (en) 1986-07-28
FI833047A0 (fi) 1983-08-25
GB8322866D0 (en) 1983-09-28
IS2845A7 (is) 1984-02-27
ZA835143B (en) 1984-04-25
JPS6353987B2 (de) 1988-10-26
KR840005718A (ko) 1984-11-15
DK381583A (da) 1984-02-27
AU560028B2 (en) 1987-03-26
SE8204879D0 (sv) 1982-08-26
CY1328A (en) 1986-06-27
ES8404993A1 (es) 1984-05-16
KR880000091B1 (ko) 1988-02-23
MY8600503A (en) 1986-12-31
GR79374B (de) 1984-10-22
FI79701C (fi) 1990-02-12
US4620008A (en) 1986-10-28
OA07498A (en) 1985-03-31
PT77249B (en) 1986-07-14
GB2126226B (en) 1985-09-18
JPS5959662A (ja) 1984-04-05
IE55865B1 (en) 1991-01-30
PT77249A (en) 1983-09-01
FI833047A (fi) 1984-02-27
DE3379222D1 (en) 1989-03-30
NO832794L (no) 1984-02-27
FI79701B (fi) 1989-10-31
DD233126A5 (de) 1986-02-19
DK381583D0 (da) 1983-08-19
IL69175A (en) 1987-01-30

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