DE10303584A1 - Erythropoietin is applied as a coating material to medical implants to improve the acceptance behavior of relevant body tissues - Google Patents

Erythropoietin is applied as a coating material to medical implants to improve the acceptance behavior of relevant body tissues Download PDF

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Publication number
DE10303584A1
DE10303584A1 DE2003103584 DE10303584A DE10303584A1 DE 10303584 A1 DE10303584 A1 DE 10303584A1 DE 2003103584 DE2003103584 DE 2003103584 DE 10303584 A DE10303584 A DE 10303584A DE 10303584 A1 DE10303584 A1 DE 10303584A1
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Germany
Prior art keywords
erythropoietin
medical implants
coating material
improve
body tissues
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DE2003103584
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German (de)
Inventor
Robert Stauss
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Stauss Robert Dr
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Stauss Robert Dr
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Priority to DE2003103584 priority Critical patent/DE10303584A1/en
Publication of DE10303584A1 publication Critical patent/DE10303584A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials

Abstract

Erythropoietin (EPO) is applied as a coating material to medical implants to improve the acceptance behavior of relevant body tissues. An independent claim is also included for medical implants with an EPO coating.

Description

In der Medizin ist der Einsatz von Erythropoietin (EPO) für eine verstärkte Erzeugung von Erythrozyten bekannt. Bekannt ist auch eine antiapoptotische (programmierter Zelltod), eine angiogenetische (Gefäßneubildung) und entzündungshemmende Wirkung. Die Applikation kann intravenös oder subkutan erfolgen.In medicine, the use of Erythropoietin (EPO) for a reinforced one Generation of erythrocytes known. An anti-apoptotic is also known (programmed cell death), angiogenic (new vascularization) and anti-inflammatory Effect. It can be administered intravenously or subcutaneously.

Bekannt ist es auch, dass das Maß des im Implantationsumfeld vorhandenen Blutgerinnsels (Blutkoagulum) das Rezeptionsverhalten des betreffenden Implantats bestimmt. Dies geschieht über eine verstärkte Gefäß- und nachfolgende Knochenneubildung.It is also known that the measure of the implantation environment existing blood clot (blood coagulum) the reception behavior of the implant in question. This is done via a increased Vascular and subsequent New bone formation.

Erfindungsgemäß ist festgestellt worden, dass das Rezeptionsverhalten, das heißt die Knochenregeneration im Implantationsgrenz- und umfeld durch eine ausschließliche oder zusätzliche Applikation des EPO direkt auf das Implantat in der Form einer Beschichtung noch erheblich über das bisher bekannte Maß hinaus verbessert werden kann.According to the invention, it has been found that the reception behavior, i.e. the bone regeneration in the implantation limit and environment by an exclusive or additional Application of the EPO directly on the implant in the form of a coating still significantly over the previously known dimension can be improved.

Die Beschichtung kann in einer besonders vorteilhaften Weise erzeugt werden an der Implantatoberfläche durch eine kovalente Bindung von Kollagen mit Kohlenhydraten/Sialinsäure. Wichtig für eine erfindungsgemäß gute Wirkung ist die Erzielung einer möglichst hohen lokalen EPO-Konzentration in der aufgebrachten Schicht. Das Erythropoietin soll über einen möglichst langen Zeitraum an das umliegende Gewebe abgegeben werden und lokal zu hohen Konzentrationen an Erythropoietin im umliegenden Gewebe beitragen.The coating can be particularly advantageous Be generated on the implant surface by a covalent bond of collagen with carbohydrates / sialic acid. Important for a good effect according to the invention is achieving one if possible high local EPO concentration in the applied layer. The Erythropoietin is said to be about one if possible long period of time to the surrounding tissue and locally too high concentrations of erythropoietin in the surrounding tissue contribute.

Die zu beschichtenden Implantate können insbesondere aus Titan, Aluminiumoxid oder Keramik bestehen oder auch abbaubare (Kollagene), nicht abbaubare Membrane (Gore-Tex®), Membrane aus Titan sein, wie sie beispielsweise in der Zahnmedizin und Chirurgie zur kontrollierten Knochenregeneration eingesetzt werden.The implants to be coated can be made in particular of titanium, aluminum oxide or ceramic, or they can also be degradable (collagens), non-degradable membranes (Gore- Tex® ), membranes made of titanium, such as those used in dentistry and surgery for controlled bone regeneration.

Besonders vorteilhaft können erfindungsgemäß beschichtete Implantate in der Zahnmedizin und Chirurgie eingesetzt werden.Coated according to the invention can be particularly advantageous Implants can be used in dentistry and surgery.

Claims (3)

Verwendung von Erythropoietin als Beschichtungsmaterial auf medizinischen Implantaten.Use of erythropoietin as a coating material on medical implants. Mit Erythropoietin beschichtete medizinische Implantate.Medical implants coated with erythropoietin. Beschichtete Dental-Implantate nach Anspruch 2.Coated dental implants according to claim 2.
DE2003103584 2003-01-30 2003-01-30 Erythropoietin is applied as a coating material to medical implants to improve the acceptance behavior of relevant body tissues Withdrawn DE10303584A1 (en)

Priority Applications (1)

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DE2003103584 DE10303584A1 (en) 2003-01-30 2003-01-30 Erythropoietin is applied as a coating material to medical implants to improve the acceptance behavior of relevant body tissues

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DE2003103584 DE10303584A1 (en) 2003-01-30 2003-01-30 Erythropoietin is applied as a coating material to medical implants to improve the acceptance behavior of relevant body tissues

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1699915A1 (en) * 2003-12-30 2006-09-13 Bionethos Holding Gmbh Tissue regeneration method
JP2011510066A (en) * 2008-01-24 2011-03-31 レメドー バイオメッド リミテッド Erythropoietin and fibronectin composition for bone regeneration
US10792338B2 (en) 2007-08-16 2020-10-06 Remedor Biomed Ltd. Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001483A1 (en) * 1992-07-02 1994-01-20 Collagen Corporation Biocompatible polymer conjugates
WO2001040272A2 (en) * 1999-12-01 2001-06-07 Selective Genetics, Inc. In situ bioreactors and methods of use thereof
WO2001074413A1 (en) * 2000-04-04 2001-10-11 Boston Scientific Limited Medical devices suitable for gene therapy regimens
US20020160033A1 (en) * 2001-04-25 2002-10-31 Noel Caplice Implantable medical devices
DE69714448T2 (en) * 1996-05-14 2002-11-14 Alkermes Inc METHOD FOR PRODUCING PREPARATIONS WITH CONTROLLED ACTIVE SUBSTANCE RELEASE BASED ON POLYMERS
WO2002098475A1 (en) * 2001-06-06 2002-12-12 Smith & Nephew Plc Fixation devices for tissue repair
DE69332222T2 (en) * 1992-06-11 2003-03-20 Alkermes Inc ENYTHROPOIETIN CONTAINING DRUG DISPENSING SYSTEM

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69332222T2 (en) * 1992-06-11 2003-03-20 Alkermes Inc ENYTHROPOIETIN CONTAINING DRUG DISPENSING SYSTEM
WO1994001483A1 (en) * 1992-07-02 1994-01-20 Collagen Corporation Biocompatible polymer conjugates
DE69714448T2 (en) * 1996-05-14 2002-11-14 Alkermes Inc METHOD FOR PRODUCING PREPARATIONS WITH CONTROLLED ACTIVE SUBSTANCE RELEASE BASED ON POLYMERS
WO2001040272A2 (en) * 1999-12-01 2001-06-07 Selective Genetics, Inc. In situ bioreactors and methods of use thereof
WO2001074413A1 (en) * 2000-04-04 2001-10-11 Boston Scientific Limited Medical devices suitable for gene therapy regimens
US20020160033A1 (en) * 2001-04-25 2002-10-31 Noel Caplice Implantable medical devices
WO2002098475A1 (en) * 2001-06-06 2002-12-12 Smith & Nephew Plc Fixation devices for tissue repair

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1699915A1 (en) * 2003-12-30 2006-09-13 Bionethos Holding Gmbh Tissue regeneration method
US10792338B2 (en) 2007-08-16 2020-10-06 Remedor Biomed Ltd. Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications
JP2011510066A (en) * 2008-01-24 2011-03-31 レメドー バイオメッド リミテッド Erythropoietin and fibronectin composition for bone regeneration

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