CY1115536T1 - NEW HYDROXY-6-Heteroarylphenylhydrides and their use as PDE4 inhibitors - Google Patents

NEW HYDROXY-6-Heteroarylphenylhydrides and their use as PDE4 inhibitors

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Publication number
CY1115536T1
CY1115536T1 CY20141100722T CY141100722T CY1115536T1 CY 1115536 T1 CY1115536 T1 CY 1115536T1 CY 20141100722 T CY20141100722 T CY 20141100722T CY 141100722 T CY141100722 T CY 141100722T CY 1115536 T1 CY1115536 T1 CY 1115536T1
Authority
CY
Cyprus
Prior art keywords
pde4 inhibitors
heteroarylphenylhydrides
hydrogen
new hydroxy
enantiomer
Prior art date
Application number
CY20141100722T
Other languages
Greek (el)
Inventor
Ulrich Kautz
Beate Schmidt
Dieter Flockerzi
Armin Hatzelmann
Christof Zitt
Johannes Barsig
Degenhard Marx
Hans-Peter Kley
Original Assignee
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Gmbh filed Critical Takeda Gmbh
Publication of CY1115536T1 publication Critical patent/CY1115536T1/en

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Abstract

Ενώσεις του τύπου I όπου το R1 είναι μεθόξυ, το R2 είναι μεθόξυ, αιθόξυ, διφθορομεθόξυ ή 2,2-διφθοροαιθόξυ, το R3 είναι υδρογόνο, το R31 είναι υδρογόνο, το R4 είναι -Ο-R41, όπου το R41 είναι υδρογόνο, το R5 είναι υδρογόνο, το Har είναι υποκατεστημένο με R6 και R7 και είναι πυριδινύλ, όπου το R6 είναι όξο και το R7 είναι μεθύλ ή εναντιομερές, άλας, Ν-οξείδιο ή άλας ενός εναντιομερούς ή Ν-οξειδίου αυτών είναι νέοι αποτελεσματικοί αναστολείς PDE4.Compounds of formula I wherein R1 is methoxy, R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy, R3 is hydrogen, R31 is hydrogen, R4 is -O-R41, where R41 is hydrogen, R5 is hydrogen, Har is substituted with R6 and R7 and is pyridinyl, where R6 is oxo and R7 is methyl or enantiomer, salt, N-oxide or salt of an enantiomer or N-oxide thereof are novel effective PDE4 inhibitors.

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