CY1113205T1 - Μεθοδος για ρυθμιση ενεργοποιησης μακροφαγου - Google Patents
Μεθοδος για ρυθμιση ενεργοποιησης μακροφαγουInfo
- Publication number
- CY1113205T1 CY1113205T1 CY20121100954T CY121100954T CY1113205T1 CY 1113205 T1 CY1113205 T1 CY 1113205T1 CY 20121100954 T CY20121100954 T CY 20121100954T CY 121100954 T CY121100954 T CY 121100954T CY 1113205 T1 CY1113205 T1 CY 1113205T1
- Authority
- CY
- Cyprus
- Prior art keywords
- macrofag
- activation
- regulation
- macrophage activation
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
Ανιονικές ενώσεις, που συμπεριλαμβάνουν σουλφονικά είναι ικανές αναστολής διεγειρόμενης από Αβ ενεργοποίησης μακροφάγου (ή ενεργοποίηση μακροφάγου που διεγείρεται από άλλες αμυλοειδογονικές πρωτεΐνες ή πεπτίδια). Τέτοιες ενώσεις μπορεί να αναστέλλουν τη φλεγμονώδη διεργασία, π.χ., εγκέφαλο ενός υποκειμένου που υποφέρει από μια ασθένεια που χαρακτηρίζεται από απόθεση Αβ, όπως ασθένεια Alzheimer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7429598P | 1998-02-11 | 1998-02-11 | |
US24839699A | 1999-02-10 | 1999-02-10 | |
EP99903869A EP1054664B1 (en) | 1998-02-11 | 1999-02-11 | Method for modulating macrophage activation |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113205T1 true CY1113205T1 (el) | 2016-04-13 |
Family
ID=26755484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100954T CY1113205T1 (el) | 1998-02-11 | 2012-10-16 | Μεθοδος για ρυθμιση ενεργοποιησης μακροφαγου |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1054664B1 (el) |
JP (1) | JP4574845B2 (el) |
AU (1) | AU2437899A (el) |
CA (2) | CA2632106A1 (el) |
CY (1) | CY1113205T1 (el) |
DK (1) | DK1054664T3 (el) |
ES (1) | ES2392391T3 (el) |
HK (1) | HK1032915A1 (el) |
IL (1) | IL137751A0 (el) |
MX (2) | MX2008014823A (el) |
NZ (2) | NZ568553A (el) |
PT (1) | PT1054664E (el) |
WO (1) | WO1999040909A1 (el) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5605938A (en) | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
AU3726299A (en) * | 1998-05-15 | 1999-12-06 | Neurochem, Inc. | Use of amyloid inhibitors for modulating neuronal cell death |
US6310073B1 (en) | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
DE60042896D1 (de) * | 1999-04-28 | 2009-10-15 | Bellus Health Int Ltd | Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten |
AU5994900A (en) * | 1999-07-09 | 2001-01-30 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
EP1251837A2 (en) * | 1999-12-23 | 2002-10-30 | Neurochem, Inc. | Compounds and methods for modulating cerebral amyloid angiopathy |
US7105336B2 (en) * | 2002-10-07 | 2006-09-12 | Biogaia Ab | Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter |
WO2004058239A1 (en) * | 2002-12-24 | 2004-07-15 | Neurochem (International) Limited | Therapeutic formulations for the treatment of beta-amyloid related diseases |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
US20050142191A1 (en) * | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
US7253306B2 (en) | 2003-06-23 | 2007-08-07 | Neurochem (International) Limited | Pharmaceutical drug candidates and methods for preparation thereof |
EP1646659B1 (en) * | 2003-06-23 | 2014-05-14 | Kiacta Sàrl | Method for the preparation of 1,3-propane disulfonic acid compounds |
WO2006085149A2 (en) | 2004-12-22 | 2006-08-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
TW200716088A (en) * | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
PL2289909T3 (pl) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał |
CN102898519B (zh) | 2005-11-30 | 2015-10-28 | Abbvie公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
EP1968561B8 (en) | 2005-12-22 | 2010-10-20 | Kiacta Sàrl | Treatment of diabetic nephropathy |
DK2089417T3 (en) | 2006-10-12 | 2015-03-23 | Bhi Ltd Partnership | Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
WO2009048539A2 (en) | 2007-10-05 | 2009-04-16 | Genentech, Inc. | Monoclonal antibody |
JP2012517822A (ja) * | 2009-02-19 | 2012-08-09 | ガラパゴス・ナムローゼ・フェンノートシャップ | 炎症を包含する疾患の診断及び治療に有用な同定方法及び化合物 |
SG10202100421XA (en) * | 2009-09-17 | 2021-02-25 | Bespoke Bioscience Llc | Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury |
EP2558494B1 (en) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta binding proteins |
NZ606357A (en) | 2010-07-30 | 2015-05-29 | Genentech Inc | Safe and functional humanized anti beta-amyloid antibody |
US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
WO2016163886A2 (en) * | 2015-04-10 | 2016-10-13 | Clues2Cure International B.V. | Administration of taurine or an analog thereof for the treatment of nerve cell damage |
CN109381452A (zh) * | 2017-08-11 | 2019-02-26 | 江西青峰药业有限公司 | 乙基硫酸类化合物的应用及其制备方法 |
CN109381453A (zh) * | 2017-08-14 | 2019-02-26 | 江西青峰药业有限公司 | 乙基硫酸钾在制备用于预防或治疗炎症性疾病药物中的应用 |
CN109394746A (zh) * | 2017-08-15 | 2019-03-01 | 江西青峰药业有限公司 | 乙基硫酸铵在制备用于预防或治疗炎症性疾病药物中的应用 |
WO2023212289A1 (en) | 2022-04-28 | 2023-11-02 | Alzheon, Inc. | Tramiprosate for treating apoe4-related diseases |
WO2024119183A1 (en) | 2022-12-02 | 2024-06-06 | Alzheon, Inc. | Methods for treating neurodegenerative disorders with tramiprosate |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1144937A (en) * | 1977-12-22 | 1983-04-19 | Dke J.E. Helgstrand | Aromatic derivatives, pharmaceutical compositions and methods for combatting virus infections |
US5087618A (en) * | 1982-05-18 | 1992-02-11 | University Of Florida | Redox carriers for brain-specific drug delivery |
US5463092A (en) * | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
US5276059A (en) * | 1992-07-10 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of diseases associated with amyloid formation |
US5840294A (en) * | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
EP1614416A3 (en) * | 1993-03-29 | 2009-07-01 | BELLUS Health (International) Limited | Method for treating amyloidosis |
US5869469A (en) * | 1997-08-18 | 1999-02-09 | Queen's University At Kingston | Phosphonocarboxylate compounds for treating amyloidosis |
IL134619A0 (en) * | 1997-08-18 | 2001-04-30 | Univ Kingston | Phosphono-carboxylate compounds for treating amyloidosis |
-
1999
- 1999-02-11 MX MX2008014823A patent/MX2008014823A/es active IP Right Grant
- 1999-02-11 IL IL13775199A patent/IL137751A0/xx not_active IP Right Cessation
- 1999-02-11 DK DK99903869.8T patent/DK1054664T3/da active
- 1999-02-11 ES ES99903869T patent/ES2392391T3/es not_active Expired - Lifetime
- 1999-02-11 CA CA002632106A patent/CA2632106A1/en not_active Abandoned
- 1999-02-11 NZ NZ568553A patent/NZ568553A/en unknown
- 1999-02-11 JP JP2000531161A patent/JP4574845B2/ja not_active Expired - Lifetime
- 1999-02-11 WO PCT/IB1999/000354 patent/WO1999040909A1/en active Application Filing
- 1999-02-11 MX MXPA00007815A patent/MXPA00007815A/es active IP Right Grant
- 1999-02-11 AU AU24378/99A patent/AU2437899A/en not_active Abandoned
- 1999-02-11 PT PT99903869T patent/PT1054664E/pt unknown
- 1999-02-11 CA CA002320224A patent/CA2320224C/en not_active Expired - Lifetime
- 1999-02-11 NZ NZ550199A patent/NZ550199A/en not_active IP Right Cessation
- 1999-02-11 EP EP99903869A patent/EP1054664B1/en not_active Expired - Lifetime
-
2001
- 2001-05-24 HK HK01103601.4A patent/HK1032915A1/xx not_active IP Right Cessation
-
2012
- 2012-10-16 CY CY20121100954T patent/CY1113205T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2320224A1 (en) | 1999-08-19 |
MX2008014823A (es) | 2009-03-06 |
JP2002502871A (ja) | 2002-01-29 |
CA2632106A1 (en) | 1999-08-19 |
PT1054664E (pt) | 2012-11-02 |
NZ568553A (en) | 2010-02-26 |
MXPA00007815A (es) | 2002-04-24 |
ES2392391T3 (es) | 2012-12-10 |
AU2437899A (en) | 1999-08-30 |
WO1999040909A1 (en) | 1999-08-19 |
EP1054664B1 (en) | 2012-08-08 |
CA2320224C (en) | 2008-08-12 |
EP1054664A1 (en) | 2000-11-29 |
NZ550199A (en) | 2008-07-31 |
JP4574845B2 (ja) | 2010-11-04 |
DK1054664T3 (da) | 2012-11-05 |
HK1032915A1 (en) | 2001-08-10 |
IL137751A0 (en) | 2001-10-31 |
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