CY1126082T1 - Τροποποιητες toy trex1 - Google Patents
Τροποποιητες toy trex1Info
- Publication number
- CY1126082T1 CY1126082T1 CY20231100328T CY231100328T CY1126082T1 CY 1126082 T1 CY1126082 T1 CY 1126082T1 CY 20231100328 T CY20231100328 T CY 20231100328T CY 231100328 T CY231100328 T CY 231100328T CY 1126082 T1 CY1126082 T1 CY 1126082T1
- Authority
- CY
- Cyprus
- Prior art keywords
- trex1
- modifiers
- compositions
- compounds
- variety
- Prior art date
Links
- 101000830956 Homo sapiens Three-prime repair exonuclease 1 Proteins 0.000 title abstract 2
- 102100024855 Three-prime repair exonuclease 1 Human genes 0.000 title abstract 2
- 239000003607 modifier Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Παρέχονται ενώσεις του Τύπου (Ι): και φαρμακευτικά αποδεκτά άλατα και συνθέσεις αυτών, που είναι χρήσιμα στη θεραπεία μιας ποικιλίας παθήσεων που σχετίζονται με TREX1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862776031P | 2018-12-06 | 2018-12-06 | |
| PCT/US2019/064825 WO2020118133A1 (en) | 2018-12-06 | 2019-12-06 | Modulators of trex1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1126082T1 true CY1126082T1 (el) | 2023-11-15 |
Family
ID=69024702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20231100328T CY1126082T1 (el) | 2018-12-06 | 2023-07-11 | Τροποποιητες toy trex1 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20220017502A1 (el) |
| EP (1) | EP3891145B1 (el) |
| JP (1) | JP7471297B2 (el) |
| KR (1) | KR20210102310A (el) |
| CN (1) | CN113396149A (el) |
| AU (1) | AU2019395005A1 (el) |
| BR (1) | BR112021010919A2 (el) |
| CA (1) | CA3122093A1 (el) |
| CL (1) | CL2021001461A1 (el) |
| CO (1) | CO2021008816A2 (el) |
| CY (1) | CY1126082T1 (el) |
| DK (1) | DK3891145T3 (el) |
| EA (1) | EA202191519A1 (el) |
| ES (1) | ES2949999T3 (el) |
| FI (1) | FI3891145T3 (el) |
| HR (1) | HRP20230701T1 (el) |
| HU (1) | HUE062866T2 (el) |
| IL (1) | IL283672A (el) |
| LT (1) | LT3891145T (el) |
| MA (1) | MA54386B1 (el) |
| MX (1) | MX2021006695A (el) |
| PE (1) | PE20212070A1 (el) |
| PL (1) | PL3891145T3 (el) |
| PT (1) | PT3891145T (el) |
| RS (1) | RS64336B1 (el) |
| SG (1) | SG11202105772SA (el) |
| SI (1) | SI3891145T1 (el) |
| WO (1) | WO2020118133A1 (el) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021016317A1 (en) * | 2019-07-23 | 2021-01-28 | Constellation Pharmaceuticals, Inc. | Modulators of trex1 |
| WO2022031640A1 (en) * | 2020-08-04 | 2022-02-10 | Wake Forest University Health Sciences | Trex1 inhibitors and uses thereof |
| TW202309019A (zh) * | 2021-04-26 | 2023-03-01 | 美商星座製藥公司 | Trex1之調節劑 |
| AU2022269596A1 (en) * | 2021-05-05 | 2023-11-16 | Constellation Pharmaceuticals, Inc. | Modulators of trex1 |
| WO2023137030A1 (en) * | 2022-01-11 | 2023-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of trex1 |
| WO2023156386A2 (en) * | 2022-02-16 | 2023-08-24 | Duke Street Bio Limited | Pharmaceutical compound |
| WO2023250439A1 (en) * | 2022-06-22 | 2023-12-28 | Tempest Therapeutics, Inc. | Trex1 inhibitors and uses thereof |
| WO2024061300A1 (en) * | 2022-09-22 | 2024-03-28 | Insilico Medicine Ip Limited | Inhibitors of trex1 and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI409070B (zh) * | 2005-11-04 | 2013-09-21 | Hydra Biosciences Inc | 用於調節ｔｒｐｖ３功能之化合物 |
| WO2009106561A1 (en) * | 2008-02-27 | 2009-09-03 | Biovitrum Ab (Publ) | Pyrazine compounds for treating gpr119 related disorders |
| EP2300440B1 (en) * | 2008-06-02 | 2013-02-27 | Janssen Pharmaceutica, N.V. | 3,4-dihydropyrimidine trpa1 antagonists |
| EP2482823A2 (en) * | 2009-10-02 | 2012-08-08 | Sanofi | Use of compounds with sglt-1/sglt-2 inhibitor activity for producing medicaments for treatment of bone diseases |
| WO2011107494A1 (de) * | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| TW201242966A (en) * | 2011-03-17 | 2012-11-01 | Bristol Myers Squibb Co | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases |
-
2019
- 2019-12-06 HR HRP20230701TT patent/HRP20230701T1/hr unknown
- 2019-12-06 PE PE2021000822A patent/PE20212070A1/es unknown
- 2019-12-06 MX MX2021006695A patent/MX2021006695A/es unknown
- 2019-12-06 AU AU2019395005A patent/AU2019395005A1/en active Pending
- 2019-12-06 PL PL19828476.2T patent/PL3891145T3/pl unknown
- 2019-12-06 FI FIEP19828476.2T patent/FI3891145T3/fi active
- 2019-12-06 PT PT198284762T patent/PT3891145T/pt unknown
- 2019-12-06 WO PCT/US2019/064825 patent/WO2020118133A1/en unknown
- 2019-12-06 BR BR112021010919-6A patent/BR112021010919A2/pt unknown
- 2019-12-06 MA MA54386A patent/MA54386B1/fr unknown
- 2019-12-06 HU HUE19828476A patent/HUE062866T2/hu unknown
- 2019-12-06 US US17/311,526 patent/US20220017502A1/en active Pending
- 2019-12-06 EP EP19828476.2A patent/EP3891145B1/en active Active
- 2019-12-06 SI SI201930577T patent/SI3891145T1/sl unknown
- 2019-12-06 SG SG11202105772SA patent/SG11202105772SA/en unknown
- 2019-12-06 CA CA3122093A patent/CA3122093A1/en active Pending
- 2019-12-06 DK DK19828476.2T patent/DK3891145T3/da active
- 2019-12-06 JP JP2021531909A patent/JP7471297B2/ja active Active
- 2019-12-06 LT LTEPPCT/US2019/064825T patent/LT3891145T/lt unknown
- 2019-12-06 EA EA202191519A patent/EA202191519A1/ru unknown
- 2019-12-06 KR KR1020217020940A patent/KR20210102310A/ko unknown
- 2019-12-06 RS RS20230531A patent/RS64336B1/sr unknown
- 2019-12-06 CN CN201980091375.4A patent/CN113396149A/zh active Pending
- 2019-12-06 ES ES19828476T patent/ES2949999T3/es active Active
-
2021
- 2021-06-03 IL IL283672A patent/IL283672A/en unknown
- 2021-06-03 CL CL2021001461A patent/CL2021001461A1/es unknown
- 2021-07-02 CO CONC2021/0008816A patent/CO2021008816A2/es unknown
-
2023
- 2023-07-11 CY CY20231100328T patent/CY1126082T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL283672A (en) | 2021-07-29 |
| JP2022510431A (ja) | 2022-01-26 |
| DK3891145T3 (da) | 2023-07-24 |
| WO2020118133A1 (en) | 2020-06-11 |
| EA202191519A1 (ru) | 2021-10-27 |
| LT3891145T (lt) | 2023-08-10 |
| MX2021006695A (es) | 2021-09-23 |
| KR20210102310A (ko) | 2021-08-19 |
| US20220017502A1 (en) | 2022-01-20 |
| EP3891145A1 (en) | 2021-10-13 |
| PL3891145T3 (pl) | 2023-08-07 |
| PE20212070A1 (es) | 2021-10-26 |
| HRP20230701T1 (hr) | 2023-10-13 |
| JP7471297B2 (ja) | 2024-04-19 |
| FI3891145T3 (fi) | 2023-07-18 |
| SI3891145T1 (sl) | 2023-11-30 |
| CA3122093A1 (en) | 2020-06-11 |
| EP3891145B1 (en) | 2023-04-12 |
| CO2021008816A2 (es) | 2021-07-19 |
| CN113396149A (zh) | 2021-09-14 |
| AU2019395005A1 (en) | 2021-06-17 |
| ES2949999T3 (es) | 2023-10-04 |
| MA54386B1 (fr) | 2023-08-31 |
| RS64336B1 (sr) | 2023-08-31 |
| CL2021001461A1 (es) | 2021-12-17 |
| BR112021010919A2 (pt) | 2021-08-24 |
| HUE062866T2 (hu) | 2023-12-28 |
| PT3891145T (pt) | 2023-07-18 |
| MA54386A (fr) | 2021-10-13 |
| SG11202105772SA (en) | 2021-06-29 |
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