DE102004016605A1 - Thiocarbamoylproline - Google Patents

Thiocarbamoylproline Download PDF

Info

Publication number
DE102004016605A1
DE102004016605A1 DE102004016605A DE102004016605A DE102004016605A1 DE 102004016605 A1 DE102004016605 A1 DE 102004016605A1 DE 102004016605 A DE102004016605 A DE 102004016605A DE 102004016605 A DE102004016605 A DE 102004016605A DE 102004016605 A1 DE102004016605 A1 DE 102004016605A1
Authority
DE
Germany
Prior art keywords
dollar
thiocarbamoylproline
prophylaxis
tumors
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102004016605A
Other languages
English (en)
Inventor
Werner Mederski
Christos Tsaklakidis
Dieter Dorsch
Bertram Cezanne
Johannes Gleitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE102004016605A priority Critical patent/DE102004016605A1/de
Priority to PCT/EP2005/002745 priority patent/WO2005097783A1/de
Publication of DE102004016605A1 publication Critical patent/DE102004016605A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Neue Verbindungen der Formel I, DOLLAR F1 worin DOLLAR A R, R·1·, R·2·, R·3· und R·4· die in Patentanspruch 1 angegebene Bedeutung haben, DOLLAR A sind Inhibitoren des Koagulationsfaktors Xa und können zur Prophylaxe und/oder Therapie von thromboembolischen Erkrankungen und zur Behandlung von Tumoren eingesetzt werden.
DE102004016605A 2004-04-03 2004-04-03 Thiocarbamoylproline Withdrawn DE102004016605A1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE102004016605A DE102004016605A1 (de) 2004-04-03 2004-04-03 Thiocarbamoylproline
PCT/EP2005/002745 WO2005097783A1 (de) 2004-04-03 2005-03-15 Thiocarbamoylproline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004016605A DE102004016605A1 (de) 2004-04-03 2004-04-03 Thiocarbamoylproline

Publications (1)

Publication Number Publication Date
DE102004016605A1 true DE102004016605A1 (de) 2005-10-20

Family

ID=34963324

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102004016605A Withdrawn DE102004016605A1 (de) 2004-04-03 2004-04-03 Thiocarbamoylproline

Country Status (2)

Country Link
DE (1) DE102004016605A1 (de)
WO (1) WO2005097783A1 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562828B1 (en) * 1998-04-10 2003-05-13 Japan Tobacco Inc. Amidine compounds
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
ATE361296T1 (de) * 2003-04-03 2007-05-15 Merck Patent Gmbh Pyrazolidin-1,2-dicarbonsäure-1-((phenyl)-amid) 2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen
CN1809346A (zh) * 2003-06-18 2006-07-26 默克专利股份公司 作为凝血因子xa和viia的抑制剂用于治疗形成血栓的1－[(4－乙炔基苯基) ]－2－[(苯基)]－吡咯烷－1,2－二酰胺衍生物

Also Published As

Publication number Publication date
WO2005097783A8 (de) 2007-04-19
WO2005097783A1 (de) 2005-10-20

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8139 Disposal/non-payment of the annual fee