CY1116721T1 - Νεες ενωσεις ως προσδεματα υποδοχεων ισταμινης η3 - Google Patents
Νεες ενωσεις ως προσδεματα υποδοχεων ισταμινης η3Info
- Publication number
- CY1116721T1 CY1116721T1 CY20151100859T CY151100859T CY1116721T1 CY 1116721 T1 CY1116721 T1 CY 1116721T1 CY 20151100859 T CY20151100859 T CY 20151100859T CY 151100859 T CY151100859 T CY 151100859T CY 1116721 T1 CY1116721 T1 CY 1116721T1
- Authority
- CY
- Cyprus
- Prior art keywords
- receptors
- histamin
- projects
- unions
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Η παρούσα εφεύρεση σχετίζεται με νέες ενώσεις του τύπου (I), και με τα φαρμακευτικώς αποδεκτά άλατά τους και με συνθέσεις που τις περιέχουν. Η παρούσα εφεύρεση σχετίζεται επίσης με μια μέθοδο για την παρασκευή των ανωτέρω αναφερόμενων νέων ενώσεων, και των φαρμακευτικώς αποδεκτών αλάτων τους. Οι ενώσεις του τύπου (I) είναι χρήσιμες στη θεραπεία ποικίλων διαταραχών οι οποίες συνδέονται με τους υποδοχείς ισταμίνης Η3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN520CH2011 | 2011-02-23 | ||
| EP11749555.6A EP2694492B1 (en) | 2011-02-23 | 2011-06-07 | Novel compounds as histamine h3 receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116721T1 true CY1116721T1 (el) | 2017-03-15 |
Family
ID=54290090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100859T CY1116721T1 (el) | 2011-02-23 | 2015-09-28 | Νεες ενωσεις ως προσδεματα υποδοχεων ισταμινης η3 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9079888B2 (el) |
| EP (1) | EP2694492B1 (el) |
| JP (1) | JP5805792B2 (el) |
| KR (1) | KR101554407B1 (el) |
| CN (1) | CN103443093B (el) |
| AP (1) | AP3340A (el) |
| AU (1) | AU2011360550B2 (el) |
| BR (1) | BR112013021496B1 (el) |
| CA (1) | CA2827567C (el) |
| CY (1) | CY1116721T1 (el) |
| DK (1) | DK2694492T3 (el) |
| EA (1) | EA023260B1 (el) |
| ES (1) | ES2548284T3 (el) |
| HK (1) | HK1187613A1 (el) |
| HR (1) | HRP20151003T1 (el) |
| HU (1) | HUE025163T2 (el) |
| IL (1) | IL228019A (el) |
| ME (1) | ME02212B (el) |
| MX (1) | MX339858B (el) |
| NZ (1) | NZ614567A (el) |
| PL (1) | PL2694492T3 (el) |
| PT (1) | PT2694492E (el) |
| RS (1) | RS54248B1 (el) |
| SG (1) | SG192858A1 (el) |
| SI (1) | SI2694492T1 (el) |
| SM (1) | SMT201500238B (el) |
| WO (1) | WO2012114348A1 (el) |
| ZA (1) | ZA201306328B (el) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP1300139A2 (en) | 2013-03-06 | 2014-09-29 | Richter Gedeon Nyrt | Phenoxypiperidine h3 antagonists |
| ES2693378T3 (es) * | 2014-08-16 | 2018-12-11 | Suven Life Sciences Limited | Proceso para la producción a gran escala de diclorhidrato de N-[4-(1- ciclobutil piperidin-4-iloxi) fenil]-2-(morfolin-4-il) acetamida |
| AU2017311666B2 (en) * | 2016-08-18 | 2019-08-22 | Suven Life Sciences Limited | Triple combination of histamine-3 receptor inverse agonists, acetylcholinesterase inhibitors and NMDA receptor antagonist |
| BR112019002645A2 (pt) * | 2016-08-18 | 2019-05-28 | Suven Life Sciences Ltd | combinação, uso da combinação, método para o tratamento de desordens cognitivas, composto, método para o tratamento de doença de alzheimer, composição farmacêutica |
| MA52850A (fr) * | 2018-05-31 | 2021-04-21 | Suven Life Sciences Ltd | Méthode de traitement avec un agoniste inverse du récepteur de l'histamine-3 |
| EP4251148A1 (en) | 2020-11-27 | 2023-10-04 | Richter Gedeon Nyrt. | Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder |
| WO2023166351A1 (zh) * | 2022-03-02 | 2023-09-07 | 杭州百诚医药科技股份有限公司 | 组胺h3受体抑制剂及其医药用途 |
| CN116693446A (zh) * | 2022-03-02 | 2023-09-05 | 杭州百诚医药科技股份有限公司 | 苯基脲类衍生物及其医药用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725541D0 (en) * | 1997-12-02 | 1998-02-04 | Pharmacia & Upjohn Spa | Amino-benzothiazole derivatives |
| EP1311482B1 (en) * | 2000-08-08 | 2007-02-21 | Ortho-McNeil Pharmaceutical, Inc. | Non-imidazole aryloxypiperidines as h3 receptor ligands |
| CA2441080A1 (en) * | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| ES2401216T3 (es) * | 2002-12-20 | 2013-04-17 | Glaxo Group Limited | Nuevos derivados de benzazepina |
| ATE454372T1 (de) * | 2004-04-01 | 2010-01-15 | Lilly Co Eli | Am histamin-h3-rezeptor wirksame mittel, herstellung und therapeutische anwendungen |
| US8008301B2 (en) * | 2004-04-01 | 2011-08-30 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| WO2006023462A1 (en) | 2004-08-23 | 2006-03-02 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| CA2697941A1 (en) | 2007-09-06 | 2009-03-12 | Glaxo Group Limited | Piperazine derivative having affinity for the histamine h3 receptor |
| ES2378011T3 (es) * | 2007-10-17 | 2012-04-04 | Sanofi | N-fenil-bipirrolidin ureas sustituidas y uso terapéutico de las mismas |
| WO2009100120A2 (en) | 2008-02-04 | 2009-08-13 | Neurogen Corporation | Pyridinyl-substituted piperazinyl oxoethyl tetrahydropyrazolopyridines |
| US20110046130A1 (en) | 2008-03-31 | 2011-02-24 | Evotec Ag | Tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists |
| JP5780954B2 (ja) | 2008-05-08 | 2015-09-16 | エヴォテック・アクチエンゲゼルシャフト | ヒスタミンｈ３受容体アンタゴニストとしてのアゼチジン類及びシクロブタン類 |
| WO2010045306A2 (en) * | 2008-10-16 | 2010-04-22 | Schering Corporation | Azine derivatives and methods of use thereof |
-
2011
- 2011-06-07 AP AP2013007088A patent/AP3340A/xx active
- 2011-06-07 HU HUE11749555A patent/HUE025163T2/en unknown
- 2011-06-07 MX MX2013009683A patent/MX339858B/es active IP Right Grant
- 2011-06-07 PL PL11749555T patent/PL2694492T3/pl unknown
- 2011-06-07 NZ NZ61456711A patent/NZ614567A/en unknown
- 2011-06-07 SI SI201130601T patent/SI2694492T1/sl unknown
- 2011-06-07 EP EP11749555.6A patent/EP2694492B1/en active Active
- 2011-06-07 CN CN201180069505.8A patent/CN103443093B/zh active Active
- 2011-06-07 SG SG2013063060A patent/SG192858A1/en unknown
- 2011-06-07 BR BR112013021496-1A patent/BR112013021496B1/pt active IP Right Grant
- 2011-06-07 RS RS20150610A patent/RS54248B1/en unknown
- 2011-06-07 US US14/000,362 patent/US9079888B2/en active Active
- 2011-06-07 KR KR1020137024919A patent/KR101554407B1/ko active IP Right Grant
- 2011-06-07 JP JP2013554978A patent/JP5805792B2/ja active Active
- 2011-06-07 ES ES11749555.6T patent/ES2548284T3/es active Active
- 2011-06-07 EA EA201391211A patent/EA023260B1/ru unknown
- 2011-06-07 ME MEP-2015-151A patent/ME02212B/me unknown
- 2011-06-07 CA CA2827567A patent/CA2827567C/en active Active
- 2011-06-07 AU AU2011360550A patent/AU2011360550B2/en active Active
- 2011-06-07 DK DK11749555.6T patent/DK2694492T3/en active
- 2011-06-07 PT PT117495556T patent/PT2694492E/pt unknown
- 2011-06-07 WO PCT/IN2011/000380 patent/WO2012114348A1/en active Application Filing
-
2013
- 2013-08-18 IL IL228019A patent/IL228019A/en active IP Right Grant
- 2013-08-22 ZA ZA2013/06328A patent/ZA201306328B/en unknown
-
2014
- 2014-01-20 HK HK14100570.2A patent/HK1187613A1/xx unknown
-
2015
- 2015-09-23 HR HRP20151003TT patent/HRP20151003T1/hr unknown
- 2015-09-28 CY CY20151100859T patent/CY1116721T1/el unknown
- 2015-10-02 SM SM201500238T patent/SMT201500238B/xx unknown
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