DD133563A5 - Verfahren zur herstellung von trisubstituierten 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepinen - Google Patents

Verfahren zur herstellung von trisubstituierten 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepinen

Info

Publication number: DD133563A5
Authority: DD; German Democratic Republic
Prior art keywords: benzazepenes; tetrahydro; phenyl; preparing trisubstituted; trisubstituted
Prior art date: 1976-11-17

Application number

DD7700202113A

Other languages

English (en)

Inventor

Joseph Weinstock

Original Assignee

Smithkline Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-11-17

Filing date

1977-11-16

Publication date

1979-01-10

1977-11-16 Application filed by Smithkline Corp filed Critical Smithkline Corp

1979-01-10 Publication of DD133563A5 publication Critical patent/DD133563A5/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DD7700202113A 1976-11-17 1977-11-16 Verfahren zur herstellung von trisubstituierten 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepinen DD133563A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/742,965 US4160765A (en)	1976-11-17	1976-11-17	Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds

Publications (1)

Publication Number	Publication Date
DD133563A5 true DD133563A5 (de)	1979-01-10

Family

ID=24986959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD7700202113A DD133563A5 (de)	1976-11-17	1977-11-16	Verfahren zur herstellung von trisubstituierten 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepinen

Country Status (37)

Country	Link
US (1)	US4160765A (de)
JP (3)	JPS5363335A (de)
AR (1)	AR224495A1 (de)
AT (1)	AT362379B (de)
AU (1)	AU509754B2 (de)
BE (1)	BE860774A (de)
BG (1)	BG30019A3 (de)
CA (1)	CA1092107A (de)
CH (1)	CH635079A5 (de)
CS (1)	CS219333B2 (de)
CY (1)	CY1246A (de)
DD (1)	DD133563A5 (de)
DE (1)	DE2751258A1 (de)
DK (1)	DK156057C (de)
ES (1)	ES464044A1 (de)
FI (1)	FI67374C (de)
FR (1)	FR2371430A1 (de)
GB (1)	GB1595502A (de)
HU (1)	HU176709B (de)
IE (1)	IE46087B1 (de)
IL (1)	IL53377A (de)
IN (1)	IN150172B (de)
IT (1)	IT1126216B (de)
LU (1)	LU78513A1 (de)
MX (1)	MX4682E (de)
MY (1)	MY8500382A (de)
NL (2)	NL185563C (de)
NO (1)	NO147029C (de)
PH (2)	PH13611A (de)
PL (1)	PL109672B1 (de)
PT (1)	PT67260B (de)
RO (1)	RO72905A (de)
SE (1)	SE436646B (de)
SG (1)	SG31784G (de)
SU (1)	SU976847A3 (de)
YU (1)	YU40490B (de)
ZA (1)	ZA775910B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4197297A (en) *	1976-11-17	1980-04-08	Smithkline Corporation	6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
JPS5481290A (en) *	1977-11-17	1979-06-28	Smithkline Corp	Benzazepin compound
US4171359A (en) *	1978-04-12	1979-10-16	Smithkline Corporation	Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
ZA792042B (en) *	1978-05-08	1980-05-28	Scherico Ltd	Substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them
US4251525A (en) *	1979-05-25	1981-02-17	Smithkline Corporation	3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
ATE5634T1 (de) *	1979-07-10	1984-01-15	Smithkline Beckman Corporation	Synergistische blutdrucksenkende zusammensetzungen.
US4285938A (en) *	1979-10-11	1981-08-25	Smithkline Corporation	7,8-Dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
US4284556A (en) *	1980-01-31	1981-08-18	Smithkline Corporation	7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4328153A (en) *	1980-07-17	1982-05-04	Smith Kline Corporation	Dopaminergic benzazepines
DE3172458D1 (en) *	1981-12-08	1985-10-31	Smithkline Beckman Corp	Pharmaceutical compositions comprising 7,8-dihydroxy-1(hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine derivatives and a beta-adrenergic blocking compound
US4782163A (en) *	1984-10-05	1988-11-01	Smithkline Beckman Corporation	2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines
US4705862A (en) *	1984-10-05	1987-11-10	Smithkline Beckman Corporation	Chemical processes for 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)oxazolidines
US5068326A (en) *	1989-04-03	1991-11-26	Kung Hank F	Dopamine receptor ligands and imaging agents
KR20010113006A (ko) *	2000-06-15	2001-12-24	주정호	항암제로서 유용한 ｎ-치환된 벤즈아제피닐우레아 유도체및 그의 제조방법
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
US7090830B2 (en)	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
US7645442B2 (en)	2001-05-24	2010-01-12	Alexza Pharmaceuticals, Inc.	Rapid-heating drug delivery article and method of use
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
US7766013B2 (en)	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US20040105818A1 (en)	2002-11-26	2004-06-03	Alexza Molecular Delivery Corporation	Diuretic aerosols and methods of making and using them
US7913688B2 (en)	2002-11-27	2011-03-29	Alexza Pharmaceuticals, Inc.	Inhalation device for producing a drug aerosol
EP1625334B9 (de)	2003-05-21	2012-07-25	Alexza Pharmaceuticals, Inc.	Schlag gezündete unabhängige heizeinheit
GB0412314D0 (en) *	2004-06-02	2004-07-07	Glaxo Group Ltd	Compounds
US7540286B2 (en)	2004-06-03	2009-06-02	Alexza Pharmaceuticals, Inc.	Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US7581540B2 (en)	2004-08-12	2009-09-01	Alexza Pharmaceuticals, Inc.	Aerosol drug delivery device incorporating percussively activated heat packages
CA2593667A1 (en) *	2005-01-24	2006-07-27	Sicor Inc.	Process for the preparation of fenoldopam mesylate
US20080216828A1 (en)	2007-03-09	2008-09-11	Alexza Pharmaceuticals, Inc.	Heating unit for use in a drug delivery device
CN103172565A (zh) *	2011-12-22	2013-06-26	四川科伦药物研究有限公司	一种手性菲诺多泮的拆分方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3393192A (en) *	1965-04-26	1968-07-16	Schering Corp	Novel benzazepines
GB1118688A (en) *	1967-02-17	1968-07-03	Scherico Ltd	Novel benzazepines and process for making same
CH555831A (de) *	1967-02-17	1974-11-15	Scherico Ltd	Verfahren zur herstellung von neuen benzazepinen.
CH498122A (de) *	1968-02-09	1970-10-31	Geigy Ag J R	Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates
DE1695844C3 (de) *	1967-02-21	1980-01-17	Scherico Ltd., Luzern (Schweiz)	l-Phenyl-23,43-tetrahydro-lH^benzazepin-Derivate und sie enthaltende pharmazeutische Zusammensetzungen
US3609138A (en) *	1967-12-22	1971-09-28	Ciba Geigy Corp	1-aryl-3-benzazepines
US4011319A (en) *	1975-07-02	1977-03-08	Smithkline Corporation	Pharmaceutical compositions and methods involving benzazepine derivatives

1976
- 1976-11-17 US US05/742,965 patent/US4160765A/en not_active Expired - Lifetime
1977
- 1977-10-04 ZA ZA00775910A patent/ZA775910B/xx unknown
- 1977-11-07 CY CY1246A patent/CY1246A/xx unknown
- 1977-11-07 GB GB46184/77A patent/GB1595502A/en not_active Expired
- 1977-11-10 CA CA290,593A patent/CA1092107A/en not_active Expired
- 1977-11-11 PT PT67260A patent/PT67260B/pt unknown
- 1977-11-11 ES ES464044A patent/ES464044A1/es not_active Expired
- 1977-11-11 YU YU2707/77A patent/YU40490B/xx unknown
- 1977-11-11 PH PH20427A patent/PH13611A/en unknown
- 1977-11-11 RO RO7792097A patent/RO72905A/ro unknown
- 1977-11-11 DK DK500477A patent/DK156057C/da not_active IP Right Cessation
- 1977-11-14 AU AU30626/77A patent/AU509754B2/en not_active Expired
- 1977-11-14 BE BE182575A patent/BE860774A/xx not_active IP Right Cessation
- 1977-11-14 NO NO773901A patent/NO147029C/no unknown
- 1977-11-14 MX MX776556U patent/MX4682E/es unknown
- 1977-11-14 BG BG7737779A patent/BG30019A3/xx unknown
- 1977-11-14 IL IL53377A patent/IL53377A/xx unknown
- 1977-11-14 IE IE2311/77A patent/IE46087B1/en not_active IP Right Cessation
- 1977-11-14 LU LU78513A patent/LU78513A1/xx unknown
- 1977-11-15 AT AT816377A patent/AT362379B/de active
- 1977-11-15 NL NLAANVRAGE7712567,A patent/NL185563C/xx not_active IP Right Cessation
- 1977-11-15 AR AR269983A patent/AR224495A1/es active
- 1977-11-15 FR FR7734311A patent/FR2371430A1/fr active Granted
- 1977-11-15 IT IT29708/77A patent/IT1126216B/it active Protection Beyond IP Right Term
- 1977-11-15 FI FI773448A patent/FI67374C/fi not_active IP Right Cessation
- 1977-11-16 SE SE7712944A patent/SE436646B/sv not_active IP Right Cessation
- 1977-11-16 DE DE19772751258 patent/DE2751258A1/de active Granted
- 1977-11-16 SU SU772544154A patent/SU976847A3/ru active
- 1977-11-16 PL PL1977202177A patent/PL109672B1/pl unknown
- 1977-11-16 JP JP13841077A patent/JPS5363335A/ja active Granted
- 1977-11-16 DD DD7700202113A patent/DD133563A5/de unknown
- 1977-11-17 HU HU77SI1605A patent/HU176709B/hu not_active IP Right Cessation
- 1977-11-17 CS CS777593A patent/CS219333B2/cs unknown
1978
- 1978-09-14 PH PH21605A patent/PH14740A/en unknown
- 1978-11-03 IN IN790/DEL/78A patent/IN150172B/en unknown
1982
- 1982-01-14 CH CH21082A patent/CH635079A5/de not_active IP Right Cessation
- 1982-12-18 JP JP57222834A patent/JPS58113153A/ja active Granted
1984
- 1984-04-19 SG SG317/84A patent/SG31784G/en unknown
1985
- 1985-12-30 MY MY382/85A patent/MY8500382A/xx unknown
1986
- 1986-08-25 JP JP61199885A patent/JPS62155218A/ja active Granted
1993
- 1993-04-14 NL NL930026C patent/NL930026I2/nl unknown

Also Published As

Publication number	Publication date
NL185563B (nl)	1989-12-18
SE7712944L (sv)	1978-05-18
FI67374C (fi)	1985-03-11
LU78513A1 (de)	1978-03-20
ATA816377A (de)	1980-10-15
DK500477A (da)	1978-05-18
FI67374B (fi)	1984-11-30
IE46087L (en)	1978-05-17
JPS58113153A (ja)	1983-07-05
NO147029B (no)	1982-10-11
FR2371430B1 (de)	1980-06-27
NO773901L (no)	1978-05-19
IT1126216B (it)	1986-05-14
NL7712567A (nl)	1978-05-19
RO72905A (ro)	1981-11-04
AU3062677A (en)	1979-05-24
NL930026I1 (nl)	1993-06-01
IN150172B (de)	1982-04-07
PH14740A (en)	1981-11-20
MX4682E (es)	1982-07-28
US4160765A (en)	1979-07-10
AT362379B (de)	1981-05-11
CS219333B2 (en)	1983-03-25
JPS5363335A (en)	1978-06-06
HU176709B (en)	1981-04-28
PT67260A (en)	1977-12-01
PL109672B1 (en)	1980-06-30
CY1246A (en)	1984-08-31
PH13611A (en)	1980-08-05
NL930026I2 (nl)	1993-11-01
CH635079A5 (de)	1983-03-15
GB1595502A (en)	1981-08-12
SG31784G (en)	1985-03-08
JPS6225658B2 (de)	1987-06-04
IL53377A (en)	1982-09-30
AR224495A1 (es)	1981-12-15
FI773448A (fi)	1978-05-18
DE2751258C2 (de)	1990-01-04
BE860774A (fr)	1978-05-16
YU40490B (en)	1986-02-28
AU509754B2 (en)	1980-05-22
CA1092107A (en)	1980-12-23
PT67260B (en)	1979-04-18
FR2371430A1 (fr)	1978-06-16
NL185563C (nl)	1990-05-16
SU976847A3 (ru)	1982-11-23
DE2751258A1 (de)	1978-06-01
PL202177A1 (pl)	1978-09-25
IE46087B1 (en)	1983-02-23
JPS6366808B2 (de)	1988-12-22
NO147029C (no)	1983-01-19
IL53377A0 (en)	1978-01-31
SE436646B (sv)	1985-01-14
ES464044A1 (es)	1978-08-01
MY8500382A (en)	1985-12-31
DK156057C (da)	1989-11-13
ZA775910B (en)	1978-05-30
YU270777A (en)	1983-02-28
DK156057B (da)	1989-06-19
BG30019A3 (en)	1981-03-16
JPS62155218A (ja)	1987-07-10
JPS6125697B2 (de)	1986-06-17

Publication	Publication Date	Title
DD133563A5 (de)	1979-01-10	Verfahren zur herstellung von trisubstituierten 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepinen
DD129103A5 (de)	1977-12-28	Verfahren zur herstellung von n-phosphonomethylglycin
DD131931A5 (de)	1978-08-09	Verfahren zur herstellung von spiro-hydantoin-verbindungen
DD136616A5 (de)	1979-07-18	Verfahren zur herstellung von 1,4:3,6-dianhydro-d-glucit-2-nitrat
DD131858A5 (de)	1978-07-26	Verfahren zur herstellung von 3-chlorcephemverbindungen
DD129443A5 (de)	1978-01-18	Verfahren zur herstellung von indazolyl-(4)-oxypropanolaminen
DD131470A5 (de)	1978-06-28	Verfahren zur herstellung von 2-oxy-5-isopropyliden-7-hydroxy-9-substituierten-2,6-methano-3,4,5,6-tetrahydro-2h-1-benzoxocinen
DD131556A5 (de)	1978-07-05	Verfahren zur herstellung von 5-m-tolyoxyuracil
DD132014A5 (de)	1978-08-16	Verfahren zur herstellung von 3,4-dihydro-2-methyl-4-oxo-2h-1,2-benzothiazin-3-carbonsaeure-1,1-dioxid
AT346437B (de)	1978-11-10	Verfahren zur herstellung von neuen azomethinverbindungen
AT348498B (de)	1979-02-26	Verfahren zur herstellung des neuen n-n-butyl- n-cetyl-6-amino-1-hexanols
DD129445A6 (de)	1978-01-18	Verfahren zur herstellung von 1-sulfonyl-5(6)-subst.-benzimidazolen
DD132431A5 (de)	1978-09-27	Verfahren zur herstellung von aryloxy-1-amino-3-propanolen-2
DD130145A5 (de)	1978-03-08	Verfahren zur herstellung von 2-methyl-4-hydroxy-1,2-benzothiazin-3-carboxamid-dioxiden
AT356815B (de)	1980-05-27	Verfahren zur herstellung von 3',4'-dideoxy- kanamycin b
DD133947A5 (de)	1979-01-31	Verfahren zur herstellung von 2-chlor-4,6-bis-alkylamino-s-triazinen
DD132263A5 (de)	1978-09-13	Verfahren zur herstellung von 2,3-dichlor-1-(c eins-sieben)-alkoxybenzolen
DD131088A5 (de)	1978-05-31	Verfahren zur herstellung von diaminoalkoxybenzolen
DD131089A1 (de)	1978-05-31	Verfahren zur herstellung von 2,5-dihydroxybenzensulfonaten
DD134640A5 (de)	1979-03-14	Verfahren zur herstellung von 1,1-dihalo-4-methyl-1,3-pentadien
DD128359A5 (de)	1977-11-16	Verfahren zur herstellung von 5,6-dehydropenicillinen
DD130416A4 (de)	1978-03-29	Verfahren zur herstellung von o-nitrobenzylbromid
DD132345A5 (de)	1978-09-20	Verfahren zur herstellung von 2-dialkoxyphosphinylimino-1,3-dithietanen
DD131025A5 (de)	1978-05-24	Verfahren zur herstellung von 2-dialkoxyphosphinyl-imino-1,3-dithietanen
DD129902A5 (de)	1978-02-15	Verfahren zur herstellung von 1-substituierten 2,2-diphenylcyclopropanderivaten