DD297564A5 - Kontrastmedien - Google Patents

Kontrastmedien Download PDF

Info

Publication number: DD297564A5
Authority: DD; German Democratic Republic
Prior art keywords: contrast; contrast medium; media; oxygen; agent
Prior art date: 1989-09-04

Application number

DD90343782A

Other languages

German (de)

English (en)

Inventor

Torsten Almen

Lars Baath

Audun N Oksendal

Original Assignee

��@��k��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-04

Filing date

1990-09-03

Publication date

1992-01-16

1990-09-03 Application filed by ��@��k�� filed Critical ��@��k��

1992-01-16 Publication of DD297564A5 publication Critical patent/DD297564A5/de

Links

239000002872 contrast media Substances 0.000 title claims abstract description 139
229940039231 contrast media Drugs 0.000 title abstract description 44
238000006213 oxygenation reaction Methods 0.000 claims abstract description 34
238000003384 imaging method Methods 0.000 claims abstract description 5
238000004519 manufacturing process Methods 0.000 claims abstract description 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 43
229910052760 oxygen Inorganic materials 0.000 claims description 43
239000001301 oxygen Substances 0.000 claims description 43
238000000034 method Methods 0.000 claims description 11
BAQCROVBDNBEEB-UBYUBLNFSA-N Metrizamide Chemical compound CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C(=O)N[C@@H]2[C@H]([C@H](O)[C@@H](CO)OC2O)O)=C1I BAQCROVBDNBEEB-UBYUBLNFSA-N 0.000 claims description 9
239000007789 gas Substances 0.000 claims description 9
229960000554 metrizamide Drugs 0.000 claims description 9
229910001415 sodium ion Inorganic materials 0.000 claims description 7
239000003795 chemical substances by application Substances 0.000 claims description 6
229960004359 iodixanol Drugs 0.000 claims description 6
NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 claims description 6
239000007788 liquid Substances 0.000 claims description 6
239000000203 mixture Substances 0.000 claims description 6
239000003690 nonionic contrast media Substances 0.000 claims description 4
241001465754 Metazoa Species 0.000 claims description 3
AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 claims description 2
FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 claims description 2
238000010438 heat treatment Methods 0.000 claims description 2
229960004537 ioversol Drugs 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims description 2
239000008365 aqueous carrier Substances 0.000 claims 1
230000000694 effects Effects 0.000 abstract description 17
230000002829 reductive effect Effects 0.000 abstract description 13
208000003663 ventricular fibrillation Diseases 0.000 abstract description 13
230000001706 oxygenating effect Effects 0.000 abstract description 4
238000002583 angiography Methods 0.000 abstract description 2
230000010247 heart contraction Effects 0.000 abstract description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 34
238000001802 infusion Methods 0.000 description 31
210000002216 heart Anatomy 0.000 description 28
230000010412 perfusion Effects 0.000 description 24
239000002609 medium Substances 0.000 description 17
239000011780 sodium chloride Substances 0.000 description 17
239000011734 sodium Substances 0.000 description 15
239000000243 solution Substances 0.000 description 14
241000283973 Oryctolagus cuniculus Species 0.000 description 12
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 11
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 11
230000008602 contraction Effects 0.000 description 11
229910052740 iodine Inorganic materials 0.000 description 11
229910052708 sodium Inorganic materials 0.000 description 11
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 10
239000011630 iodine Substances 0.000 description 10
238000012360 testing method Methods 0.000 description 10
239000012530 fluid Substances 0.000 description 7
230000006872 improvement Effects 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
210000004369 blood Anatomy 0.000 description 5
239000008280 blood Substances 0.000 description 5
229910002092 carbon dioxide Inorganic materials 0.000 description 5
239000001569 carbon dioxide Substances 0.000 description 5
230000004217 heart function Effects 0.000 description 5
NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 5
229920001971 elastomer Polymers 0.000 description 4
230000009467 reduction Effects 0.000 description 4
239000007787 solid Substances 0.000 description 4
230000001988 toxicity Effects 0.000 description 4
231100000419 toxicity Toxicity 0.000 description 4
241001442654 Percnon planissimum Species 0.000 description 3
210000000709 aorta Anatomy 0.000 description 3
206010003119 arrhythmia Diseases 0.000 description 3
230000006793 arrhythmia Effects 0.000 description 3
239000012153 distilled water Substances 0.000 description 3
239000011521 glass Substances 0.000 description 3
238000011835 investigation Methods 0.000 description 3
239000004033 plastic Substances 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
206010020772 Hypertension Diseases 0.000 description 2
230000002411 adverse Effects 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
229910001424 calcium ion Inorganic materials 0.000 description 2
238000004364 calculation method Methods 0.000 description 2
206010061592 cardiac fibrillation Diseases 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
238000002565 electrocardiography Methods 0.000 description 2
230000002600 fibrillogenic effect Effects 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
210000004072 lung Anatomy 0.000 description 2
239000000463 material Substances 0.000 description 2
210000000663 muscle cell Anatomy 0.000 description 2
210000004165 myocardium Anatomy 0.000 description 2
230000036961 partial effect Effects 0.000 description 2
WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
210000001147 pulmonary artery Anatomy 0.000 description 2
230000001603 reducing effect Effects 0.000 description 2
238000011160 research Methods 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
159000000000 sodium salts Chemical class 0.000 description 2
HUHDYASLFWQVOL-WZTVWXICSA-N 3-[[2-[[3-[acetyl(methyl)amino]-2,4,6-triiodo-5-(methylcarbamoyl)benzoyl]amino]acetyl]amino]-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoic acid;(2r,3r,4r,5s)-6-(methylamino)hexane-1,2,3,4,5-pentol Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC(=O)C1=C(I)C(N(C)C(C)=O)=C(I)C(C(=O)NCC(=O)NC=2C(=C(C(=O)NCCO)C(I)=C(C(O)=O)C=2I)I)=C1I HUHDYASLFWQVOL-WZTVWXICSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
244000187656 Eucalyptus cornuta Species 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
108010023197 Streptokinase Proteins 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
LFBLJXFZKHMOBG-UHFFFAOYSA-N [Na].[Na].[Ca].[Ca] Chemical compound [Na].[Na].[Ca].[Ca] LFBLJXFZKHMOBG-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 description 1
239000003708 ampul Substances 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
230000003712 anti-aging effect Effects 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000007321 biological mechanism Effects 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
230000008859 change Effects 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
230000007012 clinical effect Effects 0.000 description 1
238000002586 coronary angiography Methods 0.000 description 1
208000029078 coronary artery disease Diseases 0.000 description 1
238000012937 correction Methods 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
238000002059 diagnostic imaging Methods 0.000 description 1
229960005423 diatrizoate Drugs 0.000 description 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
229940009662 edetate Drugs 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
238000004817 gas chromatography Methods 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
229960004901 iodamide Drugs 0.000 description 1
VVDGWALACJEJKG-UHFFFAOYSA-N iodamide Chemical compound CC(=O)NCC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I VVDGWALACJEJKG-UHFFFAOYSA-N 0.000 description 1
229960001025 iohexol Drugs 0.000 description 1
239000002611 ionic contrast media Substances 0.000 description 1
210000005240 left ventricle Anatomy 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
229910001425 magnesium ion Inorganic materials 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229960004712 metrizoic acid Drugs 0.000 description 1
GGGDNPWHMNJRFN-UHFFFAOYSA-N metrizoic acid Chemical compound CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I GGGDNPWHMNJRFN-UHFFFAOYSA-N 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
239000002245 particle Substances 0.000 description 1
229960001412 pentobarbital Drugs 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000036470 plasma concentration Effects 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910001414 potassium ion Inorganic materials 0.000 description 1
239000011833 salt mixture Substances 0.000 description 1
229940037001 sodium edetate Drugs 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
230000009469 supplementation Effects 0.000 description 1
239000012085 test solution Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000007669 thermal treatment Methods 0.000 description 1
238000012285 ultrasound imaging Methods 0.000 description 1
230000002861 ventricular Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent

Landscapes

Health & Medical Sciences (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Devices For Indicating Variable Information By Combining Individual Elements (AREA)
Liquid Crystal (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Apparatus For Radiation Diagnosis (AREA)
Steroid Compounds (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Radar Systems Or Details Thereof (AREA)
Eye Examination Apparatus (AREA)
Compositions Of Macromolecular Compounds (AREA)

DD90343782A 1989-09-04 1990-09-03 Kontrastmedien DD297564A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898919929A GB8919929D0 (en)	1989-09-04	1989-09-04	Compositions

Publications (1)

Publication Number	Publication Date
DD297564A5 true DD297564A5 (de)	1992-01-16

Family

ID=10662482

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD90343782A DD297564A5 (de)	1989-09-04	1990-09-03	Kontrastmedien

Country Status (32)

Country	Link
US (1)	US5447711A (pt)
EP (2)	EP0490917A1 (pt)
JP (1)	JP3049366B2 (pt)
CN (1)	CN1035542C (pt)
AT (1)	ATE101798T1 (pt)
AU (1)	AU633353B2 (pt)
CA (1)	CA2064880A1 (pt)
CZ (1)	CZ281128B6 (pt)
DD (1)	DD297564A5 (pt)
DE (1)	DE69006805T2 (pt)
DK (1)	DK0416698T3 (pt)
EG (1)	EG20035A (pt)
ES (1)	ES2051461T3 (pt)
FI (1)	FI99087C (pt)
GB (1)	GB8919929D0 (pt)
HR (1)	HRP930749A2 (pt)
HU (1)	HU208639B (pt)
IE (1)	IE65527B1 (pt)
IL (1)	IL95565A (pt)
JO (1)	JO1637B1 (pt)
LT (1)	LT3582B (pt)
LV (1)	LV10057B (pt)
MY (1)	MY107103A (pt)
NO (1)	NO920837L (pt)
NZ (1)	NZ235171A (pt)
OA (1)	OA09601A (pt)
PT (1)	PT95190B (pt)
RO (1)	RO111023B1 (pt)
RU (1)	RU2106880C1 (pt)
WO (1)	WO1991003263A1 (pt)
YU (1)	YU48072B (pt)
ZA (1)	ZA907034B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5141739A (en) *	1986-07-03	1992-08-25	Advanced Magnetics, Inc.	Delivery of x-ray contrast agents using receptor mediated endocytosis
SE520688C2 (sv) *	2000-04-11	2003-08-12	Bone Support Ab	Ett injicerbart ersättningsmaterial för benmineral
SE517168C2 (sv) *	2000-07-17	2002-04-23	Bone Support Ab	En komposition för ett injicerbart ersättningsmaterial för benmineral
ATE365566T1 (de)	2001-12-20	2007-07-15	Bone Support Ab	Neuer knochenmineralien-ersatzstoff
SE522098C2 (sv) *	2001-12-20	2004-01-13	Bone Support Ab	Ett nytt benmineralsubstitut
SE0300620D0 (sv) *	2003-03-05	2003-03-05	Bone Support Ab	A new bone substitute composition
US20040175329A1 (en) *	2003-03-07	2004-09-09	Fisher John Steele	Method for continuous visualization of a body lumen
US7803352B2 (en) *	2003-03-07	2010-09-28	John Steele Fisher	Method for continuous visualization of a blood clot or plaque in body lumen
SE0302983D0 (sv) *	2003-11-11	2003-11-11	Bone Support Ab	Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
SE527528C2 (sv) *	2004-06-22	2006-04-04	Bone Support Ab	Anordning för framställning av härdbar massa samt användning av anordningen
US9180137B2 (en)	2010-02-09	2015-11-10	Bone Support Ab	Preparation of bone cement compositions
WO2013086207A1 (en) *	2011-12-06	2013-06-13	The Ohio State University	Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease
DK2958603T3 (en)	2013-02-20	2018-07-16	Bone Support Ab	IMPROVED CURE FOR HARDWARE BONE COMPENSATION
US10610366B2 (en)	2015-01-29	2020-04-07	Theracell, Inc.	Demineralized bone fiber composition for use in minimally invasive surgery
US10639157B2 (en)	2017-03-14	2020-05-05	Theracell, Inc.	Demineralized bone fiber composition for use in minimally invasive surgery

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA935153A (en)	1969-06-27	1973-10-09	Nyegaard And Co. A/S	2,4,6-triiodobenzoyl amines used as x-ray contrast agents
AR207465A1 (es) *	1974-05-31	1976-10-08	Guerbet Lab Andre	Procedimiento de preparacion de derivados de acido triiodoi2,4,6-(triiodo-2,4,6-benzoil)-amino-alcanoilaminobenzoico de acido triiodo-2,4,6-(triiodo-2,4,6-(triiodo-2,4,6-benzoil)-aminoalcanoilaminobenzoil)-amino-alcanoil-aminobenzoico y de acido triiodo-2,4,6-bis((triiodo-2,4,6-fenil)-carbamoil-metil)-aminoalcanoil-aminobenzoico
CH608189A5 (pt) *	1974-12-13	1978-12-29	Savac Ag
GB1548594A (en) *	1976-06-11	1979-07-18	Nyegaard & Co As	Triiodoisophthalic acid amides
JPS55100312A (en) *	1979-01-25	1980-07-31	Toshiro Wada	Contrast medium for blood vessel
BE881234A (fr) *	1980-01-18	1980-05-16	Solarex Corp	Generateur photovoltaique integre et son procede de fabrication
US4341756A (en)	1980-01-31	1982-07-27	The Regents Of The University Of California	Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media
US4396598A (en)	1982-01-11	1983-08-02	Mallinckrodt, Inc.	Triiodoisophthalamide X-ray contrast agent
DE3364536D1 (en)	1982-11-08	1986-08-21	Nyegaard & Co As	X-ray contrast agents
US4589412A (en) *	1984-01-03	1986-05-20	Intravascular Surgical Instruments, Inc.	Method and apparatus for surgically removing remote deposits
US4865836A (en) *	1986-01-14	1989-09-12	Fluoromed Pharmaceutical, Inc.	Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
ES2054658T3 (es) *	1986-01-24	1994-08-16	Childrens Hosp Medical Center	Metodo para la preparacion de una emulsion fisiologicamente aceptable.
GB8906130D0 (en) *	1989-03-17	1989-05-04	Nycomed As	Compositions

1989
- 1989-09-04 GB GB898919929A patent/GB8919929D0/en active Pending
1990
- 1990-09-01 ES ES90202341T patent/ES2051461T3/es not_active Expired - Lifetime
- 1990-09-01 EP EP90912752A patent/EP0490917A1/en active Pending
- 1990-09-01 HU HU9200734A patent/HU208639B/hu not_active IP Right Cessation
- 1990-09-01 WO PCT/EP1990/001481 patent/WO1991003263A1/en active IP Right Grant
- 1990-09-01 CA CA002064880A patent/CA2064880A1/en not_active Abandoned
- 1990-09-01 DK DK90202341.5T patent/DK0416698T3/da active
- 1990-09-01 AT AT90202341T patent/ATE101798T1/de active
- 1990-09-01 AU AU62784/90A patent/AU633353B2/en not_active Ceased
- 1990-09-01 RU SU5011661A patent/RU2106880C1/ru active
- 1990-09-01 DE DE69006805T patent/DE69006805T2/de not_active Expired - Lifetime
- 1990-09-01 JP JP2512015A patent/JP3049366B2/ja not_active Expired - Lifetime
- 1990-09-01 EP EP90202341A patent/EP0416698B1/en not_active Expired - Lifetime
- 1990-09-01 RO RO92-200254A patent/RO111023B1/ro unknown
- 1990-09-03 IL IL9556590A patent/IL95565A/en not_active IP Right Cessation
- 1990-09-03 YU YU167790A patent/YU48072B/sh unknown
- 1990-09-03 IE IE319390A patent/IE65527B1/en not_active IP Right Cessation
- 1990-09-03 DD DD90343782A patent/DD297564A5/de not_active IP Right Cessation
- 1990-09-03 JO JO19901637A patent/JO1637B1/en active
- 1990-09-03 PT PT95190A patent/PT95190B/pt not_active IP Right Cessation
- 1990-09-04 NZ NZ235171A patent/NZ235171A/en unknown
- 1990-09-04 CN CN90107463A patent/CN1035542C/zh not_active Expired - Fee Related
- 1990-09-04 MY MYPI90001520A patent/MY107103A/en unknown
- 1990-09-04 CZ CS904300A patent/CZ281128B6/cs unknown
- 1990-09-04 EG EG9052590A patent/EG20035A/xx active
- 1990-09-04 ZA ZA907034A patent/ZA907034B/xx unknown
1992
- 1992-02-28 OA OA60158A patent/OA09601A/en unknown
- 1992-02-28 FI FI920912A patent/FI99087C/fi not_active IP Right Cessation
- 1992-03-03 NO NO92920837A patent/NO920837L/no unknown
- 1992-12-30 LV LVP-92-584A patent/LV10057B/lv unknown
1993
- 1993-04-02 HR HR930749A patent/HRP930749A2/hr not_active Application Discontinuation
- 1993-12-07 LT LTIP1540A patent/LT3582B/lt not_active IP Right Cessation
1994
- 1994-03-14 US US08/213,454 patent/US5447711A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
OA09601A (en)	1993-04-30
JP3049366B2 (ja)	2000-06-05
JO1637B1 (en)	1991-11-27
EP0416698A1 (en)	1991-03-13
CZ430090A3 (en)	1996-04-17
IL95565A0 (en)	1991-06-30
EP0416698B1 (en)	1994-02-23
PT95190B (pt)	1997-06-30
YU48072B (sh)	1997-01-08
CA2064880A1 (en)	1991-03-05
LV10057A (lv)	1994-05-10
MY107103A (en)	1995-09-30
AU6278490A (en)	1991-04-08
PT95190A (pt)	1991-05-22
RO111023B1 (ro)	1996-06-28
LTIP1540A (en)	1995-06-26
HUT60930A (en)	1992-11-30
EP0490917A1 (en)	1992-06-24
IE65527B1 (en)	1995-11-01
ES2051461T3 (es)	1994-06-16
EG20035A (en)	1997-03-27
HU9200734D0 (en)	1992-08-28
US5447711A (en)	1995-09-05
DE69006805T2 (de)	1994-06-01
ATE101798T1 (de)	1994-03-15
AU633353B2 (en)	1993-01-28
DK0416698T3 (da)	1994-03-28
WO1991003263A1 (en)	1991-03-21
FI99087B (fi)	1997-06-30
CZ281128B6 (cs)	1996-06-12
CN1035542C (zh)	1997-08-06
DE69006805D1 (de)	1994-03-31
LT3582B (en)	1995-12-27
HRP930749A2 (en)	1994-10-31
IE903193A1 (en)	1991-03-27
LV10057B (en)	1994-10-20
CN1051508A (zh)	1991-05-22
IL95565A (en)	1995-01-24
JPH05500365A (ja)	1993-01-28
GB8919929D0 (en)	1989-10-18
FI99087C (fi)	1997-10-10
FI920912A0 (fi)	1992-02-28
NZ235171A (en)	1992-11-25
HU208639B (en)	1993-12-28
NO920837D0 (no)	1992-03-03
ZA907034B (en)	1991-06-26
NO920837L (no)	1992-03-03
YU167790A (sh)	1995-03-27
RU2106880C1 (ru)	1998-03-20

Legal Events

Date	Code	Title	Description
1997-07-03	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DE69121562T3 (de)	2000-11-23	Kontrastmittel enthaltend einen nicht-ionischen kontrast Wirkstoff und Sodium und Kalzium Sälze
EP0077752B2 (de)	1995-07-26	Flüssige Mischung zur Aufnahme und Stabilisierung von Gasbläschen zur Verwendung als Kontrastmittel für die Ultraschalldiagnostik und deren Herstellung
DE3686610T2 (de)	1993-03-25	Oxygenierter fluorkohlenstoff zur verwendung in intra-peritonialen perfusionen.
DE69527194T2 (de)	2003-02-06	Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel
DD297564A5 (de)	1992-01-16	Kontrastmedien
DE3529195A1 (de)	1987-02-26	Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
EP0365467A2 (de)	1990-04-25	Ultraschallkontrastmittel aus Gasbläschen und Fettsäure-enthaltenden Mikropartikeln
EP0131540A2 (de)	1985-01-16	Ultraschallkontrastmittel sowie dessen Herstellung
EP0122624A2 (de)	1984-10-24	Mikropartikel und Gasbläschen enthaltendes Ultraschallkontrastmittel
WO1996025954A1 (de)	1996-08-29	Verwendung von methylenmalondiesterderivaten zur herstellung von gashaltigen mikropartikeln für die ultraschalldiagnostik, sowie diese partikel enthaltende mittel
DE69020208T2 (de)	1996-03-21	Kontrastmittel.
EP0644777A1 (de)	1995-03-29	Mikropartikel, verfahren zu deren herstellung, sowie die verwendung dieser in der diagnostik
DE1951769A1 (de)	1970-07-16	Pharmazeutische Suspension und Stabilisierungsverfahren
TEIXEIRA et al.	1959	Bronchography without oil and iodine—The use of barium as a contrast medium
DE919908C (de)	1954-11-08	Roentgenkontrastmittel zur Bronchographie und Hysterosalpingographie
DE1234931B (de)	1967-02-23	Roentgenkontrastmittel
CH664492A5 (de)	1988-03-15	Fuer roentgenstrahlen undurchlaessiges mittel.
DE2950832A1 (de)	1981-06-25	Spritzfertige injizierbare waessrige loesungen der alkalisalze von canrenoinsaeure und furosemid
DE2358123A1 (de)	1974-06-12	Infusionsmaterial und verfahren zu seiner herstellung
DE3018515A1 (de)	1980-12-04	Roentgenkontrastmittel
DE2028595A1 (de)	1970-12-17	Verbessertes Röntgenkontrastmittel
DE2543004A1 (de)	1976-04-22	Pharmazeutische zubereitungen mit gefaesserweiternder wirkung