CY915A - Pyrrolo (3,4-b) pyrazine derivatives - Google Patents
Pyrrolo (3,4-b) pyrazine derivativesInfo
- Publication number
- CY915A CY915A CY915A CY91573A CY915A CY 915 A CY915 A CY 915A CY 915 A CY915 A CY 915A CY 91573 A CY91573 A CY 91573A CY 915 A CY915 A CY 915A
- Authority
- CY
- Cyprus
- Prior art keywords
- pyrrolo
- pyrazine derivatives
- pyrazine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7200505A FR2166314A1 (en) | 1972-01-07 | 1972-01-07 | 6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls |
FR7239731A FR2205318A2 (en) | 1972-11-09 | 1972-11-09 | 6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls |
Publications (1)
Publication Number | Publication Date |
---|---|
CY915A true CY915A (en) | 1977-12-23 |
Family
ID=26216824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY915A CY915A (en) | 1972-01-07 | 1973-01-05 | Pyrrolo (3,4-b) pyrazine derivatives |
Country Status (22)
Country | Link |
---|---|
US (1) | US3862149A (en) |
JP (3) | JPS523952B2 (en) |
AR (1) | AR195097A1 (en) |
AT (1) | AT323181B (en) |
AU (1) | AU466586B2 (en) |
BE (1) | BE793730A (en) |
CA (1) | CA991183A (en) |
CY (1) | CY915A (en) |
DD (1) | DD102698A5 (en) |
DE (1) | DE2300491C3 (en) |
DK (1) | DK139359B (en) |
FI (1) | FI54124C (en) |
GB (1) | GB1358680A (en) |
HK (1) | HK60077A (en) |
HU (1) | HU164821B (en) |
IE (1) | IE37056B1 (en) |
IL (1) | IL41232A (en) |
LU (1) | LU66800A1 (en) |
NL (1) | NL7217852A (en) |
NO (1) | NO136843C (en) |
OA (1) | OA04285A (en) |
SE (1) | SE398503B (en) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2322601A1 (en) * | 1975-09-04 | 1977-04-01 | Rhone Poulenc Ind | Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576) |
AR208414A1 (en) * | 1974-11-07 | 1976-12-27 | Rhone Poulenc Ind | PROCEDURE TO OBTAIN NEW DERIVATIVES OF ((ACIL-4PIPERAZINIL-1) CARBONYLOXI-5 PYRROLINONE-2) |
JPS5680585A (en) * | 1979-11-30 | 1981-07-01 | Toyoda Gosei Kk | High pressure hose |
JPS57144860A (en) * | 1981-03-04 | 1982-09-07 | Matsushita Electric Ind Co Ltd | Secondary side water pressure controller for water cooler |
DE3378763D1 (en) * | 1982-04-02 | 1989-02-02 | Takeda Chemical Industries Ltd | Condensed pyrrolinone derivatives, and their production |
JPS6169773A (en) * | 1984-09-14 | 1986-04-10 | Takeda Chem Ind Ltd | Isoindolinone derivative |
JPS6297400U (en) * | 1985-12-09 | 1987-06-20 | ||
FR2607504B1 (en) * | 1986-12-02 | 1989-01-27 | Rhone Poulenc Sante | NOVEL ISOINDOLINONE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
FR2671800B1 (en) * | 1991-01-17 | 1993-03-12 | Rhone Poulenc Rorer Sa | OPTICALLY ACTIVE 5H-PYRROLO [3,4-B] PYRAZINE DERIVATIVE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT. |
WO1993010788A1 (en) * | 1991-12-02 | 1993-06-10 | Sepracor, Inc. | Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone |
WO1993010787A1 (en) * | 1991-12-02 | 1993-06-10 | Sepracor, Inc. | Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (+) zopiclone |
US5786357A (en) | 1991-12-02 | 1998-07-28 | Sepracor Inc. | Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone |
EP1100508B8 (en) | 1998-06-09 | 2004-01-07 | Takeda Chemical Industries, Ltd. | Pharmaceutical combination comprising a tricyclic compound and at least one of zolpidem, zopiclone and brotizolam for treating or preventing sleep disorders |
US6339086B1 (en) * | 1999-05-14 | 2002-01-15 | Swpracor, Inc. | Methods of making and using N-desmethylzopiclone |
ES2203319B1 (en) * | 2002-04-03 | 2005-03-01 | Universidad De Oviedo | NEW OPTICALLY ACTIVE CARBONATES AS INTERMEDIATES IN THE SYNTHESIS OF (+) - ZOPICLONA. |
PT1691811E (en) | 2003-12-11 | 2014-10-30 | Sunovion Pharmaceuticals Inc | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
MX2008000250A (en) | 2005-07-06 | 2008-03-19 | Sepracor Inc | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2, 3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive dis |
WO2007005961A2 (en) * | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
US7476737B2 (en) * | 2005-09-05 | 2009-01-13 | Dr. Reddy's Laboratories Limited | Eszopiclone process |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) * | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
EP1984371A1 (en) * | 2006-02-03 | 2008-10-29 | Synthon B.V. | Zopiclone resolution using l-tartaric acid |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP1991212A1 (en) * | 2006-03-08 | 2008-11-19 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
US20080027223A1 (en) * | 2006-03-23 | 2008-01-31 | Teva Pharmaceutical Industries Ltd. | Polymorphs of eszopiclone malate |
EP2007768A2 (en) * | 2006-04-20 | 2008-12-31 | Teva Pharmaceutical Industries Ltd | Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone |
CN101058581B (en) * | 2006-04-21 | 2011-06-08 | 天津天士力集团有限公司 | Method of preparing eszopiclone intermediate 6-(5-chloro-2-pyridyl)-5,7-dioxy-6,7-dihydro-5H-pyrrolo[3,4-b] pyrazine |
MX2008014320A (en) * | 2006-05-09 | 2009-03-25 | Braincells Inc | 5 ht receptor mediated neurogenesis. |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
US20080015197A1 (en) * | 2006-06-26 | 2008-01-17 | Alex Mainfeld | Process for the preparatrion of zopiclone |
EP2068872A1 (en) * | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
EP2066355A2 (en) * | 2006-09-19 | 2009-06-10 | Braincells, Inc. | Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis |
US7786304B2 (en) * | 2006-11-06 | 2010-08-31 | Centaur Pharmaceutical Pvt. Ltd. | Process for the preparation of eszopiclone |
TW200846340A (en) * | 2007-01-31 | 2008-12-01 | Teva Pharma | Methods for preparing eszopiclone |
US20080305171A1 (en) * | 2007-06-07 | 2008-12-11 | Kristin Anne Arnold | Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there |
WO2009002552A1 (en) * | 2007-06-25 | 2008-12-31 | Teva Pharmaceutical Industries Ltd. | Racemization process of r-zopiclone |
EP2020403A1 (en) | 2007-08-02 | 2009-02-04 | Esteve Quimica, S.A. | Process for the resolution of zopiclone and intermediate compounds |
WO2009063486A2 (en) * | 2007-08-06 | 2009-05-22 | Usv Limited | Process for preparation of dextrorotatory isomer of 6-(5-chloro-pyrid-2-yi)-5-[(4-methyl -1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo [3,4-b] pyrazine (eszopiclone) |
JP2011506427A (en) * | 2007-12-11 | 2011-03-03 | シプラ・リミテッド | New process for the production of zopiclone and its polymorphs |
US8198277B2 (en) | 2007-12-19 | 2012-06-12 | Sunovion Pharmaceuticals Inc. | L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
WO2009085988A1 (en) * | 2007-12-19 | 2009-07-09 | Sepracor Inc. | Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7- dihydro-5h-pyrrolo[3,4-b]pyrazine |
CN100467471C (en) * | 2007-12-19 | 2009-03-11 | 齐鲁天和惠世制药有限公司 | Method for producing zopiclone |
US8212036B2 (en) * | 2007-12-19 | 2012-07-03 | Sunovion Pharmaceuticals Inc. | Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
US8268832B2 (en) * | 2007-12-19 | 2012-09-18 | Sunovion Pharmaceuticals Inc. | Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
US8269005B2 (en) * | 2007-12-19 | 2012-09-18 | Sunovion Pharmaceuticals Inc. | L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
WO2009085972A1 (en) * | 2007-12-19 | 2009-07-09 | Sepracor Inc. | Maleate, besylate, and l-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine |
US8198278B2 (en) * | 2007-12-19 | 2012-06-12 | Sunovion Pharmaceuticals Inc. | Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
AU2010208240A1 (en) | 2009-01-30 | 2011-09-22 | Sunovion Pharmaceuticals Inc | Coated tablets of 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5H-pyrrol o [3,4-b] pyrazine and methods for measuring effectiveness of coating |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
CN105399745A (en) * | 2015-12-17 | 2016-03-16 | 天津华津制药有限公司 | Preparation method of pyrazine hydroxyl pyrrolidone compound |
US11547706B2 (en) | 2016-06-08 | 2023-01-10 | President And Fellows Of Harvard College | Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, Rett syndrome, and Fragile X syndrome |
CN106220630B (en) * | 2016-07-23 | 2019-12-10 | 迪嘉药业集团有限公司 | Preparation method of N-substituted pyrrolo [3,4-B ] pyrazine-5, 7(6H) -diketone |
AU2019279858A1 (en) * | 2018-05-29 | 2020-11-26 | President And Fellows Of Harvard College | Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment |
-
1972
- 1972-12-14 OA OA54780A patent/OA04285A/en unknown
- 1972-12-28 DD DD167951A patent/DD102698A5/xx unknown
- 1972-12-29 NL NL7217852A patent/NL7217852A/xx unknown
- 1972-12-29 US US319876A patent/US3862149A/en not_active Expired - Lifetime
-
1973
- 1973-01-04 AU AU50754/73A patent/AU466586B2/en not_active Expired
- 1973-01-04 IE IE12/73A patent/IE37056B1/en unknown
- 1973-01-04 HU HURO691A patent/HU164821B/hu unknown
- 1973-01-04 IL IL41232A patent/IL41232A/en unknown
- 1973-01-05 JP JP48000069A patent/JPS523952B2/ja not_active Expired
- 1973-01-05 CA CA160,620A patent/CA991183A/en not_active Expired
- 1973-01-05 AT AT10073A patent/AT323181B/en active
- 1973-01-05 FI FI27/73A patent/FI54124C/en active
- 1973-01-05 AR AR246000A patent/AR195097A1/en active
- 1973-01-05 DK DK6973AA patent/DK139359B/en not_active IP Right Cessation
- 1973-01-05 CY CY915A patent/CY915A/en unknown
- 1973-01-05 DE DE2300491A patent/DE2300491C3/en not_active Expired
- 1973-01-05 NO NO62/73A patent/NO136843C/en unknown
- 1973-01-05 BE BE793730D patent/BE793730A/en active Protection Beyond IP Right Term
- 1973-01-05 LU LU66800A patent/LU66800A1/xx unknown
- 1973-01-05 SE SE7300159A patent/SE398503B/en active Protection Beyond IP Right Term
- 1973-01-05 GB GB79073A patent/GB1358680A/en not_active Expired
-
1976
- 1976-09-08 JP JP51106832A patent/JPS5248688A/en active Granted
- 1976-09-08 JP JP51106831A patent/JPS5248687A/en active Granted
-
1977
- 1977-12-01 HK HK600/77A patent/HK60077A/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU164821B (en) | 1974-04-11 |
DD102698A5 (en) | 1973-12-20 |
JPS5248688A (en) | 1977-04-18 |
CA991183A (en) | 1976-06-15 |
HK60077A (en) | 1977-12-09 |
JPS523952B2 (en) | 1977-01-31 |
IE37056B1 (en) | 1977-04-27 |
JPS4876892A (en) | 1973-10-16 |
DE2300491A1 (en) | 1973-07-19 |
AT323181B (en) | 1975-06-25 |
NL7217852A (en) | 1973-07-10 |
JPS535315B2 (en) | 1978-02-25 |
AU5075473A (en) | 1974-07-04 |
DE2300491B2 (en) | 1977-09-08 |
SE398503B (en) | 1977-12-27 |
IL41232A (en) | 1975-12-31 |
JPS5231358B2 (en) | 1977-08-13 |
FI54124C (en) | 1978-10-10 |
NO136843C (en) | 1977-11-16 |
DK139359B (en) | 1979-02-05 |
DE2300491C3 (en) | 1978-05-18 |
US3862149A (en) | 1975-01-21 |
GB1358680A (en) | 1974-07-03 |
LU66800A1 (en) | 1973-07-18 |
OA04285A (en) | 1979-12-31 |
FI54124B (en) | 1978-06-30 |
JPS5248687A (en) | 1977-04-18 |
IE37056L (en) | 1973-07-07 |
DK139359C (en) | 1979-07-09 |
IL41232A0 (en) | 1973-03-30 |
NO136843B (en) | 1977-08-08 |
AR195097A1 (en) | 1973-09-10 |
BE793730A (en) | 1973-07-05 |
AU466586B2 (en) | 1975-10-30 |
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