CY1115843T1 - Ετεροαρωματικες ενωσεις φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a - Google Patents

Ετεροαρωματικες ενωσεις φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a

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Publication number
CY1115843T1
CY1115843T1 CY20141100789T CY141100789T CY1115843T1 CY 1115843 T1 CY1115843 T1 CY 1115843T1 CY 20141100789 T CY20141100789 T CY 20141100789T CY 141100789 T CY141100789 T CY 141100789T CY 1115843 T1 CY1115843 T1 CY 1115843T1
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CY
Cyprus
Prior art keywords
compounds
subject
provides
compound
formula
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Application number
CY20141100789T
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English (en)
Inventor
Ask Püschl
Jacob Nielsen
Jan Kehler
John Paul Kilburn
Mauro Marigo
Morten Langgård
Original Assignee
H. Lundbeck A/S
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Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CY1115843T1 publication Critical patent/CY1115843T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Η εφεύρεση αυτή κατευθύνεται σε ενώσεις, οι οποίες είναι αναστολείς ενζύμου PDE10Α. Η εφεύρεση παρέχει φαρμακευτική σύνθεση περιλαμβάνουσα θεραπευτικώς αποτελεσματική ποσότητα μιας ένωσης της εφεύρεσης και φαρμακευτικώς αποδεκτό φορέα. Η παρούσα εφεύρεση επίσης παρέχει μεθόδους για την παρασκευή των ενώσεων του τύπου Ι. Η παρούσα εφεύρεση περαιτέρω παρέχει μέθοδο θεραπείας υποκειμένου που υποφέρει από νευροεκφυλιστική διαταραχή, περιλαμβάνουσα χορήγηση στο υποκείμενο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του τύπου Ι. Η παρούσα εφεύρεση επίσης παρέχει μία μέθοδο θεραπείας υποκειμένου που υποφέρει από εθισμό φαρμάκου, περιλαμβάνουσα χορήγηση στο υποκείμενο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του τύπου Ι. Η παρούσα εφεύρεση περαιτέρω παρέχει μέθοδο θεραπείας υποκειμένου που υποφέρει από ψυχιατρική διαταραχή, περιλαμβάνουσα χορήγηση στο υποκείμενο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του τύπου Ι.
CY20141100789T 2009-12-17 2014-09-26 Ετεροαρωματικες ενωσεις φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a CY1115843T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28731509P 2009-12-17 2009-12-17
DKPA200901339 2009-12-17
EP10798255.5A EP2513107B1 (en) 2009-12-17 2010-12-15 Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors

Publications (1)

Publication Number Publication Date
CY1115843T1 true CY1115843T1 (el) 2017-01-25

Family

ID=44246808

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100789T CY1115843T1 (el) 2009-12-17 2014-09-26 Ετεροαρωματικες ενωσεις φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a

Country Status (36)

Country Link
US (2) US9096589B2 (el)
EP (1) EP2513107B1 (el)
JP (1) JP5901535B2 (el)
KR (1) KR101803984B1 (el)
CN (1) CN102741250B (el)
AR (1) AR079495A1 (el)
AU (1) AU2010333435B2 (el)
BR (1) BR112012017205A2 (el)
CA (1) CA2783726A1 (el)
CO (1) CO6612245A2 (el)
CR (1) CR20120319A (el)
CY (1) CY1115843T1 (el)
DK (1) DK2513107T3 (el)
DO (1) DOP2012000165A (el)
EA (1) EA023663B1 (el)
ES (1) ES2514647T3 (el)
GE (1) GEP20156241B (el)
GT (1) GT201200171A (el)
HK (1) HK1177208A1 (el)
HR (1) HRP20140898T1 (el)
IL (1) IL220327A (el)
MA (1) MA33922B1 (el)
MX (1) MX2012006969A (el)
MY (1) MY158197A (el)
NZ (1) NZ600260A (el)
PL (1) PL2513107T3 (el)
PT (1) PT2513107E (el)
RS (1) RS53579B1 (el)
SG (1) SG181674A1 (el)
SI (1) SI2513107T1 (el)
SM (1) SMT201400158B (el)
TN (1) TN2012000271A1 (el)
TW (1) TWI485151B (el)
UA (1) UA108487C2 (el)
WO (1) WO2011072694A1 (el)
ZA (1) ZA201204419B (el)

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TWI481607B (zh) 2009-12-17 2015-04-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TWI485151B (zh) 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI487705B (zh) 2009-12-17 2015-06-11 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基***衍生物
AU2011258217B2 (en) * 2010-05-26 2016-12-15 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
US8552045B2 (en) 2010-11-19 2013-10-08 H. Lundbeck A/S Tricyclic imidazole compounds as PDE10 inhibitors
JO3089B1 (ar) * 2010-11-19 2017-03-15 H Lundbeck As مشتقات ايميدازول كمثبطات لانزيمات pde10a
US8765760B2 (en) 2011-01-11 2014-07-01 Sunovion Pharmaceuticals, Inc. [1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases
SG192839A1 (en) 2011-02-18 2013-09-30 Allergan Inc Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9938269B2 (en) * 2011-06-30 2018-04-10 Abbvie Inc. Inhibitor compounds of phosphodiesterase type 10A
KR101584925B1 (ko) * 2011-09-19 2016-01-12 에프. 호프만-라 로슈 아게 Pde10a 억제제로서의 트라이아졸로피리딘 화합물
WO2013050527A1 (en) 2011-10-05 2013-04-11 H. Lundbeck A/S Quinazoline derivatives as pde10a enzyme inhibitors
TWI570124B (zh) 2011-12-21 2017-02-11 Ｈ 朗德貝克公司 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物
AU2013277258B2 (en) * 2012-06-19 2017-12-07 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9790203B2 (en) 2012-11-26 2017-10-17 Abbvie Inc. Inhibitor compounds of phosphodiesterase type 10A
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)

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TWI501965B (zh) * 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
TW201200516A (en) 2009-12-17 2012-01-01 Lundbeck & Co As H Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
TWI485151B (zh) 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI481607B (zh) 2009-12-17 2015-04-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TWI487705B (zh) 2009-12-17 2015-06-11 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基***衍生物

Also Published As

Publication number Publication date
AU2010333435B2 (en) 2016-09-08
KR20120112460A (ko) 2012-10-11
TWI485151B (zh) 2015-05-21
GEP20156241B (en) 2015-02-10
GT201200171A (es) 2015-01-16
CR20120319A (es) 2012-08-16
EA201290516A1 (ru) 2013-01-30
BR112012017205A2 (pt) 2018-08-14
CN102741250B (zh) 2015-10-14
US9669029B2 (en) 2017-06-06
US20120309714A1 (en) 2012-12-06
ES2514647T3 (es) 2014-10-28
MX2012006969A (es) 2012-07-17
JP2013514284A (ja) 2013-04-25
KR101803984B1 (ko) 2017-12-01
CO6612245A2 (es) 2013-02-01
TW201200515A (en) 2012-01-01
MA33922B1 (fr) 2013-01-02
PT2513107E (pt) 2014-10-22
DOP2012000165A (es) 2012-12-15
HRP20140898T1 (hr) 2014-11-07
PL2513107T3 (pl) 2014-12-31
NZ600260A (en) 2014-08-29
SI2513107T1 (sl) 2014-11-28
AR079495A1 (es) 2012-02-01
CA2783726A1 (en) 2011-06-23
EP2513107B1 (en) 2014-07-30
UA108487C2 (en) 2015-05-12
CN102741250A (zh) 2012-10-17
US20150290191A1 (en) 2015-10-15
MY158197A (en) 2016-09-15
RS53579B1 (en) 2015-02-27
SMT201400158B (it) 2015-01-15
IL220327A0 (en) 2012-08-30
TN2012000271A1 (en) 2013-12-12
AU2010333435A1 (en) 2012-06-21
US9096589B2 (en) 2015-08-04
EA023663B1 (ru) 2016-06-30
EP2513107A1 (en) 2012-10-24
HK1177208A1 (en) 2013-08-16
JP5901535B2 (ja) 2016-04-13
WO2011072694A1 (en) 2011-06-23
ZA201204419B (en) 2013-08-28
SG181674A1 (en) 2012-07-30
DK2513107T3 (da) 2014-10-13
IL220327A (en) 2014-12-31

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