CY1119198T1 - ΣΤΑΘΕΡΗ ΣΥΝΘΕΣΗ ΠΟΥ ΠΕΡΙΛΑΜΒΑΝΕΙ PTHrP ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΗΣ - Google Patents
ΣΤΑΘΕΡΗ ΣΥΝΘΕΣΗ ΠΟΥ ΠΕΡΙΛΑΜΒΑΝΕΙ PTHrP ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΗΣInfo
- Publication number
- CY1119198T1 CY1119198T1 CY20171100860T CY171100860T CY1119198T1 CY 1119198 T1 CY1119198 T1 CY 1119198T1 CY 20171100860 T CY20171100860 T CY 20171100860T CY 171100860 T CY171100860 T CY 171100860T CY 1119198 T1 CY1119198 T1 CY 1119198T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pthrp
- stable composition
- composition including
- stable
- storage
- Prior art date
Links
- 102000043299 Parathyroid hormone-related Human genes 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 108700020797 Parathyroid Hormone-Related Proteins 0.000 title 1
- 101710123753 Parathyroid hormone-related protein Proteins 0.000 abstract 4
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000008468 bone growth Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει σύνθεση σταθερή κατά την αποθήκευση, που περιέχει ανάλογο πρωτεΐνης που σχετίζεται με ορμόνη παραθυρεοειδούς (PTHrP) και μεθόδους χρήσης του αναλόγου PTHrP και των συνθέσεων PTHrP που περιγράφονται στο παρόν για θεραπεία οστεοπόρωσης, για αύξηση οστικής μάζας ή βελτίωση της ποιότητας οστού. Η σύνθεση είναι σταθερή κατά την αποθήκευση, σε αποστειρωμένη μορφή και γενικώς μπορεί να αποθηκεύεται σε θερμοκρασία δωματίου για τουλάχιστον αρκετές εβδομάδες ώστε να επιτρέπεται κατάλληλη παρεντερική χορήγηση σε ασθενείς ανθρώπους.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84896006P | 2006-10-03 | 2006-10-03 | |
EP07870768.4A EP2073789B8 (en) | 2006-10-03 | 2007-10-03 | A stable composition comprising a bone anabolic protein, namely a pthrp analogue, and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119198T1 true CY1119198T1 (el) | 2018-02-14 |
Family
ID=39430237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100860T CY1119198T1 (el) | 2006-10-03 | 2017-08-10 | ΣΤΑΘΕΡΗ ΣΥΝΘΕΣΗ ΠΟΥ ΠΕΡΙΛΑΜΒΑΝΕΙ PTHrP ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΗΣ |
Country Status (28)
Country | Link |
---|---|
US (1) | US8148333B2 (el) |
EP (2) | EP2073789B8 (el) |
JP (1) | JP5375611B2 (el) |
KR (4) | KR101512377B1 (el) |
CN (2) | CN102274492B (el) |
AU (1) | AU2007322334B2 (el) |
BR (2) | BRPI0722428A2 (el) |
CA (1) | CA2664734C (el) |
CY (1) | CY1119198T1 (el) |
DK (2) | DK2073789T3 (el) |
ES (2) | ES2637283T3 (el) |
FR (1) | FR23C1024I2 (el) |
HK (1) | HK1214181A1 (el) |
HR (1) | HRP20171217T1 (el) |
IL (1) | IL197926A (el) |
LT (1) | LT2957278T (el) |
MX (1) | MX2009003569A (el) |
NL (1) | NL301235I2 (el) |
NO (1) | NO344885B1 (el) |
NZ (1) | NZ576682A (el) |
PL (1) | PL2957278T3 (el) |
PT (2) | PT2957278T (el) |
RS (1) | RS56164B1 (el) |
RU (1) | RU2506070C2 (el) |
SG (1) | SG175580A1 (el) |
SI (1) | SI2957278T1 (el) |
UA (1) | UA98776C2 (el) |
WO (1) | WO2008063279A2 (el) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US8148333B2 (en) | 2006-10-03 | 2012-04-03 | Radius Health, Inc. | Stable composition comprising a PTHrP analogue |
US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
DK2568806T3 (en) | 2010-05-12 | 2016-08-15 | Radius Health Inc | therapy Programs |
JP5965909B2 (ja) | 2010-09-28 | 2016-08-10 | ラジウス ヘルス,インコーポレイテッド | 選択的アンドロゲン受容体モジュレーター |
EP2472328B1 (en) | 2010-12-31 | 2013-06-19 | Rohm and Haas Electronic Materials LLC | Coating compositions for use with an overcoated photoresist |
EP2472329B1 (en) | 2010-12-31 | 2013-06-05 | Rohm and Haas Electronic Materials LLC | Coating compositions for use with an overcoated photoresist |
SG194570A1 (en) | 2011-04-22 | 2013-12-30 | Radius Health Inc | Method of drug delivery for pth, pthrp and related peptides |
KR101787956B1 (ko) * | 2011-06-07 | 2017-10-18 | 아사히 가세이 파마 가부시키가이샤 | 고순도 pth 함유 동결 건조 제제 및 그의 제조 방법 |
AU2012345768B2 (en) * | 2011-11-30 | 2016-05-12 | Kindeva Drug Delivery L.P. | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
CN108024540B (zh) | 2015-04-29 | 2021-09-17 | 雷迪厄斯制药公司 | 用于治疗癌症的方法 |
WO2017007777A2 (en) * | 2015-07-06 | 2017-01-12 | Zhengxin Dong | NOVEL FORMULATIONS OF PTHrP ANALOGUE |
KR101982103B1 (ko) | 2015-08-31 | 2019-05-27 | 롬 앤드 하스 일렉트로닉 머트어리얼즈 엘엘씨 | 오버코팅된 포토레지스트와 함께 사용하기 위한 코팅 조성물 |
SI3359241T1 (sl) * | 2015-10-09 | 2021-11-30 | Radius Health, Inc. | Formulacije PTHRP-analogov, transdermalni obliži le-teh in uporabe le-teh |
WO2017184355A1 (en) | 2016-04-18 | 2017-10-26 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
CA3027563A1 (en) | 2016-06-22 | 2017-12-28 | Radius Health, Inc. | Ar+ breast cancer treatment methods |
MX2019006189A (es) * | 2016-11-30 | 2019-11-18 | Purdue Research Foundation | Regeneracion osea dirigida a una fractura mediante estimulacion del receptor de la hormona paratiroidea. |
EP3565542B1 (en) | 2017-01-05 | 2024-04-10 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
EP3765488A1 (en) * | 2018-03-12 | 2021-01-20 | Fresenius Kabi iPSUM S.r.l. | Process for the manufacture of pthrp analogue |
WO2020010216A1 (en) | 2018-07-04 | 2020-01-09 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad 1901-2hcl |
EP4110371A1 (en) | 2020-01-24 | 2023-01-04 | Radius Health, Inc. | Methods of stimulating bone growth with abalopartide and denosumab |
WO2023281447A1 (en) | 2021-07-07 | 2023-01-12 | Radius Health, Inc. | Methods of treating a cardiovascular ischemic event |
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US5977070A (en) | 1992-07-14 | 1999-11-02 | Piazza; Christin Teresa | Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis |
US5589452A (en) | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
US5821225A (en) | 1992-07-14 | 1998-10-13 | Syntex (U.S.A.) Inc. | Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp |
KR100291620B1 (ko) | 1992-09-29 | 2001-10-24 | 추후제출 | 부갑상선호르몬의활성단편의폐를통한전달방법 |
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MY120063A (en) | 1997-12-09 | 2005-08-30 | Lilly Co Eli | Stabilized teriparatide solutions |
US6770623B1 (en) | 1997-12-09 | 2004-08-03 | Eli Lilly And Company | Stabilized teriparatide solutions |
SE9801495D0 (sv) | 1998-04-28 | 1998-04-28 | Astra Ab | Protein formulationa |
US20050124537A1 (en) | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
US7371721B2 (en) * | 2000-09-18 | 2008-05-13 | Sanos Bioscience A/S | Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes |
WO2003105772A2 (en) * | 2002-06-13 | 2003-12-24 | Beth Israel Deaconess Medical Center, Inc. | Analogs of parathyroid hormone and pth-related protein as bone anabolic agents |
WO2004060386A1 (en) | 2002-11-01 | 2004-07-22 | Amgen, Inc. | Modulators of receptors for parathyrois hormone and parathyroid hormone-related protein |
TWI359026B (en) | 2004-02-12 | 2012-03-01 | Sankyo Co | Pharmaceutical composition for the osteoclast rela |
EP1750756A2 (en) * | 2004-05-10 | 2007-02-14 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of parathyroid hormone |
US7803770B2 (en) | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
US8148333B2 (en) | 2006-10-03 | 2012-04-03 | Radius Health, Inc. | Stable composition comprising a PTHrP analogue |
-
2007
- 2007-10-03 US US12/311,418 patent/US8148333B2/en active Active
- 2007-10-03 KR KR1020097008736A patent/KR101512377B1/ko active IP Right Grant
- 2007-10-03 BR BRPI0722428-1A patent/BRPI0722428A2/pt not_active Application Discontinuation
- 2007-10-03 CA CA2664734A patent/CA2664734C/en active Active
- 2007-10-03 DK DK07870768.4T patent/DK2073789T3/da active
- 2007-10-03 KR KR1020177015557A patent/KR20170067906A/ko not_active Application Discontinuation
- 2007-10-03 RU RU2009116531/15A patent/RU2506070C2/ru not_active IP Right Cessation
- 2007-10-03 ES ES15176548.4T patent/ES2637283T3/es active Active
- 2007-10-03 SG SG2011071784A patent/SG175580A1/en unknown
- 2007-10-03 PT PT151765484T patent/PT2957278T/pt unknown
- 2007-10-03 JP JP2009531434A patent/JP5375611B2/ja active Active
- 2007-10-03 UA UAA200904264A patent/UA98776C2/ru unknown
- 2007-10-03 SI SI200731956T patent/SI2957278T1/sl unknown
- 2007-10-03 KR KR20147033817A patent/KR20150020289A/ko active Search and Examination
- 2007-10-03 WO PCT/US2007/021216 patent/WO2008063279A2/en active Application Filing
- 2007-10-03 KR KR1020187030530A patent/KR20180117738A/ko not_active Application Discontinuation
- 2007-10-03 CN CN201110220104.XA patent/CN102274492B/zh active Active
- 2007-10-03 EP EP07870768.4A patent/EP2073789B8/en active Active
- 2007-10-03 AU AU2007322334A patent/AU2007322334B2/en active Active
- 2007-10-03 LT LTEP15176548.4T patent/LT2957278T/lt unknown
- 2007-10-03 PT PT07870768T patent/PT2073789T/pt unknown
- 2007-10-03 PL PL15176548T patent/PL2957278T3/pl unknown
- 2007-10-03 BR BRPI0719821A patent/BRPI0719821B8/pt active IP Right Grant
- 2007-10-03 RS RS20170803A patent/RS56164B1/sr unknown
- 2007-10-03 ES ES07870768T patent/ES2739459T3/es active Active
- 2007-10-03 NZ NZ576682A patent/NZ576682A/xx unknown
- 2007-10-03 MX MX2009003569A patent/MX2009003569A/es active IP Right Grant
- 2007-10-03 DK DK15176548.4T patent/DK2957278T3/en active
- 2007-10-03 CN CN2007800370219A patent/CN101578093B/zh active Active
- 2007-10-03 EP EP15176548.4A patent/EP2957278B1/en not_active Revoked
-
2009
- 2009-04-05 IL IL197926A patent/IL197926A/en active IP Right Grant
- 2009-04-20 NO NO20091545A patent/NO344885B1/no unknown
- 2009-10-02 HK HK16102423.5A patent/HK1214181A1/zh unknown
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2017
- 2017-08-08 HR HRP20171217TT patent/HRP20171217T1/hr unknown
- 2017-08-10 CY CY20171100860T patent/CY1119198T1/el unknown
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2023
- 2023-06-05 FR FR23C1024C patent/FR23C1024I2/fr active Active
- 2023-06-09 NL NL301235C patent/NL301235I2/nl unknown
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