CY1121158T1 - Αντισωμα ικανο να αναγνωριζει ειδικα υποδοχεα τρανσφερρινης - Google Patents

Αντισωμα ικανο να αναγνωριζει ειδικα υποδοχεα τρανσφερρινης

Info

Publication number
CY1121158T1
CY1121158T1 CY20181101031T CY181101031T CY1121158T1 CY 1121158 T1 CY1121158 T1 CY 1121158T1 CY 20181101031 T CY20181101031 T CY 20181101031T CY 181101031 T CY181101031 T CY 181101031T CY 1121158 T1 CY1121158 T1 CY 1121158T1
Authority
CY
Cyprus
Prior art keywords
antibody
complementarity
recognize specific
transferrin receptors
specific transferrin
Prior art date
Application number
CY20181101031T
Other languages
English (en)
Inventor
Yoshikazu Kurosawa
Kazuhiro Morishita
Lilin Zhang
Gene Kurosawa
Katsuyuki Mitomo
Yukio Sudo
Fumiko Nomura
Yoshinori Ukai
Original Assignee
Perseus Proteomics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perseus Proteomics Inc. filed Critical Perseus Proteomics Inc.
Publication of CY1121158T1 publication Critical patent/CY1121158T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει ένα αντίσωμα, στο οποίο η πρώτη καθοριστική της συμπληρωματικότητας περιοχή της βαριάς αλυσίδας (VH CDR1), η δεύτερη καθοριστική της συμπληρωματικότητας περιοχή της βαριάς αλυσίδας (VH CDR2), και η τρίτη καθοριστική της συμπληρωματικότητας περιοχή της βαριάς αλυσίδας (VH CDR3) φαίνονται στις SEQ ID NOs: 1, 2 και 7, αντίστοιχα, και η πρώτη καθοριστική της συμπληρωματικότητας περιοχή της ελαφριάς αλυσίδας (VL CDR1), η δεύτερη καθοριστική της συμπληρωματικότητας περιοχή της ελαφριάς αλυσίδας (VL CDR2), και η τρίτη καθοριστική της συμπληρωματικότητας περιοχή της ελαφριάς αλυσίδας (VL CDR3) φαίνονται στις SEQ ID NOs: 4, 5 και 6, αντίστοιχα.
CY20181101031T 2012-11-08 2018-10-05 Αντισωμα ικανο να αναγνωριζει ειδικα υποδοχεα τρανσφερρινης CY1121158T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012246215 2012-11-08
PCT/JP2013/080249 WO2014073641A1 (ja) 2012-11-08 2013-11-08 トランスフェリン受容体を特異的に認識できる抗体

Publications (1)

Publication Number Publication Date
CY1121158T1 true CY1121158T1 (el) 2020-05-29

Family

ID=50684735

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181101031T CY1121158T1 (el) 2012-11-08 2018-10-05 Αντισωμα ικανο να αναγνωριζει ειδικα υποδοχεα τρανσφερρινης

Country Status (18)

Country Link
US (1) US9593165B2 (el)
EP (1) EP2918603B1 (el)
JP (1) JP6212497B2 (el)
CN (1) CN104797600A (el)
AU (1) AU2013342432A1 (el)
CA (1) CA2893794C (el)
CY (1) CY1121158T1 (el)
DK (1) DK2918603T3 (el)
ES (1) ES2689782T3 (el)
HK (1) HK1213582A1 (el)
HR (1) HRP20181453T1 (el)
HU (1) HUE039920T2 (el)
LT (1) LT2918603T (el)
PL (1) PL2918603T3 (el)
PT (1) PT2918603T (el)
RS (1) RS57696B1 (el)
SI (1) SI2918603T1 (el)
WO (1) WO2014073641A1 (el)

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SI3292149T1 (sl) 2015-05-04 2022-04-29 Cytomx Therapeutics, Inc. Aktivacijska protitelesa anti-CD71 in njihovi načini uporabe
US11230605B2 (en) * 2015-07-22 2022-01-25 Inatherys Anti-TfR antibodies and their use in treating proliferative and inflammatory disorders
US20220332838A1 (en) 2018-11-20 2022-10-20 Perseus Proteomics Inc. Agent for inhibiting iron uptake into cells
JPWO2021045184A1 (el) 2019-09-04 2021-03-11
CN114502781A (zh) * 2019-09-20 2022-05-13 纳维再生科技股份有限公司 个人化癌症免疫治疗
JPWO2021107082A1 (el) * 2019-11-27 2021-06-03
WO2022075439A1 (ja) 2020-10-08 2022-04-14 国立大学法人東海国立大学機構 抗トランスフェリンレセプター抗体の薬効又は感受性の判定方法
WO2023027164A1 (ja) 2021-08-26 2023-03-02 株式会社ペルセウスプロテオミクス Ｒｏｓ（活性酸素種）産生増強剤
EP4396231A1 (en) 2021-09-01 2024-07-10 Biogen MA Inc. Anti-transferrin receptor antibodies and uses thereof
WO2023204181A1 (ja) * 2022-04-19 2023-10-26 学校法人東海大学 Ｎｋ細胞腫瘍の治療剤

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Also Published As

Publication number Publication date
EP2918603A1 (en) 2015-09-16
DK2918603T3 (en) 2018-10-15
CA2893794A1 (en) 2014-05-15
US9593165B2 (en) 2017-03-14
RS57696B1 (sr) 2018-12-31
AU2013342432A1 (en) 2015-07-02
JP6212497B2 (ja) 2017-10-11
HRP20181453T1 (hr) 2018-12-14
US20150291697A1 (en) 2015-10-15
SI2918603T1 (sl) 2018-12-31
PT2918603T (pt) 2018-10-30
EP2918603A4 (en) 2016-06-29
HK1213582A1 (zh) 2016-07-08
CN104797600A (zh) 2015-07-22
EP2918603B1 (en) 2018-08-29
LT2918603T (lt) 2018-10-25
WO2014073641A1 (ja) 2014-05-15
JPWO2014073641A1 (ja) 2016-09-08
PL2918603T3 (pl) 2019-01-31
CA2893794C (en) 2021-11-09
ES2689782T3 (es) 2018-11-15
HUE039920T2 (hu) 2019-02-28

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