CY1119232T1 - A DIFFERENYLSULFONAMIDE COMPONENT OF THE ENDOTHILINE AND ANGIOTENSIN II RECEPTOR COMPONENT FOR TREATMENT OF SPIRAMATOLOGY - Google Patents

A DIFFERENYLSULFONAMIDE COMPONENT OF THE ENDOTHILINE AND ANGIOTENSIN II RECEPTOR COMPONENT FOR TREATMENT OF SPIRAMATOLOGY

Info

Publication number
CY1119232T1
CY1119232T1 CY20171100811T CY171100811T CY1119232T1 CY 1119232 T1 CY1119232 T1 CY 1119232T1 CY 20171100811 T CY20171100811 T CY 20171100811T CY 171100811 T CY171100811 T CY 171100811T CY 1119232 T1 CY1119232 T1 CY 1119232T1
Authority
CY
Cyprus
Prior art keywords
component
treatment
angiotensin
spiramatology
endothiline
Prior art date
Application number
CY20171100811T
Other languages
Greek (el)
Inventor
Jinkun Zhang
Zofia E Dziewanowska
Rene Belder
Ian Henderson
Joseph B Bogardus
Zhaoying Zhang
Original Assignee
Ligand Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42828649&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1119232(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ligand Pharmaceuticals filed Critical Ligand Pharmaceuticals
Publication of CY1119232T1 publication Critical patent/CY1119232T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)

Abstract

Αποκαλύπτονται μέθοδοι χορήγησης και φαρμακευτικές συνθέσεις μιας ένωσης διφαινυλο σουλφοναμιδίου, η οποία είναι ένας διπλός ανταγωνιστής του υποδοχέα της αγγειοτενσίνης και της ενδοθηλίνης, για τη θεραπεία ασθενειών.Methods of administration and pharmaceutical compositions of a diphenyl sulfonamide compound, which is a dual antagonist of angiotensin receptor and endothelin, for the treatment of diseases are disclosed.

CY20171100811T 2009-03-31 2017-07-28 A DIFFERENYLSULFONAMIDE COMPONENT OF THE ENDOTHILINE AND ANGIOTENSIN II RECEPTOR COMPONENT FOR TREATMENT OF SPIRAMATOLOGY CY1119232T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16544709P 2009-03-31 2009-03-31
US16541909P 2009-03-31 2009-03-31
EP10759268A EP2413930A4 (en) 2009-03-31 2010-03-29 Oral formulations of diphenylsulfonamide endothelin and angiotensin ii receptor agonists to treat elevated blood pressure and diabetic nephropathy

Publications (1)

Publication Number Publication Date
CY1119232T1 true CY1119232T1 (en) 2018-02-14

Family

ID=42828649

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20171100811T CY1119232T1 (en) 2009-03-31 2017-07-28 A DIFFERENYLSULFONAMIDE COMPONENT OF THE ENDOTHILINE AND ANGIOTENSIN II RECEPTOR COMPONENT FOR TREATMENT OF SPIRAMATOLOGY
CY20201100424T CY1123017T1 (en) 2009-03-31 2020-05-08 A BIPHENYLSULFONAMIDE ANTAGONIST OF ENDOTHILIN AND ANGIOTENSIN II RECEPTOR FOR THE TREATMENT OF GLIMOSCLEROSIS AND IGA-INDUCED Nephropathy

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20201100424T CY1123017T1 (en) 2009-03-31 2020-05-08 A BIPHENYLSULFONAMIDE ANTAGONIST OF ENDOTHILIN AND ANGIOTENSIN II RECEPTOR FOR THE TREATMENT OF GLIMOSCLEROSIS AND IGA-INDUCED Nephropathy

Country Status (15)

Country Link
US (4) US20140142149A1 (en)
EP (4) EP2732818B1 (en)
JP (3) JP2012522058A (en)
CN (2) CN104107176A (en)
CY (2) CY1119232T1 (en)
DK (2) DK2732818T3 (en)
ES (2) ES2636087T3 (en)
HK (1) HK1244687A1 (en)
HR (2) HRP20171197T1 (en)
HU (2) HUE033494T2 (en)
LT (2) LT2732818T (en)
PL (2) PL2732818T3 (en)
PT (2) PT3222277T (en)
SI (2) SI3222277T1 (en)
WO (1) WO2010114801A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012012750A1 (en) 2010-07-23 2012-01-26 Trustees Of Boston University ANTI-DEsupR INHIBITORS AS THERAPEUTICS FOR INHIBITION OF PATHOLOGICAL ANGIOGENESIS AND TUMOR CELL INVASIVENESS AND FOR MOLECULAR IMAGING AND TARGETED DELIVERY
AR083417A1 (en) 2010-10-14 2013-02-21 Novartis Ag PHARMACEUTICAL COMPOSITIONS CONTAINING AN INHIBITOR DGAT1
US20130022551A1 (en) * 2011-07-22 2013-01-24 Trustees Of Boston University DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS
ES2835722T3 (en) * 2011-10-17 2021-06-23 Tersera Therapeutics Llc Solid Dosage Forms of (S) -ethyl 2-amino-3- (4- (2-amino-6 - ((R) -1- (4-chloro-2- (3-methyl-1H-pyrazole-1 -yl) phenyl) -2,2,2-trifluoroethoxy) pyrimidin-4-yl) phenyl) propanoate
US9012450B2 (en) 2011-12-28 2015-04-21 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
PL2797416T3 (en) 2011-12-28 2017-12-29 Global Blood Therapeutics, Inc. Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
EP2875359A4 (en) 2012-03-30 2015-08-19 Charles R Drew University Of Medicine And Science Compositions and methods for treating or preventing metabolic syndrome disorders
US20140271923A1 (en) 2013-03-14 2014-09-18 Christopher Brian Reid Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
MY191087A (en) 2013-03-15 2022-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
KR20190041548A (en) 2013-03-15 2019-04-22 글로벌 블러드 테라퓨틱스, 인크. Compounds and uses thereof for the modulation of hemoglobin
EA201591426A1 (en) 2013-03-15 2016-02-29 Глобал Блад Терапьютикс, Инк. COMPOUNDS AND THEIR APPLICATIONS FOR MODULATION OF HEMOGLOBIN
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
SG10201910773VA (en) 2013-06-13 2020-01-30 Akebia Therapeutics Inc Compositions and methods for treating anemia
EA201992707A1 (en) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. COMPOUNDS AND THEIR APPLICATIONS FOR HEMOGLOBIN MODULATION
WO2015119848A1 (en) 2014-02-05 2015-08-13 Merck Sharp & Dohme Corp. Tablet formulation for cgrp-active compounds
BR112015032160B1 (en) 2014-02-07 2021-11-30 Global Blood Therapeutics, Inc CRYSTALLINE ANSOLVATE OF COMPOUND, COMPOSITION AND PHARMACEUTICAL COMPOSITION
CN104367576A (en) * 2014-10-24 2015-02-25 南方医科大学南方医院 Use of compound ICG-001 in preparation of medicine for treating hypertension
AU2016311265B2 (en) 2015-08-24 2023-03-16 Trustees Of Boston University Anti-DEspR monoclonal antibody targeted therapy and imaging for cancer and stroke
MA43373A (en) 2015-12-04 2018-10-10 Global Blood Therapeutics Inc DOSAGE REGIMES FOR 2-HYDROXY-6 - ((2- (1-ISOPROPYL-1H-PYRAZOL-5-YL) PYRIDIN-3-YL) METHOXY) BENZALDEHYDE
TWI752307B (en) 2016-05-12 2022-01-11 美商全球血液治療公司 Novel compound and method of preparing compound
TW202332423A (en) * 2016-10-12 2023-08-16 美商全球血液治療公司 Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
JP2019530713A (en) * 2016-10-13 2019-10-24 レトロフィン， インコーポレイテッド Biphenylsulfonamide compounds for treating kidney diseases or disorders
US11166939B2 (en) * 2017-04-25 2021-11-09 Otsuka Pharmaceutical Co. Ltd Lisinopril compositions with an ingestible event marker
JP7404230B2 (en) 2017-09-18 2023-12-25 トラスティーズ オブ ボストン ユニバーシティ Methods for treating netosis and neutrophil activation
US10953107B2 (en) 2018-06-15 2021-03-23 Trustees Of Boston University Polypeptide compositions and methods for site-specific targeting of therapeutic agents
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin
MA53817A (en) 2018-10-04 2021-08-11 Travere Therapeutics Inc BIPHENYL-SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF TYPE IV COLLAGEN DISEASES
CN114126712A (en) * 2018-12-21 2022-03-01 特拉维尔治疗公司 Amorphous spartan (SPARSENTAN) compositions
AU2019412533A1 (en) * 2018-12-28 2021-07-15 Gnt Pharma Co., Ltd. Compositions and methods for treating neurodegenerative disorders
WO2020166710A1 (en) 2019-02-15 2020-08-20 国立大学法人東北大学 1, 3-dioxolan derivative
WO2022081792A1 (en) 2020-10-15 2022-04-21 Trustees Of Boston University Antibody therapies and methods for treating coronavirus infection
CA3206184A1 (en) 2020-12-22 2022-06-30 Allergan Pharmaceuticals International Limited Treatment of migraine
WO2022246200A1 (en) 2021-05-21 2022-11-24 Travere Therapeutics, Inc. Methods of treating kidney diseases or disorders
JP7458085B2 (en) 2021-07-28 2024-03-29 株式会社三協 Disintegrant for tablets and tablets using the same
AU2022334402A1 (en) 2021-08-26 2024-02-22 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Aromatic ring-containing biological antagonist, and preparation method therefor and use thereof
TW202340183A (en) * 2021-12-28 2023-10-16 日商亞克醫藥股份有限公司 Compound, angiotensin ii type 1 receptor antagonist and pharmaceutical composition
WO2024073672A1 (en) 2022-09-30 2024-04-04 Travere Therapeutics, Inc. Combination therapy with sparsentan and a sglt2 inhibitor for treating kidney diseases or disorders
CN115636799A (en) * 2022-11-04 2023-01-24 苏州莱安医药化学技术有限公司 Preparation method of double-effect endothelin-angiotensin receptor antagonist

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US793898A (en) 1905-03-01 1905-07-04 William Mcintosh Locomotive-tender frame.
US1395298A (en) 1919-11-20 1921-11-01 Walter H Richman Container
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
TR200100149T2 (en) * 1998-07-06 2001-10-22 Bristol-Myers Squibb Company Biphenyl-sulfonamides as dual angiotensin endothelin receptor antagonists
US6638937B2 (en) * 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
US6380184B1 (en) 1998-10-28 2002-04-30 Bristol-Myers Squibb Co. Benzoazepines and analogs thereof useful as growth hormone secretagogues
US6297233B1 (en) 1999-02-09 2001-10-02 Bristol-Myers Squibb Company Lactam inhibitors of FXa and method
US6518292B1 (en) 1999-03-12 2003-02-11 Bristol-Myers Squibb Co. Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
US7390824B1 (en) 1999-09-07 2008-06-24 Bristol-Myers Squibb Company Method for treating diabetes employing an aP2 inhibitor and combination
US6586438B2 (en) 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
ES2273739T3 (en) * 1999-12-15 2007-05-16 Bristol-Myers Squibb Company BIFENYL SULFONAMIDS AS DOUBLE ANTAGONISTS OF ENDOTHELINE AND ANGIOTENSIN RECEPTORS.

Also Published As

Publication number Publication date
PL3222277T3 (en) 2020-08-24
EP3708163A1 (en) 2020-09-16
US20170354646A1 (en) 2017-12-14
JP2015052001A (en) 2015-03-19
EP2413930A1 (en) 2012-02-08
US20140142149A1 (en) 2014-05-22
HRP20171197T1 (en) 2017-10-20
US20150164865A1 (en) 2015-06-18
US9993461B2 (en) 2018-06-12
EP3222277B1 (en) 2020-02-26
EP2732818B1 (en) 2017-05-03
EP2413930A4 (en) 2012-09-26
LT2732818T (en) 2017-09-25
US20180344705A1 (en) 2018-12-06
LT3222277T (en) 2020-05-11
JP2012522058A (en) 2012-09-20
DK3222277T3 (en) 2020-05-11
EP3222277A1 (en) 2017-09-27
PT2732818T (en) 2017-08-07
US9662312B2 (en) 2017-05-30
PT3222277T (en) 2020-07-08
ES2811342T3 (en) 2021-03-11
WO2010114801A1 (en) 2010-10-07
SI3222277T1 (en) 2021-02-26
HUE033494T2 (en) 2017-12-28
HK1244687A1 (en) 2018-08-17
PL2732818T3 (en) 2017-12-29
EP2732818A1 (en) 2014-05-21
CY1123017T1 (en) 2021-10-29
DK2732818T3 (en) 2017-08-14
SI2732818T1 (en) 2017-12-29
CN102421434A (en) 2012-04-18
HUE049450T2 (en) 2020-09-28
JP2017008081A (en) 2017-01-12
CN104107176A (en) 2014-10-22
HRP20200665T1 (en) 2020-08-21
ES2636087T3 (en) 2017-10-05

Similar Documents

Publication Publication Date Title
CY1119232T1 (en) A DIFFERENYLSULFONAMIDE COMPONENT OF THE ENDOTHILINE AND ANGIOTENSIN II RECEPTOR COMPONENT FOR TREATMENT OF SPIRAMATOLOGY
CY1120939T1 (en) COMBINATION OF REGORAFENIB AND ACETYLSALYLIC ACID FOR THE TREATMENT OF COLON CANCER
CY1122786T1 (en) DOSAGE FORMS FOR Echinocandin Class Compounds
CY1120318T1 (en) Substituted benzylindazoles for use as BUB1 kinase inhibitors in the treatment of hyperplasia patients
CY1124729T1 (en) PHARMACEUTICAL FORMS OF ENZALUTHAMIDE
CY1125100T1 (en) TAPENTADOL AQUEOUS PHARMACEUTICAL FORMULATION FOR ORAL ADMINISTRATION
CY1120429T1 (en) KINAZOLIN DERIVATIVE FOR THE THERAPEUTIC TREATMENT OF VIRUS INFECTIONS AND OTHER DISEASES
CY1121694T1 (en) BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS
CY1118379T1 (en) DISEASES OF USVITIS C
CL2017003351A1 (en) Anti-human transferrin receptor antibody that passes through the blood-brain barrier.
CY1120417T1 (en) METHODS TO REDUCE BASEFLOW LEVELS
CY1122853T1 (en) SOLID FORMULATIONS OF LINACLOTIDE
CY1116645T1 (en) NOTCH-SUSPENSION SIGNAL PATH
CY1119007T1 (en) COMPOSITIONS AND METHODS OF Pulmonary Hypertension Treatment
CY1121315T1 (en) ORAL COMPOSITIONS OF DEFASIROXY
EA201170441A1 (en) THERAPEUTIC ANTI-VIRAL PEPTIDES
CL2014000504A1 (en) Compounds derived from substituted condensed pyrimidines; preparation procedure; pharmaceutical composition; and use in the treatment and / or prevention of heart failure, angina pectoris, hypertension, among other diseases.
CL2014001779A1 (en) Compounds derived from substituted fused pyrimidines and triazines; preparation procedure; Pharmaceutical composition and its use in the treatment and / or prevention of heart failure, angina pectoris, hypertension, among other diseases.
EA201201263A1 (en) PHARMACEUTICAL COMPOSITION CONTAINING DAGIGATRAN ETEXYLATE
EA201201509A1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING PIOGLITAZONE AND LINAGLIPTIN
CY1124331T1 (en) INCREASED BIOAVAILABILITY OF ACTIVE SUBSTANCE IN NALTREXONE THERAPY
CY1121999T1 (en) PHARMACEUTICAL FORMS OF DARUNAVIR COMBINATION
CL2012002716A1 (en) Use of a dgat1 inhibitor compound because it is useful in the prevention, delay of progress or treatment of a disease or condition selected from chylomicronemia, familial chylomicronemia syndrome and type v hyperlipoproteinemia; a compound derived from substituted heteroaryl; pharmaceutical composition
IT1404931B1 (en) OPHTHALMIC COMPOSITIONS FOR THE ADMINISTRATION OF LIPO-SOLUBLE ACTIVE PRINCIPLES.
CY1122313T1 (en) ORBEPITANTE FOR THE TREATMENT OF CHRONIC IGNITION