DE102017008429A1 - Means for hair treatment - Google Patents
Means for hair treatment Download PDFInfo
- Publication number
- DE102017008429A1 DE102017008429A1 DE102017008429.7A DE102017008429A DE102017008429A1 DE 102017008429 A1 DE102017008429 A1 DE 102017008429A1 DE 102017008429 A DE102017008429 A DE 102017008429A DE 102017008429 A1 DE102017008429 A1 DE 102017008429A1
- Authority
- DE
- Germany
- Prior art keywords
- extract
- agent
- hair
- caffeine
- red clover
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 23
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims abstract description 38
- 201000004384 Alopecia Diseases 0.000 claims abstract description 23
- 208000024963 hair loss Diseases 0.000 claims abstract description 23
- 230000003676 hair loss Effects 0.000 claims abstract description 23
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960001948 caffeine Drugs 0.000 claims abstract description 19
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000020746 red clover extract Nutrition 0.000 claims abstract description 18
- 239000010018 saw palmetto extract Substances 0.000 claims abstract description 12
- 229940063845 saw palmetto extract Drugs 0.000 claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 26
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 21
- 239000000284 extract Substances 0.000 claims description 21
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 19
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 14
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- 239000002904 solvent Substances 0.000 claims description 6
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
Die Erfindung betrifft ein Mittel zur Haarbehandlung bei diffusem und/oder erblich bedingtem Haarausfall oder zur Vorbeugung gegen einen solchen Haarausfall. Erfindungsgemäß enthält das Mittel Sägepalm-Extrakt, Rotklee-Extrakt, Koffein.The invention relates to an agent for hair treatment in case of diffuse and / or hereditary hair loss or to prevent such a hair loss. According to the invention, the agent contains saw palmetto extract, red clover extract, caffeine.
Description
Die Erfindung bezieht sich auf ein Mittel zur Haarbehandlung bei diffusem und/oder erblich bedingtem Haarausfall oder zur Vorbeugung gegen einen solchen Haarausfall.The invention relates to a hair treatment agent for diffuse and / or hereditary hair loss or to prevent such a hair loss.
Derartige Mittel sind im Stand der Technik vielfältig beschrieben und aus der Praxis bekannt. Sie setzen meist bei der Behandlung einzelner Symptome oder Ursachen des Haarausfalls an und sind daher in ihrer Wirkung eingeschränkt. Die dem Haarausfall zugrunde liegenden Ursachen sind komplexer Natur und insofern noch immer Gegenstand zahlreicher Untersuchungen.Such agents are widely described in the art and known in the art. They usually start in the treatment of individual symptoms or causes of hair loss and are therefore limited in their effect. The underlying causes of hair loss are complex in nature and therefore still subject of numerous studies.
Die
Der Erfindung liegt die Aufgabe zu Grunde, ein Mittel der eingangs erwähnten Art zu schaffen, dass umfassender und damit effizienter gegen Haarausfall wirkt.The invention is based on the object to provide a means of the type mentioned that more comprehensive and thus more effective against hair loss.
Diese Aufgabe wird erfindungsgemäß durch ein Mittel mit den Merkmalen des Patentanspruchs 1 gelöst. Vorteilhafte Weiterbildungen sind Gegenstand der abhängigen Ansprüche.This object is achieved by an agent with the features of claim 1. Advantageous developments are the subject of the dependent claims.
Erfindungsgemäß enthält das eingangs erwähnte Mittel Sägepalm-Extrakt, Rotklee-Extrakt, Koffein. Es wurde herausgefunden, dass bei Menschen mit Haarausfall Haarfollikel schrumpfen und schließlich ihre Funktion einstellen. Das Schrumpfen der Haarfollikel geschieht unter dem Einfluss von Dihydrotestosteron (DHT), das aus Testosteron gebildet wird. Die Bildungsreaktion läuft über das Umwandlungsenzym 5-alpha-Reduktase, von dem bislang Typ I und Typ II bekannt sind. Wenn die Bildung dieses Enzyms gehemmt wird, entsteht weniger DHT, wodurch der Schrumpfungsprozess verringert bzw. verzögert wird. Die Wachstums- bzw. Produktionsstätte für Haare kann dadurch letztlich erhalten bleiben. Es wurde ferner herausgefunden, dass Sägepalm-Extrakt und Rotklee-Extrakt Hemmstoffe der 5-alpha-Reduktase sind.According to the invention, the agent mentioned at the beginning contains saw palmetto extract, red clover extract, caffeine. It has been found that in people with hair loss, hair follicles shrink and eventually stop functioning. Shrinkage of hair follicles occurs under the influence of dihydrotestosterone (DHT), which is made from testosterone. The formation reaction proceeds via the conversion enzyme 5-alpha-reductase of which Type I and Type II have heretofore been known. When the formation of this enzyme is inhibited, less DHT is produced, thereby reducing or retarding the shrinkage process. The growth or production site for hair can be preserved in the end. It has also been found that saw palmetto extract and red clover extract are inhibitors of 5-alpha reductase.
So kann Sägepalm-Extrakt als wirksamer, unselektiver Inhibitor der 5-alpha-Reduktase zum Einsatz kommen und zwar bei beiden Isoformen, Typ I und Typ II. Eine selektive Hemmung der 5-alpha-Reduktase erhöht, stärkt und verlängert die Anagen-Phase, was den progressiven Verlauf des erfindungsgemäßen Mittels modifiziert und verbessert. Die aktive Wachstumsphase der Haare dauert somit an. Sägepalm-Extrakt enthält Phytosterole und Flavonoide, die anti-androgene Aktivitäten auf zwei Wirkweisen erreichen. Die erste Wirkweise ist direkt und wirkt sich unmittelbar auf die DHT und die androgen-sensitiven, cytoplasmatischen Rezeptoren aus. Die zweite Wirkweise ist indirekt und wird über die Hemmung der 5-alpha-Reduktasetypen I und II erreicht. Sägepalm-Extrakt von Serenoa repens enthält gesättigte Fettsäuren, wie Laurinsäure und Myristat, und die einfach ungesättigte Ölsäure. Die letztgenannte Ölsäure hemmt die Bildung des 5-alpha-Reduktasetyps I und Laurinsäure diejenige des Typs II.Thus, saw palmetto extract can be used as an effective, nonselective inhibitor of 5-alpha reductase in both isoforms, type I and type II. Selective inhibition of 5-alpha reductase increases, strengthens and prolongs the anagen phase, which modifies and improves the progressive course of the agent according to the invention. The active growth phase of the hair thus continues. Saw Palmetto Extract contains phytosterols and flavonoids that target anti-androgenic activities in two ways. The first mode of action is direct and has a direct effect on the DHT and the androgen-sensitive, cytoplasmic receptors. The second mode of action is indirect and is achieved via the inhibition of 5-alpha reductase types I and II. Saw Palmetto extract from Serenoa repens contains saturated fatty acids, such as lauric acid and myristate, and monounsaturated oleic acid. The latter oleic acid inhibits the formation of 5-alpha reductase type I and lauric acid that of type II.
Rotklee-Extrakt enthält Flavonoide, die als Phytoöstrogene bekannt sind und, wie zuvor erwähnt, ebenfalls die 5-alpha-Reduktase hemmen. Zusätzlich hat Rotklee-Extrakt antioxidative Eigenschaften und kann dadurch auch zum UV-Schutz beitragen, so dass dieser Extrakt ferner eine Pflegefunktion beinhaltet. Außerdem kann Rotklee-Extrakt aufgrund seiner antioxidativen Eigenschaften Entzündungsprozesse hemmen. Häufig wird das Schrumpfen der Haarwurzeln von Entzündungsprozessen begleitet und verstärkt, welche durch den Einsatz von Rotklee-Extrakt gehemmt bzw. verringert werden können.Red clover extract contains flavonoids, known as phytoestrogens, which, as previously mentioned, also inhibit 5-alpha reductase. In addition, red clover extract has antioxidant properties and can thus also contribute to UV protection, so that this extract also includes a care function. In addition, red clover extract can inhibit inflammatory processes due to its antioxidant properties. Frequently, the shrinkage of the hair roots is accompanied and intensified by inflammatory processes, which can be inhibited or reduced by the use of red clover extract.
Koffein regt den Stoffwechsel an, und zwar sowohl den Eiweiß- als auch den Fett- und Kohlehydrat-Stoffwechsel. Ferner regt Koffein die Durchblutung an, sodass letztlich der gesamte Bau- und Energiestoffwechsel der Haare angeregt und begünstigt wird.Caffeine stimulates the metabolism, both the protein and the fat and carbohydrate metabolism. In addition, caffeine stimulates the blood circulation, so that ultimately the entire construction and energy metabolism of the hair is stimulated and favored.
Das erfindungsgemäße Mittel verbessert damit die Durchblutung, regt die Nährstoffversorgung zum Haaraufbau an und dient letztlich zum Schutz und zur Pflege des aufgebauten Haares. Aufgrund dieser Dreifachwirkung wirkt das erfindungsgemäße Mittel sehr effizient bei Haarausfall. The agent according to the invention thus improves the blood circulation, stimulates the supply of nutrients to the hair structure and ultimately serves for the protection and care of the built-up hair. Due to this triple effect, the composition according to the invention is very effective in hair loss.
Gemäß einer anderen Weiterbildung enthält das Mittel ferner wenigstens ein Lösungsmittel, einen Emulator, ein Antioxidanz, ein Konservierungsmittel und einen Stoff zur pH-Regulation, wobei vorzugsweise das wenigstens eine Lösungsmittel Wasser und denaturierter Alkohol, der wenigstens eine Emulator hydriertes, ethoxyliertes Rizinussöl und/oder Glycerin, das wenigstens eine Antioxidanz Tocopherol, das wenigstens eine Konservierungsmittel Phenoxyethanol, Benzylalkohol, Kaliumsorbat, Natriumbenzoat und/oder Benzoesäure und der Stoff zur pH-Regulation Zitronensäure und/oder Milchsäure ist. Alkohol fördert ebenfalls die Durchblutung und macht in Form eines Tonikums vor allem die Hautbarriere durchlässiger für die Wirkstoffe in den einzelnen Bestandteilen des erfindungsgemäßen Mittels. Ein solches Mittel liegt in einer stabilen Zusammensetzung vor und kann daher aufgrund seiner zuvor erläuterten Dreifachwirkung bzw. aufgrund seiner dreistufigen Wirkung Haarausfall effizient vorbeugen bzw. gegen Haarausfall wirken.According to another embodiment, the composition further contains at least one solvent, an emulator, an antioxidant, a preservative and a substance for pH regulation, wherein preferably the at least one solvent is water and denatured alcohol, the at least one emulator is hydrogenated, ethoxylated castor oil and / or Glycerol, which is at least one antioxidant tocopherol, the at least one preservative phenoxyethanol, benzyl alcohol, potassium sorbate, sodium benzoate and / or benzoic acid and the substance for pH regulation citric acid and / or lactic acid. Alcohol also promotes blood circulation and makes in the form of a tonic, especially the skin barrier permeable to the active ingredients in the individual components of the composition according to the invention. Such an agent is present in a stable composition and can therefore effectively prevent hair loss or act against hair loss due to its previously described triple action or because of its three-stage effect.
Gemäß einer bevorzugten Weiterbildung der Erfindung enthält das Mittel
Vorteilhafterweise enthält das Mittel ferner wenigstens ein Pflegemittel, einen Feuchtigkeitsspender, einen Viskositätsregler und/oder einen Duftstoff, wobei das Pflegemittel vorzugsweise ausgewählt wird aus Panthenol, Trimethylammoniumsalz aus Stärke, Erbsensprossen-Extrakt, Arginin, Niacinamid, Weizenprotein, Biotin, der wenigstens eine Feuchtigkeitsspender vorzugsweise ausgewählt wird aus Betain, Harnstoff, Glycerin, Natriumlaktat, der wenigstens eine Viskositätsregler vorzugsweise Natriumchlorid und der Duftstoff vorzugsweise ein Parfüm ist. Panthenol Vitamin B5, Niacinamid Vitamin B3 und Biotin Vitamin H stellen wichtige Co-Faktoren für Enzyme und Coenzyme im Bau- und Energiestoffwechsel dar und unterstützen damit die vorerwähnte Nährstofffunktion des erfindungsgemäßen Mittels. Mit derartigen Vitaminen befindet sich die „Produktionsstätte Haarfollikel“ im angeregten Zustand. Nachschub- und Anlieferstrecke für die Blutversorgung und dadurch eine gute Energieversorgung der einzelnen Haarfollikel sind damit gewährleistet. Erbsensprossen-Extrakt ist das Zellkulturmedium von wachsenden, sich teilenden Erbsensprossen-Zellen. Dieses Medium enthält Wachstumsfaktoren, die die kultivierten, wachsenden Erbsensprossen-Zellen in das umgebende Zellkulturmedium abgeben. Insofern enthält das Zellkulturmedium Signalstoffe, die die Anagen-Phase begünstigen, sodass diese Phase früher eintritt und insofern ein früherer Wiederaufbau des Haares stattfinden kann. Dadurch erhalten die Haarkeimzellen das Signal, in der Haarpapille weiter zu proliferieren und einen neuen Zyklus für das Haarwachstum zu beginnen. Arginin kann zur Bildung von Stickstoffmonoxid (NO) verwendet werden. NO ist der stärkste, körpereigene Gefäßerweiterer. Eine derartige Wirkung des Arginins als Stoff zum Erweitern der Gefäße unterstützt damit die Durchblutungsförderung und trägt dadurch mit zu einer erhöhten Wirksamkeit des erfindungsgemäßen Mittels bei. Weizenprotein unterstützt die Pflegefunktion des Mittels und dient darüber hinaus auch der Aktivierung und dem Aufbau des Stoffwechsels der Zellen.Advantageously, the agent further contains at least one conditioning agent, a moisturizer, a viscosity regulator and / or a perfume, wherein the care agent is preferably selected from panthenol, trimethylammonium salt from starch, pea shoot extract, arginine, niacinamide, wheat protein, biotin, the at least one moisturizer preferably is selected from betaine, urea, glycerol, sodium lactate, the at least one viscosity regulator preferably sodium chloride and the perfume is preferably a perfume. Panthenol Vitamin B5, Niacinamide Vitamin B3 and Biotin Vitamin H are important cofactors for enzymes and coenzyme in the construction and energy metabolism and thus support the aforementioned nutritional function of the composition according to the invention. With such vitamins, the "production site hair follicles" is in the excited state. Supply and delivery route for the blood supply and thus a good energy supply of the individual hair follicles are thus guaranteed. Pea shoot extract is the cell culture medium of growing, dividing pea shoot cells. This medium contains growth factors that the cultured growing pea shoot cells release into the surrounding cell culture medium. In this respect, the cell culture medium contains signal substances that promote the anagen phase, so that this phase occurs earlier and insofar an earlier rebuilding of the hair can take place. This gives the hair germ cells the signal to continue to proliferate in the hair papilla and start a new hair growth cycle. Arginine can be used to form nitric oxide (NO). NO is the strongest endogenous vasodilator. Such an effect of arginine as a substance for dilating the vessels thus promotes blood circulation promotion and thereby contributes to an increased effectiveness of the agent according to the invention. Wheat protein supports the care function of the agent and also serves to activate and build up the metabolism of the cells.
Gemäß einer anderen, bevorzugten Weiterbildung der Erfindung enthält das Mittel
Ein solches Mittel vereinigt insbesondere die drei eingangs erwähnten pflanzlichen Wirkstoffe, ermöglicht ein wirksames Behandeln von Haarausfall und ist in der Lage, Haarausfall wirksam vorzubeugen.Such an agent combines, in particular, the three herbal active ingredients mentioned at the outset, makes it possible to effectively treat hair loss and is able to effectively prevent hair loss.
Ausführungsbeispiele des Erfindungsgegenstandes werden nachfolgend näher erläutert, wobei alle beschriebenen Merkmale für sich oder in beliebiger Kombination den Gegenstand der vorliegenden Erfindung unabhängig von ihrer Zusammenfassung in den Ansprüchen oder deren Rückbeziehung bilden.Embodiments of the subject invention will be explained in more detail below, with all described features, alone or in any combination, the subject matter of the present invention, regardless of their combination in the claims or their dependency.
Das erfindungsgemäße Mittel dient zur Haarbehandlung bei diffusem und/oder erblich bedingtem Haarausfall oder zur Vorbeugung gegen einen solchen Haarausfall und kann insbesondere zu diesem Zweck verwendet werden. Es enthält Sägepalm-Extrakt, Rotklee-Extrakt, auch Wiesenklee genannt, Koffein. Der Rotklee-Extrakt basiert insbesondere auf unverkapseltem Rotklee (Trifolium pratense extract).The composition of the invention is used for hair treatment with diffuse and / or hereditary hair loss or to prevent such a hair loss and can be used in particular for this purpose. It contains saw palmetto extract, red clover extract, also called meadow clover, caffeine. The red clover extract is based in particular on unencapsulated red clover (Trifolium pratense extract).
Sämtliche vor- und nachgenannten Inhaltsstoffe liegen soweit möglich in pharmazeutischer Qualität vor. Sägepalm-Extrakt in pharmazeutischer Qualität wirkt anti-androgen, da es die Umwandlung von Testosteron zu Dihydrotestosteron (DHT) bewirkt. Bestandteile in diesem Extrakt hemmen die Bildung des Umwandlungsenzyms 5-alpha-Reduktase. Rotklee-Extrakt wirkt durch die darin enthaltenen Phytoöstrogene ebenfalls anti-androgen, in dem es androgene Wirkungen stört bzw. hemmt. Dieser Extrakt kann auch als Hemmstoff für die vorgenannte 5-alpha-Reduktase eingesetzt werden. Wie zuvor bereits angedeutet aktiviert Koffein in pharmazeutischer Qualität die Durchblutung und damit den Stoff-/Baustoffwechsel, welcher zu einem gesunden Haarwachstum führen kann.All ingredients above and below are available in pharmaceutical grade as far as possible. Pharmaceutical Grade Saw Palmetto Extract has anti-androgenic effects as it causes the conversion of testosterone to dihydrotestosterone (DHT). Ingredients in this extract inhibit the formation of the conversion enzyme 5-alpha reductase. Red Clover Extract also has an anti-androgenic effect on the phytoestrogens it contains by interfering with or inhibiting androgenic effects. This extract can also be used as an inhibitor for the aforementioned 5-alpha-reductase. As previously indicated, caffeine in pharmaceutical quality activates the circulation and thus the metabolism / metabolism, which can lead to a healthy hair growth.
Das Mittel enthält ferner wenigstens ein Lösungsmittel, wenigstens einen Emulator, wenigstens ein Antioxidanz, wenigstens ein Konservierungsmittel und wenigstens einen Stoff zur pH-Regulation.The agent also contains at least one solvent, at least one emulator, at least one antioxidant, at least one preservative, and at least one substance for pH regulation.
Das Lösungsmittel gemäß einer bevorzugten Ausführungsform der Erfindung ist gewählt aus Wasser und denaturiertem Alkohol. Als Emulgatoren dienen hydriertes und ethoxyliertes Rizinussöl und/oder Glycerin. Das Glycerin kann polymerisiertes Glycerin (Polyglyceryl-6 Laurate) und/oder polymerisiertes und verestertes Glycerin aus Olivenöl (Olive Oil Polyglyceryl-6 Ester) sein. Das Antioxidanz ist gemäß einer bevorzugten Ausführungsform der Erfindung Tocopherol, welches insbesondere als Vitamin E vorliegt. Gemäß einer ferner bevorzugten Ausführungsform der Erfindung können als weitere Antioxidantien Honokiol (Polyphenol aus den Samen der Magnolie) und Magnolol (Polyphenol aus den Samen der Magnolie) zum Einsatz kommen, um dadurch die Pflegefunktion des erfindungsgemäßen Haarbehandlungmittels noch stärker zu fördern und die Schutzfunktion des Mittels zu verstärken. Als Konservierungsmittel dienen Phenoxyethanol, Benzylalkohol, Kaliumsorbat, Natriumbenzoat und/oder Benzoesäure. Zur pH-Regulation können Zitronensäure und/oder Milchsäure eingesetzt werden. The solvent according to a preferred embodiment of the invention is selected from water and denatured alcohol. The emulsifiers used are hydrogenated and ethoxylated castor oil and / or glycerol. The glycerol may be polymerized glycerol (polyglyceryl-6 laurate) and / or polymerized and esterified glycerin from olive oil (olive oil polyglyceryl-6 ester). The antioxidant is according to a preferred embodiment of the invention tocopherol, which is present in particular as vitamin E. According to a further preferred embodiment of the invention may be used as further antioxidants honokiol (polyphenol from the seeds of magnolia) and magnolol (polyphenol from the seeds of magnolia) to thereby further promote the care function of the hair treatment composition according to the invention and the protective function of the agent to reinforce. The preservatives used are phenoxyethanol, benzyl alcohol, potassium sorbate, sodium benzoate and / or benzoic acid. For pH regulation citric acid and / or lactic acid can be used.
Folgendes Mittel stellt eine stabile Zusammensetzung mit den wesentlichen Inhaltsstoffen dar, welche hier mit Bereichsangaben in Gewichtsprozent (Gew.-%) angegeben sind:
Gemäß einer bevorzugten Ausführungsform der Erfindung enthält das Mittel ferner wenigstens ein Pflegemittel, wenigstens einen Feuchtigkeitsspender, wenigstens einen Viskositätsregler und/oder wenigstens einen Duftstoff.According to a preferred embodiment of the invention, the agent further contains at least one care agent, at least one moisturizer, at least one viscosity regulator and / or at least one perfume.
Es ist klar, dass das wenigstens eine Pflegemittel die zuvor erwähnte Pflegefunktion des erfindungsgemäßen Mittels unterstützt. Als Pflegemittel können zum Einsatz kommen Panthenol, welches auch als Feuchtigkeitsspender wirksam ist, quartäres Trimethylammoniumsalz aus Stärke, Erbsensprossen-Extrakt, Arginin, Niacinamid (in Vitamin B3-Form), hydrolysiertes Weizenprotein und/oder Biotin. Neben der pflegenden Funktion hat das vorerwähnte Niacinamid auch eine glättende Funktion.It is clear that the at least one care agent supports the aforementioned care function of the agent according to the invention. Panthenol, which is also effective as a moisturizer, quaternary trimethylammonium salt of starch, pea shoot extract, arginine, niacinamide (in vitamin B3 form), hydrolyzed wheat protein and / or biotin can be used as care agents. In addition to the nourishing function, the aforementioned niacinamide also has a smoothing function.
Als Feuchtigkeit spendende Stoffe können gewählt werden Betain, Harnstoff, Glycerin und/oder Natriumlaktat.Suitable moisturizing substances are betaine, urea, glycerol and / or sodium lactate.
Als Bestandteil zum Einstellen der Viskosität des Mittels in dessen jeweiliger Darreichungsform dient gemäß einer bevorzugten Ausführungsform der Erfindung Natriumchlorid.As a component for adjusting the viscosity of the agent in its respective dosage form is used according to a preferred embodiment of the invention, sodium chloride.
Der Duftstoff ist beispielsweise ein Parfüm.The perfume is for example a perfume.
Gemäß einer weiteren Ausführungsform der Erfindung enthält das erfindungsgemäße Mittel zur Haarbehandlung folgende Inhaltsstoffe, die sowohl mit ihren jeweiligen Bereichsangaben in Gew.-% als auch mit jeweils spezifizierten Anteilen in Gew.-% angegeben sind. Zusätzlich sind zu den einzelnen Inhaltsstoffen auch die international üblichen Bezeichnungen angegeben.
Wie zuvor bereits erwähnt werden die Inhaltsstoffe, soweit möglich, in pharmazeutischer Qualität eingesetzt, was mit zu einer effizienteren Wirkung des erfindungsgemäßen Mittels beiträgt. Dies gilt insbesondere für die Inhaltsstoffe Sägepalm-Extrakt, Rotklee-Extrakt, Koffein, Panthenol, Biotin, Niacinamid (Nicotinamid).As already mentioned, the ingredients are, as far as possible, used in pharmaceutical grade, which contributes to a more efficient action of the composition according to the invention. This applies in particular to the ingredients saw palmetto extract, red clover extract, caffeine, panthenol, biotin, niacinamide (nicotinamide).
Das erfindungsgemäße Haarbehandlungsmittel verbessert, wie zuvor bereits angedeutet, insbesondere durch die Inhaltsstoffe Sägepalm-Extrakt, Rotklee-Extrakt, Koffein, Biotin die Durchblutung, verringert oder begrenzt die Bildung von DHT und begünstigt damit die Energieversorgung der jeweiligen Haarzwiebel. Die Haarbildung und eine gute Verankerung der Haare in der Kopfhaut bewirken Inhaltsstoffe wie Panthenol, Arginin. Die Schutz- und Pflegefunktion des Mittels wird insbesondere durch die pflanzlichen Inhaltsstoffe gefördert. Das schließt auch einen UV-Schutz mit ein. Die genannten Vitamine schützen gegen Radikale und andere Umweltschäden, so dass das erfindungsgemäße Mittel auch zur Unterstützung der Haarfärbung besonders geeignet ist und daher bei der Haarfärbung verwendet werden kann.The hair treatment agent according to the invention improves, as already indicated above, in particular through the ingredients saw palmetto extract, red clover extract, caffeine, biotin, the blood circulation, reduces or limits the formation of DHT and thus favors the energy supply of the respective hair bulb. The hair formation and a good anchoring of the hair in the scalp cause ingredients such as panthenol, arginine. The protective and care function of the agent is promoted in particular by the herbal ingredients. This also includes UV protection. The said vitamins protect against radicals and other environmental damage, so that the agent according to the invention is also particularly suitable for aiding hair coloring and can therefore be used in hair dyeing.
Das erfindungsgemäße Mittel zur Haarbehandlung kann daher insbesondere bei diffusem und/oder erblich bedingtem Haarausfall oder zur Vorbeugung gegen einen solchen Haarausfall verwendet werden.The hair treatment composition according to the invention can therefore be used in particular in the case of diffuse and / or hereditary hair loss or for the prevention of such hair loss.
Das erfindungsgemäße Mittel zur Haarbehandlung enthält damit vorrangig einen Aktivierung-/Stimulierungskomplex sowie den Baustoffwechsel fördernde Bestandteile, wodurch dieses in der Lage ist, effizienter gegen Haarausfall zu wirken.The hair treatment composition according to the invention thus primarily contains an activating / stimulating complex and constituents which promote the metabolism of the building material, as a result of which it is able to act more effectively against hair loss.
ZITATE ENTHALTEN IN DER BESCHREIBUNGQUOTES INCLUDE IN THE DESCRIPTION
Diese Liste der vom Anmelder aufgeführten Dokumente wurde automatisiert erzeugt und ist ausschließlich zur besseren Information des Lesers aufgenommen. Die Liste ist nicht Bestandteil der deutschen Patent- bzw. Gebrauchsmusteranmeldung. Das DPMA übernimmt keinerlei Haftung für etwaige Fehler oder Auslassungen.This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.
Zitierte PatentliteraturCited patent literature
- EP 1396261 B1 [0003]EP 1396261 B1 [0003]
- EP 1700617 A1 [0003]EP 1700617 A1 [0003]
- WO 0211675 A2 [0003]WO 02/1675 A2 [0003]
Claims (10)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102017008429.7A DE102017008429A1 (en) | 2017-09-07 | 2017-09-07 | Means for hair treatment |
| PCT/EP2018/073319 WO2019048326A1 (en) | 2017-09-07 | 2018-08-30 | Hair treatment product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102017008429.7A DE102017008429A1 (en) | 2017-09-07 | 2017-09-07 | Means for hair treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102017008429A1 true DE102017008429A1 (en) | 2019-03-07 |
Family
ID=63442643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102017008429.7A Pending DE102017008429A1 (en) | 2017-09-07 | 2017-09-07 | Means for hair treatment |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE102017008429A1 (en) |
| WO (1) | WO2019048326A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102020004093A1 (en) | 2020-07-07 | 2022-01-13 | Dr. Kurt Wolff Gmbh & Co. Kg | Hair and scalp treatment composition |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030311A1 (en) * | 1999-10-28 | 2001-05-03 | Avi Dascalu | Agent for inducing hair growth containing extracts of saw palmetto and swertia |
| WO2002011675A2 (en) | 2000-08-10 | 2002-02-14 | Zelickson M D Brian D | Organic nutrient for hair loss treatment |
| EP1396261B1 (en) | 2002-09-06 | 2004-10-27 | Alcina Cosmetic, Dr. Kurt Wolff GmbH & Co.KG | Skincare composition containing caffeine |
| EP1700617A1 (en) | 2005-03-02 | 2006-09-13 | Dr. Kurt Wolff GmbH & Co. KG | Composition for activating the hair follicules and use thereof |
| GB2484812A (en) * | 2010-10-19 | 2012-04-25 | Pangaea Lab Ltd | Composition for reducing hair loss/improving hair condition |
| WO2014184173A1 (en) * | 2013-05-14 | 2014-11-20 | Montero Gida Sanayi Ve Ticaret A.S. | Hair care formulations |
| US20150265528A1 (en) * | 2005-10-03 | 2015-09-24 | Pilaris Labs Llc | Composition and method for treatment of hair loss with a combination of natural ingredients |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070077222A1 (en) * | 2005-10-03 | 2007-04-05 | Shapiro Steven D | Composition and treatment for hair loss |
| WO2014120793A1 (en) * | 2013-01-30 | 2014-08-07 | The Beauty Cartel, Llc. | Hair loss treatment compositions and methods of making and using same |
-
2017
- 2017-09-07 DE DE102017008429.7A patent/DE102017008429A1/en active Pending
-
2018
- 2018-08-30 WO PCT/EP2018/073319 patent/WO2019048326A1/en active Application Filing
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030311A1 (en) * | 1999-10-28 | 2001-05-03 | Avi Dascalu | Agent for inducing hair growth containing extracts of saw palmetto and swertia |
| WO2002011675A2 (en) | 2000-08-10 | 2002-02-14 | Zelickson M D Brian D | Organic nutrient for hair loss treatment |
| EP1396261B1 (en) | 2002-09-06 | 2004-10-27 | Alcina Cosmetic, Dr. Kurt Wolff GmbH & Co.KG | Skincare composition containing caffeine |
| EP1700617A1 (en) | 2005-03-02 | 2006-09-13 | Dr. Kurt Wolff GmbH & Co. KG | Composition for activating the hair follicules and use thereof |
| US20150265528A1 (en) * | 2005-10-03 | 2015-09-24 | Pilaris Labs Llc | Composition and method for treatment of hair loss with a combination of natural ingredients |
| GB2484812A (en) * | 2010-10-19 | 2012-04-25 | Pangaea Lab Ltd | Composition for reducing hair loss/improving hair condition |
| WO2014184173A1 (en) * | 2013-05-14 | 2014-11-20 | Montero Gida Sanayi Ve Ticaret A.S. | Hair care formulations |
Non-Patent Citations (3)
| Title |
|---|
| Anti Hair Loss Tonic. Oktober 2016. Mintel GNPD [online]. Eintragsnummer 4313029 [abgerufen am 19.06.2018] * |
| Nourishing Scalp and Strand Serum. Juni 2015. Mintel GNPD [online]. Eintragsnummer 3306907 [abgerufen am 19.06.2018] * |
| Saturate Phytoflavone Moisturizing Scalp & Hair Shampoo. Januar 2010. Mintel GNPD [online]. Eintragsnummer 1255391 [abgerufen am 19.06.2018] * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102020004093A1 (en) | 2020-07-07 | 2022-01-13 | Dr. Kurt Wolff Gmbh & Co. Kg | Hair and scalp treatment composition |
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| WO2019048326A1 (en) | 2019-03-14 |
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