CY1114107T1 - Συνθεσεις και μεθοδοι για την ανιχνευση ιικων ειδικων πυρηνικων οξεων σε ουρα - Google Patents

Συνθεσεις και μεθοδοι για την ανιχνευση ιικων ειδικων πυρηνικων οξεων σε ουρα

Info

Publication number
CY1114107T1
CY1114107T1 CY20131100547T CY131100547T CY1114107T1 CY 1114107 T1 CY1114107 T1 CY 1114107T1 CY 20131100547 T CY20131100547 T CY 20131100547T CY 131100547 T CY131100547 T CY 131100547T CY 1114107 T1 CY1114107 T1 CY 1114107T1
Authority
CY
Cyprus
Prior art keywords
methods
nuclear
viruses
urine
viral
Prior art date
Application number
CY20131100547T
Other languages
English (en)
Inventor
Hovsep Melkonyan
Angela Cannas
Louis David Tomei
Samuil R Umansky
Original Assignee
Trovagene, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/137,935 external-priority patent/US7973154B2/en
Priority claimed from EP06748221A external-priority patent/EP1856295B1/en
Application filed by Trovagene, Inc. filed Critical Trovagene, Inc.
Publication of CY1114107T1 publication Critical patent/CY1114107T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με μεθόδους για την διάγνωση ή επιτήρηση ιικής λοίμωξης ανιχνεύοντας την παρουσία διανεφρικών ιικών πυρηνικών οξέων ή πυρηνικών οξέων ιικής προέλευσης σε δείγμα ούρων, με ή χωρίς απομόνωση των πυρηνικών οξέων από δείγμα ούρων. Η ανάλυση των πυρηνικών οξέων πραγματοποιείται μέσω υβριδοποίησης των πυρηνικών οξέων με ειδικούς ιχνηθέτες, ή μέσω αντίδρασης ενίσχυσης αλύσων με ειδικούς εκκινητές. Οι μέθοδοι είναι εφαρμόσιμες σε όλους τους ιικούς παθογόνους παράγοντες, που συμπεριλαμβάνουν ιούς RΝΑ, DΝΑ, επισωματικούς, ή ενσωματωμένους ιούς.
CY20131100547T 2005-02-17 2013-07-03 Συνθεσεις και μεθοδοι για την ανιχνευση ιικων ειδικων πυρηνικων οξεων σε ουρα CY1114107T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000068A ITRM20050068A1 (it) 2005-02-17 2005-02-17 Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
US11/137,935 US7973154B2 (en) 2005-02-17 2005-05-25 Kits for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine
EP06748221A EP1856295B1 (en) 2005-02-17 2006-02-16 Compositions and methods for detecting viral specific nucleic acids in urine

Publications (1)

Publication Number Publication Date
CY1114107T1 true CY1114107T1 (el) 2016-07-27

Family

ID=36763294

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100547T CY1114107T1 (el) 2005-02-17 2013-07-03 Συνθεσεις και μεθοδοι για την ανιχνευση ιικων ειδικων πυρηνικων οξεων σε ουρα

Country Status (10)

Country Link
US (1) US7803929B2 (el)
JP (2) JP5281293B2 (el)
CN (2) CN103045758A (el)
CY (1) CY1114107T1 (el)
DK (1) DK1856295T3 (el)
ES (1) ES2410598T3 (el)
HK (1) HK1110903A1 (el)
IT (1) ITRM20050068A1 (el)
PT (1) PT1856295E (el)
SI (1) SI1856295T1 (el)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20050067A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine.
US7914982B2 (en) * 2005-02-17 2011-03-29 Trovagene, Inc. Methods for detecting pathogen specific nucleic acids in urine
EP2195450B2 (en) * 2007-08-22 2016-07-20 TrovaGene, Inc. Methods of using mirna for detection of in vivo cell death
US9315802B2 (en) 2009-12-30 2016-04-19 Quest Diagnostics Investments Incorporated RNA isolation from soluble urine fractions
US20120141992A1 (en) * 2010-12-01 2012-06-07 Program For Appropriate Technology In Health Compositions and methods for trichomonas vaginalis diagnostic testing
WO2012092490A1 (en) 2010-12-30 2012-07-05 Quest Diagnostics Investments Incorporated Diagnosis of prostate cancer
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
CN103796987B (zh) 2011-06-08 2016-09-21 生命技术公司 用于pcr***的新型去污剂的设计和开发
WO2012170907A2 (en) 2011-06-08 2012-12-13 Life Technologies Corporation Polymerization of nucleic acids using proteins having low isoelectric points
CA2839693A1 (en) 2011-06-19 2012-12-27 Abogen, Inc. Devices, solutions and methods for sample collection
US10501791B2 (en) 2011-10-14 2019-12-10 President And Fellows Of Harvard College Sequencing by structure assembly
ES2953308T3 (es) 2011-12-22 2023-11-10 Harvard College Composiciones y métodos para la detección de analitos
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
KR20220061271A (ko) 2012-09-04 2022-05-12 가던트 헬쓰, 인크. 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP2971184B1 (en) 2013-03-12 2019-04-17 President and Fellows of Harvard College Method of generating a three-dimensional nucleic acid containing matrix
MY197877A (en) 2013-06-04 2023-07-22 Harvard College Rna-guided transcriptional regulation
WO2015061714A1 (en) 2013-10-25 2015-04-30 Life Technologies Corporation Novel compounds for use in pcr systems and applications thereof
BR112016010095A2 (pt) 2013-11-07 2017-09-12 Univ Leland Stanford Junior ácidos nucleicos de célula livre para a ánalise de microbioma humano e componentes do mesmos.
ES2660989T3 (es) 2013-12-28 2018-03-27 Guardant Health, Inc. Métodos y sistemas para detectar variantes genéticas
AU2015268067A1 (en) 2014-05-27 2016-12-22 Dna Genotek Inc. Composition and method for stabilizing and maintaining the viability of hardy microorganisms
CN106716140B (zh) 2014-07-11 2020-01-10 雅培分子公司 用于干斑的自动化hiv-1病毒载量测试程序
EP3169813B1 (en) 2014-07-18 2019-06-12 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in dna mixture
CN104195134A (zh) * 2014-09-18 2014-12-10 宁波有成生物医药科技有限公司 一种从尿液中提取核酸的试剂盒及提取方法
WO2016187234A1 (en) * 2015-05-18 2016-11-24 Karius, Inc. Compositions and methods for enriching populations of nucleic acids
GB2559526B (en) 2015-11-03 2021-02-17 Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
SG11201805119QA (en) 2015-12-17 2018-07-30 Guardant Health Inc Methods to determine tumor gene copy number by analysis of cell-free dna
MX2018011429A (es) 2016-03-25 2019-06-06 Karius Inc Añadiduras de ácidos nucleicos sintéticos.
WO2017181146A1 (en) 2016-04-14 2017-10-19 Guardant Health, Inc. Methods for early detection of cancer
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
CA3022290A1 (en) 2016-04-25 2017-11-02 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
WO2018045186A1 (en) 2016-08-31 2018-03-08 President And Fellows Of Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
GB2570412A (en) 2016-08-31 2019-07-24 Harvard College Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
JP6560465B1 (ja) 2016-09-30 2019-08-21 ガーダント ヘルス， インコーポレイテッド 無細胞核酸の多重解像度分析のための方法
JP2020503003A (ja) * 2016-11-30 2020-01-30 ザ チャイニーズ ユニバーシティ オブ ホンコン 尿および他のサンプルにおける無細胞ｄｎａの分析
WO2018191563A1 (en) 2017-04-12 2018-10-18 Karius, Inc. Sample preparation methods, systems and compositions
WO2019178157A1 (en) 2018-03-16 2019-09-19 Karius, Inc. Sample series to differentiate target nucleic acids from contaminant nucleic acids
CN112770776A (zh) 2018-07-30 2021-05-07 瑞德库尔有限责任公司 用于样品处理或分析的方法和***
CA3126428A1 (en) 2019-01-31 2020-08-06 Guardant Health, Inc. Compositions and methods for isolating cell-free dna
KR102286565B1 (ko) * 2020-01-13 2021-08-05 대한민국 소변에서 결핵균 trDNA 추출용 올리고머
RU2759232C1 (ru) * 2021-01-20 2021-11-11 Федеральное государственное бюджетное учреждение "Государственный научный центр дерматовенерологии и косметологии" Министерства здравоохранения Российской Федерации Способ оценки эффективности терапии лепры с использованием полимеразной цепной реакции для амплификации видоспецифичных участков геномов лепры, человека или мыши

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856088A (en) 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US5168039A (en) * 1990-09-28 1992-12-01 The Board Of Trustees Of The University Of Arkansas Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
WO1995004140A1 (en) 1993-07-28 1995-02-09 Akzo Nobel N.V. Process for isolating nucleic acid from gram positive microorganisms
US5631130A (en) * 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
WO1995033851A2 (en) * 1994-06-09 1995-12-14 Innogenetics N.V. Method for the detection of the antibiotic resistance spectrum of mycobacterium species
US5731150A (en) * 1995-11-01 1998-03-24 Chiron Diagnostic Corporation IS6110 based molecular detection of mycobacterium tuberculosis
US6027945A (en) * 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
US6492144B1 (en) 1997-05-30 2002-12-10 Diagen Corporation Methods for detection of nucleic acid sequences in urine
US20020119478A1 (en) 1997-05-30 2002-08-29 Diagen Corporation Methods for detection of nucleic acid sequences in urine
AU7703998A (en) 1997-05-30 1998-12-30 Lxr Biotechnology Inc. Methods for detection of nucleic acid sequences in urine
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
AU1600000A (en) * 1998-10-28 2000-05-15 Covaris, Inc. Apparatus and methods for controlling sonic treatment
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US20040053264A1 (en) 2002-02-01 2004-03-18 Park Sung Sup Clinical panel assay using DNA chips
WO2006088895A2 (en) 2005-02-17 2006-08-24 Istituto Nazionale Per Le Malattie Infettive Irccs Lazzaro Spallanzani Compositions and methods for detecting pathogen specific nucleic acids in urine
CA2597948A1 (en) 2005-02-17 2006-08-24 Istituto Nazionale Per Le Malattie Infettive Irccs Lazzaro Spallanzani Compositions and methods for detecting viral specific nucleic acids in urine
ITRM20050067A1 (it) * 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine.
US7914982B2 (en) 2005-02-17 2011-03-29 Trovagene, Inc. Methods for detecting pathogen specific nucleic acids in urine

Also Published As

Publication number Publication date
ITRM20050068A1 (it) 2006-08-18
CN101253273B (zh) 2013-08-28
DK1856295T3 (da) 2013-07-01
CN101253273A (zh) 2008-08-27
JP2008536481A (ja) 2008-09-11
US20060183107A1 (en) 2006-08-17
HK1110903A1 (en) 2008-07-25
PT1856295E (pt) 2013-07-10
ES2410598T3 (es) 2013-07-02
US7803929B2 (en) 2010-09-28
JP5281293B2 (ja) 2013-09-04
JP2013143946A (ja) 2013-07-25
SI1856295T1 (sl) 2013-08-30
CN103045758A (zh) 2013-04-17

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