CY1116377T1 - Αναστολεις της ανθρωπινης πρωτεϊνικης φωσφατασης της τυροσινης και μεθοδοι χρησης - Google Patents
Αναστολεις της ανθρωπινης πρωτεϊνικης φωσφατασης της τυροσινης και μεθοδοι χρησηςInfo
- Publication number
- CY1116377T1 CY1116377T1 CY20151100409T CY151100409T CY1116377T1 CY 1116377 T1 CY1116377 T1 CY 1116377T1 CY 20151100409 T CY20151100409 T CY 20151100409T CY 151100409 T CY151100409 T CY 151100409T CY 1116377 T1 CY1116377 T1 CY 1116377T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methods
- suspensions
- tyrosine protein
- human tyrosine
- protein phosphate
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Η παρούσα αποκάλυψη αναφέρεται σε ενώσεις αποτελεσματικές ως αναστολείς της ανθρώπινης πρωτεϊνικής φωσφατάσης της τυροσίνης β (ΗΡΤΡ-β) ρυθμίζοντας έτσι την αγγειογένεση. Η παρούσα αποκάλυψη αναφέρεται περαιτέρω σε συνθέσεις περιέχουσες τους ρηθέντες αναστολείς της ανθρώπινης πρωτεϊνικής φωσφατάσης της τυροσίνης β (ΗΡΤΡ-β), και σε μεθόδους για τη ρύθμιση της αγγειογένεσης.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81673106P | 2006-06-27 | 2006-06-27 | |
US81682506P | 2006-06-27 | 2006-06-27 | |
US81673006P | 2006-06-27 | 2006-06-27 | |
EP07809908.2A EP2038265B1 (en) | 2006-06-27 | 2007-06-27 | Human protein-tyrosine phosphatase inhibitors and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1116377T1 true CY1116377T1 (el) | 2017-02-08 |
Family
ID=38704715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100409T CY1116377T1 (el) | 2006-06-27 | 2015-05-08 | Αναστολεις της ανθρωπινης πρωτεϊνικης φωσφατασης της τυροσινης και μεθοδοι χρησης |
Country Status (20)
Country | Link |
---|---|
US (3) | US7795444B2 (el) |
EP (3) | EP3293182A1 (el) |
JP (6) | JP5261383B2 (el) |
KR (1) | KR101179087B1 (el) |
AU (1) | AU2007265454B2 (el) |
BR (1) | BRPI0713357A2 (el) |
CA (1) | CA2657107C (el) |
CO (1) | CO6150140A2 (el) |
CY (1) | CY1116377T1 (el) |
DK (1) | DK2038265T3 (el) |
ES (1) | ES2534392T3 (el) |
HK (1) | HK1129387A1 (el) |
HU (1) | HUE024976T2 (el) |
IL (1) | IL196129A (el) |
MX (1) | MX2009000289A (el) |
NZ (1) | NZ574406A (el) |
PL (1) | PL2038265T3 (el) |
PT (1) | PT2038265E (el) |
SI (1) | SI2038265T1 (el) |
WO (1) | WO2008002570A2 (el) |
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US7795444B2 (en) * | 2006-06-27 | 2010-09-14 | Warner Chilcott Company | Human protein tyrosine phosphatase inhibitors and methods of use |
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US20130023542A1 (en) * | 2006-06-27 | 2013-01-24 | Aerpio Therapeutics Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
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CN108635350A (zh) * | 2009-01-12 | 2018-10-12 | 爱尔皮奥治疗有限公司 | 治疗血管渗漏综合征的方法 |
AU2016203254B2 (en) * | 2009-01-12 | 2018-09-13 | EyePoint Pharmaceuticals, Inc. | Methods for treating vascular leak syndrome |
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CA2818215C (en) * | 2010-10-07 | 2015-07-21 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular edema, neovascularization and related diseases |
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MX363351B (es) | 2011-10-13 | 2019-03-20 | Aerpio Therapeutics Inc | Un agente de unión a hptp?-ecd para usarse en el tratamiento de síndrome de fuga vascular. |
US9962362B2 (en) * | 2012-03-29 | 2018-05-08 | Children's Hospital Medical Center | Use of small molecule inhibitors targeting EYA tyrosine phosphatase |
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US9539245B2 (en) | 2014-08-07 | 2017-01-10 | Aerpio Therapeutics, Inc. | Combination of immunotherapies with activators of Tie-2 |
JP6746614B2 (ja) * | 2015-05-27 | 2020-08-26 | 杏林製薬株式会社 | ウレア誘導体、またはその薬理学的に許容される塩 |
JP6959924B2 (ja) | 2015-09-23 | 2021-11-05 | エアーピオ ファーマシューティカルズ, インコーポレイテッド | Tie−2の活性化物質を用いる眼内圧を処置する方法 |
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2007
- 2007-06-26 US US11/821,846 patent/US7795444B2/en active Active
- 2007-06-27 CA CA2657107A patent/CA2657107C/en active Active
- 2007-06-27 ES ES07809908.2T patent/ES2534392T3/es active Active
- 2007-06-27 SI SI200731650T patent/SI2038265T1/sl unknown
- 2007-06-27 KR KR1020097001694A patent/KR101179087B1/ko active IP Right Grant
- 2007-06-27 WO PCT/US2007/014823 patent/WO2008002570A2/en active Application Filing
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2008
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2009
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2010
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2011
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2013
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2015
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2017
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