Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09740245.7Aexternal-prioritypatent/EP2350071B1/en
Application filed by Array Biopharma, Inc.filedCriticalArray Biopharma, Inc.
Publication of CY1115008T1publicationCriticalpatent/CY1115008T1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Οι ενώσεις του Τύπου (I), όπου τα R1, R2, R3, R4, Χ, Υ και n έχουν τις σημασίες που δίνονται στην περιγραφή, είναι αναστολείς των Trk κινασών και είναι χρήσιμες στην αντιμετώπιση των νόσων, οι οποίες μπορούν να αντιμετωπιστούν με έναν αναστολέα της Trk κινάσης.The compounds of Formula (I), wherein R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases, which may be treated with a Trk kinase inhibitor.
DERIVATIVES OF N- (HETERO) ARIL-PIRROLIDINA DE PIRAZO-4-IL-PIRROLO [2,3-D] PIRIMIDINES AND PIRROL-3-IL-PIRROLO [2,3-D] PYRIMIDINES AS IHNIBITORS OF THE JANUS KINASE