CY2080B1 - Hydrazones - Google Patents

Hydrazones

Info

Publication number
CY2080B1
CY2080B1 CY9802080A CY9802080A CY2080B1 CY 2080 B1 CY2080 B1 CY 2080B1 CY 9802080 A CY9802080 A CY 9802080A CY 9802080 A CY9802080 A CY 9802080A CY 2080 B1 CY2080 B1 CY 2080B1
Authority
CY
Cyprus
Prior art keywords
independently
hydrogen
another
lower alkyl
hydroxyl
Prior art date
Application number
CY9802080A
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY2080B1 publication Critical patent/CY2080B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/12—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Photolithography (AREA)
  • Wire Bonding (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of the formula I <IMAGE> in which A denotes a direct bond or -(CH2)n-, in which n represents 1, 2 or 3; X represents a -C(=Y)-NR6R7 radical; Y represents NR8, O or S; Z represents NR9, O or S; R1 and R2, independently of one another, denote hydrogen or one or more substituents other than hydrogen; the radicals R3, R4, R6, R8 and R9 independently of one another denote hydrogen or lower alkyl; and R5 and R7 independently of one another represent hydrogen, lower alkyl, hydroxyl, etherified or esterified hydroxyl or unsubstituted or mono- or disubstituted amino; tautomers thereof, and salts thereof. They have useful pharmaceutical properties and are particularly active against tumours. They are prepared in a manner known per se.
CY9802080A 1990-05-07 1998-10-16 Hydrazones CY2080B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH153890 1990-05-07

Publications (1)

Publication Number Publication Date
CY2080B1 true CY2080B1 (en) 1998-10-16

Family

ID=4212764

Family Applications (1)

Application Number Title Priority Date Filing Date
CY9802080A CY2080B1 (en) 1990-05-07 1998-10-16 Hydrazones

Country Status (26)

Country Link
EP (1) EP0456133B1 (en)
JP (1) JP2565602B2 (en)
KR (1) KR100203234B1 (en)
AT (1) ATE119878T1 (en)
AU (1) AU645799B2 (en)
CA (1) CA2041832C (en)
CY (1) CY2080B1 (en)
CZ (1) CZ279340B6 (en)
DE (1) DE59104930D1 (en)
DK (1) DK0456133T3 (en)
ES (1) ES2069768T3 (en)
FI (1) FI107916B (en)
GR (1) GR3015574T3 (en)
HK (1) HK1000919A1 (en)
HU (1) HU218221B (en)
ID (1) ID1040B (en)
IE (1) IE66157B1 (en)
IL (1) IL98008A (en)
NO (1) NO175097C (en)
NZ (1) NZ238033A (en)
PT (1) PT97571B (en)
RU (2) RU2057748C1 (en)
SA (1) SA91120283B1 (en)
SK (1) SK279136B6 (en)
TW (1) TW202428B (en)
ZA (1) ZA913391B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395855A (en) * 1990-05-07 1995-03-07 Ciba-Geigy Corporation Hydrazones
RU2081108C1 (en) * 1991-10-16 1997-06-10 Циба-Гейги АГ Additive salts of acids with the base and pharmaceutical composition showing antitumor activity
JPH06508375A (en) * 1992-04-03 1994-09-22 イノテラ Derivatives of indan-1,3-dione and indan-1,2,3-trione, processes for their preparation and their therapeutic uses
ES2103166B1 (en) * 1992-08-26 1998-04-01 Ciba Geigy Ag PROCEDURE FOR OBTAINING BICYCLE AMIDINOHYDRAZONES.
FR2710639B1 (en) * 1993-10-01 1995-12-22 Innothera Lab Sa Ketone indane derivatives, their process of obtaining, their therapeutic application.
AU4486796A (en) * 1995-01-26 1996-08-14 Novartis Ag Imidazole derivatives, their preparation and their use as sadenosylmethionine decarboxylase (=samdc) inhibitors
EP1408028A1 (en) * 2002-10-09 2004-04-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-adenosyl methionine decarboxylase inhibition for the treatment of a herpes simplex virus infection
EP1834669A1 (en) * 2006-03-15 2007-09-19 Heinrich-Pette-Institut Use of specific hydrazone compounds for the treatment of viral infections
EP1884515A1 (en) 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments
CN102627593A (en) * 2012-02-23 2012-08-08 河南师范大学 1,4-dihydroxy-2-formyl-9,10 anthraquinone thiosemicarbazone new compound with anticancer activity and preparation method thereof
JP6621815B2 (en) * 2014-07-02 2019-12-18 インフレクティス・バイオサイエンス O-alkyl-benzylideneguanidine derivatives and therapeutic uses for the treatment of disorders associated with the accumulation of misfolded proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7407469A (en) * 1974-06-01 1975-12-03 Akzo Nv NEW AMIDINOHYDRAZONE COMPOUNDS.
DE3416695A1 (en) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen AMIDINOHYDRAZONE OF TETRALINE, CHROMONE, THIOCHROMONE AND TRETRAHYDROQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
WO1990007495A1 (en) * 1988-12-27 1990-07-12 E.I. Du Pont De Nemours And Company Substituted semicarbazone arthropodicides

Also Published As

Publication number Publication date
SA91120283B1 (en) 2005-12-17
PT97571B (en) 1999-04-30
NO175097B (en) 1994-05-24
DE59104930D1 (en) 1995-04-20
RU2066311C1 (en) 1996-09-10
IL98008A0 (en) 1992-06-21
EP0456133A1 (en) 1991-11-13
NO175097C (en) 1994-08-31
ATE119878T1 (en) 1995-04-15
SK279136B6 (en) 1998-07-08
EP0456133B1 (en) 1995-03-15
DK0456133T3 (en) 1995-05-22
AU7596791A (en) 1991-11-07
IE911530A1 (en) 1991-11-20
PT97571A (en) 1992-01-31
KR910019964A (en) 1991-12-19
JP2565602B2 (en) 1996-12-18
HUT57183A (en) 1991-11-28
GR3015574T3 (en) 1995-06-30
AU645799B2 (en) 1994-01-27
JPH04225946A (en) 1992-08-14
CA2041832A1 (en) 1991-11-08
ID1040B (en) 1996-10-25
HU218221B (en) 2000-06-28
NO911777D0 (en) 1991-05-06
RU2057748C1 (en) 1996-04-10
NO911777L (en) 1991-11-08
NZ238033A (en) 1993-01-27
CS131791A3 (en) 1992-03-18
FI107916B (en) 2001-10-31
FI912164A (en) 1991-11-08
IL98008A (en) 1996-08-04
ES2069768T3 (en) 1995-05-16
FI912164A0 (en) 1991-05-03
CZ279340B6 (en) 1995-04-12
TW202428B (en) 1993-03-21
ZA913391B (en) 1991-12-24
KR100203234B1 (en) 1999-06-15
IE66157B1 (en) 1995-12-13
CA2041832C (en) 2002-09-17
HK1000919A1 (en) 1998-05-08

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