CY1124826T1 - Υποδοχεις τ-κυτταρων και ανοσοθεραπεια με τη χρηση των ιδιων - Google Patents
Υποδοχεις τ-κυτταρων και ανοσοθεραπεια με τη χρηση των ιδιωνInfo
- Publication number
- CY1124826T1 CY1124826T1 CY20211100944T CY211100944T CY1124826T1 CY 1124826 T1 CY1124826 T1 CY 1124826T1 CY 20211100944 T CY20211100944 T CY 20211100944T CY 211100944 T CY211100944 T CY 211100944T CY 1124826 T1 CY1124826 T1 CY 1124826T1
- Authority
- CY
- Cyprus
- Prior art keywords
- col6a3
- antigen
- antigen recognition
- tcr
- nucleic acids
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title abstract 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title abstract 4
- 238000009169 immunotherapy Methods 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 6
- 108091007433 antigens Proteins 0.000 abstract 6
- 102000036639 antigens Human genes 0.000 abstract 6
- 102100024338 Collagen alpha-3(VI) chain Human genes 0.000 abstract 4
- 101000909506 Homo sapiens Collagen alpha-3(VI) chain Proteins 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/464488—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
Abstract
Η παρούσα εφεύρεση αφορά κατασκευές αναγνώρισης αντιγόνων έναντι αντιγόνων COL6A3. Η εφεύρεση ειδικότερα παρέχει καινοτόμα μόρια που βασίζονται σε υποδοχείς Τ-κυττάρων (Τ cell receptor, TCR), τα οποία είναι επιλεκτικά και ειδικά για το αντιγόνο COL6A3 που εκφράζεται από τον όγκο. Ο TCR της εφεύρεσης και τα θραύσματα πρόσδεσης αντιγόνων COL6A3 που προέρχονται από αυτό, είναι χρήσιμα για τη διάγνωση, τη θεραπεία και την πρόληψη καρκινικών νόσων που εκφράζουν COL6A3. Περαιτέρω παρέχονται νουκλεϊκά οξέα που κωδικοποιούν τις κατασκευές αναγνώρισης αντιγόνων της εφεύρεσης, φορείς που περιλαμβάνουν αυτά τα νουκλεϊκά οξέα, ανασυνδυασμένα κύτταρα που εκφράζουν τις κατασκευές αναγνώρισης αντιγόνων και φαρμακευτικές συνθέσεις που περιλαμβάνουν τα συστατικά της εφεύρεσης.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662376059P | 2016-08-17 | 2016-08-17 | |
DE102016115246.3A DE102016115246C5 (de) | 2016-08-17 | 2016-08-17 | Neue t-zellrezeptoren und deren verwendung in immuntherapie |
US201662376632P | 2016-08-18 | 2016-08-18 | |
PCT/EP2017/066630 WO2018033291A1 (en) | 2016-08-17 | 2017-07-04 | T cell receptors and immune therapy using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124826T1 true CY1124826T1 (el) | 2022-11-25 |
Family
ID=66635579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100944T CY1124826T1 (el) | 2016-08-17 | 2021-11-02 | Υποδοχεις τ-κυτταρων και ανοσοθεραπεια με τη χρηση των ιδιων |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP3978520A1 (el) |
KR (2) | KR102381854B1 (el) |
CO (1) | CO2019002229A2 (el) |
CY (1) | CY1124826T1 (el) |
ES (1) | ES2897921T3 (el) |
HR (1) | HRP20211677T1 (el) |
HU (1) | HUE057094T2 (el) |
IL (1) | IL264855B2 (el) |
MD (1) | MD3500593T2 (el) |
MY (1) | MY195101A (el) |
NZ (1) | NZ750479A (el) |
PL (1) | PL3500593T3 (el) |
PT (1) | PT3500593T (el) |
SI (1) | SI3500593T1 (el) |
TW (1) | TWI790162B (el) |
UA (1) | UA127162C2 (el) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0546073T3 (da) | 1990-08-29 | 1998-02-02 | Genpharm Int | Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
EP1257289A1 (en) | 2000-02-08 | 2002-11-20 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
GB0911566D0 (en) | 2009-07-03 | 2009-08-12 | Immunocore Ltd | T cell receptors |
US9228007B1 (en) * | 2010-03-11 | 2016-01-05 | The Regents Of The University Of California | Recombinant human progenitor cells, engineered human thymocytes, and engineered human T cells |
GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
TWI714869B (zh) * | 2013-08-05 | 2021-01-01 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物 |
EP3169773B1 (en) | 2014-07-15 | 2023-07-12 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
-
2017
- 2017-07-04 MD MDE20190706T patent/MD3500593T2/ro unknown
- 2017-07-04 NZ NZ750479A patent/NZ750479A/en not_active IP Right Cessation
- 2017-07-04 KR KR1020197006315A patent/KR102381854B1/ko active IP Right Grant
- 2017-07-04 HR HRP20211677TT patent/HRP20211677T1/hr unknown
- 2017-07-04 SI SI201730961T patent/SI3500593T1/sl unknown
- 2017-07-04 IL IL264855A patent/IL264855B2/en unknown
- 2017-07-04 KR KR1020227010365A patent/KR20220044870A/ko active IP Right Grant
- 2017-07-04 HU HUE17739220A patent/HUE057094T2/hu unknown
- 2017-07-04 PT PT177392206T patent/PT3500593T/pt unknown
- 2017-07-04 UA UAA201900959A patent/UA127162C2/uk unknown
- 2017-07-04 ES ES17739220T patent/ES2897921T3/es active Active
- 2017-07-04 PL PL17739220T patent/PL3500593T3/pl unknown
- 2017-07-04 MY MYPI2019000499A patent/MY195101A/en unknown
- 2017-07-04 EP EP21192880.9A patent/EP3978520A1/en active Pending
- 2017-08-11 TW TW111115333A patent/TWI790162B/zh active
-
2019
- 2019-03-11 CO CONC2019/0002229A patent/CO2019002229A2/es unknown
-
2021
- 2021-11-02 CY CY20211100944T patent/CY1124826T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL3500593T3 (pl) | 2022-01-03 |
SI3500593T1 (sl) | 2021-12-31 |
TWI790162B (zh) | 2023-01-11 |
ES2897921T3 (es) | 2022-03-03 |
HRP20211677T1 (hr) | 2022-02-18 |
KR102381854B1 (ko) | 2022-04-04 |
PT3500593T (pt) | 2021-11-04 |
IL264855B2 (en) | 2023-09-01 |
MY195101A (en) | 2023-01-10 |
UA127162C2 (uk) | 2023-05-24 |
TW202233690A (zh) | 2022-09-01 |
IL264855B1 (en) | 2023-05-01 |
HUE057094T2 (hu) | 2022-04-28 |
KR20220044870A (ko) | 2022-04-11 |
KR20190039182A (ko) | 2019-04-10 |
MD3500593T2 (ro) | 2021-12-31 |
CO2019002229A2 (es) | 2019-05-31 |
IL264855A (el) | 2019-03-31 |
EP3978520A1 (en) | 2022-04-06 |
NZ750479A (en) | 2021-12-24 |
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