CY1116992T1 - Μεθοδος θεραπειας της σκληρυνσης κατα πλακας αναστελλοντας τη δραση της il-17 - Google Patents
Μεθοδος θεραπειας της σκληρυνσης κατα πλακας αναστελλοντας τη δραση της il-17Info
- Publication number
- CY1116992T1 CY1116992T1 CY20151101086T CY151101086T CY1116992T1 CY 1116992 T1 CY1116992 T1 CY 1116992T1 CY 20151101086 T CY20151101086 T CY 20151101086T CY 151101086 T CY151101086 T CY 151101086T CY 1116992 T1 CY1116992 T1 CY 1116992T1
- Authority
- CY
- Cyprus
- Prior art keywords
- activity
- treatment
- ill
- strengthening
- prophylaxis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 238000005728 strengthening Methods 0.000 title 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει μια μέθοδο θεραπείας ή/και προφύλαξης της σκλήρυνσης κατά πλάκας (MS) περιέχει τη χορήγηση μιας θεραπευτικά αποτελεσματικής ποσότητας του αναστολέα της δράσης της IL-17.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0327181A GB0327181D0 (en) | 2003-11-21 | 2003-11-21 | Biological products |
GB0417115A GB0417115D0 (en) | 2004-07-30 | 2004-07-30 | Biological products |
EP08008814.9A EP1983000B1 (en) | 2003-11-21 | 2004-11-16 | Method for the treatment of multiple sclerosis by inhibiting IL-17 activity |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1116992T1 true CY1116992T1 (el) | 2017-04-05 |
Family
ID=34635441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151101086T CY1116992T1 (el) | 2003-11-21 | 2015-11-30 | Μεθοδος θεραπειας της σκληρυνσης κατα πλακας αναστελλοντας τη δραση της il-17 |
Country Status (16)
Country | Link |
---|---|
US (2) | US20070269428A1 (el) |
EP (3) | EP1687026B1 (el) |
JP (1) | JP4833850B2 (el) |
AT (1) | ATE395083T1 (el) |
AU (1) | AU2004292393C1 (el) |
CA (1) | CA2544920C (el) |
CY (1) | CY1116992T1 (el) |
DE (1) | DE602004013825D1 (el) |
DK (1) | DK1983000T3 (el) |
ES (2) | ES2554645T3 (el) |
HR (1) | HRP20151210T1 (el) |
HU (1) | HUE026260T2 (el) |
PL (1) | PL1983000T3 (el) |
PT (1) | PT1983000E (el) |
SI (1) | SI1983000T1 (el) |
WO (1) | WO2005051422A1 (el) |
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US20040219150A1 (en) * | 2003-02-06 | 2004-11-04 | Cua Daniel J. | Uses of mammalian cytokine; related reagents |
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GB0425569D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Biological products |
SI2481753T1 (en) | 2005-12-13 | 2018-06-29 | Eli Lilly And Company | Anti-IL-17 antibodies |
WO2007071439A1 (en) * | 2005-12-22 | 2007-06-28 | Laboratoires Serono S.A. | Soluble il-17rc variant and uses thereof |
JP2009534297A (ja) | 2006-03-10 | 2009-09-24 | ザイモジェネティクス, インコーポレイテッド | Il−17aおよびil−17fの両方に結合する抗体ならびにその使用方法 |
US7790163B2 (en) | 2006-03-10 | 2010-09-07 | Zymogenetics, Inc. | Antibodies that bind both IL-17A and IL-17F and methods of using the same |
US7910703B2 (en) | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
GB0612928D0 (en) | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
PE20080739A1 (es) | 2006-08-11 | 2008-06-14 | Schering Corp | Anticuerpos para il-17a |
GB0620729D0 (en) | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
US20100331545A1 (en) | 2007-10-24 | 2010-12-30 | Nippon Chemiphar Co., Ltd. | Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient |
WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
GB0807413D0 (en) * | 2008-04-23 | 2008-05-28 | Ucb Pharma Sa | Biological products |
KR20110025649A (ko) | 2008-05-05 | 2011-03-10 | 노비뮨 에스 에이 | 항-il-17a/il-17f 교차-반응성 항체 및 그의 사용 방법 |
MX2011003184A (es) | 2008-09-29 | 2011-04-21 | Roche Glycart Ag | Anticuerpos contra il17 humana y usos de los mismos. |
US20110223169A1 (en) * | 2008-11-26 | 2011-09-15 | Stern Michael E | Il-17 antibody inhibitor for treating dry eye |
WO2010062857A1 (en) | 2008-11-26 | 2010-06-03 | Allergan, Inc. | Klk-13 antibody inhibitor for treating dry eye |
RU2605318C2 (ru) | 2009-05-05 | 2016-12-20 | Новиммун С.А. | Анти-il-17f антитела и способы их применения |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
CN102869678A (zh) | 2009-08-27 | 2013-01-09 | 科瓦根股份公司 | Il-17结合化合物及其医药用途 |
US20130046015A1 (en) | 2010-02-11 | 2013-02-21 | Robert C. Axtell | Therapeutic Inhibition of Granulocyte Function in Demyelinating Disease |
GB201100282D0 (en) | 2011-01-07 | 2011-02-23 | Ucb Pharma Sa | Biological methods |
US10208349B2 (en) * | 2011-01-07 | 2019-02-19 | Ucb Biopharma Sprl | Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy |
MA34907B1 (fr) | 2011-01-14 | 2014-02-01 | Ucb Pharma Sa | Molécules d'anticorps se liant à il-17a et il-17f |
BR112013019975A2 (pt) | 2011-02-28 | 2017-08-01 | Hoffmann La Roche | proteínas de ligação de antígeno, composição farmacêutica, uso de uma proteína de ligação de antígeno, método para o tratamento de um paciente e método para a preparação de uma proteína de ligação de antígeno, ácido nucleico, vetor e célula hospedeira" |
MX342034B (es) | 2011-02-28 | 2016-09-12 | Hoffmann La Roche | Proteinas monovalentes que se unen a antigenos. |
CA2868404A1 (en) | 2012-04-05 | 2013-10-10 | F. Hoffmann-La Roche Ag | Bispecific antibodies against human tweak and human il17 and uses thereof |
WO2014155278A2 (en) * | 2013-03-26 | 2014-10-02 | Novartis Ag | Methods of treating autoimmune diseases using il-17 antagonists |
WO2014161570A1 (en) | 2013-04-03 | 2014-10-09 | Roche Glycart Ag | Antibodies against human il17 and uses thereof |
EP3055329B1 (en) | 2013-10-11 | 2018-06-13 | F. Hoffmann-La Roche AG | Multispecific domain exchanged common variable light chain antibodies |
UA117289C2 (uk) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифічне антитіло |
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EP3150637A1 (en) | 2015-10-02 | 2017-04-05 | F. Hoffmann-La Roche AG | Multispecific antibodies |
RU2680011C2 (ru) | 2016-04-29 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы |
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PL1644412T5 (pl) | 2003-07-01 | 2019-01-31 | Ucb Biopharma Sprl | Modyfikowane fragmenty Fab przeciwciała |
SI2481753T1 (en) | 2005-12-13 | 2018-06-29 | Eli Lilly And Company | Anti-IL-17 antibodies |
-
2004
- 2004-11-16 JP JP2006540587A patent/JP4833850B2/ja not_active Expired - Fee Related
- 2004-11-16 US US10/580,164 patent/US20070269428A1/en not_active Abandoned
- 2004-11-16 HU HUE08008814A patent/HUE026260T2/en unknown
- 2004-11-16 AU AU2004292393A patent/AU2004292393C1/en not_active Ceased
- 2004-11-16 ES ES08008814.9T patent/ES2554645T3/es active Active
- 2004-11-16 PT PT80088149T patent/PT1983000E/pt unknown
- 2004-11-16 EP EP04798568A patent/EP1687026B1/en not_active Revoked
- 2004-11-16 SI SI200432278T patent/SI1983000T1/sl unknown
- 2004-11-16 DE DE602004013825T patent/DE602004013825D1/de active Active
- 2004-11-16 DK DK08008814.9T patent/DK1983000T3/en active
- 2004-11-16 EP EP08008814.9A patent/EP1983000B1/en active Active
- 2004-11-16 WO PCT/GB2004/004850 patent/WO2005051422A1/en active IP Right Grant
- 2004-11-16 EP EP15183030.4A patent/EP2974742A1/en not_active Withdrawn
- 2004-11-16 PL PL08008814T patent/PL1983000T3/pl unknown
- 2004-11-16 ES ES04798568T patent/ES2305879T3/es active Active
- 2004-11-16 AT AT04798568T patent/ATE395083T1/de not_active IP Right Cessation
- 2004-11-16 CA CA2544920A patent/CA2544920C/en not_active Expired - Fee Related
-
2008
- 2008-11-24 US US12/277,030 patent/US7931900B2/en not_active Expired - Fee Related
-
2015
- 2015-11-11 HR HRP20151210TT patent/HRP20151210T1/hr unknown
- 2015-11-30 CY CY20151101086T patent/CY1116992T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL1983000T3 (pl) | 2016-02-29 |
JP2007511593A (ja) | 2007-05-10 |
HUE026260T2 (en) | 2016-06-28 |
PT1983000E (pt) | 2015-12-30 |
EP2974742A1 (en) | 2016-01-20 |
EP1983000B1 (en) | 2015-09-02 |
DE602004013825D1 (de) | 2008-06-26 |
AU2004292393A1 (en) | 2005-06-09 |
ES2305879T3 (es) | 2008-11-01 |
US20090191200A1 (en) | 2009-07-30 |
EP1983000A2 (en) | 2008-10-22 |
EP1687026B1 (en) | 2008-05-14 |
AU2004292393B2 (en) | 2009-10-08 |
AU2004292393C1 (en) | 2011-08-04 |
WO2005051422A1 (en) | 2005-06-09 |
EP1687026A1 (en) | 2006-08-09 |
CA2544920A1 (en) | 2005-06-09 |
EP1983000A3 (en) | 2011-07-27 |
HRP20151210T1 (hr) | 2015-12-04 |
US7931900B2 (en) | 2011-04-26 |
DK1983000T3 (en) | 2015-12-07 |
SI1983000T1 (sl) | 2015-12-31 |
ES2554645T3 (es) | 2015-12-22 |
CA2544920C (en) | 2012-09-11 |
ATE395083T1 (de) | 2008-05-15 |
US20070269428A1 (en) | 2007-11-22 |
JP4833850B2 (ja) | 2011-12-07 |
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